JP2023165175A - Composition for maintaining or improving masticatory function or promoting saliva excretion - Google Patents
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Abstract
Description
本発明は、咀嚼機能維持向上又は唾液分泌促進用組成物に関する。 The present invention relates to a composition for maintaining and improving masticatory function or promoting saliva secretion.
咀嚼とは、嚥下に適した性状に調整するために食物をかみ砕き、唾液と混ぜ合わせる栄養摂取行動の一部である。食物を小さな食片に粉砕することで、消化酵素が作用する表面積が増加するため、食物をよく咀嚼することは消化吸収を助ける。また、咀嚼時に分泌される唾液には消化液としてだけでなく、咀嚼により小さな断片にした食物を飲み込みやすい塊とする役割がある。さらに、唾液が食物から溶けだした化学成分の溶媒となるため、味蕾での味の知覚においても重要である。 Mastication is a part of nutritional intake behavior in which food is chewed and mixed with saliva in order to make it suitable for swallowing. Thoroughly chewing food aids in digestion and absorption, as breaking food into smaller pieces increases the surface area for digestive enzymes to work on. Furthermore, the saliva secreted during mastication not only acts as a digestive fluid, but also plays a role in turning food into small pieces that are easier to swallow. Saliva is also important in the perception of taste by the taste buds, as saliva acts as a solvent for chemical components dissolved in food.
近年、加齢とともに咀嚼機能が低下し、摂取可能な食品が減少することで栄養不足を招き、それが筋力の低下、ひいては全身の運動機能の低下につながるおそれがあるとされ、咀嚼機能を維持、又は向上させることの重要性が認識され始めている。また、加齢により唾液の分泌量が減少すると、消化吸収力が低下するだけでなく、嚥下が困難になり誤嚥を引き起こすリスクとなる。さらに、唾液の減少により味を感じにくくなるため食の楽しみが損なわれ、QOLにも影響を与えうる。 In recent years, it has been reported that masticatory function declines with age, leading to nutritional deficiencies due to a decrease in the amount of food that can be ingested. , or the importance of improving it is beginning to be recognized. Furthermore, when the amount of saliva secreted decreases with age, not only does the ability of digestion and absorption decrease, but swallowing becomes difficult and there is a risk of aspiration. Furthermore, the decrease in saliva makes it difficult to perceive taste, which impairs the enjoyment of food and can affect QOL.
非特許文献1には、さきいかやたくあんを噛むことのできる咀嚼能力を有した高齢者は、そうでない高齢者と比べて健康余命が有意に長いことが示されており、咀嚼能力の維持又は向上は多様な食品の摂取、ひいては多様な栄養の摂取に繋がり健康余命の延伸に寄与することが示唆されている。 Non-Patent Document 1 shows that elderly people who have the masticating ability to chew sakiika and pickled radish have a significantly longer healthy life expectancy than those who do not have the ability to chew, and it is important to maintain or improve masticatory ability. It has been suggested that this leads to the intake of a variety of foods, which in turn leads to the intake of a variety of nutrients, contributing to extending healthy life expectancy.
特許文献1に開示されるように、咀嚼力を向上させるために成分の配合比を調整し、グミ組成物の硬さや粘性を好適化することが行われている。 As disclosed in Patent Document 1, in order to improve masticatory power, the blending ratio of components is adjusted to optimize the hardness and viscosity of a gummy composition.
摂取することで咀嚼機能を維持又は向上させ、唾液分泌を促進することができるグミ組成物を提供する。 To provide a gummy composition that can maintain or improve masticatory function and promote saliva secretion when ingested.
本発明者らは、上記課題を解決するために鋭意検討を行った結果、咀嚼機能を維持又は向上させ、唾液分泌を促進することができるグミ組成物の大きさ及び物性を見出した。 The present inventors conducted intensive studies to solve the above problems, and as a result, discovered the size and physical properties of a gummy composition that can maintain or improve mastication function and promote saliva secretion.
本開示は、例えば以下の項に記載の主題を包含する。
項1.
厚み1~15mm、幅1~75mm、長さ1~70mmである咀嚼機能維持向上又は唾液分泌促進用組成物。
項2.
硬度が500~50000gである、請求項1に記載の咀嚼機能維持向上又は唾液分泌促進用組成物。
項3.
