JP2022083961A - Oral solid composition - Google Patents

Abstract

To suppress changes in properties and/or smells over time, which occur during preservation of extract powder, which is powdered plant extract.SOLUTION: An oral solid composition contains (A) at least one plant extract selected from the group consisting of Cynara scolymus leaf extract powder, Carthamus tinctorius extract powder, Houttuynia cordata extract powder, Actinidia Chinensis extract powder, Hypericum perforatum extract powder, Rosa canina extract powder, Prunus persica Batsch extract powder, Angelica sinensis extract powder, Fragaria ananassa seed extract powder, Melissa officinalis extract powder, Artemisia Princeps=Artemisia indica Willd. var. maximowiczii (Nakai) H.Hara extract powder and Rosmarinus Officinalis extract powder, and (B) an iron compound.SELECTED DRAWING: None

Description

The present invention can be used in the fields of pharmaceuticals, quasi-drugs, foods and the like.

Plant extracts are used in foods, quasi-drugs, pharmaceuticals, etc., and are used in beverages and supplements, or as crude drug extracts, regardless of their dosage form, such as liquids and solids. When an extract derived from a natural material such as a plant extract is provided as a powdered extract powder, its properties and flavor change during storage depending on the temperature and humidity conditions, and its commercial value and administration as an oral solid composition are taken. There is a risk of impairing the properties and a difficulty in manufacturability for processing.

Although iron is an essential metal for living organisms, it has been reported that it tends to be deficient in intake standards, especially in women. According to the Japanese Dietary Intake Standards (2020 Edition), the recommended amount of iron for women is 10.5 mg, but according to the 2018 National Health and Nutrition Survey, the intake of iron for women is 7.5 mg, which is 3 mg per day. There is a shortage of iron (Non-Patent Document 1). Beverages and supplements containing iron compounds are used as an efficient method of ingestion in dietary habits, and Patent Document 1 describes an oral iron supplement solid composition.

In recent years, beverages and supplements containing collagen peptide have become more popular. Collagen is a major protein constituting the dermis, ligaments, tendons, bones, cartilage and the like (Non-Patent Document 2). Collagen peptide is obtained by a method such as hydrolyzing collagen obtained from animals or fish.

Patent Document 2 describes foods and drinks for improving coldness, which are a mixture of various plant extracts including safflower extract and iron, in claim 4 and paragraph [0034], but the plant extract and iron are chicken. It is only an ingredient described in parallel with beef and the like, and is not actually manufactured.

JP 2017-093397 Japanese Patent Application Laid-Open No. 2003-040788

Food and Development VOL. 55 No. 6 P. 41 Hiroki Ohara et al., Journal of Japanese Food and Chemical Engineering, VOL. 56 No. 3 P. 137-145 (2009)

An object of the present invention is to suppress changes in properties and / or odors over time that occur during storage of powdered extract powder of a plant extract.

As a result of diligent studies to solve this problem, it was found that the change with time of the solid composition containing the plant extract can be suppressed by blending the iron compound, and the present invention has been completed. The aspects of the present invention obtained from such findings are as follows.
(1) (A) Artichoke leaf extract powder, Benibana extract powder, Dokudami extract powder, Kiwi extract powder, Seiyootogirisou extract powder, Rosehip extract powder, White peach blossom extract powder, Touki extract powder, Strawberry seed extract powder, Lemon balm extract powder , At least one plant extract selected from the group consisting of yomogi extract powder and rosemary extract powder, and (B) an oral solid composition comprising an iron compound.
(2) The oral solid composition according to (1), which contains (C) collagen peptide.
(3) The oral solid composition according to (1) or (2), wherein the content of the iron compound is 0.04 part by mass or more with respect to 1 part by mass of (A) plant extract in terms of iron.
(4) The iron compound is ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, sodium iron citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, The oral solid composition according to any one of (1) to (3), which is at least one selected from the group consisting of ferric pyrophosphate and ferrous sulfate.
(5) The oral solid composition according to any one of (2) to (4), wherein the collagen peptide has an average molecular weight of 500 to 50,000.
Is.

INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to provide an oral solid composition in which changes in properties and / or odor are suppressed in a solid containing a plant extract.

In the present invention, the "plant extract powder" is an extract powder obtained by solvent-extracting and powdering a specific plant according to the present invention. Unless otherwise specified, each part or the whole of the flower, leaf, stem, rhizome, root, etc. of the plant can be used as the extraction part of the plant, and the extraction solvent is water, lower alcohol such as ethanol, 1 , 3-Butylene glycol, polyhydric alcohol such as propylene glycol, or a mixed solvent containing two or more of these can be used. Commercially available products may be used as the plant extract. The solvent-extracted plant extract is subjected to heat treatment, freeze-drying or vacuum-drying, powdering with an excipient such as dextrin, and the like to obtain dried extract powder, extract powder, and the like.

Artichoke leaf extract is an extract obtained from the leaves of artichoke (scientific name: Cynara scolymus English name: Artichoke Japanese name: Cynara), which is a plant of the Asteraceae family. Commercially available products may be used as the extract powder, and examples thereof include "Biobenefity F (Artichoke leaf extract)" (Ichimaru Falcos Co., Ltd.) and "Artichoke (leaf) extract powder" (Koshin Bussan Co., Ltd.). Will be.

The safflower extract is an extract of annual or perennial flowers of the genus Carthamus in the family Asteraceae. As the extract powder, a commercially available product may be used, and examples thereof include "safflower extract powder" (Nippon Powder Pharmaceutical Co., Ltd.) and "safflower extract D" (Matsuura Pharmaceutical Co., Ltd.).

