JP2022549192A - 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形 - Google Patents

鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形 Download PDF

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Publication number
JP2022549192A
JP2022549192A JP2022517743A JP2022517743A JP2022549192A JP 2022549192 A JP2022549192 A JP 2022549192A JP 2022517743 A JP2022517743 A JP 2022517743A JP 2022517743 A JP2022517743 A JP 2022517743A JP 2022549192 A JP2022549192 A JP 2022549192A
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JP
Japan
Prior art keywords
bupropion
daily dose
auc
hydroxybupropion
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022517743A
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English (en)
Japanese (ja)
Inventor
タビュトー、ヘリオット
Original Assignee
アクスサム セラピューティクス インコーポレイテッド
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Priority claimed from PCT/US2019/052210 external-priority patent/WO2020061486A2/en
Priority claimed from US16/830,637 external-priority patent/US20200222339A1/en
Priority claimed from US16/907,691 external-priority patent/US11433035B2/en
Application filed by アクスサム セラピューティクス インコーポレイテッド filed Critical アクスサム セラピューティクス インコーポレイテッド
Publication of JP2022549192A publication Critical patent/JP2022549192A/ja
Priority to JP2024025971A priority Critical patent/JP2024059812A/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022517743A 2019-09-20 2020-08-18 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形 Pending JP2022549192A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024025971A JP2024059812A (ja) 2019-09-20 2024-02-22 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形および方法

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
PCT/US2019/052210 WO2020061486A2 (en) 2018-09-20 2019-09-20 Dosage forms and methods for enantiomerically enriched or pure bupropion
USPCT/US2019/052210 2019-09-20
US202062971174P 2020-02-06 2020-02-06
US62/971,174 2020-02-06
US202062978626P 2020-02-19 2020-02-19
US62/978,626 2020-02-19
US202062992060P 2020-03-19 2020-03-19
US62/992,060 2020-03-19
US16/830,637 2020-03-26
US16/830,637 US20200222339A1 (en) 2018-09-20 2020-03-26 Dosage forms and methods for enantiomerically enriched or pure bupropion
US16/907,691 US11433035B2 (en) 2018-09-20 2020-06-22 Dosage forms and methods for enantiomerically enriched or pure bupropion
US16/907,691 2020-06-22
PCT/US2020/046755 WO2021055124A1 (en) 2019-09-20 2020-08-18 Dosage forms and methods for enantiomerically enriched or pure bupropion

Related Child Applications (1)

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JP2024025971A Division JP2024059812A (ja) 2019-09-20 2024-02-22 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形および方法

Publications (1)

Publication Number Publication Date
JP2022549192A true JP2022549192A (ja) 2022-11-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022517743A Pending JP2022549192A (ja) 2019-09-20 2020-08-18 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形
JP2024025971A Pending JP2024059812A (ja) 2019-09-20 2024-02-22 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形および方法

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JP2024025971A Pending JP2024059812A (ja) 2019-09-20 2024-02-22 鏡像異性体的に濃縮された、または純粋なブプロピオンの剤形および方法

Country Status (14)

Country Link
EP (1) EP4031121A4 (es)
JP (2) JP2022549192A (es)
KR (1) KR20220066930A (es)
CN (1) CN114423417A (es)
AU (2) AU2020349419B2 (es)
BR (1) BR112022005045A2 (es)
CA (1) CA3154718A1 (es)
CO (1) CO2022003126A2 (es)
CR (1) CR20220119A (es)
EC (1) ECSP22030119A (es)
IL (1) IL291514A (es)
MX (1) MX2022003346A (es)
PE (1) PE20221314A1 (es)
WO (1) WO2021055124A1 (es)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190216800A1 (en) * 2013-11-05 2019-07-18 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
WO2019165379A1 (en) * 2018-02-23 2019-08-29 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1051166A1 (en) * 1998-01-29 2000-11-15 Sepracor, Inc. Pharmaceutical uses of optically pure (+) -bupropion
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
MX2013014166A (es) * 2013-12-03 2015-06-10 Inst De Investigacion En Quimica Aplic S A De C V Enantiomeros activos y sus sales para el tratamiento de la obesidad.
WO2015095713A1 (en) * 2013-12-20 2015-06-25 Deuterx, Llc Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190216800A1 (en) * 2013-11-05 2019-07-18 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
WO2019165379A1 (en) * 2018-02-23 2019-08-29 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion

Also Published As

Publication number Publication date
EP4031121A4 (en) 2022-11-30
PE20221314A1 (es) 2022-09-07
BR112022005045A2 (pt) 2022-07-05
JP2024059812A (ja) 2024-05-01
CN114423417A (zh) 2022-04-29
WO2021055124A1 (en) 2021-03-25
CA3154718A1 (en) 2021-03-25
AU2020349419B2 (en) 2023-11-02
KR20220066930A (ko) 2022-05-24
ECSP22030119A (es) 2022-05-31
CO2022003126A2 (es) 2022-04-19
CR20220119A (es) 2022-06-22
IL291514A (en) 2022-05-01
AU2024200081A1 (en) 2024-01-25
AU2020349419A1 (en) 2022-03-24
MX2022003346A (es) 2022-04-11
EP4031121A1 (en) 2022-07-27

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