硬度が4300~24000gである、請求項2に記載の咀嚼機能維持向上又は唾液分泌促進用組成物。
項4.
ゼラチン、糖および糖類を含む、請求項3に記載の咀嚼機能維持向上又は唾液分泌促進用組成物。
The present disclosure encompasses, for example, the subject matter described in the following sections.
Item 1.
A composition for maintaining and improving masticatory function or promoting saliva secretion, which has a thickness of 1 to 15 mm, a width of 1 to 75 mm, and a length of 1 to 70 mm.
Item 2.
The composition for maintaining and improving masticatory function or promoting saliva secretion according to claim 1, which has a hardness of 500 to 50,000 g.
Item 3.
The composition for maintaining and improving masticatory function or promoting saliva secretion according to claim 2, which has a hardness of 4,300 to 24,000 g.
Item 4.
The composition for maintaining and improving masticatory function or promoting saliva secretion according to claim 3, comprising gelatin, sugar, and saccharide.
本発明の咀嚼機能維持向上又は唾液分泌促進用組成物は、適度な大きさと物性とを備え、咀嚼時に咀嚼筋の筋活動、及び/又は舌の運動を促進することで、咀嚼機能を維持又は向上させることができる。また、自発的な咀嚼を誘発し、1回の摂取あたり、又は単位時間あたりの咀嚼回数を増加させることで、唾液の分泌を促進することができる。 The composition for maintaining and improving masticatory function or promoting saliva secretion of the present invention has appropriate size and physical properties, and maintains or promotes masticatory function by promoting muscle activity of masticatory muscles and/or movement of the tongue during mastication. can be improved. In addition, saliva secretion can be promoted by inducing spontaneous mastication and increasing the number of times of mastication per ingestion or per unit time.
以下、本発明を実施するための形態について説明する。
本実施形態の咀嚼機能維持改善用組成物は、厚み1~15mm、幅1~75mm、長さ1~70mmであり、硬度が500~50000gであることで、咀嚼機能を維持又は改善し、唾液分泌を促進する効果を発揮する。以下、本明細書において当該咀嚼機能維持向上又は唾液分泌促進用組成物を、「本開示の組成物」と表記することがある。
EMBODIMENT OF THE INVENTION Hereinafter, the form for implementing this invention is demonstrated.
The composition for maintaining and improving masticatory function of the present embodiment has a thickness of 1 to 15 mm, a width of 1 to 75 mm, a length of 1 to 70 mm, and a hardness of 500 to 50,000 g, thereby maintaining or improving masticatory function and suppressing saliva. It has the effect of promoting secretion. Hereinafter, in this specification, the composition for maintaining and improving masticatory function or promoting saliva secretion may be referred to as "composition of the present disclosure".
本開示の組成物に含まれるゼラチンとしては、特に制限されないが、例えば、牛、豚、鶏、魚等の皮、骨、腱等を原料としたものを用いることができる。ゼラチンは、酸処理またはアルカリ処理が行われていてもよい。ゼラチンのブルーム値は、100~320であることが好ましく、200以上であることがより好ましい。ゼラチンは、一種を単独で使用してもよいし、二種以上を組み合わせて使用してもよい。 The gelatin contained in the composition of the present disclosure is not particularly limited, but for example, gelatin made from the skin, bones, tendons, etc. of cows, pigs, chickens, fish, etc. can be used. Gelatin may be subjected to acid treatment or alkali treatment. The bloom value of gelatin is preferably 100 to 320, more preferably 200 or more. One type of gelatin may be used alone, or two or more types may be used in combination.
本開示の組成物中のゼラチンの含有量は特に制限されないが、好ましくは、5~10質量%程度含有される。当該範囲の上限又は下限は、例えば、5.5、6、6.5、7、7.5、8、8.5、9、又は9.5質量%であってもよい。例えば、当該範囲は6~9質量%であってもよい。 The content of gelatin in the composition of the present disclosure is not particularly limited, but is preferably about 5 to 10% by mass. The upper or lower limit of the range may be, for example, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, or 9.5% by weight. For example, the range may be 6-9% by weight.
