JP2022151697A - Beverages containing iron compounds and ceramides - Google Patents
Beverages containing iron compounds and ceramides Download PDFInfo
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- JP2022151697A JP2022151697A JP2022036479A JP2022036479A JP2022151697A JP 2022151697 A JP2022151697 A JP 2022151697A JP 2022036479 A JP2022036479 A JP 2022036479A JP 2022036479 A JP2022036479 A JP 2022036479A JP 2022151697 A JP2022151697 A JP 2022151697A
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- Prior art keywords
- iron
- glycosphingolipid
- content
- terms
- collagen peptide
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 76
- 150000002506 iron compounds Chemical class 0.000 title claims abstract description 47
- 229940106189 ceramide Drugs 0.000 title description 24
- 150000001783 ceramides Chemical class 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 132
- 229910052742 iron Inorganic materials 0.000 claims abstract description 66
- 150000002339 glycosphingolipids Chemical class 0.000 claims abstract description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 45
- 102000008186 Collagen Human genes 0.000 claims abstract description 44
- 108010035532 Collagen Proteins 0.000 claims abstract description 44
- 229920001436 collagen Polymers 0.000 claims abstract description 43
- 239000002244 precipitate Substances 0.000 claims abstract description 12
- 150000002305 glucosylceramides Chemical class 0.000 claims description 32
- 235000007164 Oryza sativa Nutrition 0.000 claims description 17
- 235000009566 rice Nutrition 0.000 claims description 17
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 14
- 235000007119 Ananas comosus Nutrition 0.000 claims description 13
- 229920002752 Konjac Polymers 0.000 claims description 13
- 240000008042 Zea mays Species 0.000 claims description 13
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 11
- 244000099147 Ananas comosus Species 0.000 claims description 11
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 11
- 235000005822 corn Nutrition 0.000 claims description 11
- 239000000252 konjac Substances 0.000 claims description 11
- 235000010485 konjac Nutrition 0.000 claims description 11
- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 claims description 8
- 239000004313 iron ammonium citrate Substances 0.000 claims description 8
- 235000000011 iron ammonium citrate Nutrition 0.000 claims description 8
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims description 3
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 3
- 239000011773 ferrous fumarate Substances 0.000 claims description 3
- 235000002332 ferrous fumarate Nutrition 0.000 claims description 3
- 229960000225 ferrous fumarate Drugs 0.000 claims description 3
- 239000004222 ferrous gluconate Substances 0.000 claims description 3
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 3
- 229960001645 ferrous gluconate Drugs 0.000 claims description 3
- 239000011790 ferrous sulphate Substances 0.000 claims description 3
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 3
- 150000003278 haem Chemical class 0.000 claims description 3
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- ATEAWHILRRXHPW-UHFFFAOYSA-J iron(2+);phosphonato phosphate Chemical compound [Fe+2].[Fe+2].[O-]P([O-])(=O)OP([O-])([O-])=O ATEAWHILRRXHPW-UHFFFAOYSA-J 0.000 claims description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 3
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 claims description 3
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 3
- JHYAVWJELFKHLM-UHFFFAOYSA-H tetrasodium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Na+].[Na+].[Na+].[Na+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O JHYAVWJELFKHLM-UHFFFAOYSA-H 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 claims description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 2
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
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- 229940009714 erythritol Drugs 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 239000011706 ferric diphosphate Substances 0.000 claims description 2
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 2
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 2
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 2
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Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
本発明は、鉄化合物とスフィンゴ糖脂質を含有する飲料に関し、医薬品、医薬部外品及び食品等の分野で利用されうる。 INDUSTRIAL APPLICABILITY The present invention relates to a beverage containing an iron compound and a glycosphingolipid, and can be used in fields such as pharmaceuticals, quasi-drugs and foods.
インナービューティー市場で、高い成長率を見せている成分にスフィンゴ糖脂質の一種であるセラミドがある。セラミドは、2015年の機能性表示食品制度の開始以降、関与成分として採用されることが多くなり、売上を伸ばしている(非特許文献1)。スフィンゴ脂質は、長鎖アミノアルコールであるスフィンゴイド塩基を共通骨格に持つ脂質の一群であり、多種多様な分子種が存在する。自然界に存在するスフィンゴ脂質は、スフィンゴイド塩基に脂肪酸が酸アミド結合したセラミドを基本構造に持ち、セラミドのスフィンゴイド塩基部分にリン酸コリンの結合したスフィンゴミエリンや、糖の結合したスフィンゴ糖脂質などのかたちで存在している(非特許文献2)。食品・健康補助食品の分野においては、特にスフィンゴ糖脂質の一種であるグルコシルセラミドの利用が盛んに行われている。 In the inner beauty market, ceramide, a type of glycosphingolipid, is one of the ingredients showing a high growth rate. Since the start of the food with function claims system in 2015, ceramide has been increasingly adopted as a participating ingredient and sales are growing (Non-Patent Document 1). Sphingolipids are a group of lipids having a sphingoid base, which is a long-chain amino alcohol, as a common skeleton, and include a wide variety of molecular species. Sphingolipids that exist in nature have a basic structure of ceramide, in which a fatty acid is linked to a sphingoid base, and sphingomyelin, in which choline phosphate is linked to the sphingoid base of ceramide, and glycosphingolipids, in which sugars are linked, etc. exists in the form of (Non-Patent Document 2). Glucosylceramide, which is a type of glycosphingolipid, has been actively used in the field of foods and health supplements.
近年、食品・健康補助食品の分野において、コラーゲンペプチドの利用が広まっている。コラーゲンは、動物の体内に最も多く存在するタンパク質であり、コラーゲンペプチドは、動物や魚から得られたコラーゲンを加水分解する等の方法により、分子量を数百~数千とし、利用性を高めたものである(非特許文献3)。コラーゲンペプチド市場は急速に拡大しており、特に女性向けの製品においては、訴求成分として欠かすことのできない存在となっている。 In recent years, the use of collagen peptides has spread in the fields of foods and health supplements. Collagen is the most abundant protein in the body of animals, and collagen peptides are made more useful by increasing the molecular weight to several hundred to several thousand by hydrolyzing collagen obtained from animals and fish. (Non-Patent Document 3). The market for collagen peptides is expanding rapidly, and it has become an indispensable ingredient as an appealing ingredient, especially in products for women.
