JP2022546457A - 改変された制御性ｔ細胞 - Google Patents

改変された制御性ｔ細胞 Download PDF

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JP2022546457A
JP2022546457A JP2022513373A JP2022513373A JP2022546457A JP 2022546457 A JP2022546457 A JP 2022546457A JP 2022513373 A JP2022513373 A JP 2022513373A JP 2022513373 A JP2022513373 A JP 2022513373A JP 2022546457 A JP2022546457 A JP 2022546457A
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seq
liver
car
domain
tregs
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JP2022546457A5 (enExample
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マルティネス‐ローデラ、マーク
サンチェス‐フエヨ、アルベルト
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Kings College London
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Kings College London
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Microbiology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022513373A 2019-08-30 2020-08-28 改変された制御性ｔ細胞 Pending JP2022546457A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025178768A JP2026016543A (ja) 2019-08-30 2025-10-23 改変された制御性ｔ細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1912515.2A GB201912515D0 (en) 2019-08-30 2019-08-30 Engineered regulatory T cell
GB1912515.2 2019-08-30
PCT/GB2020/052076 WO2021038249A1 (en) 2019-08-30 2020-08-28 Engineered regulatory t cell

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JP2025178768A Division JP2026016543A (ja) 2019-08-30 2025-10-23 改変された制御性ｔ細胞

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JP2022546457A true JP2022546457A (ja) 2022-11-04
JP2022546457A5 JP2022546457A5 (enExample) 2023-09-04

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JP2022513373A Pending JP2022546457A (ja) 2019-08-30 2020-08-28 改変された制御性ｔ細胞
JP2025178768A Pending JP2026016543A (ja) 2019-08-30 2025-10-23 改変された制御性ｔ細胞

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US (1) US20230134301A1 (enExample)
EP (1) EP4021484A1 (enExample)
JP (2) JP2022546457A (enExample)
KR (1) KR20220051390A (enExample)
CN (1) CN114585730A (enExample)
AU (1) AU2020338290A1 (enExample)
CA (1) CA3148676A1 (enExample)
GB (1) GB201912515D0 (enExample)
IL (1) IL290830A (enExample)
WO (1) WO2021038249A1 (enExample)

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Publication number Priority date Publication date Assignee Title
GB202217541D0 (en) * 2022-11-24 2023-01-11 Quell Therapeutics Ltd Recombinant receptor
EP4442322A1 (en) 2023-04-06 2024-10-09 Medizinische Hochschule Hannover Liver-specific car for use against immunologic rejection
CN118001381B (zh) * 2024-01-24 2025-04-22 首都医科大学附属北京地坛医院 一种药物组合物及应用
WO2026027876A1 (en) * 2024-07-29 2026-02-05 Quell Therapeutics Limited Chimeric antigen receptor

Citations (7)

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Publication number Priority date Publication date Assignee Title
JP2013516967A (ja) * 2010-01-14 2013-05-16 グラクソ グループ リミテッド 肝臓標的化ドメイン抗体
US20140134720A1 (en) * 2011-05-17 2014-05-15 Ucl Business Plc Method
JP2018509893A (ja) * 2015-02-12 2018-04-12 ユニバーシティー ヘルス ネットワーク キメラ抗原受容体
WO2018080541A1 (en) * 2016-10-31 2018-05-03 Seattle Children's Hospital (dba Seattle Children's Research Institute) Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogennous foxp3 gene
US20180201902A1 (en) * 2014-12-04 2018-07-19 Carsgen Therapeutics Ltd Gpc3 and asgpr1 double-targeted transgenic immune effector cell and use thereof
JP2018537088A (ja) * 2015-11-13 2018-12-20 科済生物医薬（上海）有限公司 Ｐｄ−ｌ１遮断薬を持つキメラ抗原受容体修飾免疫エフェクター細胞
WO2019141774A1 (en) * 2018-01-19 2019-07-25 Miltenyi Biotec Gmbh Regulatory t cell expressing a chimeric antigen receptor

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Publication number Priority date Publication date Assignee Title
GB9803351D0 (en) 1998-02-17 1998-04-15 Oxford Biomedica Ltd Anti-viral vectors
GB0009760D0 (en) 2000-04-19 2000-06-07 Oxford Biomedica Ltd Method
EP3331918A1 (en) * 2015-08-04 2018-06-13 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
WO2019241549A1 (en) 2018-06-15 2019-12-19 A2 Biotherapeutics, Inc. Foxp3-expressing car-t regulatory cells

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516967A (ja) * 2010-01-14 2013-05-16 グラクソ グループ リミテッド 肝臓標的化ドメイン抗体
US20140134720A1 (en) * 2011-05-17 2014-05-15 Ucl Business Plc Method
US20180201902A1 (en) * 2014-12-04 2018-07-19 Carsgen Therapeutics Ltd Gpc3 and asgpr1 double-targeted transgenic immune effector cell and use thereof
JP2018509893A (ja) * 2015-02-12 2018-04-12 ユニバーシティー ヘルス ネットワーク キメラ抗原受容体
JP2018537088A (ja) * 2015-11-13 2018-12-20 科済生物医薬（上海）有限公司 Ｐｄ−ｌ１遮断薬を持つキメラ抗原受容体修飾免疫エフェクター細胞
WO2018080541A1 (en) * 2016-10-31 2018-05-03 Seattle Children's Hospital (dba Seattle Children's Research Institute) Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogennous foxp3 gene
WO2019141774A1 (en) * 2018-01-19 2019-07-25 Miltenyi Biotec Gmbh Regulatory t cell expressing a chimeric antigen receptor

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CN114585730A (zh) 2022-06-03
GB201912515D0 (en) 2019-10-16
WO2021038249A1 (en) 2021-03-04
IL290830A (en) 2022-04-01
KR20220051390A (ko) 2022-04-26
US20230134301A1 (en) 2023-05-04
CA3148676A1 (en) 2021-03-04
AU2020338290A1 (en) 2022-03-24
JP2026016543A (ja) 2026-02-03
EP4021484A1 (en) 2022-07-06

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