JP2022515377A - 活動電位の検出改善 - Google Patents
活動電位の検出改善 Download PDFInfo
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Abstract
Description
少なくとも1つの複合活動電位基底関数と少なくとも1つのアーチファクト基底関数とを含む1組の基底関数を記録するメモリと、
神経組織における電気的活動の神経記録を受信するための入力と、
1組の基底関数から複合活動電位及びアーチファクトのうちの少なくとも一方を決定することにより神経記録を分解するように構成され、さらに複合活動電位及びアーチファクトのうちの少なくとも一方の推定値を出力するように構成されたプロセッサと
を含むシステムを提供する。
少なくとも1つの複合活動電位基底関数と少なくとも1つのアーチファクト基底関数とを含む1組の基底関数を含むメモリを評価することと、
神経組織における電気的活動の神経記録を受信することと、
1組の基底関数から複合活動電位及びアーチファクトのうちの少なくとも一方を決定することにより神経記録を分解することと、
複合活動電位及びアーチファクトのうちの少なくとも一方の推定値を出力することと
を含む方法を提供する。
神経組織における電気的活動の神経記録を受信することと、
アーチファクトの部分極モデルを神経記録に適合させることと、
適合された部分極モデルを神経記録から除去することと
を含む方法を提供する。
A(t)=αΦ1(t)+βΦ2(t)+γΦ3(t)
φ(t)=(ft)k-1・e-ft/θ
a.2つ以上の追加成分を有する、合成信号を捕捉/記録する。
b.基底系のプールから、第1の信号成分に対応する、第1の基底系を選択する。基底系の別のプールから、第2の信号成分に対応する、第2の基底系を選択する。
c.基底関数に基づいて合成関数の第1の成分及び第2の成分を決定する。第1の成分の推定値を第1の基底系の線形展開として、及び第2の成分の推定値を第2の基底系の線形展開として決定する。
d.前回の反復から推定された成分を使用して基底系を反復的に改善する。
g(t)=aexp(-kt)・t1.0-α+h
t≧0の場合、i(t)=kt-α、及びt<0の場合、i(t)=0。
p(t,T)=s(t)-s(t-T) 式2
と記述することができる。
y(r,b)=k(r,b) [s(t)-s(t-pw)+s(t-pw-ipg)-s(t-2.pw-ipg)] 式3
y(c,b)=k(c,b) [i(t)-i(t-pw)+i(t-pw-ipg)-i(t-2.pw-ipg)] 式4
y(r,s)=k(r,s) [s(t-pw-ipg)-s(t-2.pw-ipg)] 式5
y(c,s)=k(r,s) [i(t-pw-ipg)-i(t-2.pw-ipg)] 式6
y=y(r,b)+y(c,b)+y(r,s)+y(c,s) 式7
である。
i(t)=kit-a
α=0.364
相数(二相又は三相)
第一相の極性(負又は正)
パルス幅
相間ギャップ
一定の時定数の指数関数
線形勾配
直流オフセット
1.電流源出力に組織インピーダンスを乗じて形成された電圧。この電圧は、組織インピーダンス及び刺激電流により変化する。組織インピーダンスは電極に固有のものであり、刺激電流はプログラミングシステムにより分かる(一方は未知である)。
2.戻り電圧(VddHV)。戻り電圧は、プログラミングシステムにより分かる。
VT=VRrs+RTIScss
g[n]=b・g[n-1]+c・g[n-2]
110 電子機器モジュール
112 バッテリ
114 遠隔測定モジュール
116 モジュールコントローラ
118 メモリ
120 患者設定
122 制御プログラム
124 パルス発生器
126 電極選択モジュール
128 測定回路
150 電極アレイ
Claims (20)
- 神経記録におけるアーチファクトから複合活動電位を分離するためのシステムであって、
少なくとも1つの複合活動電位基底関数と少なくとも1つのアーチファクト基底関数とを含む1組の基底関数を記録するメモリと、
神経組織における電気的活動の神経記録を受信するための入力と、
