JP2022546167A - コラーゲン膜を含むインプラント - Google Patents
コラーゲン膜を含むインプラント Download PDFInfo
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- JP2022546167A JP2022546167A JP2021575336A JP2021575336A JP2022546167A JP 2022546167 A JP2022546167 A JP 2022546167A JP 2021575336 A JP2021575336 A JP 2021575336A JP 2021575336 A JP2021575336 A JP 2021575336A JP 2022546167 A JP2022546167 A JP 2022546167A
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- collagen
- scaffold
- cross
- collagen membrane
- membrane
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Images
Classifications
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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Abstract
Description
Claims (21)
- 少なくとも1つの生体適合性骨格足場と、前記骨格足場表面の少なくとも一部に堆積した少なくとも1つの生体適合性および生分解性コラーゲン膜とを含む移植可能構造体であって、
前記コラーゲン膜の生分解速度が制御可能に構成されている、移植可能構造体。 - 前記骨格足場が、チタン、ニチノール、ポリテトラフルオロエチレン(PTFE、テフロン(登録商標))、ステンレス鋼、ポリプロピレン、ポリスチレン、ポリエステル、シリコン、またはそれらの組み合わせのうちの少なくとも1つから形成されている、請求項1に記載の移植可能構造体。
- 前記骨格足場が、織布または不織布のメッシュ、ワイヤ、ロッド、またはそれらの任意の組み合わせから形成されている、請求項1に記載の移植可能構造体。
- 前記コラーゲン膜が、少なくとも1つの薬学的活性剤をさらに含む、請求項1に記載の移植可能構造体。
- 前記薬学的活性剤が、抗菌剤、抗炎症剤、組織再生誘導特性を有する因子、およびそれらの任意の組み合わせから選択される、請求項4に記載の移植可能構造体。
- 前記コラーゲン膜が、架橋コラーゲンを含む、請求項1に記載の移植可能構造体。
- 保隙装置をさらに含む、請求項1に記載の移植可能構造体。
- 請求項1~7に記載の移植可能構造体を調製する方法であって、
少なくとも1つの生体適合性骨格足場を提供するステップと、
前記骨格足場の少なくとも一部を、コラーゲンを含む溶液中に浸漬するステップと、
前記コラーゲンをフィブリル化するステップと、
前記コラーゲンを架橋することにより、前記骨格足場の表面上に堆積した架橋コラーゲン膜を提供するステップとを含む、方法。 - 前記溶液が少なくとも1つのフィブリル化剤を含む、請求項8に記載の方法。
- 少なくとも1つの前記フィブリル化剤が、リン酸ナトリウム、トリスHCl、水酸化カリウムまたは水酸化ナトリウムから選択される、請求項9に記載の方法。
- 前記コラーゲン膜が、酵素媒介処理、熱、UV照射、少なくとも1つの架橋剤、またはそれらの任意の組み合わせのうちの少なくとも1つによって架橋される、請求項8に記載の方法。
- 少なくとも1つの前記架橋剤が、グリセロース、トレオース、エリスロース、リキソース、キシロース、アラビノース、リボース、アロース、アルトロース、グルコース、マンノース、グロース、イドース、ガラクトース、タロース、もしくは任意の他のジオース、トリオース、テトロース、ペントース、ヘキソース、セプトース、オクトース、ナノース、もしくはデコース、またはそれらの任意の組み合わせから選択される、請求項11に記載の方法。
- 前記コラーゲン膜が1つまたは複数の領域を含み、各前記領域が異なる架橋度によって架橋されている、請求項8に記載の方法。
- 前記コラーゲン膜を洗浄して残留反応物を除去するステップをさらに含む、請求項8に記載の方法。
- 前記コラーゲン膜を脱水するステップをさらに含む、請求項8に記載の方法。
- 歯科または整形外科の骨再生、ヘルニア修復、硬膜修復、およびそれらの任意の組み合わせの少なくとも1つで使用するための、請求項1~7のいずれか一項に記載の移植可能構造体。
- 少なくとも1つの保隙装置と組み合わせて使用するための、請求項1~7のいずれか一項に記載の移植可能構造体。
- 請求項1~7のいずれか一項に記載の移植可能構造体を含むキット。
- 少なくとも1つの生体適合性骨格足場と、少なくとも1つのコラーゲン溶液と、およびそれらの使用説明書とを含むキット。
- 少なくとも1つのフィブリル化剤をさらに含む、請求項19に記載のキット。
- 少なくとも1つの架橋剤をさらに含む、請求項19に記載のキット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IL2019/050690 WO2020255113A1 (en) | 2019-06-20 | 2019-06-20 | An implantable structure having a collagen membrane |
ILPCT/IL2019/050690 | 2019-06-20 | ||
PCT/IL2020/050686 WO2020255143A1 (en) | 2019-06-20 | 2020-06-18 | An implant comprising a collagen membrane |
Publications (1)
Publication Number | Publication Date |
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JP2022546167A true JP2022546167A (ja) | 2022-11-04 |
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JP2021575336A Pending JP2022546167A (ja) | 2019-06-20 | 2020-06-18 | コラーゲン膜を含むインプラント |
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Country | Link |
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US (1) | US20220241459A1 (ja) |
EP (1) | EP3986490A4 (ja) |
JP (1) | JP2022546167A (ja) |
KR (1) | KR20220141274A (ja) |
CN (1) | CN114222595A (ja) |
AU (1) | AU2020297034B2 (ja) |
BR (1) | BR112021025835A2 (ja) |
CA (1) | CA3143899A1 (ja) |
IL (1) | IL289150A (ja) |
MX (1) | MX2021015975A (ja) |