本開示の組成物に含まれる増粘多糖類としては、特に制限されないが、例えば、ペクチンに限らず、カラギーナン、グルコマンナン、アラビアガムなどを用いることができる。ペクチンは、一種を単独で使用してもよいし、二種以上を組み合わせて使用してもよい。 The polysaccharide thickener contained in the composition of the present disclosure is not particularly limited, but is not limited to pectin, and for example, carrageenan, glucomannan, gum arabic, and the like can be used. One type of pectin may be used alone, or two or more types may be used in combination.
本開示の組成物中の増粘多糖類の含有量は特に制限されないが、好ましくは、0.01~0.5質量%程度含有される。当該範囲の上限又は下限は、例えば、0.05、0.1、0.2、0.3、又は0.4質量%であってもよい。 The content of the polysaccharide thickener in the composition of the present disclosure is not particularly limited, but is preferably about 0.01 to 0.5% by mass. The upper or lower limit of the range may be, for example, 0.05, 0.1, 0.2, 0.3, or 0.4% by weight.
本開示の組成物に含まれる糖質および糖類としては、砂糖、水あめ、還元水あめ、ソルビトール、マルチトールが挙げられる。砂糖は、特に制限されないが、例えば、グラニュー糖、上白糖や三温糖などを用いることができる。水あめは、特に制限されないが、例えば、酵素糖化処理や酸糖化処理されたDE値が20~60の粉末状、液体状の原料を用いることができる。還元水あめは、特に制限されないが、例えば、糖組成比は様々で、平均分子量が300~3000である粉末状、液体状の原料を用いることができる。ソルビトールは、特に制限されないが、例えば、粉末状、液体状の原料を用いることができる。マルチトールは、特に制限されないが、例えば、粉末状、液体状の原料を用いることができる。これらの甘味料は、一種を単独で使用してもよいし、二種以上を組み合わせて使用してもよい。 Carbohydrates and saccharides included in the composition of the present disclosure include sugar, starch syrup, reduced starch syrup, sorbitol, and maltitol. Sugar is not particularly limited, and for example, granulated sugar, caster sugar, or warm sugar can be used. The starch syrup is not particularly limited, but for example, powdered or liquid raw materials that have been subjected to enzyme saccharification treatment or acid saccharification treatment and have a DE value of 20 to 60 can be used. The reduced starch syrup is not particularly limited, but for example, powdered or liquid raw materials having various sugar composition ratios and an average molecular weight of 300 to 3000 can be used. Sorbitol is not particularly limited, but for example, powdered or liquid raw materials can be used. Maltitol is not particularly limited, but for example, powdered or liquid raw materials can be used. These sweeteners may be used alone or in combination of two or more.
本開示の組成物中の砂糖、水あめ、還元水あめの含有量は特に制限されないが、好ましくは、20~65質量%程度含有される。当該範囲の上限又は下限は、例えば、25、30、35、40、45、50、55、又は60質量%であってもよい。例えば、当該含有量は30~55質量%であってもよい。 The content of sugar, starch syrup, and reduced starch syrup in the composition of the present disclosure is not particularly limited, but is preferably about 20 to 65% by mass. The upper or lower limit of the range may be, for example, 25, 30, 35, 40, 45, 50, 55, or 60% by weight. For example, the content may be 30-55% by weight.
本開示の組成物中のソルビトール、マルチトールの含有量は特に制限されないが、好ましくは、5~60質量%程度含有される。当該範囲の上限又は下限は、例えば、10、15、20、25、30、35、40、45、50、又は55質量%であってもよい。例えば、当該含有量は25~55質量%であってもよい。 The content of sorbitol and maltitol in the composition of the present disclosure is not particularly limited, but is preferably about 5 to 60% by mass. The upper or lower limit of the range may be, for example, 10, 15, 20, 25, 30, 35, 40, 45, 50, or 55% by weight. For example, the content may be 25-55% by weight.
本開示の組成物に含まれるポリデキストロースとしては、特に制限されないが、例えば、食物繊維含量が固形分量に対して60%以上の粉末状、液体状の原料を用いることができる。また水素添加により還元されたポリデキストロースも同様に用いることができる。ポリデキストロースは、一種を単独で使用してもよいし、二種以上を組み合わせて使用してもよい。 The polydextrose contained in the composition of the present disclosure is not particularly limited, but for example, a powdered or liquid raw material having a dietary fiber content of 60% or more based on the solid content can be used. Polydextrose reduced by hydrogenation can also be used in the same way. One type of polydextrose may be used alone, or two or more types may be used in combination.
