JP2023518930A - Gpc3 car-t細胞組成物、並びにそれを作製する方法及び使用する方法 - Google Patents
Gpc3 car-t細胞組成物、並びにそれを作製する方法及び使用する方法 Download PDFInfo
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- JP2023518930A JP2023518930A JP2022555955A JP2022555955A JP2023518930A JP 2023518930 A JP2023518930 A JP 2023518930A JP 2022555955 A JP2022555955 A JP 2022555955A JP 2022555955 A JP2022555955 A JP 2022555955A JP 2023518930 A JP2023518930 A JP 2023518930A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K2207/00—Modified animals
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K2267/03—Animal model, e.g. for test or diseases
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/53—Liver
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062991493P | 2020-03-18 | 2020-03-18 | |
| US62/991,493 | 2020-03-18 | ||
| US202063004827P | 2020-04-03 | 2020-04-03 | |
| US63/004,827 | 2020-04-03 | ||
| US202063043237P | 2020-06-24 | 2020-06-24 | |
| US63/043,237 | 2020-06-24 | ||
| PCT/IB2021/052294 WO2021186397A1 (en) | 2020-03-18 | 2021-03-18 | Gpc3 car-t cell compositions and methods of making and using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023518930A true JP2023518930A (ja) | 2023-05-09 |
| JPWO2021186397A5 JPWO2021186397A5 (https=) | 2024-03-29 |
| JP2023518930A5 JP2023518930A5 (https=) | 2024-03-29 |
Family
ID=77768047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022555955A Pending JP2023518930A (ja) | 2020-03-18 | 2021-03-18 | Gpc3 car-t細胞組成物、並びにそれを作製する方法及び使用する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230146706A1 (https=) |
| EP (1) | EP4121516A4 (https=) |
| JP (1) | JP2023518930A (https=) |
| CN (1) | CN115667500B (https=) |
| WO (1) | WO2021186397A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| JP7778081B2 (ja) * | 2020-03-18 | 2025-12-01 | ユーティレックス カンパニー リミテッド | Il-18を分泌するgpc3 car-t細胞、並びにそれを作製する方法及び使用する方法 |
| EP4308133A4 (en) | 2021-03-17 | 2025-01-22 | Myeloid Therapeutics, Inc. | MANIPULATED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2025183436A1 (ko) * | 2024-02-27 | 2025-09-04 | (주)이노베이션바이오 | Gpc3을 표적으로 하는 키메릭 항원 수용체 및 cd276을 표적으로 하는 키메릭 항원 수용체를 발현하는 면역 이펙터 세포 및 이의 용도 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523518A (ja) * | 2013-05-08 | 2016-08-12 | 科済生物医薬(上海)有限公司 | Gpc3キメラ抗原受容体蛋白質をコードする核酸及びgpc3キメラ抗原受容体蛋白質を発現するtリンパ球 |
| WO2017002934A1 (ja) * | 2015-07-01 | 2017-01-05 | 中外製薬株式会社 | Gpc3標的治療剤が有効である患者に投与されるgpc3標的治療剤 |
| JP2017529851A (ja) * | 2014-09-26 | 2017-10-12 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 養子免疫療法のためのグリピカン−3特異的キメラ抗原レセプター |
| JP2019530431A (ja) * | 2016-07-26 | 2019-10-24 | テッサ・セラピューティクス・プライベート・リミテッド | キメラ抗原受容体 |
| WO2020017479A1 (ja) * | 2018-07-17 | 2020-01-23 | ノイルイミューン・バイオテック株式会社 | 抗gpc3一本鎖抗体を含むcar |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1842540B (zh) * | 2004-07-09 | 2012-07-04 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
| CN101068836B (zh) * | 2004-10-26 | 2013-08-14 | 中外制药株式会社 | 糖链改变的抗磷脂酰肌醇聚糖3抗体 |
| CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
| CN105713881B (zh) * | 2014-12-04 | 2019-12-06 | 科济生物医药(上海)有限公司 | 双靶向gpc3和asgpr1的转基因免疫效应细胞及其应用 |
| BR112019013947A2 (pt) * | 2017-01-10 | 2020-02-11 | Yamaguchi University | Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3. |
| EP3829312A4 (en) * | 2018-08-04 | 2022-07-06 | Abcyte Therapeutics Inc. | MULTIFUNCTIONAL AND MULTI-TARGETING CAR SYSTEM AND METHODS OF USE |
| CN111116743B (zh) * | 2018-10-30 | 2022-01-28 | 迈威(上海)生物科技股份有限公司 | Hsp90抗体及其在抗真菌感染中的应用 |
-
2021
- 2021-03-18 EP EP21771035.9A patent/EP4121516A4/en active Pending
- 2021-03-18 WO PCT/IB2021/052294 patent/WO2021186397A1/en not_active Ceased
- 2021-03-18 JP JP2022555955A patent/JP2023518930A/ja active Pending
- 2021-03-18 CN CN202180029132.5A patent/CN115667500B/zh active Active
- 2021-03-18 US US17/906,718 patent/US20230146706A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016523518A (ja) * | 2013-05-08 | 2016-08-12 | 科済生物医薬(上海)有限公司 | Gpc3キメラ抗原受容体蛋白質をコードする核酸及びgpc3キメラ抗原受容体蛋白質を発現するtリンパ球 |
| JP2017529851A (ja) * | 2014-09-26 | 2017-10-12 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 養子免疫療法のためのグリピカン−3特異的キメラ抗原レセプター |
| WO2017002934A1 (ja) * | 2015-07-01 | 2017-01-05 | 中外製薬株式会社 | Gpc3標的治療剤が有効である患者に投与されるgpc3標的治療剤 |
| JP2019530431A (ja) * | 2016-07-26 | 2019-10-24 | テッサ・セラピューティクス・プライベート・リミテッド | キメラ抗原受容体 |
| WO2020017479A1 (ja) * | 2018-07-17 | 2020-01-23 | ノイルイミューン・バイオテック株式会社 | 抗gpc3一本鎖抗体を含むcar |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4121516A4 (en) | 2024-06-05 |
| CN115667500A (zh) | 2023-01-31 |
| KR20220155588A (ko) | 2022-11-23 |
| WO2021186397A1 (en) | 2021-09-23 |
| EP4121516A1 (en) | 2023-01-25 |
| US20230146706A1 (en) | 2023-05-11 |
| CN115667500B (zh) | 2026-02-06 |
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