JP2022547434A - 標的化デンドリマー複合体 - Google Patents

標的化デンドリマー複合体 Download PDF

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JP2022547434A
JP2022547434A JP2022513525A JP2022513525A JP2022547434A JP 2022547434 A JP2022547434 A JP 2022547434A JP 2022513525 A JP2022513525 A JP 2022513525A JP 2022513525 A JP2022513525 A JP 2022513525A JP 2022547434 A JP2022547434 A JP 2022547434A
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conjugate
dendrimer
group
compound
peg
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JP2022547434A5 (https=
Inventor
オーウェン，デイビッド
ツェゲイ，サミ
シェンガル，サドハー
レイテノー，ポーライン
ポーター，クリストファー
ジョンストン，アンガス
ユエン，ダニエル
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スターファーマ プロプライアタリー リミティド
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Priority claimed from AU2019903152A external-priority patent/AU2019903152A0/en
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Publication of JP2022547434A publication Critical patent/JP2022547434A/ja
Publication of JP2022547434A5 publication Critical patent/JP2022547434A5/ja
Priority to JP2025153569A priority Critical patent/JP2026026483A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022513525A 2019-08-28 2020-08-28 標的化デンドリマー複合体 Pending JP2022547434A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025153569A JP2026026483A (ja) 2019-08-28 2025-09-16 標的化デンドリマー複合体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019903152A AU2019903152A0 (en) 2019-08-28 Targeted Dendrimer Conjugates
AU2019903152 2019-08-28
PCT/AU2020/050910 WO2021035310A1 (en) 2019-08-28 2020-08-28 Targeted dendrimer conjugates

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JP2022547434A true JP2022547434A (ja) 2022-11-14
JP2022547434A5 JP2022547434A5 (https=) 2023-09-04

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JP2025153569A Pending JP2026026483A (ja) 2019-08-28 2025-09-16 標的化デンドリマー複合体

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US (1) US20220288216A1 (https=)
EP (1) EP4021511A4 (https=)
JP (2) JP2022547434A (https=)
KR (1) KR20220052960A (https=)
CN (1) CN114502201B (https=)
AU (1) AU2020338481B2 (https=)
BR (1) BR112022003628A2 (https=)
CA (1) CA3149263A1 (https=)
WO (1) WO2021035310A1 (https=)

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US20180326081A1 (en) * 2011-06-06 2018-11-15 Starpharma Pty Ltd Macromolecules
JP7541978B2 (ja) * 2018-11-29 2024-08-29 スターファーマ ピーティーワイ エルティーディー 治療および画像化のためのデンドリマー
WO2023283537A2 (en) * 2021-07-07 2023-01-12 Institute For Systems Biology Cell analysis methods, compositions, and uses
EP4430076A2 (en) 2021-11-08 2024-09-18 Life Technologies AS Polymer-interaction molecule conjugates and methods of use
CN115991880B (zh) * 2022-12-08 2024-03-19 中国药科大学 一种树状大分子pamam-g5-tco及其制备方法与应用
WO2024182810A2 (en) * 2023-03-02 2024-09-06 Inmune Bio Inc. Bioconjugates of dominant negative tnf
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