JP2023006915A - Translucent or transparent topical skin preparation - Google Patents

Abstract

To provide a topical skin preparation with improved stability in which a solid or semisolid oil solution is blended in a transparent or translucent soluble system.SOLUTION: A translucent or transparent topical skin preparation contains (A) a solid or semisolid oil solution, (B) an oil solution of hydrocarbons that is liquid at normal temperature, (C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24), (D) a C18-22 higher alcohol, (E) a polyhydric alcohol, and (F) water.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a translucent or transparent external preparation for skin, and in particular, an external preparation for skin with improved stability, which is obtained by blending a solid or semi-solid oil agent in a transparent or translucent solubilized system.

A transparent or semi-solid external preparation for skin is one in which various moisturizing agents are dissolved in water for the purpose of water replenishment and moisturizing, and the stratum corneum of the skin is moisturized. However, while it is essential to prevent evaporation of moisture in order to impart the effect of improving texture, moisture given to the stratum corneum of the skin evaporates over time, resulting in the effect of improving texture. was not expected. For this reason, formulations prepared by diluting water-in-oil (O/W) emulsions have been used, but they are thermodynamically unstable and have good usability, such as stickiness and a lack of freshness. I had a problem with the face.

Therefore, in order to solve this problem, it is desirable to use highly clogging oils, specifically solid or semi-solid oils. For example, for the purpose of moisturizing the stratum corneum and improving the barrier function, Patent Document 1 discloses polyglycerol with a degree of polymerization of 3 to 7, a diester of a fatty acid monoester with a carbon number of 10 to 22, a fatty acid diglycerin, and a saturated dibasic acid, and squalane. , beeswax (solid wax), and jojoba oil are disclosed. Further, Patent Document 2 discloses a structural composition containing branched fatty acid phytosteryl, fatty acid triglyceride with 10 to 22 carbon atoms, squalane, beeswax (solid wax), and jojoba oil.

Furthermore, in Patent Document 3, as a method for producing a thermodynamically unstable water-in-oil type (O / W type) emulsion, a liquid oil at room temperature and a hydrogenated phospholipid (HLB: 9 to 16) A cloudy oil-in-water (O/W) emulsion containing an ionic surfactant, divalent glycols and water is disclosed.

JP 2008-056586 A JP 2009-234920 A JP 2007-254405 A

However, the techniques described in Patent Documents 1 and 2 cannot provide a refreshing feel due to the stickiness of the surfactant emulsion. In addition, since it is an emulsion, coalescence of oil droplets over time cannot be avoided, and sufficient stability over time of oil droplets cannot be obtained.

In addition, Patent Document 3 discloses a method for producing a white turbid oil-in-water type (O/W type) lotion that is stable even with a low viscosity and a milky lotion in one, in order to provide a refreshing feeling in use. However, since it is essential to incorporate an oil agent that is liquid at room temperature, it does not have the skin-improving effect of Patent Documents 1 and 2, and its improvement has been desired.

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to solve the above-mentioned problems of the prior art, and to obtain an external preparation for skin with improved stability by blending a solid or semi-solid oil in a transparent or translucent solubilized system. .

The inventors of the present invention conducted intensive studies to solve the above problems, and found that the above objects can be achieved by combining a solid or semi-solid oil with a specific surfactant. Completed.

That is, the translucent or transparent external preparation for skin of the present invention is
(A) a solid or semi-solid oil,
(B) a hydrocarbon oil that is liquid at room temperature;
(C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24);
(D) a higher alcohol having 18 to 22 carbon atoms;
(E) a polyhydric alcohol;
and (F) water. Here, (1 to 40 E.O.) means that the number of added moles of oxyethylene is 1 to 40, and (1 to 30 PO) means that the number of added moles of oxypropylene is 1. 30, and (C16-C24) indicates that the number of carbon atoms in the alkyl group is 16-24.

Further, the translucent or transparent external preparation for skin of the present invention has (G) polyoxyethylene hydrogenated castor oil, and the (G) polyoxyethylene hydrogenated castor oil is PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG- It is preferably one or more selected from the group consisting of 80 hydrogenated castor oil and PEG-100 hydrogenated castor oil.

