JP2022538174A5 - - Google Patents

Info

Publication number
JP2022538174A5
JP2022538174A5 JP2021577171A JP2021577171A JP2022538174A5 JP 2022538174 A5 JP2022538174 A5 JP 2022538174A5 JP 2021577171 A JP2021577171 A JP 2021577171A JP 2021577171 A JP2021577171 A JP 2021577171A JP 2022538174 A5 JP2022538174 A5 JP 2022538174A5
Authority
JP
Japan
Prior art keywords
cancer
inhibitor
cbl
cells
immune cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021577171A
Other languages
English (en)
Japanese (ja)
Other versions
JP7831995B2 (ja
JP2022538174A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/039957 external-priority patent/WO2020264398A1/en
Publication of JP2022538174A publication Critical patent/JP2022538174A/ja
Publication of JP2022538174A5 publication Critical patent/JP2022538174A5/ja
Application granted granted Critical
Publication of JP7831995B2 publication Critical patent/JP7831995B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021577171A 2019-06-26 2020-06-26 Cbl-b阻害のための置換ベンジル-トリアゾール化合物、及びそのさらなる使用 Active JP7831995B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962866914P 2019-06-26 2019-06-26
US62/866,914 2019-06-26
US201962880285P 2019-07-30 2019-07-30
US62/880,285 2019-07-30
US201962888870P 2019-08-19 2019-08-19
US201962888845P 2019-08-19 2019-08-19
US62/888,870 2019-08-19
US62/888,845 2019-08-19
PCT/US2020/039957 WO2020264398A1 (en) 2019-06-26 2020-06-26 Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof

Publications (3)

Publication Number Publication Date
JP2022538174A JP2022538174A (ja) 2022-08-31
JP2022538174A5 true JP2022538174A5 (enExample) 2023-07-14
JP7831995B2 JP7831995B2 (ja) 2026-03-17

Family

ID=71662363

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021577171A Active JP7831995B2 (ja) 2019-06-26 2020-06-26 Cbl-b阻害のための置換ベンジル-トリアゾール化合物、及びそのさらなる使用

Country Status (11)

