JP2022549172A5 - - Google Patents
Info
- Publication number
- JP2022549172A5 JP2022549172A5 JP2022517452A JP2022517452A JP2022549172A5 JP 2022549172 A5 JP2022549172 A5 JP 2022549172A5 JP 2022517452 A JP2022517452 A JP 2022517452A JP 2022517452 A JP2022517452 A JP 2022517452A JP 2022549172 A5 JP2022549172 A5 JP 2022549172A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- antibody
- acid sequence
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025112231A JP2025165930A (ja) | 2019-09-18 | 2025-07-02 | Gipr抗体及びglp-1とのその融合タンパク質、並びにその医薬組成物及び用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910882351.2 | 2019-09-18 | ||
| CN201910882351.2A CN112521501A (zh) | 2019-09-18 | 2019-09-18 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| PCT/CN2020/115483 WO2021052349A1 (zh) | 2019-09-18 | 2020-09-16 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025112231A Division JP2025165930A (ja) | 2019-09-18 | 2025-07-02 | Gipr抗体及びglp-1とのその融合タンパク質、並びにその医薬組成物及び用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022549172A JP2022549172A (ja) | 2022-11-24 |
| JP2022549172A5 true JP2022549172A5 (https=) | 2023-09-27 |
Family
ID=74883118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022517452A Pending JP2022549172A (ja) | 2019-09-18 | 2020-09-16 | Gipr抗体及びglp-1とのその融合タンパク質、並びにその医薬組成物及び用途 |
| JP2025112231A Pending JP2025165930A (ja) | 2019-09-18 | 2025-07-02 | Gipr抗体及びglp-1とのその融合タンパク質、並びにその医薬組成物及び用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025112231A Pending JP2025165930A (ja) | 2019-09-18 | 2025-07-02 | Gipr抗体及びglp-1とのその融合タンパク質、並びにその医薬組成物及び用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220411520A1 (https=) |
| EP (1) | EP4063385A4 (https=) |
| JP (2) | JP2022549172A (https=) |
| KR (1) | KR20220063221A (https=) |
| CN (4) | CN112521501A (https=) |
| AU (1) | AU2020350715A1 (https=) |
| CA (1) | CA3154756A1 (https=) |
| MX (1) | MX2022003251A (https=) |
| TW (1) | TWI889705B (https=) |
| WO (1) | WO2021052349A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022291264A1 (en) * | 2021-06-09 | 2023-12-14 | Swiftnovo Therapeutics Inc. | Therapeutics and methods for treating or ameliorating metabolic disorders |
| CN119744271A (zh) * | 2022-09-08 | 2025-04-01 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与fgf21的融合蛋白,以及其药物组合物和应用 |
| CN120019167A (zh) * | 2022-10-12 | 2025-05-16 | 首尔大学医院 | 利用gipr标记物的用于预测磺酰脲类依赖性的组合物及其预测方法 |
| EP4613768A1 (en) * | 2022-11-02 | 2025-09-10 | Suzhou Alphamab Co., Ltd | Gipr binding protein and use thereof |
| WO2025092705A1 (zh) * | 2023-10-31 | 2025-05-08 | 山东博安生物技术股份有限公司 | Gipr阻断型抗体及其抗体偶联物 |
| WO2025237353A1 (zh) * | 2024-05-15 | 2025-11-20 | 信立泰(成都)生物技术有限公司 | 一种抗gipr抗体或其抗原结合片段及用途 |
| WO2025252023A1 (en) * | 2024-06-03 | 2025-12-11 | Fortvita Biologics Inc. | Modulators for gipr, glp1r and/or gcgr and uses thereof |
| WO2026021575A1 (zh) * | 2024-07-26 | 2026-01-29 | 鸿运华宁(杭州)生物医药有限公司 | 一种gipr抗体融合蛋白质的药用稳定溶液制剂及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| ATE251465T1 (de) | 1998-07-31 | 2003-10-15 | Novo Nordisk As | In-vitro stimulation von beta zellen vermehrung |
| US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
| BR112014013925B1 (pt) * | 2011-12-12 | 2022-02-22 | Receptos Llc | Compostos moduladores do receptor de glp-1 e composição e combinação farmacêutica compreendendo os ditos compostos |
| CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
| UA127495C2 (uk) | 2015-12-23 | 2023-09-13 | Амджен Інк. | Виділений антигензв'язуючий білок, який специфічно зв'язується з поліпептидом рецептора шлункового інгібіторного пептиду (gipr) людини, та фармацевтична композиція, яка його містить |
| IL313587A (en) * | 2017-01-17 | 2024-08-01 | Amgen Inc | Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr) |
| EA201992502A1 (ru) * | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
| EP3642238A1 (en) * | 2017-06-21 | 2020-04-29 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins |
| CN117126279A (zh) * | 2018-03-20 | 2023-11-28 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
-
2019
- 2019-09-18 CN CN201910882351.2A patent/CN112521501A/zh active Pending
-
2020
- 2020-09-16 US US17/761,128 patent/US20220411520A1/en not_active Abandoned
- 2020-09-16 WO PCT/CN2020/115483 patent/WO2021052349A1/zh not_active Ceased
- 2020-09-16 MX MX2022003251A patent/MX2022003251A/es unknown
- 2020-09-16 KR KR1020227012130A patent/KR20220063221A/ko active Pending
- 2020-09-16 AU AU2020350715A patent/AU2020350715A1/en active Pending
- 2020-09-16 EP EP20866016.7A patent/EP4063385A4/en active Pending
- 2020-09-16 CN CN202310832321.7A patent/CN116942811A/zh active Pending
- 2020-09-16 CN CN202080065099.7A patent/CN114641495B/zh active Active
- 2020-09-16 CA CA3154756A patent/CA3154756A1/en active Pending
- 2020-09-16 CN CN202510478075.9A patent/CN120289653A/zh active Pending
- 2020-09-16 JP JP2022517452A patent/JP2022549172A/ja active Pending
- 2020-09-17 TW TW109132123A patent/TWI889705B/zh active
-
2025
- 2025-07-02 JP JP2025112231A patent/JP2025165930A/ja active Pending
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