JP2022545415A - 造血誘導用の培養培地 - Google Patents

造血誘導用の培養培地 Download PDF

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JP2022545415A
JP2022545415A JP2022510803A JP2022510803A JP2022545415A JP 2022545415 A JP2022545415 A JP 2022545415A JP 2022510803 A JP2022510803 A JP 2022510803A JP 2022510803 A JP2022510803 A JP 2022510803A JP 2022545415 A JP2022545415 A JP 2022545415A
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cells
medium
induction medium
hematopoietic
cell
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JP2022545415A5 (enExample
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チェン タオ ヤン
リー カーペンター
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アダプティミューン・リミテッド
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Priority claimed from GBGB1911955.1A external-priority patent/GB201911955D0/en
Priority claimed from GBGB2012306.3A external-priority patent/GB202012306D0/en
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Publication of JP2022545415A publication Critical patent/JP2022545415A/ja
Publication of JP2022545415A5 publication Critical patent/JP2022545415A5/ja
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Genetics & Genomics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2022510803A 2019-08-20 2020-08-20 造血誘導用の培養培地 Pending JP2022545415A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1911955.1 2019-08-20
GBGB1911955.1A GB201911955D0 (en) 2019-08-20 2019-08-20 Culture medium for haematopoietic induction
GBGB2012306.3A GB202012306D0 (en) 2020-08-07 2020-08-07 Culture medium for haematopoietic induction
GB2012306.3 2020-08-07
PCT/EP2020/073407 WO2021032855A1 (en) 2019-08-20 2020-08-20 Culture medium for haematopoietic induction

Publications (2)

Publication Number Publication Date
JP2022545415A true JP2022545415A (ja) 2022-10-27
JP2022545415A5 JP2022545415A5 (enExample) 2023-08-18

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JP2022510803A Pending JP2022545415A (ja) 2019-08-20 2020-08-20 造血誘導用の培養培地

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US (1) US20220275335A1 (enExample)
EP (1) EP4017969A1 (enExample)
JP (1) JP2022545415A (enExample)
KR (1) KR20220047375A (enExample)
CN (1) CN114341349A (enExample)
AU (1) AU2020333918A1 (enExample)
BR (1) BR112022003083A2 (enExample)
CA (1) CA3150037A1 (enExample)
IL (1) IL290602A (enExample)
MX (1) MX2022001961A (enExample)
WO (1) WO2021032855A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201911953D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd T cell production fram RAG inacivated iPSCs
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
WO2022241558A1 (en) * 2021-05-18 2022-11-24 The University Of British Columbia A method for producing blood progenitor and progenitor t cells, resulting cells and methods and uses thereof
GB202205572D0 (en) 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
GB202208545D0 (en) 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
WO2024050534A2 (en) * 2022-09-01 2024-03-07 Regents Of The University Of Minnesota In vitro generated hematopoietic stem progenitor cells and t cells and methods of making and using the same
KR102566680B1 (ko) * 2022-09-28 2023-08-14 (주)포에버엔케이 면역세포 및 자연살해세포 배양을 위한 신규한 이중배양 제조방법 및 이의 용도
WO2024107010A1 (ko) * 2022-11-17 2024-05-23 주식회사 씨티셀즈 미분화 줄기세포로부터 자연 살해 세포로의 분화 방법 및 이의 용도
CN118360247A (zh) * 2023-01-19 2024-07-19 中国科学院动物研究所 一种iSCLP细胞及其制备方法和应用
GB202318950D0 (en) 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells

Citations (2)

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JP2018502591A (ja) * 2015-01-26 2018-02-01 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
JP2018533363A (ja) * 2015-11-04 2018-11-15 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物

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SG11201507275TA (en) * 2013-03-13 2015-10-29 Wisconsin Alumni Res Found Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
JPWO2015199127A1 (ja) * 2014-06-24 2017-04-20 国立大学法人京都大学 中胚葉細胞および造血細胞の製造方法
ES2862676T3 (es) * 2015-10-20 2021-10-07 Fujifilm Cellular Dynamics Inc Producción de células precursoras hematopoyéticas multilinaje mediante programación genética
US12270050B2 (en) * 2015-12-08 2025-04-08 Regents Of The University Of Minnesota Human T cell derived from T cell-derived induced pluripotent stem cell and methods of making and using
US11141471B2 (en) * 2016-04-25 2021-10-12 Regen BioPharma, Inc. Universal donor checkpoint inhibitor silenced/gene edited cord blood killer cells
WO2017193177A1 (en) * 2016-05-13 2017-11-16 Murdoch Childrens Research Institute Haematopoietic stem/progenitor cells
US20200080058A1 (en) * 2017-03-21 2020-03-12 Etablissement Francais Du Sang Methods of improving hematopoietic grafts
CN112041428B (zh) * 2018-01-18 2024-05-24 新加坡科技研究局 用于在悬浮培养物中分化人多能干细胞系的方法
GB201911953D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd T cell production fram RAG inacivated iPSCs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502591A (ja) * 2015-01-26 2018-02-01 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
JP2018533363A (ja) * 2015-11-04 2018-11-15 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物

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US20220275335A1 (en) 2022-09-01
MX2022001961A (es) 2022-03-11
IL290602A (en) 2022-04-01
WO2021032855A1 (en) 2021-02-25
BR112022003083A2 (pt) 2022-08-02
AU2020333918A1 (en) 2022-03-24
CN114341349A (zh) 2022-04-12
CA3150037A1 (en) 2021-02-25
KR20220047375A (ko) 2022-04-15
EP4017969A1 (en) 2022-06-29

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