JP2022541164A - 抗菌組成物及びその使用法 - Google Patents
抗菌組成物及びその使用法 Download PDFInfo
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- JP2022541164A JP2022541164A JP2022502094A JP2022502094A JP2022541164A JP 2022541164 A JP2022541164 A JP 2022541164A JP 2022502094 A JP2022502094 A JP 2022502094A JP 2022502094 A JP2022502094 A JP 2022502094A JP 2022541164 A JP2022541164 A JP 2022541164A
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Images
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
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- A—HUMAN NECESSITIES
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Abstract
Description
[0019]本開示の完全かつ実施可能な開示を、添付図面への参照も含めて本明細書の残り部分に示す。
[0022]一般に、本開示は、過酸化水素源を有機スルホン酸及び過酸化物アジュバントと組み合わせて含有する抗菌組成物に向けられる。過酸化物アジュバントは、有機酸及び/又はその塩、特に低分子量の有機酸及び/又はその塩である。有機スルホン酸と組み合わせた過酸化物アジュバントの存在は、特に過酸化水素だけを含有する組成物、又は過酸化水素と酢酸を含有する組成物と比較した場合、組成物の抗菌特性を劇的に改良する。過酸化水素源と有機スルホン酸及び過酸化物アジュバントとの組合せは、広範囲の微生物に対する抗菌活性を著しく増強することが見出された。さらに詳しくは、本開示の抗菌組成物は、接触時間が比較的短い場合でも、クロストリジウム・ディフィシレの破壊及び増殖阻害に特によく適していることが見出された。例えば、本開示の抗菌組成物は、ASTM試験法ASTM E2197-11及びE2839-11に従って試験された場合に3分間の接触時間後、C.ディフィシレに対して少なくとも3log10の減少を達成することができる。本開示の抗菌組成物は、3分間の接触時間後、C.ディフィシレに対して少なくとも4log10の減少、例えば少なくとも5log10の減少、例えば少なくとも6log10の減少を達成することもできる。
[0048]抗菌組成物は、消毒、衛生化、清浄化及び/又は漂白が所望される任意の適切な用途に使用できる。抗菌組成物は、消費者の家庭での用途、保健医療分野での用途、食品加工分野又は食品サービス分野での用途、酪農場及び醸造所における表面滅菌用途、獣医分野での用途、及び/又はクリーンルームでの用途のために使用できる。
[0059]様々な抗菌製剤を製造し、クロストリジウム・ディフィシレに対して試験した。下記の試験手順を使用した。
[0068]表2
[0071]表3
[0073]表4
[0075]さらに3種類の抗菌製剤を処方した。製剤のpHを調整して、その効果を判定した。
[0078]以下は、後から水で希釈して抗菌組成物として使用できる濃縮製剤の例である。
[0081]表8
[0083]表9
12 ディスペンサー
14 底部
16 頂部
18 スロット
20 ワイプ
22 ワイピング製品
24 ハンドル
26 基材ホルダー
28 取付装置
30 ワイプ
Claims (28)
- 抗菌組成物であって、
過酸化水素源と;
過酸化物アジュバントと
を含み、前記過酸化物アジュバントは約1~約6のpKaを有する有機酸及び/又はその塩を含み、前記抗菌組成物は酢酸を含まず、そしてASTM試験法E2197-11及びE2839-11に従ってクロストリジウム・ディフィシレに対して試験された場合に3分間の接触時間後、当該組成物が3log10以上の減少を達成するのに十分な量で、前記過酸化物アジュバントが当該組成物中に存在する、前記抗菌組成物。 - 有機スルホン酸をさらに含む、請求項1に記載の抗菌組成物。
- 過酸化物アジュバントが、1個又は2個の炭素原子を含有する有機酸及び/又はその塩を含む、請求項1又は2に記載の抗菌組成物。
- 過酸化物アジュバントが、ギ酸、ギ酸塩、又はそれらの混合物を含む、請求項1~3のいずれかに記載の抗菌組成物。
- 過酸化物アジュバントが、グリコール酸、グリコール酸の塩、又はそれらの混合物を含む、請求項1~2のいずれかに記載の抗菌組成物。