本開示の組成物中のポリデキストロースの含有量は特に制限されないが、好ましくは、10~20質量%程度含有される。当該範囲の上限又は下限は、例えば、11、12、13、14、15、16、17、18、又は19質量%であってもよい。例えば、当該含有量は12~18質量%であってもよい。 The content of polydextrose in the composition of the present disclosure is not particularly limited, but is preferably about 10 to 20% by mass. The upper or lower limit of the range may be, for example, 11, 12, 13, 14, 15, 16, 17, 18, or 19% by weight. For example, the content may be 12-18% by weight.
本開示の組成物に含まれる酸味料としては、特に制限されないが、例えば、酢酸、クエン酸、グルコン酸、コハク酸、乳酸、リンゴ酸、フィチン酸、アジピン酸、酒石酸、フマル酸、氷酢酸、グルコノデルタラクトン、リン酸などの有機酸およびその有機酸塩類を用いることができる。酸味料は、一種を単独で使用してもよいし、二種以上を組み合わせて使用してもよい。 The acidulant contained in the composition of the present disclosure is not particularly limited, but includes, for example, acetic acid, citric acid, gluconic acid, succinic acid, lactic acid, malic acid, phytic acid, adipic acid, tartaric acid, fumaric acid, glacial acetic acid, Organic acids such as glucono delta-lactone and phosphoric acid and their organic acid salts can be used. One type of acidulant may be used alone, or two or more types may be used in combination.
本開示の組成物中の酸味料の含有量は特に制限されないが、好ましくは、0.1~2.0質量%程度含有される。当該範囲の上限又は下限は、例えば、0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.1、1.2、1.3,1.4、1.5、1.6、1.7,1.8,又は1.9質量%であってもよい。例えば、当該含有量は0.6~1.5質量%であってもよい。なお、本開示の組成物のpHは特に制限はないが、25℃におけるpHは3~7、好ましくは2.8~4とすることができる。当該pHは、組成物を固める前の組成液の状態で測定することができる。 The content of the acidulant in the composition of the present disclosure is not particularly limited, but is preferably about 0.1 to 2.0% by mass. The upper or lower limit of the range is, for example, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, It may be 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9% by weight. For example, the content may be 0.6 to 1.5% by weight. Note that the pH of the composition of the present disclosure is not particularly limited, but the pH at 25° C. can be 3 to 7, preferably 2.8 to 4. The pH can be measured in the state of the composition liquid before solidifying the composition.
本開示の組成物には、上記成分に加えて、本発明の効果を妨げない範囲で、公知の成分を含有してもよい。例えば香料、着色料、果汁、食物繊維、酸味料、酸化防止剤、乳化剤、加工澱粉、でんぷん、増粘多糖類、pH調整剤、油脂、タンパク質等が挙げられる。香料は、組成物全量に対して0.1~2質量%含有させることができる。 In addition to the above-mentioned components, the composition of the present disclosure may contain known components to the extent that the effects of the present invention are not impaired. Examples include fragrances, colorants, fruit juices, dietary fibers, acidulants, antioxidants, emulsifiers, modified starches, starch, polysaccharide thickeners, pH adjusters, oils and fats, proteins, and the like. The fragrance can be contained in an amount of 0.1 to 2% by mass based on the total amount of the composition.
本開示の組成物の有する物性は、当該技術分野において通常用いられるTA.XT plus 100C (Stable Microsystems社製)等のテクスチャーアナライザーを用い、測定することができる。測定条件は、例えば、直径2又は3mmの円柱プローブ、くさび形プローブを用い、測定速度3mm/秒、圧縮率100%が挙げられる。本明細書中では、前記測定条件での測定結果を硬度(g)と定義する。 The physical properties of the composition of the present disclosure can be determined by TA. It can be measured using a texture analyzer such as XT plus 100C (manufactured by Stable Microsystems). The measurement conditions include, for example, using a cylindrical probe or a wedge-shaped probe with a diameter of 2 or 3 mm, a measurement speed of 3 mm/sec, and a compression rate of 100%. In this specification, the measurement result under the above measurement conditions is defined as hardness (g).