Furthermore, the translucent to transparent external preparation for skin of the present invention contains (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 P.O.) alkyl (C16 to C24) is PPG-6 decyltetradeceth-30, PPG-6 decyltetradeceth-12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1 , PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34 Or it is preferable that they are 2 or more types.

According to the present invention, it is possible to provide an external preparation for skin with improved stability in which a solid or semi-solid oil agent is blended with a transparent or translucent solubilized system.

Hereinafter, the translucent or transparent external preparation for skin of the present invention will be specifically described.
The translucent or transparent external preparation for skin of the present invention comprises (A) a solid or semi-solid oil, (B) a hydrocarbon oil that is liquid at room temperature, and (C) a polyoxyethylenated (1 to 40 E. O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24), (D) a higher alcohol having 18 to 22 carbon atoms, (E) a polyhydric alcohol, and (F) and water. It is a solubilized external preparation for skin that is transparent or translucent in appearance, has the effect of improving skin texture, and has refreshing usability without stickiness. In addition, in the thermodynamically stable solubilization region, by blending an oil that is solid or semi-solid at room temperature and has a high occlusive effect, the skin improvement effect is improved, and the feeling of use is improved without stickiness and refreshing. It is an external skin preparation. In addition, translucent or transparent in the present invention means not only visual observation, but also means that the lightness (L ^* a ^* b ^* L value in the color system) is 99.0 or more, more preferably 99.4. It refers to a state of 1 to 99, and translucent refers to a state of 1 to 99. Lightness is one of the attributes of color, and the degree of lightness and darkness of the color is expressed from 0.0 to 100.0. As the L value increases, the transparency becomes more transparent. The measurement can be performed with a spectrocolorimeter or the like, but is not particularly limited as long as it is another method that can measure the normal brightness. For example, using a spectrophotometer, the transparency when 5 mL of purified water is put in a glass cell and light is transmitted is set to 100, and the transparency when the light is completely blocked and no light is transmitted can be measured as 0. can.

In the present invention, the (A) solid or semi-solid oil means an oil having a melting point of room temperature (approximately 20 to 25° C.) or higher, and can be used in ordinary skin preparations for external use. is not particularly limited as long as it is obtained. Examples of (A) solid or semi-solid oils include highly occlusive ozokerite, ceresin, microcrystalline wax, petrolatum, candelilla wax hydrocarbons, beeswax, mango butter, coconut oil, palm oil, and palm kernel oil. , cocoa butter, shea butter, hydrogenated coconut oil, beef tallow, milk fat, horse fat, whale wax, lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lecithin (30°C, normal temperature) paste), phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, cholesterol , dihydrocholesterol, phytosterol, sterols such as cholic acid, sapogenins, saponins, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di(cholesteryl/behenyl/octyldodecyl), N- lauroyl-L-glutamic acid di(phytosteryl/behenyl/2-octyldodecyl), cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, nonanoic acid Cholesteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, lanolin fatty acid octyldodecyl, cetyl palmitate, hydrogenated castor oil isostearate, isopropyl lanolin fatty acid, cetyl lactate, hydrogenated castor oil isostearate paste, chicken water Glyceryl rosinate, glyceryl (behenate/eicosanedioate), hexa(hydroxystearate/stearate/rosinate) dipentaerythrityl, glycol distearate (ethylene glycol distearate), dimer dilinoleate (phytosteryl/isostearyl/cetyl) /stearyl/behenyl), dimer dilinoleyl dimer dilinoleate, hydrogenated rosin condensate of dimer dilinoleyl, hydrogenated castor oil of dimer dilinoleate, hydroxyalkyl (C16-18) hydroxy dimer dilinoleyl ether, etc. or Derivatives of dimer diol, cetanol, myristyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, chimyl alcohol, batyl alcohol, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, 12- Hydroxystearic acid, coconut oil fatty acid monoethanolamide (cocamide MEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA) and the like can be mentioned.

In the present invention, the (B) hydrocarbon oil that is liquid at room temperature is not particularly limited as long as it can be used in ordinary skin preparations for external use and the effects of the present invention can be obtained. Examples of such (B) hydrocarbon oils that are liquid at room temperature include liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, and olive-derived oils. Squalane, squalene and the like can be mentioned. In the present invention, "ordinary temperature" means a so-called general indoor temperature (room temperature), and indicates a temperature range of 20 to 25°C, for example.

