JP2022538174A5 - - Google Patents
Info
- Publication number
- JP2022538174A5 JP2022538174A5 JP2021577171A JP2021577171A JP2022538174A5 JP 2022538174 A5 JP2022538174 A5 JP 2022538174A5 JP 2021577171 A JP2021577171 A JP 2021577171A JP 2021577171 A JP2021577171 A JP 2021577171A JP 2022538174 A5 JP2022538174 A5 JP 2022538174A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- inhibitor
- cbl
- cells
- immune cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962866914P | 2019-06-26 | 2019-06-26 | |
| US62/866,914 | 2019-06-26 | ||
| US201962880285P | 2019-07-30 | 2019-07-30 | |
| US62/880,285 | 2019-07-30 | ||
| US201962888870P | 2019-08-19 | 2019-08-19 | |
| US201962888845P | 2019-08-19 | 2019-08-19 | |
| US62/888,870 | 2019-08-19 | ||
| US62/888,845 | 2019-08-19 | ||
| PCT/US2020/039957 WO2020264398A1 (en) | 2019-06-26 | 2020-06-26 | Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022538174A JP2022538174A (ja) | 2022-08-31 |
| JP2022538174A5 true JP2022538174A5 (enExample) | 2023-07-14 |
| JP7831995B2 JP7831995B2 (ja) | 2026-03-17 |
Family
ID=71662363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577171A Active JP7831995B2 (ja) | 2019-06-26 | 2020-06-26 | Cbl-b阻害のための置換ベンジル-トリアゾール化合物、及びそのさらなる使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11401267B2 (enExample) |
| EP (1) | EP3990117A1 (enExample) |
| JP (1) | JP7831995B2 (enExample) |
| KR (1) | KR20220026581A (enExample) |
| CN (1) | CN114364670B (enExample) |
| AU (2) | AU2020303696B2 (enExample) |
| BR (1) | BR112021026241A2 (enExample) |
| CA (2) | CA3144450A1 (enExample) |
| IL (1) | IL289290B1 (enExample) |
| MX (2) | MX2021015675A (enExample) |
| WO (1) | WO2020264398A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004191A (es) | 2018-10-15 | 2021-05-27 | Nurix Therapeutics Inc | Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma. |
| US11174263B2 (en) | 2018-12-31 | 2021-11-16 | Biomea Fusion, Inc. | Inhibitors of menin-MLL interaction |
| SG11202106304RA (en) | 2018-12-31 | 2021-07-29 | Biomea Fusion Llc | Irreversible inhibitors of menin-mll interaction |
| US12582722B2 (en) | 2019-02-13 | 2026-03-24 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| CA3136348A1 (en) | 2019-04-09 | 2020-10-15 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| AU2020278592B2 (en) | 2019-05-17 | 2024-10-10 | Nurix Therapeutics, Inc. | Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof |
| MX2021015675A (es) | 2019-06-26 | 2022-02-03 | Nurix Therapeutics Inc | Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos. |
| EP4034140A1 (en) | 2019-09-24 | 2022-08-03 | Nurix Therapeutics, Inc. | Cbl inhibitors and compositions for use in adoptive cell therapy |
| WO2021113557A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| AR124800A1 (es) * | 2021-02-03 | 2023-05-03 | Genentech Inc | Lactamas como inhibidores cbl-b |
| WO2022217123A2 (en) * | 2021-04-08 | 2022-10-13 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds |
| US12325697B2 (en) * | 2021-04-09 | 2025-06-10 | Nimbus Clio, Inc. | CBL-B modulators and uses thereof |
| AU2022256514A1 (en) * | 2021-04-16 | 2023-10-19 | Hotspot Therapeutics, Inc. | Compounds, compositions and methods of treating cancer |
| EP4359381A4 (en) * | 2021-06-21 | 2025-04-30 | Nimbus Clio, Inc. | Cbl-b modulators and uses thereof |
| TW202320796A (zh) | 2021-08-11 | 2023-06-01 | 美商拜歐米富士恩股份有限公司 | 用於糖尿病的menin-mll相互作用之共價抑制劑 |
