JP2022516170A - Ｐａｒｐインヒビターおよび抗体放射性物質結合体の組み合わせを使用してがんを処置するための方法 - Google Patents

Ｐａｒｐインヒビターおよび抗体放射性物質結合体の組み合わせを使用してがんを処置するための方法 Download PDF

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JP2022516170A
JP2022516170A JP2021538752A JP2021538752A JP2022516170A JP 2022516170 A JP2022516170 A JP 2022516170A JP 2021538752 A JP2021538752 A JP 2021538752A JP 2021538752 A JP2021538752 A JP 2021538752A JP 2022516170 A JP2022516170 A JP 2022516170A
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デール ルドウィグ，
サンデシュ セス，
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アクティニウム ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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JP2021538752A 2019-01-04 2020-01-02 Ｐａｒｐインヒビターおよび抗体放射性物質結合体の組み合わせを使用してがんを処置するための方法 Pending JP2022516170A (ja)

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US201962788206P 2019-01-04 2019-01-04
US62/788,206 2019-01-04
PCT/US2020/012016 WO2020142583A1 (en) 2019-01-04 2020-01-02 Methods for treating cancer using combinations of parp inhibitors and antibody radioconjugates

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JP2022516170A true JP2022516170A (ja) 2022-02-24
JP2022516170A5 JP2022516170A5 (https=) 2023-01-19

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EP4209217A1 (en) * 2022-01-11 2023-07-12 Fundación Profesor Novoa Santos Method for the treatment of brca1/2 mutated cancer
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WO2024263637A1 (en) * 2023-06-20 2024-12-26 The Regents Of The University Of California Combination therapy with peptide receptor radionuclide and dna repair inhibitor
CN116726187B (zh) * 2023-07-26 2025-09-30 珠海市人民医院 一种小分子配体-鲁卡帕尼偶联物及其制备方法
CN117180277A (zh) * 2023-08-04 2023-12-08 中国辐射防护研究院 一种核素标记的靶向探针及其制备方法和应用
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
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CA3125197A1 (en) 2020-07-09
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