しかしながら、グルコシルセラミドは水に難溶性であり、飲料へ適用した際に、分散性の悪い沈殿物を生じるという課題があった。分散性の悪い沈殿物は、服用時の舌触りの悪化や容器への成分の残留に繋がり、商品価値を高めるために少しでも改善されるべきである。かかる課題を解決するために、レシチンと併用する方法(特許文献1)、キサンタンガムとウェランガムを併用して用いる方法(特許文献2)が報告されている。特許文献1に記載の方法では、グルコシルセラミドの粒子径を小さくする必要があるという課題がある。特許文献2に記載の方法では、キサンタンガムやウェランガムの配合による独特の粘性のコントロールやコストアップといった課題がある。よって、グルコシルセラミドを飲料に配合する方法は、いまだ改善の余地があるといえる。
一方、鉄は生体にとって必須の金属であるにも関わらず、特に女性において、摂取基準に対して不足しがちであることが報告されている。日本人の食事摂取基準(2020年版)において女性の鉄の推奨量は10.5mgであるが、平成30年国民健康・栄養調査では女性の鉄の摂取量は7.5mgであり、1日当たり3mg程度鉄が不足している(非特許文献1)。食生活上の効率的な摂取の方法として、鉄化合物を配合した飲料やサプリメント等が利用されているが、鉄化合物が他の配合成分と反応し、風味や品質を損なうという問題があった(特許文献3、4)
However, glucosylceramide is sparingly soluble in water, and when applied to beverages, there is a problem in that it forms precipitates with poor dispersibility. Poorly dispersible sediments lead to poor texture on the tongue when ingested and residual ingredients in the container, and should be improved as much as possible in order to increase commercial value. In order to solve such problems, a method of using lecithin in combination (Patent Document 1), and a method of using xanthan gum and welan gum in combination (Patent Document 2) have been reported. The method described in Patent Document 1 has a problem that it is necessary to reduce the particle size of glucosylceramide. In the method described in Patent Document 2, there are problems such as unique viscosity control and cost increase due to the blending of xanthan gum and welan gum. Therefore, it can be said that there is still room for improvement in the method of blending glucosylceramide into beverages.
On the other hand, although iron is an essential metal for the living body, it has been reported that women, in particular, tend to be deficient in the intake standard. According to the Dietary Reference Intakes for Japanese (2020 edition), the recommended amount of iron for women is 10.5 mg. There is a lack of iron to some extent (Non-Patent Document 1). Beverages and supplements containing iron compounds have been used as an efficient method of ingesting them in the diet, but there is a problem that the iron compounds react with other ingredients and impair the flavor and quality ( Patent documents 3, 4)
本発明の目的は、鉄化合物を鉄換算で0.006w/w%以上含有する飲料において、鉄由来の不快味(鉄味)を低減することである。また、スフィンゴ糖脂質由来の沈殿物の分散性を向上させることである。 An object of the present invention is to reduce the iron-derived unpleasant taste (iron taste) in a beverage containing 0.006 w/w % or more of iron compounds in terms of iron. Another object is to improve the dispersibility of precipitates derived from glycosphingolipids.
本発明者らは、この問題を解決すべく鋭意検討を重ねた結果、意外にも、鉄化合物を鉄換算で0.006w/w%以上含む飲料において、鉄を含むことにより感じられる鉄由来の不快味(鉄味)を、スフィンゴ糖脂質を配合することにより低減することを見出した。
他方、飲料中におけるスフィンゴ糖脂質由来の沈殿物の分散性が、一定量以上の鉄化合物の配合により向上することを発見した。
また、飲料中にスフィンゴ糖脂質を一定量配合した場合、一定量の鉄化合物の配合に加えてさらにコラーゲンペプチドを配合することにより、スフィンゴ糖脂質由来の沈殿物の分散性が向上することを発見した。
また、スフィンゴ糖脂質由来の沈殿物の分散性が、一定量の鉄化合物の配合に加えて、一定量のコラーゲンペプチドを配合することにより、向上することを発見した。
The present inventors have made intensive studies to solve this problem.Unexpectedly, in beverages containing iron compounds of 0.006 w / w% or more in terms of iron, iron-derived iron-derived It was found that the unpleasant taste (iron taste) is reduced by blending glycosphingolipids.
On the other hand, they have found that the dispersibility of glycosphingolipid-derived precipitates in beverages is improved by adding a certain amount or more of an iron compound.
In addition, when a certain amount of glycosphingolipid is blended in a beverage, it was discovered that the dispersibility of precipitates derived from glycosphingolipid is improved by adding collagen peptide in addition to blending a certain amount of iron compound. did.
In addition, they have found that the dispersibility of precipitates derived from glycosphingolipids is improved by adding a certain amount of collagen peptide in addition to adding a certain amount of an iron compound.