Furthermore, in the present invention, if the effects of the present invention can be obtained, a liquid oil other than (B) the hydrocarbon oil that is liquid at room temperature can be blended together. Examples of (B) oils other than hydrocarbon oils that are liquid at room temperature include safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, Kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, hydrogenated castor vegetable oils such as jojoba oil and hydrogenated jojoba oil, animal oils such as egg yolk oil, mink oil, turtle oil, orange roughy oil, liquid lanolin, acetic acid liquid lanolin, N-lauroyl-L-glutamic acid di (cholesteryl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/octyldodecyl), N-lauroylsarcosine alkyl esters such as isopropyl, phytosteryl isostearate, octyldodecyl myristate, 2-hexyldecyl myristate, Octyldodecyl isostearate, cetyl 2-ethylhexanoate, hexyldecyl ethylhexanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isostearyl neopentanoate, oleyl oleate, octyl oleate Dodecyl, octyldodecyl ricinoleate, octyldodecyl erucate, ethyl oleate, ethyl avocado oil, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate , methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, monoalcohol carboxylic acid esters such as triethyl citrate, dimalic acid Isostearyl, Glyceryl Trioctanoate, Glyceryl Trioleate, Glyceryl Triisostearate, Glyceryl Diisostearate, Caprylic/Capric Triglyceryl, Caprylic/Capric/Myristic/Stearic Triglyceryl, Triethylhexanoic Acid trimethylolpropane, triisostearin trimethylolpropane acid, neopentyl glycol diethylhexanoate, neopentyl glycol dicaprate, propylene glycol dioleate, pentaerythrityl tetraethylhexanoate, (isostearate/sebacate) ditrimethylolpropane oligoester, diglyceryl diisostearate, tetraisostearin Polyglyceryl-2 acid, polyglyceryl-10 nonisostearate, methyl pentanediol dineopentanoate, diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, dimer dilinoleyl diisostearate, oleyl alcohol, jojoba alcohol , oleylglyceryl, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, higher alcohols such as dimer diol, aralkyl alcohols and derivatives such as benzyl alcohol, isostearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, Fatty acid alkanolamides such as isohexadecanoic acid, coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid diethanolamide (lauramide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), and the like can be mentioned.

In the present invention, the (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 P.O.) alkyl (C16 to C24) may be used for general skin external use. Although it is not particularly limited as long as it can be used as an agent and the effect of the present invention can be obtained, PPG-6 decyltetradeceth-30, PPG-6 decyltetradeceth-12, PPG-13 decyltetradeceth-24 , PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth -20 and PPG-23 steareth-34, preferably one or more selected from the group consisting of steareth-34. Specifically, NIKKOL SG-DTD630 (trade name), NIKKOL PEN-4612 (trade name), NIKKOL SG-DTD620 (trade name), NIKKOL PBC-31 (trade name), NIKKOL PBC- manufactured by Nikko Chemicals Co., Ltd. 33 (trade name), NIKKOL SG-C420 (trade name), NIKKOL PBC-44 (trade name), and the like.

Furthermore, in the present invention, the (D) higher alcohol having 18 to 22 carbon atoms improves the solubilization of the (A) solid or semi-solid oil agent and the (B) hydrocarbon oil agent that is liquid at room temperature. be able to. The (D) higher alcohol having 18 to 22 carbon atoms is not particularly limited as long as it can be used in ordinary external preparations for skin and the effects of the present invention can be obtained. Examples include stearyl alcohol, cetostearyl alcohol, Oleyl alcohol, behenyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, decyltetradecanol, arachyl alcohol, arachidyl alcohol, behenyl alcohol and the like can be mentioned. These higher alcohols may be used alone or in combination.

Furthermore, in the present invention, the (E) polyhydric alcohol improves the solubility of the surfactant, and in particular, the dihydric polyhydric alcohol can improve the moisturizing sensation of the stratum corneum of the skin. Such (E) polyhydric alcohols are not particularly limited as long as they can be used in ordinary external skin preparations and can achieve the effects of the present invention. Examples include glycerin, 1,3-butylene glycol, propylene glycol, iso Pentyldiol, diglycerin, sorbitol, hexylene glycol, pentylene glycol, polyethylene glycol and the like can be mentioned. These (E) polyhydric alcohols may be used alone or in combination.

