JP2022520996A - デジタル式画像形成処理を備えるモジュール式走査共焦点光学プロファイル顕微鏡 - Google Patents

デジタル式画像形成処理を備えるモジュール式走査共焦点光学プロファイル顕微鏡 Download PDF

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JP2022520996A
JP2022520996A JP2021549210A JP2021549210A JP2022520996A JP 2022520996 A JP2022520996 A JP 2022520996A JP 2021549210 A JP2021549210 A JP 2021549210A JP 2021549210 A JP2021549210 A JP 2021549210A JP 2022520996 A JP2022520996 A JP 2022520996A
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modular
confocal microscope
array
target sites
microscope according
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JPWO2020176173A5 (https=
JP2022520996A5 (https=
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マシュー ダグラス マクラスキー
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ワシントン ステイト ユニバーシティー
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/04—Measuring microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0016—Technical microscopes, e.g. for inspection or measuring in industrial production processes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938—Using specific optical elements
    • G02B27/095—Refractive optical elements
    • G02B27/0955—Lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09—Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938—Using specific optical elements
    • G02B27/095—Refractive optical elements
    • G02B27/0972—Prisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2021549210A 2018-02-26 2020-01-17 デジタル式画像形成処理を備えるモジュール式走査共焦点光学プロファイル顕微鏡 Pending JP2022520996A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862635134P 2018-02-26 2018-02-26
US16/286,038 US10989903B2 (en) 2018-02-26 2019-02-26 Modular scanning confocal optical profile microscopy with digital imaging processing
US16/286,038 2019-02-26
PCT/US2020/013986 WO2020176173A1 (en) 2018-02-26 2020-01-17 Modular scanning confocal optical profile microscopy with digital imaging processing

Publications (3)

Publication Number Publication Date
JP2022520996A true JP2022520996A (ja) 2022-04-04
JPWO2020176173A5 JPWO2020176173A5 (https=) 2022-12-27
JP2022520996A5 JP2022520996A5 (https=) 2022-12-27

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JP2021549210A Pending JP2022520996A (ja) 2018-02-26 2020-01-17 デジタル式画像形成処理を備えるモジュール式走査共焦点光学プロファイル顕微鏡

Country Status (4)

Country Link
US (1) US10989903B2 (https=)
EP (1) EP3931617A4 (https=)
JP (1) JP2022520996A (https=)
WO (1) WO2020176173A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3828617A1 (de) * 2019-11-26 2021-06-02 Siemens Healthcare Diagnostics Inc. Verfahren zur digitalen anfärbung von zellen
CN111239047B (zh) * 2020-03-09 2023-10-27 深圳中科飞测科技股份有限公司 一种光学设备及实现自动聚焦的方法
US11561179B2 (en) 2020-09-04 2023-01-24 Trustees Of Boston University Fluorescence-coded mid-infrared photothermal microscope
CN112462497A (zh) * 2020-12-07 2021-03-09 中国科学院长春光学精密机械与物理研究所 光子集成干涉大视场成像系统
EP4012476A1 (fr) * 2020-12-10 2022-06-15 Centre National de la Recherche Scientifique Microscope confocal avec réallocation de photons
WO2024064266A2 (en) * 2022-09-21 2024-03-28 Board Of Regents, The University Of Texas System Quad-view image splitter for multicolor fluorescence microscopy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523731A (ja) * 1998-08-21 2002-07-30 サーロメッド・インコーポレーテッド マイクロ容積レーザ走査細胞測定法用の新規な光学的アーキテクチャ
JP2009522604A (ja) * 2005-12-30 2009-06-11 ゼネラル・エレクトリック・カンパニイ 自動顕微鏡の自動焦点調節法及びシステム
CN101779155A (zh) * 2007-08-16 2010-07-14 皇家飞利浦电子股份有限公司 对样本成像的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4825061A (en) * 1987-08-07 1989-04-25 Center For Innovative Technology Optically controlled bulk semiconductor switch not requiring radiation to sustain conduction
US5072122A (en) * 1990-10-15 1991-12-10 Kansas State University Research Foundation Charge storage image device using persistent photoconductivity crystals
ATE137588T1 (de) * 1990-11-10 1996-05-15 Grosskopf Rudolf Dr Ing Optische abtastvorrichtung mit konfokalem strahlengang, in der lichtquellen- und detektormatrix verwendet werden
US5548661A (en) * 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US6038067A (en) * 1996-05-23 2000-03-14 The Regents Of The University Of California Scanning computed confocal imager
DE10344060A1 (de) * 2003-09-23 2005-05-04 Zeiss Carl Jena Gmbh Konfokales Laser-Scanning-Mikroskop
GB0606788D0 (en) * 2006-04-03 2006-05-10 Ind Co Ltd Confocal microscopy
US8193537B2 (en) * 2006-06-19 2012-06-05 Ss Sc Ip, Llc Optically controlled silicon carbide and related wide-bandgap transistors and thyristors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523731A (ja) * 1998-08-21 2002-07-30 サーロメッド・インコーポレーテッド マイクロ容積レーザ走査細胞測定法用の新規な光学的アーキテクチャ
JP2009522604A (ja) * 2005-12-30 2009-06-11 ゼネラル・エレクトリック・カンパニイ 自動顕微鏡の自動焦点調節法及びシステム
CN101779155A (zh) * 2007-08-16 2010-07-14 皇家飞利浦电子股份有限公司 对样本成像的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
VIOLET M. POOLE ET AL.: "The role of hydrogen and oxygen in the persistent photoconductivity of strontium titanate", JOURNAL OF APPLIED PHYSICS, vol. 123, JPN7023003999, 15 December 2017 (2017-12-15), pages 161545, ISSN: 0005316740 *
VIOLET M. POOLE ET AL.: "Using A persistent photoconductivity to write a low-resistance path in SrTiO3", SCIENTIFIC REPORTS，NATURE RESEARCH, vol. 7, Article number: 6659, JPN7023003998, 27 July 2017 (2017-07-27), ISSN: 0005316739 *

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EP3931617A1 (en) 2022-01-05
US10989903B2 (en) 2021-04-27
US20190293915A1 (en) 2019-09-26
EP3931617A4 (en) 2023-03-01
WO2020176173A1 (en) 2020-09-03

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