| US12018032B2 (en) | 2021-08-20 | 2024-06-25 | Biomea Fusion, Inc. | Crystalline forms of N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide as an irreversible inhibitor of menin-MLL interaction |
| CA3236073A1 (en) | 2021-10-26 | 2023-05-04 | Robert J. Brown | Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk |
| US20250042896A1 (en) * | 2021-10-29 | 2025-02-06 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | Polycyclic compound as cbl-b inhibitor |
| AU2022379959A1 (en) * | 2021-11-05 | 2024-05-09 | Genentech, Inc. | Lactams as cbl-b inhibitors selective over c-cbl |
| US20250009731A1 (en) * | 2021-11-08 | 2025-01-09 | Nurix Therapeutics, Inc. | Toll-like receptor therapy combinations with cbl-b inhibitor compounds |
| TW202342013A (zh) * | 2022-02-10 | 2023-11-01 | 英屬開曼群島商百濟神州有限公司 | 雜環化合物、其組成物及用其進行治療之方法 |
| CN116715632B (zh) * | 2022-03-07 | 2025-09-30 | 苏州恩华生物医药科技有限公司 | 螺[环丁烷1,4′-异喹啉]酮类衍生物顺反异构体的制备方法 |
| AU2023230346A1 (en) * | 2022-03-09 | 2024-10-17 | Orum Therapeutics, Inc. | Activators of effector t cells |
| WO2023205180A1 (en) * | 2022-04-19 | 2023-10-26 | Nurix Therapeutics, Inc. | Biomarkers for cbl, and compositions and methods for their use |
| WO2023217067A1 (zh) * | 2022-05-09 | 2023-11-16 | 上海先博生物科技有限公司 | 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用 |
| US20230414598A1 (en) * | 2022-06-22 | 2023-12-28 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds and antiemetic agents |
| EP4554586A1 (en) * | 2022-07-12 | 2025-05-21 | Hotspot Therapeutics, Inc. | Cbl-b inhibitors and anti-pd1/anti-pd-l1 for use in the treatment of cancer |
| AU2023307165A1 (en) * | 2022-07-12 | 2025-02-06 | Hotspot Therapeutics, Inc. | Methods of preparation of heterocyclic compounds |
| WO2024015863A1 (en) * | 2022-07-12 | 2024-01-18 | Hotspot Therapeutics, Inc. | Cbl-b inhibitor, compositions comprising a cbl-b inhibitor in a method of treating a disease associated with cell proliferation |
| CA3261875A1 (en) * | 2022-07-12 | 2024-01-18 | Hotspot Therapeutics, Inc. | SOLID FORMS OF A TRIAZINE DERIVATIVE AS A CBL-B MODULATOR |
| EP4558504A1 (en) * | 2022-07-18 | 2025-05-28 | Insilico Medicine IP Limited | Cbl-b inhibitors and methods of uses thereof |
| EP4558501A1 (en) | 2022-07-20 | 2025-05-28 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| KR20250050018A (ko) | 2022-08-16 | 2025-04-14 | 그렌마크 파머수티칼스 엘티디. | Cbl-b 저해제로서의 치환된 피리디논 화합물 |
| WO2024062363A1 (en) * | 2022-09-21 | 2024-03-28 | Glenmark Pharmaceuticals Ltd | Bicyclic heterocyclic compounds as cbl-b inhibitors |
| WO2024074977A1 (en) * | 2022-10-04 | 2024-04-11 | Pfizer Inc. | Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds |
| EP4602028A1 (en) * | 2022-10-11 | 2025-08-20 | Nimbus Clio, Inc. | Cbl-b modulators and uses thereof |
| WO2024086730A1 (en) * | 2022-10-19 | 2024-04-25 | Hotspot Therapeutics, Inc. | Heterocyclic cbl-b inhibitors for the treatment of cancer |
| WO2024105563A1 (en) * | 2022-11-16 | 2024-05-23 | Pfizer Inc. | Substituted bicyclic pyridone derivatives |
| WO2024131939A1 (en) * | 2022-12-23 | 2024-06-27 | Insilico Medicine Ip Limited | Cbl-b inhibitors and methods of uses thereof |
| WO2024155710A1 (en) | 2023-01-18 | 2024-07-25 | Biomea Fusion, Inc. | Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2-pyridinecarboxamide as a covalent inhibitor of menin-mll interaction |
| EP4653436A1 (en) * | 2023-01-19 | 2025-11-26 | Guangzhou Yufan Nantu Biotechnologies Co., Ltd | Heterocyclic compounds, preparation method therefor and use thereof |