前記1組の基底関数から複合活動電位及びアーチファクトのうちの少なくとも一方を決定することにより前記神経記録を分解するように構成され、さらに複合活動電位及びアーチファクトのうちの少なくとも一方の推定値を出力するように構成されたプロセッサと
を含むシステム。 - 前記電気的活動は、前記神経組織に印加された電気的刺激により誘発された、誘発複合活動電位を含む、請求項1に記載のシステム。
- 前記アーチファクト基底関数は、1つ又は複数のそのような電気的刺激により生じることが知られている電気的アーチファクトに適合される、請求項1又は2に記載のシステム。
- 2つ以上の基礎信号のそれぞれの推定値は出力され、前記2つ以上の基礎信号は、前記神経記録の前記複合活動電位信号成分と前記神経記録の前記アーチファクト成分とを含む、請求項1~3のいずれか一項に記載のシステム。
- 前記2つ以上の基礎信号は、バックグラウンドニューロン活動及び誘発された遅発応答の1つ又は複数をさらに含む、請求項4に記載のシステム。
- 誘発複合活動電位(ECAP)とアーチファクトの両方は同時に推定される、請求項1~5のいずれか一項に記載のシステム。
- ノイズのないECAPの推定値は出力される、請求項1~6のいずれか一項に記載のシステム。
- オーダーO(n)に従い、計算効率が高い前記神経記録における前記アーチファクトから前記複合活動電位を分離すること、請求項1~7のいずれか一項に記載のシステム。
- 前記神経記録における前記アーチファクトから前記複合活動電位を分離するための計算プロセスは、決定性時間内に実行される、請求項1~8のいずれか一項に記載のシステム。
- 前記神経記録における前記アーチファクトから前記複合活動電位を分離するための計算プロセスは、埋め込み型装置のファームウェアで実施される、請求項1~9のいずれか一項に記載のシステム。
- 各基礎信号は、基底関数の線形結合として表される、請求項1~10のいずれか一項に記載のシステム。
- 前記ECAPは、予測されるノイズのないECAP形態に適合された関数による基底関数でモデル化される、請求項1~11のいずれか一項に記載のシステム。
- 前記ECAPは、導関数がそれらの境界において連続であるように、指数関数が後続する1周期の正弦波で構成された区分関数による基底関数でモデル化される、請求項12に記載のシステム。
- 前記ECAPは、2つ以上の基底関数による基底関数でモデル化される、請求項12又は13に記載のシステム。
- 前記2つ以上の基底関数は、シングルエンド神経記録用に最適化された第1の基底関数と、差動神経記録用に最適化された第2の基底関数とを含む、請求項14に記載のシステム。
- アーチファクトは、直流基底関数、線形基底関数、及び指数基底関数を含む、3つの基底関数による基底関数でモデル化される、請求項1~15のいずれか一項に記載のシステム。
- アーチファクトは、直流基底関数、線形基底関数、及び部分極関数を含む、3つの基底関数による基底関数でモデル化される、請求項1~15のいずれか一項に記載のシステム。
- さらに、いかなるECAPもない、アーチファクトのみが存在する記録を検出するように構成される、請求項1~17のいずれか一項に記載のシステム。
- 神経記録におけるアーチファクトから複合活動電位を分離するための方法であって、
少なくとも1つの複合活動電位基底関数と少なくとも1つのアーチファクト基底関数とを含む1組の基底関数を含むメモリを評価することと、
神経組織における電気的活動の神経記録を受信することと、
前記1組の基底関数から複合活動電位及びアーチファクトのうちの少なくとも一方を決定することにより前記神経記録を分解することと、
複合活動電位及びアーチファクトのうちの少なくとも一方の推定値を出力することと
を含む方法。 - 神経記録におけるアーチファクトから複合活動電位を分離するための手順をコンピュータに実行させるためのコンピュータプログラムコード手段を含むコンピュータプログラム製品であって、請求項19に記載の方法を実行するためのコンピュータプログラムコード手段を含むコンピュータプログラム製品。
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