本開示の組成物の物性は、特に制限されないが、好ましくは上記測定方法で測定される硬度(g)が、500~50000gである。当該範囲の上限又は下限は、例えば、1000,1500,2000,2500,3000,3500,4000,4500、5000、5500、6000、6500、7000、7500、8000、8500、9000、9500、10000、12000、14000、16000、18000、20000、22000、24000、26000、28000、30000、32000、34000、36000、38000、40000,42000、44000、46000,又は48000gであってもよい。例えば、当該硬度(g)は4300~24000g、さらに好ましくは4300~15000gであってもよい。 The physical properties of the composition of the present disclosure are not particularly limited, but preferably the hardness (g) measured by the above measuring method is 500 to 50,000 g. The upper or lower limit of the range is, for example, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500, 8000, 8500, 9000, 9500, 10000, 12000, It may be 14000, 16000, 18000, 20000, 22000, 24000, 26000, 28000, 30000, 32000, 34000, 36000, 38000, 40000, 42000, 44000, 46000, or 48000g. For example, the hardness (g) may be 4,300 to 24,000 g, more preferably 4,300 to 15,000 g.
本開示の組成物の大きさは、特に制限されないが、好ましくは厚みが1~15mm、幅が1~75mm、長さが1~70mmである。当該範囲の上限又は下限は、例えば、厚み2、3、4、5、6、7、8、9、10、11、12、13、又は14mmであってもよく、幅2、3、4、5、6、7、8、9、10、12、14、16、18、20、25、30、35、40、45、50、55、60、65又は、70mmであってもよく、長さ2、3、4、5、6、7、8、9、10、12、14、16、18、20、25、30、35、40、45、50、55、60、又は65mmであってもよい。 The size of the composition of the present disclosure is not particularly limited, but preferably has a thickness of 1 to 15 mm, a width of 1 to 75 mm, and a length of 1 to 70 mm. The upper or lower limit of the range may be, for example, a thickness of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 mm, and a width of 2, 3, 4, The length may be 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65 or 70 mm. Whether 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 25, 30, 35, 40, 45, 50, 55, 60, or 65mm good.
本明細書において、「厚み」、「幅」、及び「長さ」は、1つの独立した組成物において、それぞれが直交する3つの軸方向における長さのいずれかであればよい。例えば、物体を静置した際の上面または底面を含む平面上において直交する2つの方向の一方の長さを「幅」、他方の長さを「長さ」とし、前記平面に直交する方向の長さを「厚み」としてもよい。本開示の組成物が、全体的に丸みを帯びた略直方体である場合、厚み、幅、及び長さは、それぞれの方向における最も長い距離を表してもよい。 In this specification, "thickness", "width", and "length" may be any length in three orthogonal axial directions in one independent composition. For example, when an object is left still, the length in one of two orthogonal directions on a plane including the top or bottom surface is defined as "width", and the length in the other direction is defined as "length", and the length in the direction orthogonal to the plane is defined as "width". The length may also be referred to as "thickness." When the composition of the present disclosure is generally a rounded rectangular parallelepiped, the thickness, width, and length may represent the longest distance in each direction.
本開示の組成物は、前記厚み、幅、長さを備えた形状であればよく、例えば略直方体であってもよい。略直方体には、角あるいは辺が丸みを帯びたもの、面に凹凸を設けた直方体も含まれる。 The composition of the present disclosure may have any shape as long as it has the thickness, width, and length described above, and may have a substantially rectangular parallelepiped shape, for example. Substantially rectangular parallelepipeds include ones with rounded corners or sides, and rectangular parallelepipeds with uneven surfaces.