Country Link
US (3) US11401267B2 (enExample)
EP (1) EP3990117A1 (enExample)
JP (1) JP7831995B2 (enExample)
KR (1) KR20220026581A (enExample)
CN (1) CN114364670B (enExample)
AU (2) AU2020303696B2 (enExample)
BR (1) BR112021026241A2 (enExample)
CA (2) CA3144450A1 (enExample)
IL (1) IL289290B1 (enExample)
MX (2) MX2021015675A (enExample)
WO (1) WO2020264398A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021004191A (es) 2018-10-15 2021-05-27 Nurix Therapeutics Inc Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
US11174263B2 (en) 2018-12-31 2021-11-16 Biomea Fusion, Inc. Inhibitors of menin-MLL interaction
SG11202106304RA (en) 2018-12-31 2021-07-29 Biomea Fusion Llc Irreversible inhibitors of menin-mll interaction
US12582722B2 (en) 2019-02-13 2026-03-24 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CA3136348A1 (en) 2019-04-09 2020-10-15 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
AU2020278592B2 (en) 2019-05-17 2024-10-10 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
EP4034140A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for use in adoptive cell therapy
WO2021113557A1 (en) 2019-12-04 2021-06-10 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
AR124800A1 (es) * 2021-02-03 2023-05-03 Genentech Inc Lactamas como inhibidores cbl-b
WO2022217123A2 (en) * 2021-04-08 2022-10-13 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds
US12325697B2 (en) * 2021-04-09 2025-06-10 Nimbus Clio, Inc. CBL-B modulators and uses thereof
AU2022256514A1 (en) * 2021-04-16 2023-10-19 Hotspot Therapeutics, Inc. Compounds, compositions and methods of treating cancer
EP4359381A4 (en) * 2021-06-21 2025-04-30 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
TW202320796A (zh) 2021-08-11 2023-06-01 美商拜歐米富士恩股份有限公司 用於糖尿病的menin-mll相互作用之共價抑制劑
US12018032B2 (en) 2021-08-20 2024-06-25 Biomea Fusion, Inc. Crystalline forms of N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide as an irreversible inhibitor of menin-MLL interaction
CA3236073A1 (en) 2021-10-26 2023-05-04 Robert J. Brown Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk
US20250042896A1 (en) * 2021-10-29 2025-02-06 Hainan Simcere Zaiming Pharmaceutical Co., Ltd. Polycyclic compound as cbl-b inhibitor
AU2022379959A1 (en) * 2021-11-05 2024-05-09 Genentech, Inc. Lactams as cbl-b inhibitors selective over c-cbl
US20250009731A1 (en) * 2021-11-08 2025-01-09 Nurix Therapeutics, Inc. Toll-like receptor therapy combinations with cbl-b inhibitor compounds
TW202342013A (zh) * 2022-02-10 2023-11-01 英屬開曼群島商百濟神州有限公司 雜環化合物、其組成物及用其進行治療之方法
CN116715632B (zh) * 2022-03-07 2025-09-30 苏州恩华生物医药科技有限公司 螺[环丁烷1,4′-异喹啉]酮类衍生物顺反异构体的制备方法
AU2023230346A1 (en) * 2022-03-09 2024-10-17 Orum Therapeutics, Inc. Activators of effector t cells
WO2023205180A1 (en) * 2022-04-19 2023-10-26 Nurix Therapeutics, Inc. Biomarkers for cbl, and compositions and methods for their use
WO2023217067A1 (zh) * 2022-05-09 2023-11-16 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
US20230414598A1 (en) * 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents
EP4554586A1 (en) * 2022-07-12 2025-05-21 Hotspot Therapeutics, Inc. Cbl-b inhibitors and anti-pd1/anti-pd-l1 for use in the treatment of cancer
AU2023307165A1 (en) * 2022-07-12 2025-02-06 Hotspot Therapeutics, Inc. Methods of preparation of heterocyclic compounds
WO2024015863A1 (en) * 2022-07-12 2024-01-18 Hotspot Therapeutics, Inc. Cbl-b inhibitor, compositions comprising a cbl-b inhibitor in a method of treating a disease associated with cell proliferation
CA3261875A1 (en) * 2022-07-12 2024-01-18 Hotspot Therapeutics, Inc. SOLID FORMS OF A TRIAZINE DERIVATIVE AS A CBL-B MODULATOR
EP4558504A1 (en) * 2022-07-18 2025-05-28 Insilico Medicine IP Limited Cbl-b inhibitors and methods of uses thereof
EP4558501A1 (en) 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
KR20250050018A (ko) 2022-08-16 2025-04-14 그렌마크 파머수티칼스 엘티디. Cbl-b 저해제로서의 치환된 피리디논 화합물
WO2024062363A1 (en) * 2022-09-21 2024-03-28 Glenmark Pharmaceuticals Ltd Bicyclic heterocyclic compounds as cbl-b inhibitors
WO2024074977A1 (en) * 2022-10-04 2024-04-11 Pfizer Inc. Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds
EP4602028A1 (en) * 2022-10-11 2025-08-20 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
WO2024086730A1 (en) * 2022-10-19 2024-04-25 Hotspot Therapeutics, Inc. Heterocyclic cbl-b inhibitors for the treatment of cancer
WO2024105563A1 (en) * 2022-11-16 2024-05-23 Pfizer Inc. Substituted bicyclic pyridone derivatives
WO2024131939A1 (en) * 2022-12-23 2024-06-27 Insilico Medicine Ip Limited Cbl-b inhibitors and methods of uses thereof
WO2024155710A1 (en) 2023-01-18 2024-07-25 Biomea Fusion, Inc. Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2-pyridinecarboxamide as a covalent inhibitor of menin-mll interaction
EP4653436A1 (en) * 2023-01-19 2025-11-26 Guangzhou Yufan Nantu Biotechnologies Co., Ltd Heterocyclic compounds, preparation method therefor and use thereof
CN120530105A (zh) * 2023-01-20 2025-08-22 海南先声再明医药股份有限公司 取代的三环化合物及其应用
TW202435863A (zh) 2023-01-28 2024-09-16 芬蘭商奧利安公司 Cbl-b抑制劑
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202448456A (zh) 2023-05-09 2024-12-16 美商建南德克公司 作為對c-cbl具選擇性之cbl-b抑制劑的6-經取代-3-苯基-異吲哚啉-1-酮類
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202502751A (zh) * 2023-06-13 2025-01-16 大陸商上海齊魯製藥研究中心有限公司 Cbl-b抑制劑
CN121816192A (zh) 2023-09-14 2026-04-07 因斯布鲁克医科大学 通过抑制NR2f6增强CAR-T细胞疗效
TW202543601A (zh) * 2024-04-22 2025-11-16 大陸商杭州中美華東製藥有限公司 作為Cbl-b抑制劑的化合物
