JP2022529065A5 - - Google Patents

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Publication number
JP2022529065A5
JP2022529065A5 JP2021561943A JP2021561943A JP2022529065A5 JP 2022529065 A5 JP2022529065 A5 JP 2022529065A5 JP 2021561943 A JP2021561943 A JP 2021561943A JP 2021561943 A JP2021561943 A JP 2021561943A JP 2022529065 A5 JP2022529065 A5 JP 2022529065A5
Authority
JP
Japan
Prior art keywords
ttd
sequence
domain
nucleic acid
rich
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021561943A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022529065A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/028797 external-priority patent/WO2020214973A1/en
Publication of JP2022529065A publication Critical patent/JP2022529065A/ja
Publication of JP2022529065A5 publication Critical patent/JP2022529065A5/ja
Priority to JP2025077741A priority Critical patent/JP2025121988A/ja
Pending legal-status Critical Current

Links

JP2021561943A 2019-04-17 2020-04-17 効率的なｒｎａトランススプライシングのための三重らせんターミネータ Pending JP2022529065A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025077741A JP2025121988A (ja) 2019-04-17 2025-05-08 効率的なｒｎａトランススプライシングのための三重らせんターミネータ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962835164P 2019-04-17 2019-04-17
US62/835,164 2019-04-17
PCT/US2020/028797 WO2020214973A1 (en) 2019-04-17 2020-04-17 Triple helix terminator for efficient rna trans-splicing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025077741A Division JP2025121988A (ja) 2019-04-17 2025-05-08 効率的なｒｎａトランススプライシングのための三重らせんターミネータ

Publications (2)

Publication Number Publication Date
JP2022529065A JP2022529065A (ja) 2022-06-16
JP2022529065A5 true JP2022529065A5 (enExample) 2023-04-25

Family

ID=72837942

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021561943A Pending JP2022529065A (ja) 2019-04-17 2020-04-17 効率的なｒｎａトランススプライシングのための三重らせんターミネータ
JP2025077741A Pending JP2025121988A (ja) 2019-04-17 2025-05-08 効率的なｒｎａトランススプライシングのための三重らせんターミネータ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025077741A Pending JP2025121988A (ja) 2019-04-17 2025-05-08 効率的なｒｎａトランススプライシングのための三重らせんターミネータ

Country Status (10)

Country Link
US (1) US20220204989A1 (enExample)
EP (1) EP3956442A4 (enExample)
JP (2) JP2022529065A (enExample)
KR (1) KR20220002910A (enExample)
CN (1) CN114040974B (enExample)
BR (1) BR112021020539A2 (enExample)
CA (1) CA3133555A1 (enExample)
IL (1) IL287243A (enExample)
MX (1) MX2021012702A (enExample)
WO (1) WO2020214973A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020010959A (es) 2018-04-17 2021-01-15 Univ Pennsylvania Moleculas de empalme trans.
CN114040974B (zh) * 2019-04-17 2025-11-04 宾夕法尼亚州大学信托人 用于高效rna反式剪接的三螺旋终止子
AU2022259416A1 (en) * 2021-04-15 2023-11-16 Tacit Therapeutics, Inc. High efficiency trans-splicing for replacement of targeted rna sequences in human cells
IL311101A (en) 2021-09-03 2024-04-01 Tacit Therapeutics Inc RNA editing through recruitment of SPLICEOSOME components
WO2023205694A2 (en) * 2022-04-20 2023-10-26 Tacit Therapeutics, Inc. Stabilization of therapeutic trans-splicing rna molecules in human cells
US20250290067A1 (en) * 2022-05-03 2025-09-18 Tacit Therapeutics, Inc. Localization of trans-splicing nucleic acid molecules to and within the cellular nucleus
IL316944A (en) * 2022-05-13 2025-01-01 Ascidian Therapeutics Inc ABCA4 cross-linking molecules
EP4622662A1 (en) 2022-11-23 2025-10-01 Amber Bio Inc. Gene-modifying endonucleases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151248A1 (en) * 2008-07-30 2010-02-10 Johann Bauer Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
CN104955951A (zh) * 2012-10-16 2015-09-30 麻省理工学院 稳定的非多腺苷酸化rna的产生
GB201219762D0 (en) * 2012-11-02 2012-12-19 Bauer Johann A RNA trans-splicing molecule (RTM) for use in the treatment of cancer
EP2986635B1 (en) * 2013-04-18 2018-10-03 Fondazione Telethon Effective delivery of large genes by dual aav vectors
AU2016355343C1 (en) * 2015-11-19 2024-10-03 Lloyd G. Mitchell Compositions and methods for correction of heritable ocular disease
WO2019027869A1 (en) * 2017-07-31 2019-02-07 Massachusetts Institute Of Technology RNA-CLUSTER INDUCED TRANSCRIPT STABILIZER AND USES THEREOF
MX2020010959A (es) * 2018-04-17 2021-01-15 Univ Pennsylvania Moleculas de empalme trans.
CN114040974B (zh) * 2019-04-17 2025-11-04 宾夕法尼亚州大学信托人 用于高效rna反式剪接的三螺旋终止子

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