かかる知見により得られた本発明の態様は次のとおりである。
(1)スフィンゴ糖脂質、及び鉄化合物を含有し、鉄化合物の含有量が鉄換算で0.006~0.2w/w%である飲料(ただし、クエン酸鉄アンモニウムが鉄換算で0.01w/w%、コラーゲンペプチド2w/w%、グルコシルセラミド0.006w/w%、炭水化物量8.0w/w%、ヒアルロン酸0.02w/w%、エリスリトール、還元水飴、トレハロース、ペクチン、アセスルファムカリウム、スクラロース、及びビタミンB2を含有する飲料を除く)、
(2)スフィンゴ糖脂質、鉄化合物、及びコラーゲンペプチドを含有し、鉄化合物の含有量が鉄換算で0.006~0.2w/w%、スフィンゴ糖脂質の含有量が0.00001~0.0052w/w%である飲料、
(3)スフィンゴ糖脂質、鉄化合物、コラーゲンペプチドを含有し、鉄化合物の含有量が鉄換算で0.006~0.04w/w%、コラーゲンペプチドの含有量がスフィンゴ糖脂質1質量部に対して400質量部以上である飲料、
(4)スフィンゴ糖脂質の含有量が0.00001~0.02w/w%である、(1)又は(3)に記載の飲料、
(5)鉄化合物が、フマル酸第一鉄、塩化第二鉄、クエン酸鉄、クエン酸鉄アンモニウム、クエン酸第一鉄ナトリウム、グルコン酸第一鉄、乳酸鉄、ピロリン酸第一鉄、ピロリン酸第二鉄、硫酸第一鉄、およびヘム鉄からなる群から選ばれる少なくとも1種である、(1)~(4)に記載の飲料、
(6)スフィンゴ糖脂質が、米、パイナップル、トウモロコシ、又はこんにゃく由来である、(1)~(5)に記載の飲料、
(7)スフィンゴ糖脂質がグルコシルセラミドである、(1)~(6)のいずれかに記載の飲料、
(8)コラーゲンペプチドの含有量が0.02~50w/w%である、(2)~(7)のいずれかに記載の飲料、
(9)鉄化合物の含有量が、スフィンゴ糖脂質1質量部に対して鉄換算で0.1~100質量部である、(1)~(8)のいずれかに記載の飲料、
(10)一回の経口摂取量当たり、鉄化合物の量にして鉄換算で3mg~20mgである、(1)~(9)のいずれかに記載の飲料、
(11)pHが2.0~4.5である、(1)~(10)のいずれかに記載の飲料、
(12)鉄化合物およびコラーゲンペプチドを配合することにより、飲料中のスフィンゴ糖脂質由来の沈殿物の分散性を向上させる方法、
である。
The aspects of the present invention obtained from such findings are as follows.
(1) Beverages containing glycosphingolipids and iron compounds, wherein the content of iron compounds is 0.006 to 0.2 w/w% in terms of iron (however, ammonium ferric citrate is 0.01 w in terms of iron /w%, collagen peptide 2w/w%, glucosylceramide 0.006w/w%, carbohydrate content 8.0w/w%, hyaluronic acid 0.02w/w%, erythritol, reduced starch syrup, trehalose, pectin, acesulfame potassium, excluding beverages containing sucralose and vitamin B2),
(2) Contains a glycosphingolipid, an iron compound, and a collagen peptide, the content of the iron compound is 0.006 to 0.2 w/w% in terms of iron, and the content of the glycosphingolipid is 0.00001 to 0.2 w/w% in terms of iron. 0052 w/w% beverage,
(3) Contains a glycosphingolipid, an iron compound, and a collagen peptide, the content of the iron compound is 0.006 to 0.04 w/w% in terms of iron, and the content of the collagen peptide is 1 part by mass of the glycosphingolipid a beverage that is 400 parts by mass or more,
(4) The beverage according to (1) or (3), which has a glycosphingolipid content of 0.00001 to 0.02 w/w%,
(5) Iron compounds include ferrous fumarate, ferric chloride, iron citrate, ammonium ferric citrate, sodium ferrous citrate, ferrous gluconate, ferrous lactate, ferrous pyrophosphate, pyroline The beverage according to (1) to (4), which is at least one selected from the group consisting of ferric acid, ferrous sulfate, and heme iron,
(6) The beverage according to (1) to (5), wherein the glycosphingolipid is derived from rice, pineapple, corn, or konjac,
(7) the beverage according to any one of (1) to (6), wherein the glycosphingolipid is glucosylceramide;
(8) The beverage according to any one of (2) to (7), wherein the collagen peptide content is 0.02 to 50 w/w%.
(9) The beverage according to any one of (1) to (8), wherein the content of the iron compound is 0.1 to 100 parts by mass in terms of iron with respect to 1 part by mass of glycosphingolipid,
(10) The beverage according to any one of (1) to (9), wherein the amount of iron compound per oral intake is 3 mg to 20 mg in terms of iron,
(11) The beverage according to any one of (1) to (10), which has a pH of 2.0 to 4.5,
(12) A method for improving the dispersibility of precipitates derived from glycosphingolipids in beverages by incorporating an iron compound and a collagen peptide,
is.
本発明により、鉄由来の不快な味(鉄味)を低減した飲料を提供することが可能となった。また、スフィンゴ糖脂質由来の沈殿物の分散性を向上した飲料を提供することが可能となった。 ADVANTAGE OF THE INVENTION By this invention, it became possible to provide the drink which reduced the unpleasant taste (iron taste) derived from iron. Moreover, it has become possible to provide a beverage in which the dispersibility of the glycosphingolipid-derived precipitate is improved.
