JP2022509589A - 機械学習技術を使用するナノ細孔シグナルの分析 - Google Patents

機械学習技術を使用するナノ細孔シグナルの分析 Download PDF

Info

Publication number
JP2022509589A
JP2022509589A JP2021525061A JP2021525061A JP2022509589A JP 2022509589 A JP2022509589 A JP 2022509589A JP 2021525061 A JP2021525061 A JP 2021525061A JP 2021525061 A JP2021525061 A JP 2021525061A JP 2022509589 A JP2022509589 A JP 2022509589A
Authority
JP
Japan
Prior art keywords
polymer
label
labels
polymer unit
unit type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021525061A
Other languages
English (en)
Japanese (ja)
Inventor
マッシンガム,ティモシー,リー
Original Assignee
オックスフォード ナノポール テクノロジーズ ピーエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オックスフォード ナノポール テクノロジーズ ピーエルシー filed Critical オックスフォード ナノポール テクノロジーズ ピーエルシー
Publication of JP2022509589A publication Critical patent/JP2022509589A/ja
Priority to JP2023106581A priority Critical patent/JP2023126856A/ja
Priority to JP2025139101A priority patent/JP2025172079A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G06N20/20—Ensemble learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G06N3/0442—Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/0464—Convolutional networks [CNN, ConvNet]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/084—Backpropagation, e.g. using gradient descent
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/09—Supervised learning
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Software Systems (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Mathematical Physics (AREA)
  • Computing Systems (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Computational Linguistics (AREA)
  • Microbiology (AREA)
  • Signal Processing (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
JP2021525061A 2018-11-28 2019-11-26 機械学習技術を使用するナノ細孔シグナルの分析 Pending JP2022509589A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023106581A JP2023126856A (ja) 2018-11-28 2023-06-29 機械学習技術を使用するナノ細孔シグナルの分析
JP2025139101A JP2025172079A (ja) 2018-11-28 2025-08-22 機械学習技術を使用するナノ細孔シグナルの分析

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1819378.9 2018-11-28
GBGB1819378.9A GB201819378D0 (en) 2018-11-28 2018-11-28 Analysis of nanopore signal using a machine-learning technique
PCT/GB2019/053334 WO2020109773A1 (en) 2018-11-28 2019-11-26 Analysis of nanopore signal using a machine-learning technique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023106581A Division JP2023126856A (ja) 2018-11-28 2023-06-29 機械学習技術を使用するナノ細孔シグナルの分析

Publications (1)

Publication Number Publication Date
JP2022509589A true JP2022509589A (ja) 2022-01-21

Family

ID=65024631

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021525061A Pending JP2022509589A (ja) 2018-11-28 2019-11-26 機械学習技術を使用するナノ細孔シグナルの分析
JP2023106581A Pending JP2023126856A (ja) 2018-11-28 2023-06-29 機械学習技術を使用するナノ細孔シグナルの分析
JP2025139101A Pending JP2025172079A (ja) 2018-11-28 2025-08-22 機械学習技術を使用するナノ細孔シグナルの分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023106581A Pending JP2023126856A (ja) 2018-11-28 2023-06-29 機械学習技術を使用するナノ細孔シグナルの分析
JP2025139101A Pending JP2025172079A (ja) 2018-11-28 2025-08-22 機械学習技術を使用するナノ細孔シグナルの分析

Country Status (10)

