JP2022516086A - 神経網膜疾患の治療および／または予防における治療活性物質として使用するための化合物 - Google Patents
神経網膜疾患の治療および／または予防における治療活性物質として使用するための化合物 Download PDFInfo
- Publication number
- JP2022516086A JP2022516086A JP2021537220A JP2021537220A JP2022516086A JP 2022516086 A JP2022516086 A JP 2022516086A JP 2021537220 A JP2021537220 A JP 2021537220A JP 2021537220 A JP2021537220 A JP 2021537220A JP 2022516086 A JP2022516086 A JP 2022516086A
- Authority
- JP
- Japan
- Prior art keywords
- group
- retinal
- compound
- atom
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C=CC(C1)NC(Cc2c(*)c(*)c(*)c(*)c2*)=O)=C1I Chemical compound *C(C=CC(C1)NC(Cc2c(*)c(*)c(*)c(*)c2*)=O)=C1I 0.000 description 4
- JZZFRTXYKLGFCF-UHFFFAOYSA-N COc(cc(cc1)NC(Cc2ccccc2)=O)c1-c1ccncc1 Chemical compound COc(cc(cc1)NC(Cc2ccccc2)=O)c1-c1ccncc1 JZZFRTXYKLGFCF-UHFFFAOYSA-N 0.000 description 1
- DSQPJPCADQCPRC-UHFFFAOYSA-N COc(cc(cc1)NC(Cc2ccccc2Cl)=O)c1-c1ccncc1 Chemical compound COc(cc(cc1)NC(Cc2ccccc2Cl)=O)c1-c1ccncc1 DSQPJPCADQCPRC-UHFFFAOYSA-N 0.000 description 1
- VOEOOXPPXZHFQM-UHFFFAOYSA-N COc1c(CC(Nc(cc2)cc(Cl)c2-c2cnc[o]2)=O)cccc1 Chemical compound COc1c(CC(Nc(cc2)cc(Cl)c2-c2cnc[o]2)=O)cccc1 VOEOOXPPXZHFQM-UHFFFAOYSA-N 0.000 description 1
- QXDILVUCFQVKTM-UHFFFAOYSA-N COc1cc(CC(Nc(cc2)ccc2-c2ccncc2)=O)ccc1 Chemical compound COc1cc(CC(Nc(cc2)ccc2-c2ccncc2)=O)ccc1 QXDILVUCFQVKTM-UHFFFAOYSA-N 0.000 description 1
- BBNNLJMGPASZPD-UHFFFAOYSA-N Cc(cc1)ccc1S(CC#N)(=O)=O Chemical compound Cc(cc1)ccc1S(CC#N)(=O)=O BBNNLJMGPASZPD-UHFFFAOYSA-N 0.000 description 1
- YBEAMOBHNFDQMM-UHFFFAOYSA-N Nc1cnc[o]1 Chemical compound Nc1cnc[o]1 YBEAMOBHNFDQMM-UHFFFAOYSA-N 0.000 description 1
- LWOMDEOMDYBFGJ-UHFFFAOYSA-N O=C(Cc(cc1)ccc1Cl)Nc(cc1)cc(Cl)c1-c1cnc[o]1 Chemical compound O=C(Cc(cc1)ccc1Cl)Nc(cc1)cc(Cl)c1-c1cnc[o]1 LWOMDEOMDYBFGJ-UHFFFAOYSA-N 0.000 description 1
- CQJDPVVGJCSKSV-UHFFFAOYSA-N O=C(Cc(ccc(F)c1)c1F)Nc(cc1)cc(Cl)c1-c1cnc[o]1 Chemical compound O=C(Cc(ccc(F)c1)c1F)Nc(cc1)cc(Cl)c1-c1cnc[o]1 CQJDPVVGJCSKSV-UHFFFAOYSA-N 0.000 description 1
- OVFPQBROLOGEMT-UHFFFAOYSA-N O=C(Cc(cccc1)c1Cl)Nc(cc1)cc(Cl)c1-c1cnc[o]1 Chemical compound O=C(Cc(cccc1)c1Cl)Nc(cc1)cc(Cl)c1-c1cnc[o]1 OVFPQBROLOGEMT-UHFFFAOYSA-N 0.000 description 1
- PHLMJLIUEODRIV-UHFFFAOYSA-N O=C(Cc(cccc1)c1Cl)Nc(cc1)cc(F)c1-c1cnc[o]1 Chemical compound O=C(Cc(cccc1)c1Cl)Nc(cc1)cc(F)c1-c1cnc[o]1 PHLMJLIUEODRIV-UHFFFAOYSA-N 0.000 description 1
- XYVMTOOLDHJRMH-UHFFFAOYSA-N O=C(Cc(cccc1)c1OC(F)F)Nc(cc1)cc(F)c1-c1cnc[o]1 Chemical compound O=C(Cc(cccc1)c1OC(F)F)Nc(cc1)cc(F)c1-c1cnc[o]1 XYVMTOOLDHJRMH-UHFFFAOYSA-N 0.000 description 1
