JP2023505513A - カンナビノイド誘導体 - Google Patents

カンナビノイド誘導体 Download PDF

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Publication number
JP2023505513A
JP2023505513A JP2022534425A JP2022534425A JP2023505513A JP 2023505513 A JP2023505513 A JP 2023505513A JP 2022534425 A JP2022534425 A JP 2022534425A JP 2022534425 A JP2022534425 A JP 2022534425A JP 2023505513 A JP2023505513 A JP 2023505513A
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JP
Japan
Prior art keywords
alkyl
compound
hydrogen
bis
dien
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JP2022534425A
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Japanese (ja)
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JP2023505513A5 (https=
JPWO2021113958A5 (https=
Inventor
アラン オメーラ，ジェフリー
フィ ト，クアン
Original Assignee
キャノピー グロウス コーポレイション
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Publication of JP2023505513A publication Critical patent/JP2023505513A/ja
Publication of JP2023505513A5 publication Critical patent/JP2023505513A5/ja
Publication of JPWO2021113958A5 publication Critical patent/JPWO2021113958A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/303—Compounds having groups having acetal carbon atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/305—Compounds having groups having acetal carbon atoms as rings members or bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022534425A 2019-12-09 2020-11-27 カンナビノイド誘導体 Pending JP2023505513A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962945669P 2019-12-09 2019-12-09
US62/945,669 2019-12-09
US202063074603P 2020-09-04 2020-09-04
US63/074,603 2020-09-04
US202063112970P 2020-11-12 2020-11-12
US63/112,970 2020-11-12
PCT/CA2020/051638 WO2021113958A1 (en) 2019-12-09 2020-11-27 Cannabinoid derivatives

Publications (3)

Publication Number Publication Date
JP2023505513A true JP2023505513A (ja) 2023-02-09
JP2023505513A5 JP2023505513A5 (https=) 2023-11-22
JPWO2021113958A5 JPWO2021113958A5 (https=) 2023-11-22

Family

ID=76329189

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022534425A Pending JP2023505513A (ja) 2019-12-09 2020-11-27 カンナビノイド誘導体

Country Status (4)

Country Link
US (1) US20230059582A1 (https=)
EP (1) EP4073033A4 (https=)
JP (1) JP2023505513A (https=)
WO (1) WO2021113958A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3997098A4 (en) 2019-07-12 2023-10-11 Canopy Growth Corporation CANNABINOIDS DERIVATIVES
WO2021007663A1 (en) 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives
JP2022540586A (ja) 2019-07-12 2022-09-16 キャノピー グロウス コーポレイション カンナビノイド誘導体
WO2021062559A1 (en) 2019-10-02 2021-04-08 Canopy Growth Corporation Cannabinoid derivatives
EP4065554A4 (en) 2019-11-26 2024-01-10 Canopy Growth Corporation CANNABIGEROL DERIVATIVES AND THEIR USE AS CANNABINOID RECEPTOR MODULATORS
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
TWI894435B (zh) * 2021-02-26 2025-08-21 日商丸善石油化學股份有限公司 縮醛化合物、含有該化合物之添加劑及含有該化合物之阻劑用組成物
AU2022324615A1 (en) * 2021-08-04 2024-02-15 Demeetra Agbio, Inc. Cannabinoid derivatives and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505519A (ja) * 2001-07-23 2005-02-24 ガリレオ ファーマシューティカルズ， インコーポレイテッド 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法
JP2009539961A (ja) * 2006-06-15 2009-11-19 ジーダブリュー・ファーマ・リミテッド カンナビゲロールを含有する医薬組成物のうつ病の治療のための使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098287A1 (en) * 2008-02-06 2009-08-13 Noscira S.A. Phenyl-prenyl derivatives, of marine and synthetic origin, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
CA3119729A1 (en) * 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005505519A (ja) * 2001-07-23 2005-02-24 ガリレオ ファーマシューティカルズ， インコーポレイテッド 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法
JP2009539961A (ja) * 2006-06-15 2009-11-19 ジーダブリュー・ファーマ・リミテッド カンナビゲロールを含有する医薬組成物のうつ病の治療のための使用

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHAKRAPANI, LAKKOJU: "First Total Synthesis of Mappain with a Prenylated and Geranylated Stilbene", HELVETICA CHIMICA ACTA, vol. 93(5), JPN7024003601, 2010, pages 829 - 836, ISSN: 0005407687 *
CHIARELLO, JACK: "Synthetic routes to cristatic acid and derivatives", TETRAHEDRON, vol. 44(1), JPN7024003598, 1988, pages 41 - 48, ISSN: 0005407684 *
EICHER, THEOPHIL: "Synthesis of bryophyte components. 2. Syntheses of prenylated bibenzyl derivatives", SYNTHESIS, vol. (1), JPN7024003599, 1991, pages 98 - 102, ISSN: 0005407685 *
IIKUBO, KAZUHIKO: "The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase", TETRAHEDRON LETTERS, vol. 43(2), JPN7024003596, 2002, pages 291 - 293, ISSN: 0005407682 *
KIM, TAEJUNG: "Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22(12), JPN7024003593, 2012, pages 4122 - 4126, ISSN: 0005407679 *
NONCOVICH, ALAIN: "Total synthesis of the novel benzophenone NP-011694", TETRAHEDRON LETTERS, vol. 56(33), JPN7024003595, 2015, pages 4836 - 4839, ISSN: 0005407681 *
RAIKAR, SANJAY B.: "Synthesis of polyprenylated benzoylphloroglucinols by regioselective prenylation of phloroglucinol i", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. (8), JPN7024003597, 2008, pages 1358 - 1369, ISSN: 0005407683 *
SAKAKURA, AKIRA: "Chiral Lewis base-assisted Bronsted acid (LBBA)-catalyzed enantioselective cyclization of 2-geranylp", ORGANIC LETTERS, vol. 13(12), JPN7024003600, 2011, pages 3130 - 3133, ISSN: 0005407686 *
STOCKDALE, DAVID P.: "Synthesis of amide isosteres of schweinfurthin-based stilbenes", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25(20), JPN7024003594, 2017, pages 5483 - 5489, ISSN: 0005407680 *

Also Published As

Publication number Publication date
EP4073033A4 (en) 2024-01-24
WO2021113958A1 (en) 2021-06-17
US20230059582A1 (en) 2023-02-23
EP4073033A1 (en) 2022-10-19

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