JP2022526856A - 臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法 - Google Patents

臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法 Download PDF

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JP2022526856A
JP2022526856A JP2021560665A JP2021560665A JP2022526856A JP 2022526856 A JP2022526856 A JP 2022526856A JP 2021560665 A JP2021560665 A JP 2021560665A JP 2021560665 A JP2021560665 A JP 2021560665A JP 2022526856 A JP2022526856 A JP 2022526856A
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ドナルド オルーク
ゼヴ バインダー
マイケル ミローネ
ラディカ トーカーラ
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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JP2021560665A 2019-04-12 2020-04-11 臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法 Pending JP2022526856A (ja)

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JP2025044320A JP2025102823A (ja) 2019-04-12 2025-03-19 臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法

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US201962833456P 2019-04-12 2019-04-12
US62/833,456 2019-04-12
US201962892343P 2019-08-27 2019-08-27
US62/892,343 2019-08-27
PCT/US2020/027859 WO2020210768A1 (en) 2019-04-12 2020-04-11 Compositions and Methods Comprising a High Affinity Chimeric Antigen Receptor (CAR) with Cross-Reactivity to Clinically-Relevant EGFR Mutated Proteins

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JP2025044320A Division JP2025102823A (ja) 2019-04-12 2025-03-19 臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法

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JP2025044320A Pending JP2025102823A (ja) 2019-04-12 2025-03-19 臨床的に意義のあるｅｇｆｒ変異型タンパク質との交差反応性を有する高親和性キメラ抗原受容体（ｃａｒ）を含む、組成物および方法

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US (1) US20220184129A1 (enExample)
EP (1) EP3952885A4 (enExample)
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AU (1) AU2020272074A1 (enExample)
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WO2021168000A1 (en) * 2020-02-17 2021-08-26 University Of Virginia Patent Foundation CAR T CELLS TARGETING THE INTEGRIN ALPHAv BETA3 EXHIBIT ROBUST ANTI-TUMOR RESPONSES AGAINST GLIOMAS AND OTHER SOLID TUMOR MALIGNANCIES
US20240043544A1 (en) * 2020-12-08 2024-02-08 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-egfr chimeric antigen receptors
US20240293546A1 (en) * 2021-07-01 2024-09-05 Duke University D2c7 egfr and egfr viii bi-specific chimeric antigen receptor constructs and methods of making and using same
US20240285757A1 (en) * 2021-08-06 2024-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing car t cell efficacy through the engineered secretion of c. perfringens neuraminidase

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JP2014507118A (ja) * 2010-12-09 2014-03-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2015535689A (ja) * 2012-10-02 2015-12-17 メモリアル スローン−ケタリング キャンサー センター 免疫療法のための組成物および方法
WO2017181101A1 (en) * 2016-04-15 2017-10-19 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric alloantigen receptor t cells
JP2018522567A (ja) * 2015-08-07 2018-08-16 シアトル チルドレンズ ホスピタル， ディービーエー シアトル チルドレンズ リサーチ インスティテュート 固形腫瘍を標的とする二重特異性ｃａｒ ｔ細胞

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JP2014507118A (ja) * 2010-12-09 2014-03-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2015535689A (ja) * 2012-10-02 2015-12-17 メモリアル スローン−ケタリング キャンサー センター 免疫療法のための組成物および方法
JP2018522567A (ja) * 2015-08-07 2018-08-16 シアトル チルドレンズ ホスピタル， ディービーエー シアトル チルドレンズ リサーチ インスティテュート 固形腫瘍を標的とする二重特異性ｃａｒ ｔ細胞
WO2017181101A1 (en) * 2016-04-15 2017-10-19 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric alloantigen receptor t cells

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US20220184129A1 (en) 2022-06-16
EP3952885A4 (en) 2023-01-18
JP2025102823A (ja) 2025-07-08
AU2020272074A1 (en) 2021-11-25
WO2020210768A1 (en) 2020-10-15
EP3952885A1 (en) 2022-02-16

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