In the present invention, the water (F) is essential for rehydrating the skin and improving the skin by retaining water. The water (F) is not particularly limited as long as it can be used in ordinary external preparations for skin and the effects of the present invention can be obtained, but purified water and the like can be used.

Further, the translucent or transparent external preparation for skin of the present invention has (G) polyoxyethylene hydrogenated castor oil, and the (G) polyoxyethylene hydrogenated castor oil is PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG- It is preferably one or more selected from the group consisting of 80 hydrogenated castor oil and PEG-100 hydrogenated castor oil. The polyoxyethylene hydrogenated castor oil (G) is not particularly limited as long as it can be used in ordinary skin preparations for external use and the effects of the present invention can be obtained. For example, NIKKOL HCO-5 manufactured by Nikko Chemicals Co., Ltd. (trade name), NIKKOL HCO-10 (trade name), NIKKOL HCO-20 (trade name), NIKKOL HCO-30 (trade name), NIKKOL HCO-40 (trade name), NIKKOL HCO-50 (trade name), NIKKOL HCO-60 (trade name), NIKKOL HCO-80 (trade name), NIKKOL HCO-100 (trade name) and the like can be mentioned.

Furthermore, the translucent or transparent external skin preparation of the present invention preferably contains a pH adjuster. Such pH adjusters are not particularly limited as long as they can be used in ordinary external preparations for skin and provide the effects of the present invention. Examples include citric acid, malic acid, tartaric acid, lactic acid, glycolic acid, glutamic acid, and asparagine. acid, malonic acid, succinic acid, adipic acid, 2-amino-2-methyl-1-propanol and the like.

In addition, the translucent or transparent external skin preparation of the present invention preferably contains a stabilizer. Such stabilizers improve the stability of external preparations for skin by means of sequestering agents, antioxidants, preservatives, and the like. The stabilizing agent is not particularly limited as long as it can be used in usual external preparations for skin and the effects of the present invention can be obtained. Antioxidants such as hydroxytoluene, butylated hydroxyanisole, sorbic acid, sodium sulfite, erythorbic acid, L-cysteine hydrochloride, methylparaben, ethylparaben, benzoic acid, benzoate, salicylic acid, salicylate, phenoxyethanol, water-soluble cationic antibacterial agents, antiseptics such as ethylhexylglycerin, bisabolol, poly-ε-lysine, and the like.

Furthermore, the semi-transparent to transparent external preparation for skin of the present invention can obtain the effects of the present invention, if the (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 40 E.O.) 30 P.O.) alkyl (C16-C24) and (G) a surfactant other than polyoxyethylene hydrogenated castor oil can be blended together. Examples of the surfactant include propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin and fatty acid ester, polyoxyethylene glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, poly Oxyethylene lanolin/lanolin alcohol/beeswax derivative, polyoxyethylene sterol/hydrogenated sterol, polyethylene glycol fatty acid ester, polyoxyethylene alkylphenyl ether, polyoxyethylene alkylamine/fatty acid amide, polyoxyethylene alkylphenyl formaldehyde condensate, poly Oxyethylene alkyl ether phosphoric acid/phosphate and the like can be mentioned.

Further, the translucent or transparent external preparation for skin of the present invention contains 1 to 5% by mass of the (A) solid or semi-solid oil, and (B) the hydrocarbon oil that is liquid at room temperature. The content is 0.5 to 8% by mass, and the (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 PO) alkyl (C16 to C24) is 1 to 8% by mass, the content of the (D) higher alcohol having 18 to 22 carbon atoms is 0.5 to 2.0% by mass, and the content of the (E) polyhydric alcohol The amount is 1 to 20% by mass, and it is preferable to (contain) 100% by mass by adjusting with (F) water. With such a blending amount, it is possible to obtain an external preparation for skin that has a refreshing feeling in use and an effect of improving the texture. (B) A hydrocarbon oil that is liquid at room temperature can be used as a solvent for the above-mentioned (A) solid or semi-solid oil as well as a water evaporation suppressing function.

