JP2023519931A5 - - Google Patents

Info

Publication number
JP2023519931A5
JP2023519931A5 JP2022559338A JP2022559338A JP2023519931A5 JP 2023519931 A5 JP2023519931 A5 JP 2023519931A5 JP 2022559338 A JP2022559338 A JP 2022559338A JP 2022559338 A JP2022559338 A JP 2022559338A JP 2023519931 A5 JP2023519931 A5 JP 2023519931A5
Authority
JP
Japan
Prior art keywords
subunit
pp2a
amino
agent according
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022559338A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023519931A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/025230 external-priority patent/WO2021202780A2/en
Publication of JP2023519931A publication Critical patent/JP2023519931A/ja
Publication of JP2023519931A5 publication Critical patent/JP2023519931A5/ja
Pending legal-status Critical Current

Links

JP2022559338A 2020-04-01 2021-03-31 癌を治療するための方法及び組成物 Pending JP2023519931A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003736P 2020-04-01 2020-04-01
US63/003,736 2020-04-01
PCT/US2021/025230 WO2021202780A2 (en) 2020-04-01 2021-03-31 Methods and compositions for treating cancer

Publications (2)

Publication Number Publication Date
JP2023519931A JP2023519931A (ja) 2023-05-15
JP2023519931A5 true JP2023519931A5 (enExample) 2024-04-19

Family

ID=77927411

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022559338A Pending JP2023519931A (ja) 2020-04-01 2021-03-31 癌を治療するための方法及び組成物

Country Status (9)

Country Link
US (1) US20230149415A1 (enExample)
EP (1) EP4127722A4 (enExample)
JP (1) JP2023519931A (enExample)
KR (1) KR20230017167A (enExample)
CN (1) CN115769077A (enExample)
AU (1) AU2021249111A1 (enExample)
CA (1) CA3173799A1 (enExample)
MX (1) MX2022012181A (enExample)
WO (1) WO2021202780A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240398799A1 (en) * 2021-08-19 2024-12-05 Engine Biosciences Pte. Ltd. Compositions and methods for generating synthetic lethality in tumors
WO2023177356A2 (en) * 2022-03-18 2023-09-21 Engine Biosciences Pte. Ltd. Compounds and method for pkmyt1 inhibition
KR20250136774A (ko) * 2024-03-08 2025-09-16 보로노이 주식회사 헤테로아릴 유도체 화합물 및 이의 용도
WO2025215187A1 (en) 2024-04-11 2025-10-16 My-T Bio Limited Therapeutic compounds and their use
WO2025215188A1 (en) 2024-04-11 2025-10-16 My-T Bio Limited Therapeutic compounds and their use as inhibitors of pkmyt1
WO2025242880A1 (en) 2024-05-24 2025-11-27 My-T Bio Limited Therapeutic compounds and their use
WO2026057597A1 (en) 2024-09-10 2026-03-19 My-T Bio Limited Pkmyt1 inhibitors and their use
WO2026057598A1 (en) 2024-09-10 2026-03-19 My-T Bio Limited Therapeutic compounds as pkmyt1 inhibitors and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002607A1 (en) * 2007-05-01 2008-12-31 Dana-Farber Cancer Institute, Inc. Compositions and methods for identifying transforming and tumor suppressor genes
RS56680B1 (sr) * 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
EP3313819A1 (en) * 2015-06-23 2018-05-02 Case Western Reserve University Compositions and methods for treating cancer

Similar Documents

Publication Publication Date Title
JP2023519931A5 (enExample)
Maira et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Baillache et al. Recent developments in anticancer kinase inhibitors based on the pyrazolo [3, 4-d] pyrimidine scaffold
Apsel et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
US11701353B2 (en) Methods, compositions, and uses of novel FYN kinase inhibitors
Ihle et al. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
Chang et al. Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine790→ methionine790 mutant
J Shuttleworth et al. Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors
Gupta et al. Medical management of meningioma in the era of precision medicine
EP4045047A1 (en) Combination therapy of kras inhibitor and shp2 inhibitor for treatment of cancers
WO2021126816A1 (en) Dosing regimen of a kras g12c inhibitor
Wang et al. Synthesis and biological activity of 6-substituted pyrrolo [2, 3-d] pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier
KR20100055423A (ko) Fab 관련 질환의 치료에 사용하기 위한 푸린 유도체
CA2406278A1 (en) Inhibitors of human phosphatidyl-inositol 3-kinase delta
Patel et al. 2, 4, 6-Triaminopyrimidine as a novel hinge binder in a series of PI3Kδ selective inhibitors
AU2004312049A1 (en) Treatment of malignant gliomas with TFG-beta inhibitors
CN105611933A (zh) 抗增生性化合物
EA035391B1 (ru) Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы
Gustin et al. The PIK3CA gene as a mutated target for cancer therapy
Kong et al. In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA
US20160303137A1 (en) Dual pi3k and wnt pathway inhibition as a treatment for cancer
WO2016193955A1 (en) Combinations of kinase inhibitors for treating colorectal cancer
EP3325100A1 (en) Combination therapy using pdk1 and pi3k inhibitors
Abdelhamed et al. Pyrazolopyrimidines: a promising frontier in cancer treatment‐reviewing their potential as inhibitors of serine/threonine kinases
Zhang et al. Discovery and optimization of a series of novel morpholine-containing USP1 inhibitors