JP2023005651A - Hypochlorous acid generation tablet - Google Patents

Abstract

To provide a tablet or the like containing sodium chloride and acid, which is usable for the generation of hypochlorous acid, and in which cracks and chippings are suppressed.SOLUTION: A hypochlorous acid generation tablet contains: at least one kind of organic acid selected from the group consisting of succinic acid, fumaric acid, malic acid and adipic acid; and sodium chloride, and is used for generating hypochlorous acid by electrolysis in water, wherein tensile strength of the tablet obtained when directly being compressed under the pressure of 10 kN is 0.5 MPa or more.SELECTED DRAWING: None

Description

It relates to tablets for generating hypochlorous acid.

Hypochlorous acid water is known to be obtained by electrolyzing an aqueous solution containing sodium chloride. , spraying, etc. (Patent Documents 1 and 2).

In addition, it is known that hypochlorous acid water can be classified into, for example, strongly acidic hypochlorous acid water and weakly acidic/slightly acidic hypochlorous acid water. It is also said that weakly acidic and slightly acidic hypochlorous acid water has a higher sterilizing power than strongly acidic hypochlorous acid water because chlorine is also generated.

Utility Model Registration No. 3227580 Japanese Patent No. 5866743

In view of this background, the present inventors combined sodium chloride and acid to produce hypochlorous acid water that can be called weakly acidic/slightly acidic hypochlorous acid water (pH 2.7 to 6.5). I focused on doing. In addition, hypochlorous acid water is generally prepared for use by pouring an aqueous solution containing sodium chloride into an electrolysis tank and electrolyzing it. We paid our attention to the fact that it is troublesome, such as the need to measure the aqueous solution.

For this reason, the present inventor attempted to produce a tablet containing sodium chloride and an acid that can be used to generate hypochlorous acid, but the tablet sometimes cracked or chipped. Therefore, an object of the present disclosure is to provide a tablet containing sodium chloride and an acid that can be used to generate hypochlorous acid and that is inhibited from cracking or chipping.

Further, conventionally, the hypochlorous acid water produced by electrolysis in this way is sometimes put into a substantially transparent spray container or the like so that the remaining amount can be easily grasped. However, if the tablets remain undissolved after electrolysis, there are problems such as unsightly appearance and clogging of the spray, etc. over time. also connected. In addition, in containers and devices other than spray containers, such undissolved residue can cause various problems, which is not preferable. Therefore, another object of the present disclosure is to provide a tablet in which cracking and chipping are suppressed as described above, and in which residual dissolution after electrolysis is suppressed.

Means for Solving the Problems The inventor of the present invention has made extensive studies to solve the above problems, and found that a tablet that is resistant to cracking and chipping can be obtained by combining sodium chloride and a specific organic acid. In addition, the inventors have found that even when such a tablet contains silicon dioxide or the like, it is possible to obtain a tablet that is less likely to crack or chip and that is less likely to remain undissolved after electrolysis. The present invention has been completed through further studies based on these findings, and the present disclosure includes the following aspects, for example.
Section 1. A tablet containing at least one organic acid selected from the group consisting of succinic acid, fumaric acid, malic acid and adipic acid and sodium chloride,
A tablet for hypochlorous acid generation used to generate hypochlorous acid by electrolysis in water,
A tablet having a tensile strength of 0.5 MPa or more when directly compressed at a pressure of 10 kN.
Section 2. Furthermore, 2.4% by mass of at least one selected from the group consisting of silicon dioxide, synthetic aluminum silicate, magnesium aluminometasilicate, magnesium aluminosilicate, magnesium silicate, calcium silicate and synthetic hydrosartite Item 1. The tablet according to Item 1, containing:
Item 3. Item 3. The tablet according to Item 1 or 2, further comprising a lubricant.

It is possible to provide a tablet containing sodium chloride and a specific organic acid, which can be used in the production of hypochlorous acid by electrolysis in water, and which is suppressed in cracking and chipping. It is possible to provide a tablet containing sodium chloride and a specific organic acid, in which cracking and chipping are suppressed, and undissolved residue after electrolysis in water is suppressed.

Embodiments encompassed by the present disclosure are described in further detail below.

The present disclosure is a tablet containing at least one organic acid selected from the group consisting of succinic acid, fumaric acid, malic acid and adipic acid and sodium chloride, wherein hypochlorous acid is produced by electrolysis in water. Hypochlorous acid-generating tablets used for the production include tablets having a tensile strength of 0.5 MPa or more when directly compressed at a pressure of 10 kN.