Further, the content of the (A) solid or semi-solid oil agent is 1 to 3% by mass, the content of the (B) hydrocarbon oil agent that is liquid at room temperature is 1 to 5% by mass, and the ( C) the content of polyoxyethylenated (1 to 40 E.O.) and polyoxypropylenated (1 to 30 PO) alkyl (C16 to C24) is 1 to 3% by mass; ) The content of a higher alcohol having 18 to 22 carbon atoms is 0.5 to 1.0% by mass, the content of the (E) polyhydric alcohol is 5 to 12% by mass, and the (F) water It is more preferable to adjust (contain) to 100% by mass. By setting such a blending amount, it is possible to obtain an external preparation for skin having a refreshing feeling in use and an effect of improving the texture. (B) A hydrocarbon oil that is liquid at room temperature is used as an emollient and as a solvent for (A) the solid or semi-solid oil, and (D) the higher alcohol having 18 to 22 carbon atoms is used as the (C) polyol. Micelles can be increased by dissolving in oxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24) palisade layers, and (E) The stickiness of the polyhydric alcohol can be reduced.

In the translucent or transparent external preparation for skin of the present invention, the content of (G) polyoxyethylene hydrogenated castor oil is preferably 1 to 5% by mass, more preferably 2.5 to 3.5% by mass. is more preferable. With such a blending amount, the stability of the translucent or transparent skin preparation for external use of the present invention can be further improved.

In the present invention, the external preparation for skin is one that can be used on the human body and the like, belongs to the classification of ordinary cosmetics, and does not exclude applications such as quasi-drugs and pharmaceuticals. Furthermore, the above-mentioned external preparation for skin includes uses such as basic cosmetics, make-up cosmetics, and hair cosmetics.

Furthermore, in the present invention, other ingredients can be added as appropriate within a range that does not impair the effects of the present invention. Any ingredient other than the above can be blended within a qualitative and quantitative range, and ingredients that are usually blended in external skin preparations, such as moisturizers, fragrances, various vitamins, ultraviolet absorbers, powders and colorants. , medicinal ingredients, inorganic salts, and useful ingredients such as plant extracts.

Examples of extract components include chamomile extract, parsley extract, honeysuckle extract, rice extract, rice bran extract, hop extract, Phellodendron bark extract, coix seed extract, assembly extract, melilot extract, birch extract, licorice extract, peony extract, soapwort extract, loofah extract. , Capsicum extract, Lemon extract, Gentian extract, Perilla extract, Aloe extract, Rosemary extract, Sage extract, Thyme extract, Eucalyptus extract, Tea extract, Seaweed extract, Cucumber extract, Clove extract, Carrot extract, Horse chestnut extract, Hamamelis extract, Mulberry extract , chimp extract, pecan nut extract, grapefruit extract, shikuwasa extract, passion fruit extract, loquat extract, grape extract, rose fruit extract, clara extract, and peppermint extract.

Examples of moisturizing ingredients include xylitol, maltitol, sodium chondroitin sulfate, elastin, glucosamine, hyaluronic acid, cyclodextrin, collagen, and bile salts.

Examples of medicinal ingredients include vitamins such as vitamin A, vitamin B, vitamin C, vitamin D, and vitamin E and their derivatives, glycyrrhizic acid and its derivatives, glycyrrhizic acid and its derivatives, various salts such as urea, creatinine, and CoQ10. , astaxanthin, polyphenols, and ceramide.

In the present invention, the translucent or transparent external preparation for skin can be produced by a conventional method for producing an external preparation for skin. can be used.

In the present invention, as an example of a method for producing a translucent or transparent external skin preparation, the (E) polyhydric alcohol is converted to the (C) polyoxyethylenated (1 to 40 E.O.) and polyoxypropylene (1-30 P.O.) Alkyl (C16-C24) is dissolved, and the above (A) solid or semi-solid oil, the above (B) the hydrocarbon oil that is liquid at room temperature, and the above (D) carbon number There is a method of adding and mixing an oil phase in which a higher alcohol of 18 to 22 is dissolved.