Country Link
US (2) US12264360B2 (enExample)
EP (1) EP3887543B1 (enExample)
JP (3) JP2022509589A (enExample)
CN (1) CN113166804A (enExample)
AU (1) AU2019389841B2 (enExample)
BR (1) BR112021008198A2 (enExample)
CA (1) CA3118632A1 (enExample)
GB (1) GB201819378D0 (enExample)
SG (1) SG11202103410TA (enExample)
WO (1) WO2020109773A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
EP3971300B1 (en) 2014-10-16 2024-06-05 Oxford Nanopore Technologies plc Sorting of polymers
GB201707138D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
EP3731959B1 (en) 2017-12-29 2025-10-08 Clear Labs, Inc. Automated priming and library loading device
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11347965B2 (en) 2019-03-21 2022-05-31 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US10911471B1 (en) * 2019-11-27 2021-02-02 The Florida International University Board Of Trustees Systems and methods for network-based intrusion detection
US12592298B2 (en) 2020-02-20 2026-03-31 Illumina, Inc. Hardware execution and acceleration of artificial intelligence-based base caller
JP7747643B2 (ja) 2020-02-20 2025-10-01 イルミナ インコーポレイテッド 人工知能ベースの多対多ベースコール
US12354008B2 (en) 2020-02-20 2025-07-08 Illumina, Inc. Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller
US12591780B2 (en) 2020-02-20 2026-03-31 Illumina, Inc. Data compression for artificial intelligence-based base calling
WO2021214516A1 (en) * 2020-04-21 2021-10-28 Neural Concept Sa Radius based neural network operations on sets of points
GB202103605D0 (en) 2021-03-16 2021-04-28 Oxford Nanopore Tech Ltd Alignment of target and reference sequences of polymer units
US20220301657A1 (en) 2021-03-16 2022-09-22 Illumina, Inc. Tile location and/or cycle based weight set selection for base calling
EP4309080A1 (en) * 2021-03-16 2024-01-24 Illumina Software, Inc. Neural network parameter quantization for base calling
IL307398A (en) * 2021-04-12 2023-12-01 Univ Hong Kong Chinese Base change analysis using electrical signals
US12217829B2 (en) 2021-04-15 2025-02-04 Illumina, Inc. Artificial intelligence-based analysis of protein three-dimensional (3D) structures
US12444482B2 (en) 2021-04-15 2025-10-14 Illumina, Inc. Multi-channel protein voxelization to predict variant pathogenicity using deep convolutional neural networks
US20240240248A1 (en) 2021-05-19 2024-07-18 Oxford Nanopore Technologies Plc Methods for complement strand sequencing
US12530882B2 (en) 2021-07-01 2026-01-20 Illumina, Inc. Efficient artificial intelligence-based base calling of index sequences
CN117063240A (zh) 2021-12-24 2023-11-14 上海芯像生物科技有限公司 基于深度学习的核酸测序方法和系统
EP4594523A2 (en) 2022-09-28 2025-08-06 Massachusetts Institute of Technology High throughput stochastic bio-molecular sensor
GB202215442D0 (en) 2022-10-19 2022-11-30 Oxford Nanopore Tech Plc Analysis of a polymer
CN120202306A (zh) 2022-11-01 2025-06-24 牛津纳米孔科技公开有限公司 生化分析系统以及控制生化分析系统的方法
WO2025024791A1 (en) * 2023-07-27 2025-01-30 University Of Washington Systems and methods for mobile-enabled targeted nanopore sequencing with mobile-enabled real-time fusion detection
CN116884503B (zh) * 2023-09-06 2023-12-26 北京齐碳科技有限公司 序列和后验矩阵的处理方法、装置和计算设备
WO2026000404A1 (zh) * 2024-06-28 2026-01-02 深圳华大生命科学研究院 碱基识别方法、碱基识别模型训练方法及电子设备
GB2644084A (en) 2024-09-16 2026-03-18 Oxford Nanopore Tech Plc Augmented consensus and variant calling
GB202413747D0 (en) 2024-09-18 2024-10-30 Oxford Nanopore Tech Plc Preprocessing nanopore signals

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014531901A (ja) * 2011-09-23 2014-12-04 オックスフォード ナノポール テクノロジーズ リミテッド ポリマー単位を含むポリマーの解析
WO2015173587A1 (en) * 2014-05-15 2015-11-19 Oxford Nanopore Technologies Limited Model adjustment during analysis of a polymer from nanopore measurements

