JP2022529065A5 - - Google Patents
Info
- Publication number
- JP2022529065A5 JP2022529065A5 JP2021561943A JP2021561943A JP2022529065A5 JP 2022529065 A5 JP2022529065 A5 JP 2022529065A5 JP 2021561943 A JP2021561943 A JP 2021561943A JP 2021561943 A JP2021561943 A JP 2021561943A JP 2022529065 A5 JP2022529065 A5 JP 2022529065A5
- Authority
- JP
- Japan
- Prior art keywords
- ttd
- sequence
- domain
- nucleic acid
- rich
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025077741A JP2025121988A (ja) | 2019-04-17 | 2025-05-08 | 効率的なｒｎａトランススプライシングのための三重らせんターミネータ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962835164P | 2019-04-17 | 2019-04-17 | |
| US62/835,164 | 2019-04-17 | ||
| PCT/US2020/028797 WO2020214973A1 (en) | 2019-04-17 | 2020-04-17 | Triple helix terminator for efficient rna trans-splicing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025077741A Division JP2025121988A (ja) | 2019-04-17 | 2025-05-08 | 効率的なｒｎａトランススプライシングのための三重らせんターミネータ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022529065A JP2022529065A (ja) | 2022-06-16 |
| JP2022529065A5 true JP2022529065A5 (https=) | 2023-04-25 |
Family
ID=72837942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021561943A Pending JP2022529065A (ja) | 2019-04-17 | 2020-04-17 | 効率的なｒｎａトランススプライシングのための三重らせんターミネータ |
| JP2025077741A Pending JP2025121988A (ja) | 2019-04-17 | 2025-05-08 | 効率的なｒｎａトランススプライシングのための三重らせんターミネータ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025077741A Pending JP2025121988A (ja) | 2019-04-17 | 2025-05-08 | 効率的なｒｎａトランススプライシングのための三重らせんターミネータ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220204989A1 (https=) |
| EP (1) | EP3956442A4 (https=) |
| JP (2) | JP2022529065A (https=) |
| KR (1) | KR20220002910A (https=) |
| CN (1) | CN114040974B (https=) |
| AU (1) | AU2020260154A1 (https=) |
| BR (1) | BR112021020539A2 (https=) |
| CA (1) | CA3133555A1 (https=) |
| IL (1) | IL287243A (https=) |
| MX (1) | MX2021012702A (https=) |
| WO (1) | WO2020214973A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102866133B1 (ko) | 2018-04-17 | 2025-09-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 트랜스-스플라이싱 분자 |
| BR112021020539A2 (pt) * | 2019-04-17 | 2022-01-04 | Univ Pennsylvania | Terminador de hélice tripla para trans-splicing de rna eficiente |
| WO2022220968A1 (en) * | 2021-04-15 | 2022-10-20 | U1 Bio, Inc. | High efficiency trans-splicing for replacement of targeted rna sequences in human cells |
| AU2022337146A1 (en) | 2021-09-03 | 2024-03-14 | Tacit Therapeutics, Inc. | Rna editing via recruitment of spliceosome components |
| EP4511488A2 (en) * | 2022-04-20 | 2025-02-26 | Tacit Therapeutics, Inc. | Stabilization of therapeutic trans-splicing rna molecules in human cells |
| WO2023215761A1 (en) * | 2022-05-03 | 2023-11-09 | Tacit Therapeutics, Inc. | Localization of trans-splicing nucleic acid molecules to and within the cellular nucleus |
| EP4522758A4 (en) * | 2022-05-13 | 2026-05-06 | Ascidian Therapeutics Inc | Abca4 trans-splicing molecules |
| WO2024112957A1 (en) | 2022-11-23 | 2024-05-30 | Amber Bio Inc. | Gene-modifying endonucleases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2151248A1 (en) * | 2008-07-30 | 2010-02-10 | Johann Bauer | Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses |
| US9717749B2 (en) * | 2012-10-16 | 2017-08-01 | Massachusetts Institute Of Technology | Production of stable non-polyadenylated RNAs |
| GB201219762D0 (en) * | 2012-11-02 | 2012-12-19 | Bauer Johann | A RNA trans-splicing molecule (RTM) for use in the treatment of cancer |
| AU2014255665B2 (en) * | 2013-04-18 | 2018-08-02 | Fondazione Telethon | Effective delivery of large genes by dual AAV vectors |
| CA3005474A1 (en) * | 2015-11-19 | 2017-05-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for correction of heritable ocular disease |
| WO2019027869A1 (en) * | 2017-07-31 | 2019-02-07 | Massachusetts Institute Of Technology | RNA-CLUSTER INDUCED TRANSCRIPT STABILIZER AND USES THEREOF |
| KR102866133B1 (ko) * | 2018-04-17 | 2025-09-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 트랜스-스플라이싱 분자 |
| BR112021020539A2 (pt) * | 2019-04-17 | 2022-01-04 | Univ Pennsylvania | Terminador de hélice tripla para trans-splicing de rna eficiente |
-
2020
- 2020-04-17 BR BR112021020539A patent/BR112021020539A2/pt unknown
- 2020-04-17 KR KR1020217034092A patent/KR20220002910A/ko active Pending
- 2020-04-17 CA CA3133555A patent/CA3133555A1/en active Pending
- 2020-04-17 EP EP20791307.0A patent/EP3956442A4/en active Pending
- 2020-04-17 CN CN202080044745.1A patent/CN114040974B/zh active Active
- 2020-04-17 US US17/604,228 patent/US20220204989A1/en active Pending
- 2020-04-17 JP JP2021561943A patent/JP2022529065A/ja active Pending
- 2020-04-17 AU AU2020260154A patent/AU2020260154A1/en active Pending
- 2020-04-17 MX MX2021012702A patent/MX2021012702A/es unknown
- 2020-04-17 WO PCT/US2020/028797 patent/WO2020214973A1/en not_active Ceased
-
2021
- 2021-10-13 IL IL287243A patent/IL287243A/en unknown
-
2025
- 2025-05-08 JP JP2025077741A patent/JP2025121988A/ja active Pending
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