Succinic acid, fumaric acid, malic acid, and adipic acid are all known organic acids. These may be used singly or in combination of two or more in the tablet of the present disclosure. In addition, sodium chloride is also a conventionally known component.

In the tablet of the present disclosure, at least one organic acid selected from the group consisting of succinic acid, fumaric acid, malic acid and adipic acid (hereinafter sometimes referred to as a specific organic acid) and sodium chloride content It is not limited, and may be used as appropriate within the range where the tensile strength of the tablet obtained when directly compressed at a pressure of 10 kN is 0.5 MPa or more, as described above. Although not limited to this limit, the total amount of the specific organic acid is preferably 0.1 to 1.7 parts by mass, more preferably 0.2 to 1.5 parts by mass, per 1 part by mass of sodium chloride. parts, more preferably 0.3 to 1.2 parts by mass.

In addition, in the tablet of the present disclosure, the content of the specific organic acid and sodium chloride is not limited as described above. 85 mass %, more preferably 45 to 75 mass % is exemplified.

In addition, although the content of the specific organic acid and sodium chloride is not limited in this way, the total amount of the specific organic acid and sodium chloride in the tablet of the present disclosure is preferably 92 to 100% by mass. , more preferably 95% by mass or more, and still more preferably 97% by mass or more.

Tablets of the present disclosure are selected from, but not limited to, the group consisting of silicon dioxide, synthetic aluminum silicate, magnesium aluminometasilicate, magnesium aluminosilicate, magnesium silicate, calcium silicate, synthetic hydrosaltite. may further contain at least one of These components are used, for example, for the purpose of improving tablet moldability, and may be used singly or in combination of two or more. When these ingredients are contained, these ingredients may be blended in any amount in the tablet, and the present disclosure is not limited, but the undissolved tablet after electrolysis in water is further suppressed. From the point of view, the total content of these components in the tablet is preferably 2.4% by mass or less, more preferably 0.01 to 2% by mass, and still more preferably 0.1 to 1.8% by mass. Mass is exemplified.

In addition, the tablet of the present disclosure may further contain a lubricant within a range that does not impair the effects of the present disclosure. Non-limiting examples of lubricants include magnesium stearate, calcium stearate, sucrose fatty acid esters, talc, and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type. If a lubricant is included, the lubricant may be included in any amount and is not a limitation of the present disclosure, but in the tablets of the present disclosure, the lubricant is preferably greater than 0% by mass and 3% by mass. % or less, more preferably 0.001 to 2% by mass, and even more preferably less than 1% by mass. The aforementioned silicon dioxide, synthetic aluminum silicate, magnesium aluminometasilicate, magnesium aluminosilicate, magnesium silicate, calcium silicate, and synthetic hydrosartite are components that are sometimes used as lubricants. , these components are not included in lubricants in this disclosure.

The tablet of the present disclosure may further contain any other component as long as the effects of the present disclosure are not impaired. Examples of other ingredients include perfumes, colorants, binders, extenders, disintegrants, disintegration aids, coating agents, and the like. These other components may be used singly or in combination of two or more, and the content thereof may be appropriately determined.

The tablets of the present disclosure are prepared according to conventionally known procedures, the specific organic acid and sodium chloride, and, if necessary, the above-mentioned silicon dioxide and / or lubricant, and optionally any It can be produced by mixing other ingredients and compressing the resulting mixture. In the present disclosure, tablets may be compressed after being subjected to a granulation process, for example, but the granulation process may not be performed. Tablets in the present disclosure are preferably manufactured by mixing the above ingredients and then directly compressing the resulting mixture into tablets (direct compression method). In addition, the tablet may be a tablet (uncoated tablet) without a coating (coating), and optionally a tablet with a coating, such as a film-coated tablet, a gelatin-coated tablet, a sugar-coated tablet, and a double tablet. , multi-layer tablets, and the like.

The shape, size, etc. of the tablet of the present disclosure are not limited as long as they do not interfere with the effects of the present disclosure, and are determined as appropriate. For example, the shape includes all shapes such as round (cylindrical, etc.), elliptical, triangular, and square. As a measure of the size per tablet, in the case of a round tablet, the diameter is preferably 15 mm or less, more preferably about 8 to 12 mm, more preferably about 9 to 12 mm, and the thickness is 8 mm or less, preferably 3 to 6 mm. degree is exemplified. Even if the shape is not round, for example, in the case of an elliptical shape, the value obtained by dividing the total value of the major axis and minor axis by 2 is the value of the above diameter. be done. The weight per tablet is 200-600 mg, preferably 200-400 mg.