- NYJDZFHYWCGKOI-UHFFFAOYSA-N O=C(Cc1cc(C(F)(F)F)ccc1)Nc(cc1)cc(Cl)c1-c1cnc[o]1 Chemical compound O=C(Cc1cc(C(F)(F)F)ccc1)Nc(cc1)cc(Cl)c1-c1cnc[o]1 NYJDZFHYWCGKOI-UHFFFAOYSA-N 0.000 description 1
- NIPNGJSDFBOBES-UHFFFAOYSA-N O=C(Cc1ccccc1OC(F)F)Nc(cc1)cc(Cl)c1-c1cnc[o]1 Chemical compound O=C(Cc1ccccc1OC(F)F)Nc(cc1)cc(Cl)c1-c1cnc[o]1 NIPNGJSDFBOBES-UHFFFAOYSA-N 0.000 description 1
- LXRXBYOUAYVTHT-UHFFFAOYSA-N [O-][N+](c(cc1)cc(F)c1-c1cnc[o]1)=O Chemical compound [O-][N+](c(cc1)cc(F)c1-c1cnc[o]1)=O LXRXBYOUAYVTHT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/235,543 | 2018-12-28 | ||
| US16/235,543 US10752593B2 (en) | 2018-12-28 | 2018-12-28 | Compounds for use as therapeutically active substances in the treatment of retinal diseases |
| PCT/US2019/068759 WO2020140043A1 (en) | 2018-12-28 | 2019-12-27 | Compounds for use as therapeutically active substances in the treatment and/or prevention of neuroretinal diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022516086A true JP2022516086A (ja) | 2022-02-24 |
| JP2022516086A5 JP2022516086A5 (enExample) | 2022-11-30 |
Family
ID=69188012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537220A Withdrawn JP2022516086A (ja) | 2018-12-28 | 2019-12-27 | 神経網膜疾患の治療および／または予防における治療活性物質として使用するための化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10752593B2 (enExample) |
| EP (1) | EP3902606A1 (enExample) |
| JP (1) | JP2022516086A (enExample) |
| KR (1) | KR20210110849A (enExample) |
| CN (1) | CN113301958A (enExample) |
| AU (1) | AU2019414950A1 (enExample) |
| BR (1) | BR112021011599A2 (enExample) |
| CA (1) | CA3125278A1 (enExample) |
| CL (1) | CL2021001725A1 (enExample) |
| EA (1) | EA202191057A1 (enExample) |
| IL (1) | IL284298A (enExample) |
| MX (1) | MX2021007813A (enExample) |
| PH (1) | PH12021551092A1 (enExample) |
| SG (1) | SG11202104958UA (enExample) |
| WO (1) | WO2020140043A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10807973B2 (en) | 2018-12-28 | 2020-10-20 | Endogena Therapeutics, Inc. | Compounds for use as therapeutically active substances in the treatment of retinal diseases |
| AU2020454040B2 (en) | 2020-06-19 | 2025-03-06 | Endogena Therapeutics, Inc. | New compounds and their use as therapeutically active substances in the treatment and/or prevention of diseases involving the retinal pigment epithelium |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066675A (en) | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
| CA2216439A1 (en) | 1996-09-25 | 1998-03-25 | Derek Van Der Kooy | Pharmaceuticals containing retinal stem cells |
| AU1920501A (en) | 1999-12-03 | 2001-06-12 | Alcon Universal Limited | The use of caspase 9 inhibitors to treat ocular neural pathology |