| CN120530105A (zh) * | 2023-01-20 | 2025-08-22 | 海南先声再明医药股份有限公司 | 取代的三环化合物及其应用 |
| TW202435863A (zh) | 2023-01-28 | 2024-09-16 | 芬蘭商奧利安公司 | Cbl-b抑制劑 |
| WO2024233360A1 (en) | 2023-05-05 | 2024-11-14 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| TW202448456A (zh) | 2023-05-09 | 2024-12-16 | 美商建南德克公司 | 作為對c-cbl具選擇性之cbl-b抑制劑的6-經取代-3-苯基-異吲哚啉-1-酮類 |
| EP4720055A1 (en) | 2023-05-25 | 2026-04-08 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| TW202502751A (zh) * | 2023-06-13 | 2025-01-16 | 大陸商上海齊魯製藥研究中心有限公司 | Cbl-b抑制劑 |
| CN121816192A (zh) | 2023-09-14 | 2026-04-07 | 因斯布鲁克医科大学 | 通过抑制NR2f6增强CAR-T细胞疗效 |
| TW202543601A (zh) * | 2024-04-22 | 2025-11-16 | 大陸商杭州中美華東製藥有限公司 | 作為Cbl-b抑制劑的化合物 |
| WO2025243317A1 (en) * | 2024-05-20 | 2025-11-27 | Jubilant Biosys Limited | Substituted bicyclic sulfonamide derivatives as modulators of cbl-b |
| WO2026022749A2 (en) | 2024-07-26 | 2026-01-29 | Aurigene Oncology Limited | Cbl-b inhibitors |
| WO2026040995A1 (zh) * | 2024-08-19 | 2026-02-26 | 北京望实智慧科技有限公司 | 用作Cbl-b抑制剂的化合物 |
| CN120000656B (zh) * | 2025-03-20 | 2025-11-07 | 北京大学 | 小分子化合物nx-1607在制备治疗肝纤维化的产品中的应用 |
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| US12582722B2 (en) | 2019-02-13 | 2026-03-24 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| CA3136348A1 (en) | 2019-04-09 | 2020-10-15 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| AU2020278592B2 (en) | 2019-05-17 | 2024-10-10 | Nurix Therapeutics, Inc. | Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof |
| MX2021015675A (es) | 2019-06-26 | 2022-02-03 | Nurix Therapeutics Inc | Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos. |
| AU2020320195A1 (en) | 2019-07-30 | 2022-03-10 | Nurix Therapeutics, Inc. | Urea, amide, and substituted heteroaryl compounds for Cbl-b inhibition |
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| US20230024442A1 (en) | 2019-11-08 | 2023-01-26 | Nurix Therapeutics, Inc. | Bifunctional compounds for grading btk via ubiquitin proteosome pathway |
| WO2021113557A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| WO2022217123A2 (en) | 2021-04-08 | 2022-10-13 | Nurix Therapeutics, Inc. | Combination therapies with cbl-b inhibitor compounds |
-
2020
- 2020-06-26 MX MX2021015675A patent/MX2021015675A/es unknown
- 2020-06-26 CN CN202080060696.0A patent/CN114364670B/zh active Active
- 2020-06-26 JP JP2021577171A patent/JP7831995B2/ja active Active
- 2020-06-26 KR KR1020227001977A patent/KR20220026581A/ko active Pending
- 2020-06-26 EP EP20742593.5A patent/EP3990117A1/en active Pending
- 2020-06-26 CA CA3144450A patent/CA3144450A1/en active Pending
- 2020-06-26 US US16/913,949 patent/US11401267B2/en active Active
- 2020-06-26 IL IL289290A patent/IL289290B1/en unknown
- 2020-06-26 WO PCT/US2020/039957 patent/WO2020264398A1/en not_active Ceased
- 2020-06-26 AU AU2020303696A patent/AU2020303696B2/en active Active
- 2020-06-26 BR BR112021026241A patent/BR112021026241A2/pt unknown
- 2020-06-26 CA CA3294689A patent/CA3294689A1/en active Pending
-
2021
- 2021-12-15 MX MX2025000627A patent/MX2025000627A/es unknown
-
2022
- 2022-06-29 US US17/853,904 patent/US12234230B2/en active Active
-
2024
- 2024-10-25 US US18/927,712 patent/US20250136590A1/en active Pending
-
2026
- 2026-03-17 AU AU2026202030A patent/AU2026202030A1/en active Pending
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