WO (2) | WO2020255113A1 (ja) |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
FR2679778B1 (fr) * | 1991-08-02 | 1995-07-07 | Coletica | Utilisation de collagene reticule par un agent de reticulation pour la fabrication d'une membrane suturable, biocompatible, a resorption lente, ainsi qu'une telle membrane. |
IL110367A (en) * | 1994-07-19 | 2007-05-15 | Colbar Lifescience Ltd | Collagen-based matrix |
US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
KR20080031735A (ko) * | 2005-06-10 | 2008-04-10 | 셀진 코포레이션 | 인간 태반 콜라겐 조성물, 그의 제조 방법, 그의 사용 방법및 상기 조성물을 포함하는 키트 |
JP2009507103A (ja) * | 2005-09-02 | 2009-02-19 | コルバー・ライフサイエンス・リミテツド | 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法 |
US20080026032A1 (en) * | 2006-07-27 | 2008-01-31 | Zubery Yuval | Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use |
FR2922434B1 (fr) * | 2007-10-18 | 2010-08-20 | Rech S Et De Fabrication Serf | Implant dentaire |
EP2389204B1 (en) * | 2009-01-23 | 2019-07-03 | Royal College of Surgeons in Ireland | Layered scaffold suitable for osteochondral repair |
US20140248328A1 (en) * | 2012-08-31 | 2014-09-04 | Jennifer L. Wehmeyer | Methods of treating amniotic membranes using supercritical fluids and compositions and apparatuses prepared therefrom |
US9878071B2 (en) * | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
CN103785061B (zh) * | 2014-01-08 | 2015-05-20 | 浙江大学 | 胶原/羟基磷灰石复合涂层人工关节植入体及制备方法 |
SE539167C2 (en) * | 2015-12-22 | 2017-05-02 | Rafat Mehrdad | A composite collagen hydrogel material, an implantable ophthalmic device comprising such material and methods of producing the composite collagen hydrogel material and the implantable ophthalmic device |
ES2806990T3 (es) * | 2016-02-15 | 2021-02-19 | Modern Meadow Inc | Procedimiento para fabricar un material biofabricado que contiene fibrillas de colágeno |
CN107913435B (zh) * | 2016-10-10 | 2022-09-09 | 北京邦塞科技有限公司 | 复合型硬脑(脊)膜植入物及其制备方法和用途 |
CN106730037B (zh) * | 2016-11-17 | 2019-12-13 | 北京华信佳音医疗科技发展有限责任公司 | 一种复合胶原生物膜及其制备方法 |
-
2019
- 2019-06-20 WO PCT/IL2019/050690 patent/WO2020255113A1/en active Application Filing
- 2019-06-20 MX MX2021015975A patent/MX2021015975A/es unknown
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2020
- 2020-06-18 CA CA3143899A patent/CA3143899A1/en active Pending
- 2020-06-18 AU AU2020297034A patent/AU2020297034B2/en active Active
- 2020-06-18 CN CN202080057740.2A patent/CN114222595A/zh active Pending
- 2020-06-18 EP EP20826193.3A patent/EP3986490A4/en active Pending
- 2020-06-18 JP JP2021575336A patent/JP2022546167A/ja active Pending
- 2020-06-18 US US17/620,708 patent/US20220241459A1/en active Pending
- 2020-06-18 BR BR112021025835A patent/BR112021025835A2/pt unknown
- 2020-06-18 KR KR1020227002142A patent/KR20220141274A/ko unknown
- 2020-06-18 WO PCT/IL2020/050686 patent/WO2020255143A1/en active Application Filing
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CA3143899A1 (en) | 2020-12-24 |
KR20220141274A (ko) | 2022-10-19 |
EP3986490A4 (en) | 2023-07-19 |
IL289150A (en) | 2022-02-01 |
AU2020297034B2 (en) | 2023-12-21 |
CN114222595A (zh) | 2022-03-22 |
WO2020255143A1 (en) | 2020-12-24 |
BR112021025835A2 (pt) | 2022-02-08 |
EP3986490A1 (en) | 2022-04-27 |
WO2020255113A1 (en) | 2020-12-24 |
US20220241459A1 (en) | 2022-08-04 |
AU2020297034A1 (en) | 2022-02-10 |
MX2021015975A (es) | 2022-05-24 |
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