JP2022523320A - 加齢黄斑変性の処置のためのオリゴヌクレオチドおよび方法 - Google Patents
加齢黄斑変性の処置のためのオリゴヌクレオチドおよび方法 Download PDFInfo
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- JP2022523320A JP2022523320A JP2021544320A JP2021544320A JP2022523320A JP 2022523320 A JP2022523320 A JP 2022523320A JP 2021544320 A JP2021544320 A JP 2021544320A JP 2021544320 A JP2021544320 A JP 2021544320A JP 2022523320 A JP2022523320 A JP 2022523320A
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14041—Use of virus, viral particle or viral elements as a vector
- C12N2750/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798048P | 2019-01-29 | 2019-01-29 | |
| US62/798,048 | 2019-01-29 | ||
| PCT/US2020/015638 WO2020160121A1 (en) | 2019-01-29 | 2020-01-29 | Oligonucleotides and methods for the treatment of age-related macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022523320A true JP2022523320A (ja) | 2022-04-22 |
| JP2022523320A5 JP2022523320A5 (https=) | 2023-02-06 |
| JPWO2020160121A5 JPWO2020160121A5 (https=) | 2023-02-06 |
Family
ID=71840609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544320A Pending JP2022523320A (ja) | 2019-01-29 | 2020-01-29 | 加齢黄斑変性の処置のためのオリゴヌクレオチドおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220195428A1 (https=) |
| EP (1) | EP3918072A4 (https=) |
| JP (1) | JP2022523320A (https=) |
| WO (1) | WO2020160121A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2022230987A1 (https=) * | 2021-04-30 | 2022-11-03 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110281933A1 (en) * | 2010-05-13 | 2011-11-17 | Saint Louis University | Methods and compositions for the management of cardiovascular disease with oligonucleotides |
| WO2012027704A1 (en) * | 2010-08-27 | 2012-03-01 | New York University | Mir-33 inhibitors and uses thereof |
| US20120301439A1 (en) * | 2011-05-24 | 2012-11-29 | Washington University | Inhibition of choroidal neovascularization |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517864B2 (en) * | 2001-05-18 | 2009-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| EP1791567B1 (en) * | 2004-08-10 | 2015-07-29 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
| CA2577519A1 (en) * | 2004-08-23 | 2006-03-30 | Nucleonics, Inc. | Multiple rna polymerase iii promoter expression constructs |
| US20110130440A1 (en) * | 2008-03-26 | 2011-06-02 | Alnylam Pharmaceuticals, Inc. | Non-natural ribonucleotides, and methods of use thereof |
| US8057295B2 (en) * | 2008-11-10 | 2011-11-15 | Wms Gaming Inc. | Wagering game having award group selection feature |
| US9241950B2 (en) * | 2011-04-28 | 2016-01-26 | New York University | MiR-33 inhibitors and uses thereof to decrease inflammation |
| US20140363469A1 (en) * | 2012-01-19 | 2014-12-11 | Alnylam Pharmaceuticals, Inc. | Viral attenuation and vaccine production |
| US11046955B2 (en) * | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| GB201607797D0 (en) * | 2016-05-04 | 2016-06-15 | Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin | Glaucoma therapy |
| US10426817B2 (en) * | 2017-01-24 | 2019-10-01 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics |
-
2020
- 2020-01-29 EP EP20748388.4A patent/EP3918072A4/en active Pending
- 2020-01-29 JP JP2021544320A patent/JP2022523320A/ja active Pending
- 2020-01-29 US US17/310,235 patent/US20220195428A1/en active Pending
- 2020-01-29 WO PCT/US2020/015638 patent/WO2020160121A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110281933A1 (en) * | 2010-05-13 | 2011-11-17 | Saint Louis University | Methods and compositions for the management of cardiovascular disease with oligonucleotides |
| WO2012027704A1 (en) * | 2010-08-27 | 2012-03-01 | New York University | Mir-33 inhibitors and uses thereof |
| US20120301439A1 (en) * | 2011-05-24 | 2012-11-29 | Washington University | Inhibition of choroidal neovascularization |
Non-Patent Citations (1)
| Title |
|---|
| SENE ET AL., CELL METABOLISM, vol. 17, no. 4, JPN6023053987, 2013, pages 549 - 561, ISSN: 0005395199 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3918072A1 (en) | 2021-12-08 |
| WO2020160121A1 (en) | 2020-08-06 |
| US20220195428A1 (en) | 2022-06-23 |
| EP3918072A4 (en) | 2023-02-01 |
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