Further, as another example of the method for producing a translucent or transparent skin preparation for external use, the (E) polyhydric alcohol is dissolved in the (F) water to form an aqueous phase, and the (C) polyoxyethylenated ( 1 to 40 E.O.) and polyoxypropylenated (1 to 30 P.O.) alkyl (C16 to C24) are dissolved, and the (A) solid or semi-solid oil solution and the (B) room temperature There is a method of dissolving the liquid hydrocarbon oil and (D) a higher alcohol having 18 to 22 carbon atoms to form an oil phase, and mixing the oil phase with the water phase to solubilize it.

Further, as still another example of the method for producing a semi-transparent or transparent skin preparation for external use, the above-mentioned (E) polyhydric alcohol is dissolved in the above-mentioned (F) water to form an aqueous phase, and the above-mentioned (C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24) are dissolved, and the (A) solid or semi-solid oil and the (B) A hydrocarbon oil that is liquid at room temperature and the (D) higher alcohol having 18 to 22 carbon atoms are dissolved to form an oil phase. There is a method of mixing stabilizers.

EXAMPLES The present invention will be described in more detail below using examples, but the present invention is not limited to these examples. Further, the numerical values in the formulations below indicate % by mass.

(Examples 1-3, Comparative Examples 1-5)
Using the formulations shown in Tables 1 and 2 below, external preparations for skin of Examples 1 to 3 and Comparative Examples 1 to 5 were prepared according to the production method below. The resulting external preparations for skin were evaluated by the following evaluation methods, and the results are shown in Tables 1 and 2 below.

(Production method)
A polyhydric alcohol (pentylene glycol and BG) was dissolved in purified water to form an aqueous phase. Nonionic surfactants (PPG-4 ceteth-20 and PEG-10 hydrogenated castor oil) are dissolved, solid and semi-solid oils, liquid oils and higher alcohols in Tables 1 and 2 below are dissolved to obtain an oil phase. and After the oil phase was mixed with the water phase and solubilized, phenoxyethanol was mixed and dissolved.

(Evaluation method)
(appearance, stability)
The stability of the resulting external preparation for skin was visually observed on the day of preparation and one month and three months after preparation, and evaluated according to the following evaluation criteria.
◎: Translucent to transparent 〇: Translucent △: Cloudy ×: Cloudy, separated

(Usability)
A sensory test was conducted on usability "stickiness" and "freshness" by a panel (sensory test participants aged 27 to 75, 1 male and 1 female). The evaluation method is a 5-point scale with (+) for the positive sentence of the evaluation term "stickiness", (-) for the absence, and +2 and -2 for neither (±). evaluated with Similarly, for "refreshing", the direction of "refreshing" was given by (+), and the direction of "not refreshing" was given by (-).

From the results in Tables 1 and 2, the external preparations for skin of Examples 1 to 3 were good in both stability and usability. On the other hand, the external preparations for skin of Comparative Examples 1 to 5 were poor in stability and felt sticky to the touch.

(Examples 4 to 7, Comparative Example 6)
Using the formulations shown in Table 3 below, external preparations for skin of Examples 4 to 7 and Comparative Example 6 were prepared according to the production method described above. The obtained external preparation for skin was evaluated for stability by the evaluation method described above, and the results are also shown in Table 3 below.

From the results in Table 3, the external preparations for skin of Examples 4 to 7 had good stability. On the other hand, the external preparation for skin of Comparative Example 6 had poor stability.

Claims (3)

(A) a solid or semi-solid oil,
(B) a hydrocarbon oil that is liquid at room temperature;
(C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 P.O.) alkyl (C16-C24);
(D) a higher alcohol having 18 to 22 carbon atoms;
(E) a polyhydric alcohol;
(F) A translucent or transparent skin preparation for external use, characterized by containing water. (G) having polyoxyethylene hydrogenated castor oil,
The (G) polyoxyethylene hydrogenated castor oil is PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated One or more selected from the group consisting of castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil and PEG-100 hydrogenated castor oil. 2. The translucent or transparent skin preparation for external use according to 1. The (C) polyoxyethylenated (1-40 E.O.) and polyoxypropylenated (1-30 PO) alkyl (C16-C24) are PPG-6 decyltetradeceth-30, PPG -6 decyltetradeceth-12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, 3. The translucent material according to claim 1 or 2, which is one or more selected from the group consisting of PPG-4 ceteth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34. to transparent skin preparations for external use.