本開示の組成物の用途は、特に制限されないが、例えば、一般食品や保健機能食品、特別用途食品等に使用することができる。また、保健機能食品としては、特定保健用食品、栄養機能食品、機能性表示食品等に使用することができる。これらの中でも、咀嚼機能の維持、咀嚼機能の向上、咀嚼力の維持、咀嚼力の向上、咬合圧の維持、咬合圧の向上、嚥下機能の維持、嚥下機能の向上、舌機能の維持、舌機能の向上、オーラルフレイルの予防、オーラルフレイルの解消、口腔機能改善、咀嚼訓練、咀嚼トレーニング、唾液分泌促進、口腔乾燥予防、及び口腔乾燥改善に対して、本開示の組成物を好適に用いることができる。 The use of the composition of the present disclosure is not particularly limited, but it can be used, for example, in general foods, foods with health claims, foods for special purposes, and the like. Moreover, as a food with health claims, it can be used as a food for specified health uses, a food with nutritional function claims, a food with functional claims, etc. Among these, maintenance of masticatory function, improvement of masticatory function, maintenance of masticatory force, improvement of masticatory force, maintenance of occlusal pressure, improvement of occlusal pressure, maintenance of swallowing function, improvement of swallowing function, maintenance of tongue function, tongue The composition of the present disclosure can be suitably used for improving function, preventing oral frailty, eliminating oral frailty, improving oral function, chewing training, chewing training, promoting saliva secretion, preventing dry mouth, and improving dry mouth. I can do it.
本開示の組成物の適用対象としては、ヒトを含む哺乳動物(例えばイヌ、ネコ、マウス、ラット、ヒツジ、ウマ、ウシ、サル等)等が例示される。中でもヒトが好ましい。本開示の組成物の適用対象となるヒトとしては、例えば、咀嚼機能が低下している、又はその疑いがあるヒト;咀嚼力が低下している、又はその疑いがあるヒト;咬合圧が低下している、又はその疑いがあるヒト;嚥下機能が低下している、又はその疑いがあるヒト;舌機能が低下している、又はその疑いがあるヒト;オーラルフレイルである、又はその疑いのあるヒト;唾液分泌が低下している、又はその疑いがあるヒト;口腔が乾燥している、又はその疑いがあるヒト;等に限らず、健常者(例えば、口腔機能を改善したいヒト、咀嚼を訓練したいヒト、咀嚼筋をトレーニングしたいヒト)等であってもよい。 Examples of subjects to which the composition of the present disclosure can be applied include mammals including humans (eg, dogs, cats, mice, rats, sheep, horses, cows, monkeys, etc.). Among these, humans are preferred. Humans to whom the composition of the present disclosure can be applied include, for example, people who have or are suspected of having a reduced masticatory function; people who have a reduced masticatory force or are suspected of having a reduced masticatory function; and reduced occlusal pressure. People who have or are suspected of having decreased swallowing function; People who have or are suspected of having decreased swallowing function; People who have or are suspected of having decreased oral frailty. People who have or are suspected of having decreased saliva secretion; People who have or are suspected of having dry mouth; Healthy people (e.g., people who want to improve their oral function, This may be a person who wants to train the muscles of mastication, a person who wants to train the muscles of mastication, etc.
咀嚼機能維持向上又は唾液分泌促進用組成物について、以下の実施例に基づいてさらに詳細に説明する。なお、本開示の組成物は、実施例に記載の構成に限定されるものではない。 The composition for maintaining and improving masticatory function or promoting saliva secretion will be described in more detail based on the following examples. Note that the composition of the present disclosure is not limited to the configuration described in the Examples.
表1および2に記載の処方1~160の配合量にて、常法によりグミ組成物を調製した。処方番号1~160の各組成物について、表3および4に記載の形状1~349の形状とした。 Gummy compositions were prepared by a conventional method using formulations 1 to 160 in the amounts listed in Tables 1 and 2. For each of the compositions with formulation numbers 1 to 160, shapes 1 to 349 listed in Tables 3 and 4 were prepared.
表1および2に記載の処方番号1~160のグミ組成物は、それぞれ硬度(g)が500~50000gの範囲内であった。また、表3および4の形状を有することにより、被験者に当該組成物を摂取させることで、咀嚼機能が維持・向上し、唾液分泌が促進された。 The gummy compositions with formulation numbers 1 to 160 listed in Tables 1 and 2 each had a hardness (g) within the range of 500 to 50,000 g. Further, by having the shapes shown in Tables 3 and 4, chewing function was maintained and improved and saliva secretion was promoted by making the subjects ingest the compositions.
表5に、本開示の組成物の処方例を示す。
Table 5 shows formulation examples of the compositions of the present disclosure.
Claims (4)
The composition for maintaining and improving masticatory function or promoting saliva secretion according to claim 3, comprising gelatin, sugar, and saccharide.
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