- 過酸化物アジュバントが、シュウ酸などのジカルボン酸又はトリカルボン酸を含む、請求項1~5のいずれかに記載の抗菌組成物。
- 過酢酸を含まない、請求項1~6のいずれかに記載の抗菌組成物。
- 漂白剤を含まない、請求項1~7のいずれかに記載の抗菌組成物。
- 有機スルホン酸が、C1-C5アルキルスルホン酸、スルホン化C1-C5カルボン酸、置換又は非置換芳香族スルホン酸、モノ-アルキルフェニルスルホン酸、ジ-アルキルフェニルスルホン酸、又はそれらの混合物を含み、前記置換芳香族スルホン酸が少なくとも一つのC1-C3アルキル基で置換されている、請求項2に記載の抗菌組成物。
- 有機スルホン酸が、メタンスルホン酸又はベンゼンスルホン酸を含む、請求項2に記載の抗菌組成物。
- 有機スルホン酸が、トルエンスルホン酸、キシレンスルホン酸、エチルベンゼンスルホン酸、又はそれらの混合物を含む、請求項2に記載の抗菌組成物。
- 過酸化水素源が過酸化水素を含み、過酸化水素と過酸化物アジュバントが当該組成物中に、約100:1~約1:2、例えば約20:1~約1:1、例えば約8:1~約2:1の重量比で存在する、請求項1~11のいずれかに記載の抗菌組成物。
- 過酸化水素源が過酸化水素を含み、過酸化水素と有機スルホン酸が当該組成物中に、約100:1~約1:3、例えば約10:1~約1:1.1、例えば約3:1~約1:0.9の重量比で存在する、請求項2に記載の抗菌組成物。
- 過酸化水素源が過酸化水素を含み、過酸化水素が当該組成物中に約0.2重量%~約20重量%、例えば約1重量%~約15重量%、例えば約1重量%~約8重量%の量で存在する、請求項1~13のいずれかに記載の抗菌組成物。
- 過酸化物アジュバントが当該組成物中に、約0.05重量%~約7重量%、例えば約0.08重量%~約5重量%、例えば約0.1重量%~約4重量%の量で存在する、請求項1~14のいずれかに記載の抗菌組成物。
- 有機スルホン酸が当該組成物中に、約0.1重量%~約8重量%の量、例えば約0.5重量%~約6重量%の量、例えば約1重量%~約5重量%の量で存在する、請求項2に記載の抗菌組成物。
- ギ酸及び/又はギ酸塩をグリコール酸及び/又はグリコール酸塩と組み合わせて含有する、請求項1~16のいずれかに記載の抗菌組成物。
- 約1~約5のpHを有する、請求項1~17のいずれかに記載の抗菌組成物。
- 液体担体をさらに含有し、前記液体担体は、水、アルコール、又はそれらの混合物を含む、請求項1~18のいずれかに記載の抗菌組成物。
- 前記組成物が、ASTM試験法E2197-11及びE2839-11に従ってC.ディフィシレに対して試験された場合に3分間の接触時間後、少なくとも4log10の減少、例えば少なくとも5log10の減少、例えば少なくとも6log10の減少を達成する、請求項1~19のいずれかに記載の抗菌組成物。
- ワイピング製品であって、
液体吸収基材と;そして
請求項1~20のいずれかに記載の抗菌組成物と
を含み、前記抗菌組成物が当該基材に吸収されている製品。 - 硬質表面の消毒法であって、
請求項1~20のいずれかに記載の抗菌組成物を表面に接触させることを含む方法。 - 硬質表面が、保健医療業界又は獣医業界で使用される表面を含む、請求項22に記載の方法。
- 硬質表面が、食品加工装置又は食品調理表面を含む、請求項22に記載の方法。
- 前記抗菌組成物が、液体吸収基材に適用された後、前記基材を用いて前記表面に接触される、請求項22~24のいずれかに記載の方法。
- 抗菌組成物前駆体であって、
有機スルホン酸と;
過酸化物アジュバントと
を含み、前記過酸化物アジュバントは約1~約6のpKaを有する有機酸及び/又はその塩を含み、前記抗菌組成物前駆体は酸性酸(acidic acid)を含まず、有機スルホン酸は当該組成物中に約15重量%~約60重量%の量で存在し、前記過酸化物アジュバントは当該組成物中に約5重量%~約20重量%の量で存在する、前記抗菌組成物前駆体。 - 過酸化物アジュバントが、ギ酸、ギ酸塩、又はそれらの混合物を含む、請求項26に記載の抗菌組成物前駆体。
- 過酸化水素源と組み合わされた請求項26又は27に記載の抗菌組成物前駆体を含む抗菌組成物。
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BR112022000569A2 (pt) | 2022-06-07 |
WO2021011197A1 (en) | 2021-01-21 |
TW202116163A (zh) | 2021-05-01 |
AU2020315254A1 (en) | 2022-02-03 |
CN114364258A (zh) | 2022-04-15 |
EP3982728A1 (en) | 2022-04-20 |
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