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
EP1192103A1 (en) 1999-06-22 2002-04-03 President And Fellows of Harvard College Control of solid state dimensional features
WO2005124888A1 (en) 2004-06-08 2005-12-29 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
US20080113833A1 (en) 2006-11-15 2008-05-15 Francisco Fernandez Methods of playing soccer games
EP1962392A1 (en) 2007-02-23 2008-08-27 C & C Marshall Limited Connector
GB0713402D0 (en) 2007-07-11 2007-08-22 Cardiff & Vale Nhs Trust A method of diagnosing a condition using a neural network
EP3540436B1 (en) 2007-09-12 2023-11-01 President And Fellows Of Harvard College High-resolution molecular sensor
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
EP2391732B1 (en) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Methods using adaptors for nucleic acid constructs in transmembrane sequencing
CN102482330A (zh) 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
CA2758617C (en) 2009-04-20 2017-10-03 Oxford Nanopore Technologies Limited Lipid bilayer sensor array
AU2010307229B2 (en) 2009-09-18 2016-02-25 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
EP2507387B1 (en) 2009-12-01 2017-01-25 Oxford Nanopore Technologies Limited Biochemical analysis instrument and method
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
EP2614156B1 (en) 2010-09-07 2018-08-01 The Regents of The University of California Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme
BR112013020411B1 (pt) 2011-02-11 2021-09-08 Oxford Nanopore Technologies Limited Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo
WO2012138357A1 (en) 2011-04-04 2012-10-11 President And Fellows Of Harvard College Nanopore sensing by local electrical potential measurement
KR20140050067A (ko) 2011-07-25 2014-04-28 옥스포드 나노포어 테크놀로지즈 리미티드 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법
EP3736339B1 (en) * 2012-02-16 2022-07-27 Oxford Nanopore Technologies plc Analysis of measurements of a polymer
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
US20140006308A1 (en) 2012-06-28 2014-01-02 Google Inc. Portion-by-portion feedback for electronic books
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
JP6375301B2 (ja) 2012-10-26 2018-08-15 オックスフォード ナノポール テクノロジーズ リミテッド 液滴界面
CN106255767A (zh) 2014-03-21 2016-12-21 牛津楠路珀尔科技有限公司 由多维测量分析聚合物
CN119899249A (zh) 2014-09-01 2025-04-29 弗拉芒区生物技术研究所 突变csgg孔
GB201508003D0 (en) 2015-05-11 2015-06-24 Oxford Nanopore Tech Ltd Apparatus and methods for measuring an electrical current
GB201508669D0 (en) 2015-05-20 2015-07-01 Oxford Nanopore Tech Ltd Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
JP6719773B2 (ja) * 2015-12-25 2020-07-08 国立大学法人大阪大学 分類分析方法、分類分析装置および分類分析用記憶媒体
GB201707138D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
CA3095030A1 (en) * 2018-03-30 2019-10-03 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
GB201814369D0 (en) 2018-09-04 2018-10-17 Oxford Nanopore Tech Ltd Method for determining a polymersequence

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014531901A (ja) * 2011-09-23 2014-12-04 オックスフォード ナノポール テクノロジーズ リミテッド ポリマー単位を含むポリマーの解析
WO2015173587A1 (en) * 2014-05-15 2015-11-19 Oxford Nanopore Technologies Limited Model adjustment during analysis of a polymer from nanopore measurements

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BMC BIOINFORMATICS, vol. Vol.8(Suppl 7), S12, JPN6022026534, 2007, pages 1 - 16, ISSN: 0005001288 *

Also Published As

Publication number Publication date
SG11202103410TA (en) 2021-06-29
JP2023126856A (ja) 2023-09-12
BR112021008198A2 (pt) 2021-08-03
CA3118632A1 (en) 2020-06-04
US20250197929A1 (en) 2025-06-19
AU2019389841A1 (en) 2021-05-20
JP2025172079A (ja) 2025-11-20
US12264360B2 (en) 2025-04-01
EP3887543B1 (en) 2024-08-28
EP3887543A1 (en) 2021-10-06
GB201819378D0 (en) 2019-01-09
AU2019389841B2 (en) 2026-05-07
US20200176082A1 (en) 2020-06-04
KR20210095641A (ko) 2021-08-02
WO2020109773A1 (en) 2020-06-04
CN113166804A (zh) 2021-07-23

Similar Documents

Publication Publication Date Title
EP3887543B1 (en) Analysis of nanopore signal using a machine-learning technique
US20250371230A1 (en) Machine learning analysis of nanopore measurements
US20250006308A1 (en) Nanopore measurement signal analysis
US20170096703A1 (en) Analysis of a polymer from multi-dimensional measurements
JP6226888B2 (ja) ポリマーの測定の解析
KR102916805B1 (ko) 중합체 서열을 결정하는 방법
EP3143538B1 (en) Model adjustment during analysis of a polymer from nanopore measurements
Azad et al. Effects of choice of DNA sequence model structure on gene identification accuracy
US7840358B2 (en) Hierarchical statistical framework for separating mixed data
Huang Computational Methods Using Large-scale Population Whole-genome Sequencing Data

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210510

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220628

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220920

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221114

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230228