JP2022526669A5 - - Google Patents
Info
- Publication number
- JP2022526669A5 JP2022526669A5 JP2021560108A JP2021560108A JP2022526669A5 JP 2022526669 A5 JP2022526669 A5 JP 2022526669A5 JP 2021560108 A JP2021560108 A JP 2021560108A JP 2021560108 A JP2021560108 A JP 2021560108A JP 2022526669 A5 JP2022526669 A5 JP 2022526669A5
- Authority
- JP
- Japan
- Prior art keywords
- cas
- crispr
- editing system
- base editing
- based base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962833454P | 2019-04-12 | 2019-04-12 | |
| US62/833,454 | 2019-04-12 | ||
| PCT/US2020/027867 WO2020210776A1 (en) | 2019-04-12 | 2020-04-12 | Crispr/cas-based base editing composition for restoring dystrophin function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022526669A JP2022526669A (ja) | 2022-05-25 |
| JP2022526669A5 true JP2022526669A5 (https=) | 2023-04-24 |
Family
ID=72750921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560108A Pending JP2022526669A (ja) | 2019-04-12 | 2020-04-12 | ジストロフィン機能を修復するためのＣＲＩＳＰＲ／Ｃａｓをベースにした塩基編集組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220177879A1 (https=) |
| EP (1) | EP3952884A4 (https=) |
| JP (1) | JP2022526669A (https=) |
| WO (1) | WO2020210776A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163628A2 (en) | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| WO2017035416A2 (en) | 2015-08-25 | 2017-03-02 | Duke University | Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases |
| EP4089175A1 (en) | 2015-10-13 | 2022-11-16 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| KR102787119B1 (ko) | 2015-11-30 | 2025-03-27 | 듀크 유니버시티 | 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| EP3740580A4 (en) | 2018-01-19 | 2021-10-20 | Duke University | GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS |
| WO2021113390A1 (en) * | 2019-12-02 | 2021-06-10 | Shape Therapeutics Inc. | Compositions for treatment of diseases |
| US20240165271A1 (en) * | 2021-03-26 | 2024-05-23 | The Board Of Regents Of The University Of Texas System | Nucleotide editing to reframe dmd transcripts by base editing and prime editing |
| IL317874A (en) | 2022-06-24 | 2025-02-01 | Tune Therapeutics Inc | Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression |
| CN119912582B (zh) * | 2024-06-17 | 2025-11-04 | 中国农业大学 | 单碱基编辑器及其所用脱氨酶与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| WO2017035416A2 (en) * | 2015-08-25 | 2017-03-02 | Duke University | Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases |
| IL310721B2 (en) * | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| KR102787119B1 (ko) * | 2015-11-30 | 2025-03-27 | 듀크 유니버시티 | 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법 |
| WO2018017751A1 (en) * | 2016-07-19 | 2018-01-25 | Supereye, Inc. | Systems and methods for predictive visual rendering |
| JP7490211B2 (ja) * | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| AU2017364106A1 (en) * | 2016-11-28 | 2019-06-20 | The Board Of Regents Of The University Of Texas System | Prevention of muscular dystrophy by CRISPR/Cpfl-mediated gene editing |
| JOP20190166A1 (ar) * | 2017-01-05 | 2019-07-02 | Univ Texas | استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي |
| EP3617311B1 (en) * | 2017-03-30 | 2024-11-20 | Kyoto University | Method for inducing exon skipping by genome editing |
| AU2018251801B2 (en) * | 2017-04-12 | 2024-11-07 | Massachusetts Institute Of Technology | Novel type VI CRISPR orthologs and systems |
| CA3108281A1 (en) * | 2018-08-03 | 2020-02-06 | Beam Therapeutics Inc. | Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence |
-
2020
- 2020-04-12 JP JP2021560108A patent/JP2022526669A/ja active Pending
- 2020-04-12 WO PCT/US2020/027867 patent/WO2020210776A1/en not_active Ceased
- 2020-04-12 US US17/603,243 patent/US20220177879A1/en active Pending
- 2020-04-12 EP EP20786814.2A patent/EP3952884A4/en active Pending
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