| JP2011506445A (ja) | 2007-12-13 | 2011-03-03 | アムジエン・インコーポレーテツド | γ−セクレターゼ調節剤 |
| US9018202B2 (en) | 2010-12-03 | 2015-04-28 | Allergan, Inc. | Methods for treating diseases of the retina |
| US20130046003A1 (en) | 2011-07-22 | 2013-02-21 | Mohammed I. Dibas | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating retinal diseases |
| WO2013029338A1 (en) | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
| WO2014079850A1 (en) | 2012-11-23 | 2014-05-30 | F. Hoffmann-La Roche Ag | Substituted heterocyclic derivatives |
| DE102013110714A1 (de) | 2013-09-27 | 2015-04-02 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Prophylaxe und Behandlung einer nicht auf einer Proteinfaltungsstörung beruhenden neurodegenerativen Erkrankung |
| US12472157B2 (en) | 2014-11-07 | 2025-11-18 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa with n-acetylcysteine amide |
-
2018
- 2018-12-28 US US16/235,543 patent/US10752593B2/en not_active Expired - Fee Related
-
2019
- 2019-12-27 MX MX2021007813A patent/MX2021007813A/es unknown
- 2019-12-27 AU AU2019414950A patent/AU2019414950A1/en not_active Abandoned
- 2019-12-27 SG SG11202104958UA patent/SG11202104958UA/en unknown
- 2019-12-27 CA CA3125278A patent/CA3125278A1/en active Pending
- 2019-12-27 WO PCT/US2019/068759 patent/WO2020140043A1/en not_active Ceased
- 2019-12-27 CN CN201980085675.1A patent/CN113301958A/zh active Pending
- 2019-12-27 BR BR112021011599-4A patent/BR112021011599A2/pt not_active Application Discontinuation
- 2019-12-27 EP EP19842557.1A patent/EP3902606A1/en not_active Withdrawn
- 2019-12-27 JP JP2021537220A patent/JP2022516086A/ja not_active Withdrawn
- 2019-12-27 EA EA202191057A patent/EA202191057A1/ru unknown
- 2019-12-27 KR KR1020217023914A patent/KR20210110849A/ko not_active Ceased
-
2021
- 2021-05-11 PH PH12021551092A patent/PH12021551092A1/en unknown
- 2021-06-22 IL IL284298A patent/IL284298A/en unknown
- 2021-06-25 CL CL2021001725A patent/CL2021001725A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113301958A (zh) | 2021-08-24 |
| EP3902606A1 (en) | 2021-11-03 |
| EA202191057A1 (ru) | 2021-10-07 |
| IL284298A (en) | 2021-08-31 |
| KR20210110849A (ko) | 2021-09-09 |
| CA3125278A1 (en) | 2020-07-02 |
| US20200207719A1 (en) | 2020-07-02 |
| US10752593B2 (en) | 2020-08-25 |
| BR112021011599A2 (pt) | 2021-08-31 |
| CL2021001725A1 (es) | 2021-12-17 |
| PH12021551092A1 (en) | 2021-12-06 |
| AU2019414950A1 (en) | 2021-06-03 |
| SG11202104958UA (en) | 2021-07-29 |
| WO2020140043A1 (en) | 2020-07-02 |
| MX2021007813A (es) | 2021-10-01 |
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