The tablet of the present disclosure has a tensile strength of 0.5 MPa or more when directly compressed at a pressure of 10 kN. Although the tensile strength is not limited to this limit, it is preferably 0.6 MPa or more, more preferably 0.8 MPa, and still more preferably 1 MPa or more. As long as the effects of the present disclosure can be obtained, the upper limit of the tensile strength is not limited, but is preferably 4 MPa or less, more preferably 3 MPa or less. From this point of view, the tensile strength of tablets is more preferably 0.5 to 4 MPa.

Here, the tablet tensile strength is a value measured and calculated according to the following procedure. Tablets (cylindrical) obtained by direct compression at a pressure of 10 kN were crushed and fractured in the diameter direction using a hardness tester (load cell type tablet hardness tester PC-30 type: manufactured by Okada Seiko Co., Ltd.). Measure the breaking load using the following formula to calculate the tensile strength.
Tensile strength T.S. S. (MPa)=2P/(π×D×T)
P: breaking load (N), D: tablet diameter (mm), t: tablet thickness (mm)

In addition, when the tablet has a shape other than a cylindrical shape, it may be any shape that satisfies the above tensile strength when the tablet is cylindrical. Cracking and chipping of the tablet can be suppressed by setting it as such strength. Tablets may be cracked or chipped, for example, due to vibration during transportation or when multiple tablets are put together in one container. put away. As a result, even if a tablet with cracks or the like is put into water, there may be a problem that the amount of the predetermined component is not reached, or the desired amount of hypochlorous acid is not generated. It takes time and effort, such as needing to measure the amount of the material to put it in. For this reason, suppression of cracking and chipping of tablets is important for easily producing desired hypochlorous acid.

In addition, the tablets of the present disclosure are not limited in this respect, but more preferably, the generation of undissolved tablets after electrolysis in water is suppressed. Hypochlorous acid water is sometimes used in a nearly transparent spray container, etc., so that the remaining amount can be easily grasped. There is a problem that the spray or the like clogs. In addition, undissolved tablets lead to problems such as inefficient electrolysis. Therefore, these problems can be reduced or eliminated by making a tablet in which the occurrence of undissolved residue is suppressed. From this point of view, as described above, in the present disclosure, the It is preferable that the content of at least one of the elements is 0 to 2.4% by mass. In the present disclosure, the hypochlorous acid water does not necessarily have to be contained in a substantially transparent container, and any container or device may be used as appropriate. Here, the term "substantially transparent container" means a container having a transparent portion to the extent that the hypochlorous acid water contained in the container can be visually confirmed from the outside of the container.

The tablets of the present disclosure are used to put the tablets in water and generate hypochlorous acid by electrolysis in the water. Conventionally, hypochlorous acid is produced by electrolyzing an aqueous solution containing sodium chloride, and procedures (including conditions) for producing hypochlorous acid by electrolysis in water are known. Therefore, in the present disclosure, the procedure for electrolyzing to generate hypochlorous acid may follow a known procedure, except that the tablet of the present disclosure is put into water and electrolyzed instead of the conventional aqueous solution. . As far as this is concerned, the equipment used for electrolysis is not limited. For this reason, in the present disclosure, the occurrence of undissolved tablets after electrolysis is suppressed means that undissolved residues are suppressed in hypochlorous acid water immediately after production obtained in this way. do. In the present disclosure, whether or not the occurrence of undissolved residue is suppressed is determined by putting 1 L of water at 25° C. into the electrolyzer, inserting 1 tablet, and then setting a voltage of 24 V and a current of 2 A, as shown in the examples below. It is judged in the solution (hypochlorous acid water) when it is visually confirmed that the bubbles generated in the obtained electrolytic solution disappear after electrolysis is performed by energizing for 15 minutes. The judgment criteria follow the examples described later.

In addition, although the tablet of the present disclosure is not limited in this respect, the above conditions (1 L of water at 25 ° C. is put in the electrolyzer, and after inserting 1 tablet, a voltage of 24 V and a current of 2 A are applied for 15 minutes to electrolyze ) is preferably 2.7 to 6.5, more preferably 4 to 6.5, and still more preferably 5 to 6.5 at 25 ° C. . The pH is measured with a pH meter (pH METER F-52: manufactured by HORIBA, Ltd.).

Water into which the tablets are added may be tap water, distilled water, ion-exchanged water, RO water, Elix water, or the like. In addition, the water may further contain any component as necessary, as long as the effects of the present disclosure are not hindered. Examples include silver ions, copper ions, etc. Electrolysis may be carried out below. In addition, such components such as silver ions may be added to hypochlorous acid water obtained after electrolysis using the tablets of the present disclosure. These are useful, for example, for easily obtaining both the effect caused by hypochlorous acid water and the effect caused by such an optional component.

