JP2022546861A - マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用 - Google Patents

マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用 Download PDF

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JP2022546861A
JP2022546861A JP2022515704A JP2022515704A JP2022546861A JP 2022546861 A JP2022546861 A JP 2022546861A JP 2022515704 A JP2022515704 A JP 2022515704A JP 2022515704 A JP2022515704 A JP 2022515704A JP 2022546861 A JP2022546861 A JP 2022546861A
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cancer
pyridin
crystalline form
compound
xrpd
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Japanese (ja)
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JPWO2021050580A5 (https=
JP2022546861A5 (https=
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レペル，フランク
レペル，ステファーヌ・エル
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Mirati Therapeutics Inc
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Mirati Therapeutics Inc
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Publication of JPWO2021050580A5 publication Critical patent/JPWO2021050580A5/ja
Publication of JP2022546861A5 publication Critical patent/JP2022546861A5/ja
Priority to JP2025061710A priority Critical patent/JP2025102940A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2022515704A 2019-09-10 2020-09-09 マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用 Pending JP2022546861A (ja)

Priority Applications (1)

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JP2025061710A JP2025102940A (ja) 2019-09-10 2025-04-03 マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用

Applications Claiming Priority (3)

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US201962898469P 2019-09-10 2019-09-10
US62/898,469 2019-09-10
PCT/US2020/049986 WO2021050580A1 (en) 2019-09-10 2020-09-09 Crystalline form of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof

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JP2025061710A Division JP2025102940A (ja) 2019-09-10 2025-04-03 マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用

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JP2022546861A true JP2022546861A (ja) 2022-11-09
JPWO2021050580A5 JPWO2021050580A5 (https=) 2023-06-16
JP2022546861A5 JP2022546861A5 (https=) 2023-06-16

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JP2025061710A Pending JP2025102940A (ja) 2019-09-10 2025-04-03 マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用

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US (1) US12466838B2 (https=)
EP (1) EP4027999B1 (https=)
JP (2) JP2022546861A (https=)
CN (1) CN114401720A (https=)
CA (1) CA3150267A1 (https=)
WO (1) WO2021050580A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202302597A (zh) * 2021-03-10 2023-01-16 美商米拉蒂醫療公司 多重酪胺酸激酶抑制劑之結晶鹽、其製備方法及用途
WO2022240802A1 (en) 2021-05-10 2022-11-17 Teva Pharmaceuticals International Gmbh Solid state forms of sitravatinib salts and processes for preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511689A (ja) * 2006-12-06 2010-04-15 ファイザー・インク （３Ｓ）−３−［Ｎ−（Ｎ’−（２−ｔｅｒｔ−ブチルフェニル）オキサミル）アラニニル］アミノ−５−（２’，３’，５’，６’−テトラフルオロフェノキシ）−４−オキソペンタン酸の結晶形態
JP2010536887A (ja) * 2007-08-29 2010-12-02 メチルジーン インコーポレイテッド タンパク質チロシンキナーゼ活性の阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8907091B2 (en) * 2007-08-29 2014-12-09 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
US20180237378A1 (en) * 2015-08-19 2018-08-23 Sandoz Ag Asymmetric Bisamidation of Malonic Ester Derivatives
EP3740491A1 (en) * 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CN109384799B (zh) * 2018-11-12 2020-07-14 深圳海王医药科技研究院有限公司 一种多靶点激酶抑制剂化合物的晶型a及制备方法和含有其的药物组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010511689A (ja) * 2006-12-06 2010-04-15 ファイザー・インク （３Ｓ）−３−［Ｎ−（Ｎ’−（２−ｔｅｒｔ−ブチルフェニル）オキサミル）アラニニル］アミノ−５−（２’，３’，５’，６’−テトラフルオロフェノキシ）−４−オキソペンタン酸の結晶形態
JP2010536887A (ja) * 2007-08-29 2010-12-02 メチルジーン インコーポレイテッド タンパク質チロシンキナーゼ活性の阻害剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0005355367 *

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Publication number Publication date
EP4027999A1 (en) 2022-07-20
EP4027999C0 (en) 2026-03-04
US12466838B2 (en) 2025-11-11
EP4027999A4 (en) 2023-08-16
US20220402936A1 (en) 2022-12-22
CA3150267A1 (en) 2021-03-18
EP4027999B1 (en) 2026-03-04
CN114401720A (zh) 2022-04-26
JP2025102940A (ja) 2025-07-08
WO2021050580A1 (en) 2021-03-18

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