本発明において「スフィンゴ糖脂質」としては、スフィンゴイド塩基にグルコースが結合したグルコシルセラミド、スフィンゴイド塩基にガラクトースが結合したガラクトシルセラミド、スフィンゴイド塩基にシアル酸が結合したガングリオシド、スフィンゴイド塩基にラクトースが結合したラクトシルセラミド等が挙げられ、より好ましくはグルコシルセラミドを使用することができる。これらの1種又は2以上の混合物を用いてもよく、合成であってもよく、牛や馬等の哺乳動物の組織から抽出してもよく、植物から抽出したものでもよい。好ましくは、米、米ぬか、ビート、小麦、トウモロコシ、大豆、こんにゃく芋、パイナップル等の穀物類、豆類、芋類、果実類のような植物から抽出されたものであり、より好ましくは、米、パイナップル、トウモロコシ、こんにゃく芋由来である。本発明の「スフィンゴ糖脂質」としては、市販品を用いてもよく、例えば、パインセラ粉末(丸善製薬(株))、パインセラ乳化物(丸善製薬(株))、ブライトニングパイン粉末(丸善製薬(株))、ブライトニングパイン乳化物(丸善製薬(株))、オリザセラミド(登録商標)-PCD(オリザ油化(株))、オリザセラミド(登録商標)-WSP(オリザ油化(株))、オリザセラミド(登録商標)-L(オリザ油化(株))、ニップンセラミドRPS((株)ニップン)、ニップンセラミドRLG((株)ニップン)、ニップンセラミドCP((株)ニップン)、フィトセラマイド(一丸ファルコス(株))、フィトセラNW-1(一丸ファルコス(株))、フィトセラNW-10(一丸ファルコス(株))、フィトセラマイドL(一丸ファルコス(株))、こんにゃくセラミド((株)ダイセル)、ビードセラミドEX-1((株)明治フードマテリア)、こんにゃくセラミド(ユニチカ(株))、コーンセラミドME-1(辻製油(株))、コーンセラミドP10(辻製油(株))、ミルクセラミドMC-5(雪印メグミルク(株))が挙げられる。 In the present invention, the "glycosphingolipid" includes glucosylceramide in which glucose is bound to the sphingoid base, galactosylceramide in which galactose is bound to the sphingoid base, ganglioside in which sialic acid is bound to the sphingoid base, and lactose to the sphingoid base. bound lactosylceramide and the like, and more preferably glucosylceramide can be used. One or a mixture of two or more of these may be used, or they may be synthesized, extracted from tissues of mammals such as cows and horses, or extracted from plants. Preferably, it is extracted from grains such as rice, rice bran, beets, wheat, corn, soybeans, konjac potatoes, pineapples, beans, potatoes, and plants such as fruits, and more preferably rice and pineapples. , corn, and konjac potatoes. As the "glycosphingolipid" of the present invention, commercially available products may be used. )), brightening pine emulsion (Maruzen Pharmaceutical Co., Ltd.), Oryza Ceramide (registered trademark)-PCD (Oryza Oil & Chemicals Co., Ltd.), Oryza Ceramide (registered trademark)-WSP (Oryza Oil & Chemicals Co., Ltd.), Oryza Ceramide (registered trademark)-L (Oryza Yuka Co., Ltd.), Nippon Ceramide RPS (Nippon Co., Ltd.), Nippon Ceramide RLG (Nippon Co., Ltd.), Nippon Ceramide CP (Nippon Co., Ltd.), Phytoceramide (Ichimaru Farcos Co., Ltd.), Phytocera NW-1 (Ichimaru Farcos Co., Ltd.), Phytocera NW-10 (Ichimaru Farcos Co., Ltd.), Phytoceramide L (Ichimaru Farcos Co., Ltd.), Konnyaku Ceramide (Daisel Co., Ltd.), Bead ceramide EX-1 (Meiji Food Materia Co., Ltd.), konjac ceramide (Unitika Ltd.), corn ceramide ME-1 (Tsuji Oil Co., Ltd.), corn ceramide P10 (Tsuji Oil Co., Ltd.), milk ceramide MC -5 (Megmilk Snow Brand Co., Ltd.).
スフィンゴ糖脂質の含有量は、本発明の効果の観点から、飲料中、0.00001~0.02w/w%が好ましく、0.0001~0.01w/w%がより好ましく、0.0002~0.005w/w%がさらに好ましい。 From the viewpoint of the effect of the present invention, the content of glycosphingolipids in the beverage is preferably 0.00001 to 0.02 w/w%, more preferably 0.0001 to 0.01 w/w%, and 0.0002 to 0.005 w/w% is more preferred.
本発明において「コラーゲンペプチド」とは、その起源は特に限定されず、合成であってもよく、牛や豚等の家畜や魚を加工する際に副生する皮、骨、靭帯、腱、軟骨等から抽出して製造されるコラーゲンペプチドであってもよいが、豚由来のコラーゲンペプチドが好ましい。コラーゲンタンパク質を酵素や化学的処理等により分解して得られるコラーゲンペプチドが好ましい。コラーゲンペプチドの平均分子量としては、特に限定されないが、100~50000であることが好ましく、1000~25000であることがより好ましい。本発明のコラーゲンペプチドは、市販品を用いてもよく、例えば「ニッピペプタイドPS-1」((株)ニッピ製)、「ニッピペプタイドPRA-P」((株)ニッピ製)、「ニッピペプタイドFCP-EX」((株)ニッピ製)、「HACP-CF」(ゼライス(株)製)、「HACP-TF」(ゼライス(株)製)、「コラペプPU」(新田ゼラチン(株)製)、「コラペプJB」(新田ゼラチン(株)製)、「HDL-50SP」(新田ゼラチン(株)製)、「SCP-3100」(新田ゼラチン(株)製)、「peptan P2000HD」(ルスロ(株)製)等が挙げられる。 In the present invention, the "collagen peptide" is not particularly limited in its origin, may be synthetic, and is a by-product of processing livestock such as cattle and pigs and fish, skin, bone, ligament, tendon, and cartilage. Although it may be a collagen peptide produced by extracting from, etc., pig-derived collagen peptide is preferable. Collagen peptides obtained by enzymatically or chemically degrading collagen proteins are preferred. Although the average molecular weight of the collagen peptide is not particularly limited, it is preferably from 100 to 50,000, more preferably from 1,000 to 25,000. Commercially available collagen peptides of the present invention may be used, for example, "Nippi Peptide PS-1" (manufactured by Nippi Co., Ltd.), "Nippi Peptide PRA-P" (manufactured by Nippi Co., Ltd.), "Nippi Peptide FCP -EX” (manufactured by Nippi Co., Ltd.), “HACP-CF” (manufactured by Zerais Co., Ltd.), “HACP-TF” (manufactured by Zerais Co., Ltd.), “Corapep PU” (manufactured by Nitta Gelatin Co., Ltd.) , “Corapep JB” (manufactured by Nitta Gelatin Co., Ltd.), “HDL-50SP” (manufactured by Nitta Gelatin Co., Ltd.), “SCP-3100” (manufactured by Nitta Gelatin Co., Ltd.), “peptan P2000HD” ( Rousselot Co., Ltd.) and the like.
コラーゲンペプチドの含有量は、本発明の飲料中、0.02~50w/w%が好ましく、0.2~30w/w%がより好ましく、0.2~20w/w%がさらに好ましい。 The content of collagen peptide in the beverage of the present invention is preferably 0.02 to 50 w/w%, more preferably 0.2 to 30 w/w%, even more preferably 0.2 to 20 w/w%.
また、本発明の効果の観点から、飲料中、コラーゲンペプチドの含有量は、スフィンゴ糖脂質1質量部に対して、50~100000質量部が好ましく、200~10000質量部がより好ましく、400~10000質量部がさらに好ましく、700~10000質量部がよりさらに好ましい。また、コラーゲンペプチドの含有量は、鉄換算で、鉄1質量部に対して1~2000質量部が好ましく、10~1500質量部がより好ましく、20~1500質量部がさらに好ましい。 From the viewpoint of the effects of the present invention, the content of the collagen peptide in the beverage is preferably 50 to 100,000 parts by mass, more preferably 200 to 10,000 parts by mass, more preferably 400 to 10,000 parts by mass, based on 1 part by mass of glycosphingolipid. Parts by weight are more preferred, and 700 to 10,000 parts by weight are even more preferred. In addition, the content of the collagen peptide is preferably 1 to 2000 parts by mass, more preferably 10 to 1500 parts by mass, and even more preferably 20 to 1500 parts by mass in terms of iron per 1 part by mass of iron.
本発明において「鉄化合物」としては、二価の鉄化合物及び三価の鉄化合物のいずれでもよく、例えば、フマル酸第一鉄、塩化第二鉄、クエン酸鉄、クエン酸鉄アンモニウム、クエン酸第一鉄ナトリウム、グルコン酸第一鉄、乳酸鉄、ピロリン酸第一鉄、ピロリン酸第二鉄、硫酸第一鉄、ヘム鉄を挙げることができる。
本発明において、鉄化合物の含有量は、本発明の効果の点から、飲料中、鉄換算としては0.006~0.2w/w%が好ましく、0.006~0.04w/w%がより好ましい。また、鉄化合物としては0.03~1.2w/w%が好ましく、0.03~0.6w/w%がより好ましい。鉄化合物の含有量は、スフィンゴ糖脂質1質量部に対して、鉄換算で0.1~100質量部が好ましく、0.5~50質量部がより好ましい。
また、本発明の飲料における鉄化合物の含有量は、好ましくは一回の経口摂取量当たり、鉄化合物の量にして鉄換算で、3mg~20mgがより好ましい。
In the present invention, the "iron compound" may be either a divalent iron compound or a trivalent iron compound, such as ferrous fumarate, ferric chloride, iron citrate, ferric ammonium citrate, citric acid Mention may be made of ferrous sodium, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, heme iron.
In the present invention, the content of the iron compound is preferably 0.006 to 0.2 w/w% in terms of iron in the beverage, and 0.006 to 0.04 w/w% in terms of the effect of the present invention. more preferred. The iron compound is preferably 0.03 to 1.2 w/w%, more preferably 0.03 to 0.6 w/w%. The content of the iron compound is preferably 0.1 to 100 parts by mass, more preferably 0.5 to 50 parts by mass in terms of iron, per 1 part by mass of glycosphingolipid.
Further, the content of the iron compound in the beverage of the present invention is more preferably 3 mg to 20 mg in terms of iron per one oral intake.
本発明の飲料は、一回の経口摂取で1日不足分以上の鉄(3mg以上)を補うことができる。 A single oral intake of the beverage of the present invention can compensate for more than the daily iron deficiency (3 mg or more).
また、一回の経口摂取量とは、本発明の飲料が一度に経口摂取される量であり、例えば、30~200ml、典型的には30ml、50ml、100ml、150ml、200mlがその量である。密度比重を用いて重量充填する場合は、例えば15~200g、典型的には15g、30g、50g、100g、150g、200gがその量である。また、容器詰め飲料とする場合の飲料用容器の形態は特に限定されない。容器の容量は特に限定されないが、例えば30ml~200ml(典型的には50ml、100ml、150ml、又は200ml)、重量充填する場合には、例えば15g~200g(典型的には15g、30g、50g、100g、150g、200g)とすることができる。 In addition, a single oral intake is the amount of the beverage of the present invention that is orally ingested at one time. . For weight filling using density specific gravity, the amount is, for example, 15 to 200 g, typically 15 g, 30 g, 50 g, 100 g, 150 g, 200 g. Moreover, the shape of the beverage container is not particularly limited when the beverage is packed in a container. The capacity of the container is not particularly limited, but is for example 30 ml to 200 ml (typically 50 ml, 100 ml, 150 ml, or 200 ml). 100 g, 150 g, 200 g).
本発明における飲料とは、経口摂取できる液体であれば特に制限はなく、医薬品、医薬部外品、又は食品(一般の食品だけでなく、栄養機能食品や特定保健用食品も含む)を挙げることができる。医薬品及び医薬部外品としては、例えば内服液剤、ドリンク剤等を挙げることができる。食品としては、清涼飲料水、炭酸飲料、スポーツ・機能性飲料、ノンアルコール飲料、乳飲料、茶飲料、コーヒー飲料、果実・野菜系飲料、ゼリー飲料等が挙げられる。より好ましくは、医薬品及び医薬部外品であれば内服液剤、ドリンク剤、食品であれば、栄養機能食品、特定保健用食品等の各種飲料、炭酸飲料、ゼリー飲料である。 The beverage in the present invention is not particularly limited as long as it is a liquid that can be taken orally, and includes pharmaceuticals, quasi-drugs, or foods (including not only general foods but also nutritional functional foods and foods for specified health uses). can be done. Examples of pharmaceuticals and quasi-drugs include internal liquids and drinks. Foods include soft drinks, carbonated drinks, sports/functional drinks, non-alcoholic drinks, milk drinks, tea drinks, coffee drinks, fruit/vegetable drinks, jelly drinks and the like. More preferably, medicines and quasi-drugs are oral liquid preparations and drink preparations, and foods are various beverages such as food with nutrient function claims and food for specified health use, carbonated beverages, and jelly beverages.
本発明の飲料のpHは、特に限定されないが、口当たりの良さという点から2.0~4.5が好ましく、2.5~4.0がより好ましい。pHを上記範囲に保つために、必要に応じて有機酸等のpH調整剤を配合することができる。 The pH of the beverage of the present invention is not particularly limited, but is preferably 2.0 to 4.5, more preferably 2.5 to 4.0, from the viewpoint of good taste. In order to maintain the pH within the above range, a pH adjuster such as an organic acid may be blended as necessary.
また、本発明の飲料のカロリーは、150kcal/100g以下が好ましく、より好ましくは0.5~100kcal/100g、さらにより好ましくは1~70kcal/100gである。 The calorie content of the beverage of the present invention is preferably 150 kcal/100 g or less, more preferably 0.5 to 100 kcal/100 g, still more preferably 1 to 70 kcal/100 g.
本発明の飲料は、常法により製造することができ、その方法は特に限定されるものではない。通常、各成分を量りとり、適量の精製水で溶解、撹拌した後、pHを調整し、さらに精製水を加えて容量調整し、必要に応じてろ過、殺菌処理を施すことにより得られる。 The beverage of the present invention can be produced by a conventional method, and the method is not particularly limited. Usually, each component is weighed, dissolved in an appropriate amount of purified water, stirred, then the pH is adjusted, purified water is added to adjust the volume, and if necessary, filtration and sterilization are performed.
また、本発明の飲料には、その他の成分として、ビタミン類、ミネラル類、アミノ酸及びその塩類、生薬、生薬抽出物、カフェイン、ローヤルゼリー、デキストリン等を本発明の効果を損なわない範囲で適宜に配合することができる。さらに必要に応じて、抗酸化剤、着色剤、香料、矯味剤、保存剤、甘味料、酸味剤等の添加物を本発明の効果を損なわない範囲で適宜に配合することができる。 In addition, the beverage of the present invention may contain other ingredients such as vitamins, minerals, amino acids and their salts, herbal medicines, herbal extracts, caffeine, royal jelly, dextrin, etc. as appropriate within a range that does not impair the effects of the present invention. can be compounded. Furthermore, if necessary, additives such as antioxidants, coloring agents, flavoring agents, corrigents, preservatives, sweeteners, acidulants and the like can be appropriately blended within limits that do not impair the effects of the present invention.
以下に、実施例、比較例を挙げ、本発明を更に詳細に説明する。 EXAMPLES The present invention will be described in more detail below with reference to examples and comparative examples.
(鉄味の評価)
下記表2~4に記載の処方を次の方法に従い調製した。まず、クエン酸、クエン酸鉄アンモニウムを精製水に溶解し、クエン酸溶液、鉄溶液を得た。グルコシルセラミド含有原料(米胚芽抽出物A、パイナップル果実抽出物、トウモロコシ抽出物、こんにゃく抽出物)を量り取り、クエン酸溶液、鉄溶液を添加し、安息香酸ナトリウムを添加し、十分に撹拌した。その後、全量近くまで精製水を加え、十分に撹拌した後、塩酸または水酸化ナトリウムを用いてpHを調整し、精製水を加えて重量調整して全量とし、飲料を得た。これらの飲料をスクリュー管No.7((株)マルエム製)に50mlずつ充填し、80℃25分の殺菌を行った。
米胚芽抽出物AはニップンセラミドRPS((株)ニップン製)、パイナップル果実抽出物はパインセラ乳化物(丸善製薬(株)製)、トウモロコシ抽出物はニップンセラミドCP((株)ニップン製)、こんにゃく抽出物はこんにゃくセラミド(乳化液タイプ)((株)ダイセル製)を用いた。
米胚芽抽出物Aは、米から抽出し粉末状態に加工した原料であり、スフィンゴ糖脂質の一種であるグルコシルセラミドの含有量を6.4%含む原料を使用した。パイナップル果実抽出物は、パイナップルから抽出し液状に加工し、スフィンゴ糖脂質の一種であるグルコシルセラミドを1.09%含む原料を使用した。トウモロコシ抽出物のグルコシルセラミドの含有量は3.3%、こんにゃく抽出物のグルコシルセラミドの含有量は0.43%であった。
以上の通り調製した飲料の室温保管品について、グルコシルセラミドを含まない処方(比較例1~6)をカップに注ぎ、口に含んだときに感じる鉄味について、VAS(Visual Analog Scale)法を用いて評価した。VAS法は、「基本味における味覚機能のスクリーニング検査法の構築(顎機能誌,J. Jpn. Soc. Stomattognath. Funct. 20:115-129, 2014)」および「簡易な嗅覚評価のための「日常のにおいアンケート」(日鼻誌48(1):1~7. 2009)」を参照した。すなわち、10cmの水平な直線の両端を短い縦線で閉じ、左端を「鉄味を感じない」、右端を「鉄味を非常に感じる」とし、鉄味の程度を線上に縦線で表記し、左端から縦線までの距離を測定し、VAS点数とした。評価は専門パネル4名により行い、平均値を示した。グルコシルセラミドを含む処方(実施例2~6)の評価は同量の鉄を含み、グルコシルセラミドを含まない処方(比較例2~6)をコントロールとし、表1の基準で鉄味を評価した。
(Evaluation of iron taste)
The formulations shown in Tables 2-4 below were prepared according to the following method. First, citric acid and ferric ammonium citrate were dissolved in purified water to obtain a citric acid solution and an iron solution. Glucosylceramide-containing raw materials (rice germ extract A, pineapple fruit extract, corn extract, konjac extract) were weighed, added with citric acid solution, iron solution, added with sodium benzoate, and stirred thoroughly. Thereafter, purified water was added to nearly the total amount, and after sufficiently stirring, the pH was adjusted using hydrochloric acid or sodium hydroxide, and purified water was added to adjust the weight to the total amount to obtain a beverage. These beverages were passed through screw tube no. 7 (manufactured by Maruem Co., Ltd.) was filled with 50 ml each and sterilized at 80° C. for 25 minutes.
Rice germ extract A is nippon ceramide RPS (manufactured by Nippn Co., Ltd.), pineapple fruit extract is pine cera emulsion (manufactured by Maruzen Pharmaceutical Co., Ltd.), corn extract is nippon ceramide CP (manufactured by Nippn Co., Ltd.), konnyaku Konjac ceramide (emulsion type) (manufactured by Daicel Corporation) was used as the extract.
Rice germ extract A is a raw material extracted from rice and processed into a powdered state, and used a raw material containing 6.4% of the content of glucosylceramide, which is a type of glycosphingolipid. The pineapple fruit extract was extracted from pineapple, processed into a liquid, and used as a raw material containing 1.09% of glucosylceramide, which is a type of glycosphingolipid. The glucosylceramide content of the maize extract was 3.3%, and the glucosylceramide content of the konjac extract was 0.43%.
For the beverages prepared as described above and stored at room temperature, the formulations not containing glucosylceramide (Comparative Examples 1 to 6) were poured into a cup, and the iron taste felt when held in the mouth was evaluated using the VAS (Visual Analog Scale) method. evaluated. The VAS method is "Construction of a screening test method for taste function in basic taste (Joint Function Journal, J. Jpn. Soc. Stomattognath. Funct. 20: 115-129, 2014)" and "For simple olfactory evaluation""Daily Odor Questionnaire" (Nichinoshi 48(1): 1-7. 2009)" was referred to. That is, both ends of a 10 cm horizontal straight line are closed with short vertical lines, the left end is indicated as “no iron taste”, the right end is indicated as “very iron taste”, and the degree of iron taste is indicated by vertical lines on the line. , the distance from the left end to the vertical line was measured and used as the VAS score. Evaluation was performed by 4 specialist panels, and the average value is shown. Formulations containing glucosylceramide (Examples 2 to 6) were evaluated for iron taste according to the criteria shown in Table 1, using the same amount of iron and formulations not containing glucosylceramide (Comparative Examples 2 to 6) as controls.
(分散性の評価)
下記表5~10に記載の処方を次の方法に従い調製した。まず、クエン酸、クエン酸鉄アンモニウムを精製水に溶解し、クエン酸溶液、鉄溶液を得た。グルコシルセラミド含有原料(米胚芽抽出物又はパイナップル果実抽出物、トウモロコシ抽出物、こんにゃく抽出物)を量り取り、クエン酸溶液、鉄溶液を添加し、安息香酸ナトリウムを添加し、十分に撹拌した。コラーゲンペプチドを配合する場合はグルコシルセラミド含有原料の後に添加した。その後、全量近くまで精製水を加え、十分に撹拌した後、塩酸または水酸化ナトリウムを用いてpHを調整し、精製水を加えて重量調整して全量とし、飲料を得た。これらの飲料をスクリュー管No.7((株)マルエム製)に50mlずつ充填し、80℃25分の殺菌を行った。
コラーゲンペプチドとしてはコラペプJB(豚由来、分子量約5000、新田ゼラチン(株)製)、ニッピペプタイドPRA-P(豚由来、分子量約4000~12000、(株)ニッピ製)、ニッピペプタイドFCP-EX(魚由来、分子量約4000、(株)ニッピ製)を用いた。米胚芽抽出物AはニップンセラミドRPS((株)ニップン製)、米胚芽抽出物Bは、ニップンセラミドRLG((株)ニップン製)、パイナップル果実抽出物はパインセラ粉末(丸善製薬(株)製)、トウモロコシ抽出物はニップンセラミドCP((株)ニップン製)、こんにゃく抽出物はこんにゃくセラミド(粉末タイプ)((株)ダイセル製)を用いた。
米胚芽抽出物Aは、米から抽出し粉末状態に加工した原料であり、スフィンゴ糖脂質の一種であるグルコシルセラミドの含有量を6.4%含む原料を使用した。米胚芽抽出物Bは、米から抽出し液状に加工した原料であり、スフィンゴ糖脂質の一種であるグルコシルセラミドの含有量を3.8%含む原料を使用した。パイナップル果実抽出物は、パイナップルから抽出し粉末状態に加工した原料であり、スフィンゴ糖脂質の一種であるグルコシルセラミドの含有量は4.5%であった。トウモロコシ抽出物のグルコシルセラミドの含有量は3.3%、こんにゃく抽出物のグルコシルセラミドの含有量は3.8%であった。
以上の通り調製した飲料の室温保管品について、表11に示す基準により、分散性を評価した。
(Evaluation of dispersibility)
The formulations shown in Tables 5-10 below were prepared according to the following method. First, citric acid and ferric ammonium citrate were dissolved in purified water to obtain a citric acid solution and an iron solution. Glucosylceramide-containing raw materials (rice germ extract or pineapple fruit extract, corn extract, konjac extract) were weighed, added with citric acid solution, iron solution, added with sodium benzoate, and stirred thoroughly. When collagen peptide was added, it was added after the glucosylceramide-containing material. Thereafter, purified water was added to nearly the total amount, and after sufficiently stirring, the pH was adjusted using hydrochloric acid or sodium hydroxide, and purified water was added to adjust the weight to the total amount to obtain a beverage. These beverages were passed through screw tube no. 7 (manufactured by Maruem Co., Ltd.) was filled with 50 ml each and sterilized at 80° C. for 25 minutes.
Collagen peptides include Corapep JB (derived from pigs, molecular weight about 5000, manufactured by Nitta Gelatin Co., Ltd.), Nippi Peptide PRA-P (derived from pigs, molecular weight about 4000 to 12000, manufactured by Nippi Co., Ltd.), and Nippi Peptide FCP-EX. (derived from fish, molecular weight of about 4000, manufactured by Nippi Co., Ltd.) was used. Rice germ extract A is nippon ceramide RPS (manufactured by Nippn Co., Ltd.), rice germ extract B is nippon ceramide RLG (manufactured by Nippn Co., Ltd.), and pineapple fruit extract is pine sera powder (manufactured by Maruzen Pharmaceutical Co., Ltd.). , Nippun Ceramide CP (manufactured by Nippn Co., Ltd.) was used as the corn extract, and Konnyaku Ceramide (powder type) (manufactured by Daicel Co., Ltd.) was used as the konjac extract.
Rice germ extract A is a raw material extracted from rice and processed into a powdered state, and used a raw material containing 6.4% of the content of glucosylceramide, which is a type of glycosphingolipid. Rice germ extract B was a raw material extracted from rice and processed into a liquid, and used a raw material containing 3.8% of the content of glucosylceramide, which is a type of glycosphingolipid. The pineapple fruit extract was a raw material extracted from pineapple and processed into powder, and contained 4.5% of glucosylceramide, which is a type of glycosphingolipid. The glucosylceramide content of the maize extract was 3.3%, and the glucosylceramide content of the konjac extract was 3.8%.
The dispersibility was evaluated according to the criteria shown in Table 11 for the beverage prepared as described above and stored at room temperature.
表5に示す通り、グルコシルセラミドを0.0006w/w%配合した飲料について、鉄化合物を鉄換算で0.002w/w%配合した飲料(比較例7-1)と比較して、鉄化合物を鉄換算で0.01w/w%配合した飲料(実施例7-1)では、分散性が向上し、鉄化合物による分散性向上効果が見られた。また、鉄化合物を鉄換算で0.002w/w%配合した飲料(比較例7-1)と比較して、さらにコラーゲンペプチドを4.0w/w%配合した飲料(比較例7-2)では分散性に顕著な影響は認められなかった。すなわち、鉄の濃度が低い範囲においてはコラーゲンペプチドによる分散性向上効果は認められなかった。
一方、鉄化合物を鉄換算で0.01w/w%配合し、コラーゲンペプチドを4.0w/w%配合した飲料(実施例7-2)では、顕著な分散性向上効果が確認された。
なお、比較例7-1のグルコシルセラミドの含有量は、飲料50g中に0.3mg含まれるので、0.0006w/w%であり、鉄化合物の含有量は、鉄換算で1mg含まれるので0.002w/w%である。
As shown in Table 5, the beverage containing 0.0006 w/w% of glucosylceramide was compared with the beverage containing 0.002 w/w% iron compound in terms of iron (Comparative Example 7-1). In the beverage containing 0.01 w/w% in terms of iron (Example 7-1), the dispersibility was improved, and the dispersibility improvement effect of the iron compound was observed. In addition, compared with the beverage containing 0.002 w/w% iron compound in terms of iron (Comparative Example 7-1), the beverage containing 4.0 w/w% collagen peptide (Comparative Example 7-2) No significant effect on dispersibility was observed. In other words, in the range where the iron concentration was low, the effect of improving the dispersibility by the collagen peptide was not observed.
On the other hand, in the beverage containing 0.01 w/w% iron compound and 4.0 w/w% collagen peptide in terms of iron (Example 7-2), a remarkable effect of improving dispersibility was confirmed.
In addition, the content of glucosylceramide in Comparative Example 7-1 is 0.0006 w/w% because it is contained in 50 g of the beverage at 0.3 mg. .002 w/w%.
表6に示す通り、グルコシルセラミド0.0026w/w%配合した飲料について、鉄化合物を鉄換算で0.006~0.04w/w%配合した飲料(比較例8~10)に対し、コラーゲンペプチドを0.2~15w/w%配合した飲料(実施例8~10)では、顕著な分散性向上効果が確認された。コラーゲンの種類を変更しても分散性向上効果は同様であった。
また、実施例9-1~9-3に示す通り、コラーゲンペプチドの配合量依存的に、分散性向上効果が高まることが確認された。
As shown in Table 6, for beverages containing 0.0026 w / w% glucosylceramide, collagen peptide 0.2 to 15 w / w% blended beverages (Examples 8 to 10) were confirmed to have a remarkable dispersibility improving effect. Even if the type of collagen was changed, the effect of improving the dispersibility was the same.
In addition, as shown in Examples 9-1 to 9-3, it was confirmed that the effect of improving dispersibility increased depending on the blending amount of collagen peptide.
表7に示す通り、比較例11に対してさらにコラーゲンペプチドを配合した飲料では顕著な分散性向上効果が得られた(実施例11)。 As shown in Table 7, the beverage containing collagen peptide in addition to Comparative Example 11 exhibited a remarkable effect of improving dispersibility (Example 11).
また、比較例12-1に対してコラーゲンペプチドを2w/w%配合した飲料では、分散性向上効果が得られなかった(比較例12-2)が、さらにコラーゲンペプチドを10w/w%配合した飲料では顕著な分散性向上効果が得られた(実施例12)。
よって、グルコシルセラミドの含有量を0.0052w/w%以下とする、もしくは、グルコシルセラミド1質量部に対するコラーゲンペプチドの含有量の比を調整することで、顕著な分散性向上効果を得ることができると示された。
In addition, in the beverage containing 2 w/w% collagen peptide as compared to Comparative Example 12-1, the effect of improving dispersibility was not obtained (Comparative Example 12-2), but 10 w/w% collagen peptide was further mixed. A remarkable effect of improving dispersibility was obtained in beverages (Example 12).
Therefore, by adjusting the content of glucosylceramide to 0.0052 w/w% or less, or by adjusting the ratio of the content of collagen peptide to 1 part by mass of glucosylceramide, a remarkable effect of improving dispersibility can be obtained. was shown.
表8に示す通り、pH4.0の場合においても、顕著な分散性向上効果が確認された(実施例13)。 As shown in Table 8, a remarkable effect of improving dispersibility was confirmed even at pH 4.0 (Example 13).
表9に示す通り、米胚芽抽出物B由来のグルコシルセラミドに対しても分散性向上効果が確認された(実施例14)。また、パイナップル果実抽出物由来、トウモロコシ抽出物由来、こんにゃく抽出物由来のグルコシルセラミドを用いた場合でも、分散性向上効果が確認された(実施例15、16、17)。 As shown in Table 9, an effect of improving dispersibility was also confirmed for glucosylceramide derived from rice germ extract B (Example 14). Further, even when glucosylceramide derived from pineapple fruit extract, corn extract, and konjac extract was used, an effect of improving dispersibility was confirmed (Examples 15, 16, 17).
本発明により、鉄化合物を鉄換算で0.006w/w%以上配合時において、スフィンゴ糖脂質の含有量、又は、スフィンゴ糖脂質とコラーゲンペプチドの含有量の比を調整することにより、スフィンゴ糖脂質由来の沈殿物の分散性の向上が可能となった。
また、鉄化合物を鉄換算で0.006w/w%以上配合時において、鉄由来の不快味(鉄味)をスフィンゴ糖脂質の配合により低減できた。よって、医薬品、医薬部外品及び食品の分野において、商品価値の高い飲料を提供することが期待される。
According to the present invention, by adjusting the content of glycosphingolipid or the ratio of the content of glycosphingolipid and collagen peptide when adding an iron compound of 0.006 w / w% or more in terms of iron, glycosphingolipid It became possible to improve the dispersibility of the precipitates derived from.
Moreover, when the iron compound was blended at 0.006 w/w% or more in terms of iron, the unpleasant taste (iron taste) derived from iron could be reduced by blending the glycosphingolipid. Therefore, it is expected to provide beverages with high commercial value in the fields of pharmaceuticals, quasi-drugs and foods.
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