The amount of tablets of the present disclosure to be put into water (the amount used) is not limited to this limit, and may be set as appropriate according to the amount of water to be put in, the electrolysis conditions, etc. One tablet is used at a time. Multiple tablets may be used as required, for example 2 to 5 tablets. Although not limited in this respect, for example, the tablet of the present disclosure is used so that the effective chlorine concentration in the obtained hypochlorous acid water is preferably 35 ppm or more, more preferably about 35 to 500 ppm. According to the present disclosure, hypochlorous acid water can be easily produced by counting the number of tablets even when multiple tablets are used at once.

The tablet of the present disclosure contains sodium chloride and the above-mentioned specific organic acid, and can suppress the occurrence of cracks and chips that are likely to occur during distribution, etc. can be reduced, and hypochlorous acid can be generated more easily. In addition, when the tablets of the present disclosure are those in which the occurrence of undissolved residues is suppressed, the appearance of the obtained hypochlorous acid water can be further improved, and containers such as spray containers and It is also possible to suppress the occurrence of problems such as clogging in the apparatus. For this reason, according to the present disclosure, it is possible to provide tablets that are extremely easy to use in the production of hypochlorous acid by electrolysis. In addition, from this, the tablets of the present disclosure may be individually packaged, for example, one tablet at a time, but a plurality of tablets may be collectively accommodated in one container. The hypochlorous acid water thus produced can be used by coating, spraying, or the like on an object in the same manner as conventionally known hypochlorous acid water.

The present disclosure will be described in more detail below with examples, but the present disclosure is not limited thereto.
Test example 1
manufacture of tablets
Each component was weighed and mixed according to Table 1. The resulting mixture was directly compressed using a punch with a diameter of 9 mm at a compression pressure of 10 kN to obtain cylindrical tablets with a diameter of 9 mm, a thickness of 4 to 4.5 mm and a weight of 320 mg per tablet (n = 5).

Evaluation of Tensile Strength The tensile strength of the tablets thus obtained was calculated as follows. Using a hardness meter (load cell type tablet hardness tester PC-30 type: manufactured by Okada Seiko Co., Ltd.), the tablet was crushed and fractured in the diameter direction to measure the breaking load, and the tensile strength was calculated using the following formula. .
Tensile strength T.I. S. (MPa)=2P/(π×D×T)
P: breaking load (N), D: tablet diameter (mm), t: tablet thickness (mm)

The tensile strength thus calculated was evaluated according to the following criteria.
◎: 0.7 or more ○: 0.5 or more to less than 0.7
×: less than 0.5

Evaluation of Friability In order to evaluate cracks and chips in the tablets obtained as described above, the friability of the tablets was measured and calculated. For each tablet of Examples or Comparative Examples, the number of tablets with a total weight close to 6.5 g was used as a sample, and the weight was precisely measured (tablet weight before test). These tablets were placed in a friability tester (TFT-1200: manufactured by Toyama Sangyo Co., Ltd.) and rotated 100 times. tablet mass). The friability was calculated using the following formula.
Friability (%) = (tablet mass before test - tablet mass after test) x 100/tablet mass before test

Transparency of Solution 1 L of tap water at 25° C. was placed in an electrolyzer, and after one tablet was put therein, a voltage of 24 V and a current of 2 A were applied for 15 minutes to carry out electrolysis. After that, after confirming that the bubbles generated in the obtained electrolytic solution have disappeared, the obtained electrolytic solution (hypochlorous acid water) is visually checked for turbidity and insoluble matter floating on the surface of the solution. was confirmed, and the transparency of the solution was evaluated according to the following criteria.
○: Transparent and no turbidity △: Transparent and no turbidity in a static state, but a few suspended substances are observed when stirred ×: Always turbid and opaque even in a static state

The pH of the electrolytic solution (hypochlorous acid water) is measured using a pH meter (pH METER F-52: manufactured by HORIBA, Ltd.) using standard solutions in the order of pH 7, pH 2, pH 4, and pH 9. ” was measured at 25°C.

Results The results are shown in Table 1.