WO2025243317A1 (en) * 2024-05-20 2025-11-27 Jubilant Biosys Limited Substituted bicyclic sulfonamide derivatives as modulators of cbl-b
WO2026022749A2 (en) 2024-07-26 2026-01-29 Aurigene Oncology Limited Cbl-b inhibitors
WO2026040995A1 (zh) * 2024-08-19 2026-02-26 北京望实智慧科技有限公司 用作Cbl-b抑制剂的化合物
CN120000656B (zh) * 2025-03-20 2025-11-07 北京大学 小分子化合物nx-1607在制备治疗肝纤维化的产品中的应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5273986A (en) 1992-07-02 1993-12-28 Hoffmann-La Roche Inc. Cycloalkylthiazoles
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
US7199124B2 (en) 2001-02-02 2007-04-03 Takeda Pharmaceutical Company Limited JNK inhibitor
US20070054355A1 (en) 2003-03-05 2007-03-08 Yuval Reiss Cbl-b polypeptides, complexes and related methods
US7320992B2 (en) 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
WO2007072225A2 (en) 2005-12-01 2007-06-28 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
WO2008033403A2 (en) 2006-09-13 2008-03-20 The Trustees Of Columbia University In The City Of New York Agents and methods to elicit anti-tumor immune response
AT506041A1 (de) 2007-12-10 2009-05-15 Univ Innsbruck Verfahren zur erhöhung der immunreaktivität
PL2242749T3 (pl) 2008-02-05 2013-09-30 Hoffmann La Roche Nowe pirydynony i pirydazynony
CN102762551A (zh) 2009-12-21 2012-10-31 拜尔农作物科学股份公司 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途
EP2566869B1 (en) 2010-05-07 2016-03-02 Gilead Connecticut, Inc. Pyridone and aza-pyridone compounds and methods of use
ES2666746T3 (es) 2010-07-13 2018-05-07 Anthrogenesis Corporation Métodos para generar linfocitos citolíticos naturales
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
EP2471548A1 (de) 2010-12-28 2012-07-04 Apeiron Biologics AG siRNA gegen Cbl-b und optional IL2 und IL12 zur Verwendung in der Behandlung von Krebs
AR086992A1 (es) 2011-06-20 2014-02-05 Bayer Ip Gmbh Tienilpiri(mi)dinilpirazoles
US20130110678A1 (en) 2011-11-02 2013-05-02 Apple Inc. Purchasing a product in a store using a mobile device
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
MX2014005282A (es) 2011-11-03 2014-05-30 Hoffmann La Roche Compuestos de 8-fluoroftalazin-1 (2h) -ona.
KR102668696B1 (ko) 2012-01-12 2024-05-29 예일 유니버시티 E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
WO2014040965A1 (en) 2012-09-13 2014-03-20 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
US9382246B2 (en) 2013-12-05 2016-07-05 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CA2946312A1 (en) 2014-04-23 2015-10-29 Juno Therapeutics, Inc. Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy
KR20170032406A (ko) 2014-07-15 2017-03-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료를 위한 조작된 세포
CN106922146B (zh) * 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
MX2017015574A (es) 2015-06-02 2018-08-09 Pharmacyclics Llc Inhibidores de tirosina quinasa de bruton.
AU2016297362B2 (en) 2015-07-17 2020-04-16 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as HDAC inhibitors
EP3138905A1 (en) 2015-09-04 2017-03-08 Miltenyi Biotec GmbH Method for natural killer cell expansion
EP4212547A1 (en) 2015-12-03 2023-07-19 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods
EP3254701A1 (en) 2016-06-09 2017-12-13 IMBA-Institut für Molekulare Biotechnologie GmbH Cbl-b inhibitor comprising a cbl-b binding peptide for the prevention or treatment of fungal infections
CA3042297A1 (en) 2016-11-22 2018-05-31 Dana-Farber Cancer Institute, Inc. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
EP3743063A4 (en) * 2018-01-26 2021-10-20 Nurix Therapeutics, Inc. CBL-B INHIBITORS AND THEIR METHODS OF USE
MX2021004191A (es) 2018-10-15 2021-05-27 Nurix Therapeutics Inc Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
US12582722B2 (en) 2019-02-13 2026-03-24 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CA3136348A1 (en) 2019-04-09 2020-10-15 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
AU2020278592B2 (en) 2019-05-17 2024-10-10 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
AU2020320195A1 (en) 2019-07-30 2022-03-10 Nurix Therapeutics, Inc. Urea, amide, and substituted heteroaryl compounds for Cbl-b inhibition
EP4034140A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for use in adoptive cell therapy
US20230024442A1 (en) 2019-11-08 2023-01-26 Nurix Therapeutics, Inc. Bifunctional compounds for grading btk via ubiquitin proteosome pathway
WO2021113557A1 (en) 2019-12-04 2021-06-10 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
WO2022217123A2 (en) 2021-04-08 2022-10-13 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds

Similar Documents

Publication Publication Date Title
JP2022538174A5 (enExample)
JP2022532247A5 (enExample)
JP2022526025A5 (enExample)
JP2022542323A5 (enExample)
US12049471B2 (en) Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
US12485144B2 (en) 3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
US12234230B2 (en) Substituted benzyl-triazole compounds for Cbl-b inhibition, and further uses thereof
US12269812B2 (en) PD-1/PD-L1 inhibitors
CN112969505A (zh) 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
BR112020016466A2 (pt) Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1, para tratar câncer e para aprimorar a função de células-t em pacientes com hepatite b crônica (chb), e, kit para tratar ou prevenir câncer ou uma doença ou condição.
US20210008084A1 (en) Mevalonate pathway inhibitor and pharmaceutical composition thereof
HK40098549A (en) Pd-1/pd-l1 inhibitors
HK40051993B (zh) 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
HK40051993A (en) Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity