JP2022130637A5 - - Google Patents
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- Publication number
- JP2022130637A5 JP2022130637A5 JP2022105784A JP2022105784A JP2022130637A5 JP 2022130637 A5 JP2022130637 A5 JP 2022130637A5 JP 2022105784 A JP2022105784 A JP 2022105784A JP 2022105784 A JP2022105784 A JP 2022105784A JP 2022130637 A5 JP2022130637 A5 JP 2022130637A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- immunogenic
- nomv
- immunogenic conjugate
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 229920001282 polysaccharide Polymers 0.000 claims 8
- 239000005017 polysaccharide Substances 0.000 claims 8
- 150000004676 glycans Chemical class 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 4
- 241000607768 Shigella Species 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 241000607142 Salmonella Species 0.000 claims 3
- 241000194017 Streptococcus Species 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- -1 33F polysaccharides Chemical class 0.000 claims 1
- 101100451792 Bacillus subtilis (strain 168) htrB gene Proteins 0.000 claims 1
- 101710186862 Factor H binding protein Proteins 0.000 claims 1
- 241000224016 Plasmodium Species 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 101000983333 Plasmodium falciparum (isolate NF54) 25 kDa ookinete surface antigen Proteins 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 101100021843 Shigella flexneri lpxM1 gene Proteins 0.000 claims 1
- 101100021844 Shigella flexneri lpxM2 gene Proteins 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 230000037006 agalactosis Effects 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 101150011311 lpxL gene Proteins 0.000 claims 1
- 101150060640 lpxM gene Proteins 0.000 claims 1
- 101150052479 lpxP gene Proteins 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims 1
- 235000010265 sodium sulphite Nutrition 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1619946.5A GB201619946D0 (en) | 2016-11-25 | 2016-11-25 | Conjugated immunogenic derivatives and use thereof |
| GB1619946.5 | 2016-11-25 | ||
| GB1712096.5 | 2017-07-27 | ||
| GBGB1712096.5A GB201712096D0 (en) | 2017-07-27 | 2017-07-27 | Immunogenic conjugates and use thereof |
| JP2019527901A JP7100031B2 (ja) | 2016-11-25 | 2017-11-23 | 免疫原性コンジュゲート及びその使用 |
| PCT/EP2017/080145 WO2018096007A2 (en) | 2016-11-25 | 2017-11-23 | Immunogenic conjugates and use thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527901A Division JP7100031B2 (ja) | 2016-11-25 | 2017-11-23 | 免疫原性コンジュゲート及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022130637A JP2022130637A (ja) | 2022-09-06 |
| JP2022130637A5 true JP2022130637A5 (enExample) | 2022-09-30 |
| JP7439174B2 JP7439174B2 (ja) | 2024-02-27 |
Family
ID=60702606
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527901A Active JP7100031B2 (ja) | 2016-11-25 | 2017-11-23 | 免疫原性コンジュゲート及びその使用 |
| JP2022105784A Active JP7439174B2 (ja) | 2016-11-25 | 2022-06-30 | 免疫原性コンジュゲート及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527901A Active JP7100031B2 (ja) | 2016-11-25 | 2017-11-23 | 免疫原性コンジュゲート及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12036285B2 (enExample) |
| EP (1) | EP3544625A2 (enExample) |
| JP (2) | JP7100031B2 (enExample) |
| CN (1) | CN110214022A (enExample) |
| BE (1) | BE1025210B1 (enExample) |
| BR (1) | BR112019010227A2 (enExample) |
| CA (1) | CA3044569A1 (enExample) |
| MX (1) | MX2019006104A (enExample) |
| WO (1) | WO2018096007A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3544625A2 (en) | 2016-11-25 | 2019-10-02 | GlaxoSmithKline Biologicals S.A. | Immunogenic conjugates and use thereof |
| MX2019006105A (es) * | 2016-11-25 | 2019-08-21 | Glaxosmithkline Biologicals Sa | Conjugados de vmen-antigeno y uso de los mismos. |
| GB201712824D0 (en) | 2017-08-10 | 2017-09-27 | Glaxosmithkline Biologicals Sa | Multi-functionalized nOMV Conjugates |
| CN111358942A (zh) * | 2018-12-25 | 2020-07-03 | 国家纳米科学中心 | 一种疫苗及其制备方法 |
| JP7462864B2 (ja) * | 2019-04-19 | 2024-04-08 | 国立感染症研究所長 | メンブレンヴェシクル |
| US20220378902A1 (en) * | 2019-08-22 | 2022-12-01 | Sichuan University | Bacterial membrane vesicles, and separation and preparation system and method therefor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271147A (en) | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| NZ214503A (en) | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| US4707543A (en) | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| EP0467714A1 (en) | 1990-07-19 | 1992-01-22 | Merck & Co. Inc. | The class II protein of the outer membrane of neisseria meningitidis |
| CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
| EP1228217B1 (en) | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
| IL150822A0 (en) | 2000-01-25 | 2003-02-12 | Univ Queensland | PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| WO2006124712A2 (en) | 2005-05-16 | 2006-11-23 | Merck & Co., Inc. | A method for improving the immunogenicity of plasmodium antigens |
| GB2441094B (en) | 2005-05-19 | 2010-11-03 | Edward Jenner Inst For Vaccine | Methods for treatment and prevention of infection |
| CA2840096C (en) * | 2011-07-07 | 2021-07-06 | Bas VAN DE WATERBEEMD | A process for detergent-free production of outer membrane vesicles of a gram-negative bacterium |
| AU2013265336A1 (en) | 2012-05-22 | 2014-12-04 | Novartis Ag | Meningococcus serogroup X conjugate |
| EP2870974A1 (en) * | 2013-11-08 | 2015-05-13 | Novartis AG | Salmonella conjugate vaccines |
| AU2015352404A1 (en) * | 2014-11-28 | 2017-05-18 | Janssen Vaccines & Prevention B.V. | Meningitis B vaccine |
| US11066453B2 (en) * | 2015-05-18 | 2021-07-20 | Biomvis Srl | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| US10248164B2 (en) | 2016-07-11 | 2019-04-02 | Boe Technology Group Co., Ltd. | Chip on film, flexible display apparatus having the same, and fabricating method thereof |
| EP3544625A2 (en) | 2016-11-25 | 2019-10-02 | GlaxoSmithKline Biologicals S.A. | Immunogenic conjugates and use thereof |
| MX2019006105A (es) | 2016-11-25 | 2019-08-21 | Glaxosmithkline Biologicals Sa | Conjugados de vmen-antigeno y uso de los mismos. |
-
2017
- 2017-11-23 EP EP17816487.7A patent/EP3544625A2/en active Pending
- 2017-11-23 JP JP2019527901A patent/JP7100031B2/ja active Active
- 2017-11-23 WO PCT/EP2017/080145 patent/WO2018096007A2/en not_active Ceased
- 2017-11-23 MX MX2019006104A patent/MX2019006104A/es unknown
- 2017-11-23 BE BE2017/5855A patent/BE1025210B1/fr active IP Right Grant
- 2017-11-23 BR BR112019010227A patent/BR112019010227A2/pt unknown
- 2017-11-23 US US16/462,624 patent/US12036285B2/en active Active
- 2017-11-23 CN CN201780084552.7A patent/CN110214022A/zh active Pending
- 2017-11-23 CA CA3044569A patent/CA3044569A1/en active Pending
-
2022
- 2022-06-30 JP JP2022105784A patent/JP7439174B2/ja active Active
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