As shown in Table 1, when sodium chloride was combined with citric acid (Comparative Example 1), the tensile strength was as low as 0.39 MPa, and the desired strength was not obtained. Also, when tartaric acid was used instead of citric acid (Comparative Example 2), similarly to the case of using citric acid, the tensile strength was as low as 0.39 MPa, and the desired strength was not obtained. On the other hand, when sodium chloride was combined with succinic acid, malic acid, fumaric acid or adipic acid (Examples 1 to 4), a tensile strength of 0.6 MPa or more was obtained, especially when adipic acid was combined. obtained a tensile strength of 0.7 MPa or more. Thus, when sodium chloride was combined with succinic acid, malic acid, fumaric acid, and adipic acid, tablets with desired tensile strength were obtained.

In order to evaluate cracking and chipping of these tablets, the friability was measured as described above, and as shown in Table 1, the same tendency was observed for the friability. Friability was lower when succinic acid, malic acid, fumaric acid or adipic acid were combined than when combined. From this, it was found that by combining succinic acid, malic acid, fumaric acid, and adipic acid, it is possible to obtain a tablet that has a desired tensile strength and is less likely to crack or chip during transportation.

In addition, the transparency of the electrolyzed water produced using these tablets was evaluated as ◯, meaning that the water was transparent and free of turbidity. From this, when sodium chloride is combined with succinic acid, malic acid, fumaric acid, and adipic acid, it is possible to obtain a tablet that suppresses the occurrence of cracking, etc., and suppresses the undissolved residue after electrolysis. I have found that I can get

Test example 2
Each component was weighed and mixed according to Table 2. The resulting mixture was tableted under the same conditions as in Test Example 1 to obtain cylindrical tablets (n=5). As shown in Table 2, in Test Example 2, tablets were prepared using sodium chloride, succinic acid or adipic acid, silicon dioxide, and a lubricant (magnesium stearate). In the table, the amount of each component indicates the amount per tablet. Further, in the same manner as in Test Example 1, tensile strength, friability, and solution transparency were evaluated, and pH was measured.

Results The results are shown in Table 2.

As shown in Examples 5 to 8, tablets with desired tensile strength were obtained even when silicon dioxide was further combined with sodium chloride, succinic acid and adipic acid. It was found that these tablets also had a low degree of friability and were less likely to crack or chip. The transparency of the solution was evaluated as Δ in Example 7, but was evaluated as ◯ in Examples 5, 6 and 8. Also in Example 9, in which a lubricant was further combined with silicon dioxide, a tablet having the desired tensile strength and solution transparency was similarly obtained. From the results of Test Example 2, even when silicon dioxide is used in addition to organic acids such as sodium chloride and succinic acid, and even when a lubricant is used, the occurrence of cracks etc. is suppressed. It was also found that a tablet with a reduced cracking and the like, and a tablet with reduced undissolved residue after electrolysis can be obtained.

Test example 3
Each component was weighed and mixed according to Table 3. The obtained mixture was tableted under the same conditions as in Test Example 1 to obtain tablets (n=5). As shown in Table 3, Examples 10 and 11 of Test Example 3 are tablets prepared in the same manner as Example 9 of Table 2 except that the contents of sodium chloride and succinic acid were changed. Examples 12 to 14 are tablets prepared by using synthetic aluminum silicate, magnesium aluminometasilicate or magnesium silicate in place of silicon dioxide in Example 9 of Table 2 above. In the table, the amount of each component indicates the amount per tablet. Tensile strength, friability and solution transparency were evaluated in the same manner as in Test Example 1, and pH was measured.

Results The results are shown in Table 3.

As shown in Examples 10 to 14 in Table 3, tablets with desired tensile strength, friability, and solution transparency could be produced in all cases. From this, it was found that desired tablets could be similarly obtained by using the aforementioned synthetic aluminum silicate or the like in place of silicon dioxide.

Formulation Examples Non-limiting examples of tablets of the present disclosure are provided. In the table, the amount of each component indicates the amount per tablet. In any tablet, the occurrence of cracks and the like is suppressed, and further, the occurrence of cracks and the like is suppressed and the undissolved residue after electrolysis is suppressed.

Claims (3)

A tablet containing at least one organic acid selected from the group consisting of succinic acid, fumaric acid, malic acid and adipic acid and sodium chloride,
A tablet for hypochlorous acid generation used to generate hypochlorous acid by electrolysis in water,
A tablet having a tensile strength of 0.5 MPa or more when directly compressed at a pressure of 10 kN. Furthermore, 2.4% by mass of at least one selected from the group consisting of silicon dioxide, synthetic aluminum silicate, magnesium aluminometasilicate, magnesium aluminosilicate, magnesium silicate, calcium silicate and synthetic hydrosartite 2. A tablet according to claim 1, containing: 3. The tablet of claim 1 or 2, further comprising a lubricant.