Houttuynia extract is an extract of a perennial plant belonging to the genus Houttuynia in the family Houttuynia. As the extract powder, a commercially available product may be used, and examples thereof include "Houttuynia cordata extract powder MF" (Maruzen Pharmaceuticals Co., Ltd.) and "Houttuynia cordata DXP100 (100% extract powder)" (Ichimaru Falcos Co., Ltd.).

Kiwi extract is an extract obtained from the fruit of Kiwifruit (scientific name: Actinidia Chinensis English name: Chinese gooseberry), which is a plant of the Actinidiaceae family. As the extract powder, a commercially available product may be used, and examples thereof include "kiwifruit juice powder" (NOF Corporation) and "Falcolex Kiwi" (Ichimaru Falcos Co., Ltd.).

The St. John's wort extract is an extract of the perforate St. John's wort (scientific name: Hypericum perforatum, English name: St. John's wort), which is a perforate plant belonging to the genus Hypericum of the family St. John's wort, and contains a hypericum derivative and hyperforin. As the extract powder, a commercially available product may be used, and examples thereof include "Dried St. John's Wort Extract" (Indena Japan Co., Ltd.) and "St. John's Wort" (Joban Phytochemical Research Institute Co., Ltd.).

Rose hip extract is an extract derived from the fruit of the Rosaceae plant Canina rose (scientific name: Rosa canina English name: Rose hip). As the extract powder, a commercially available product may be used, and examples thereof include "Rosehip Extract Powder-N (Nippon Powder Chemicals)".

White peach blossom extract is an extract derived from the flowers of Rosaceae peach (scientific name: Prunus persica Batsch). As the extract powder, a commercially available product may be used, and examples thereof include "Shiratohana Extract Powder-N (Nippon Powder Chemicals)".

Angelica acutiloba extract is an extract derived from the roots of the Umbelliferae plant Angelica acutiloba (scientific name: Angelica acutiloba English name: Japanese angelica). As the extract powder, a commercially available product may be used, and examples thereof include "Angelica acutiloba extract S (Koshiro Pharmaceutical Co., Ltd.)".

The strawberry seed extract is an extract derived from the seeds of strawberry (scientific name: Fragaria × ananassa) of the Rosaceae family. As the extract powder, a commercially available product may be used, and examples thereof include "strawberry seed extract-P (oriza oiling)".

Lemon balm extract is an extract derived from the leaves of lemon balm (also known as Melissa officinalis) of the Labiatae family Melissa officinalis. As the extract powder, a commercially available product may be used, and examples thereof include "lemon balm extract powder MF" (Nippon Powder Chemicals) and "Falcolex Melissa B (Ichimaru Falcos)".

Mugwort extract is an extract derived from the leaves of the Asteraceae plant Mugwort (scientific name: Artemisia Princeps = Artemisia indica Willd. Var. Maximowiczii (Nakai) H. Hara English name: mugwort). As the extract powder, a commercially available product may be used, and examples thereof include "Yomogi dried extract F (Maruzen Pharmaceuticals)".

Rosemary extract is an extract derived from the leaves of the Labiatae plant rosemary (scientific name: Rosmarinus Officinalis). As the extract powder, a commercially available product may be used, and examples thereof include "rosemary extract (Bioactives Japan)".

(A) The content of the plant extract according to the present invention (when a plurality of plant extracts according to the present invention are contained, the total amount thereof; the same applies hereinafter) is 0.01 to 50 wt% in the oral solid composition of the present invention. It is preferably 0.02 to 30 wt%, more preferably 0.03 to 20 wt%, and even more preferably 0.03 to 20 wt%.

In the present invention, the "iron compound" may be either a divalent iron compound or a trivalent iron compound, for example, ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, citrate. Examples thereof include sodium iron, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, and ferrous sulfate, preferably ferric pyrophosphate or ammonium iron citrate.

(B) The content of the iron compound (when a plurality of iron compounds are contained, the total amount thereof; the same applies hereinafter) is preferably 0.01 to 50 wt% in the oral solid composition in terms of iron, preferably 0.05. It is more preferably from 30 wt%, further preferably 0.05 to 10 wt%, and particularly preferably 0.05 to 5 wt%.
The content of the iron compound (B) is preferably 0.04 parts by mass or more, more preferably 0.09 parts by mass or more, and 0.4 parts by mass or more with respect to 1 part by mass of the plant extract in terms of iron. More preferred.
Further, the content of the iron compound (B) is preferably 0.01 part by mass or more, and more preferably 0.02 part by mass or more with respect to 1 part by mass of collagen peptide in terms of iron.

In the present invention, the origin of the "collagen peptide" is not particularly limited and may be synthetic, and the skin, bone, ligament, tendon, and cartilage produced as a by-product when processing livestock such as cows and pigs and fish It may be a collagen peptide produced by extracting from the above, but a collagen peptide derived from pig is preferable. A collagen peptide obtained by decomposing collagen protein by enzyme, chemical treatment or the like is preferable. The weight average molecular weight of the collagen peptide is not particularly limited, but is preferably 500 to 50,000, more preferably 700 to 25,000, further preferably 800 to 15,000, and particularly preferably 1,000 to 10,000.

As the collagen peptide of the present invention, a commercially available product may be used, for example, "Nippi Peptide PS-1" (Nippi Co., Ltd.), "Nippi Peptide PRA-P" (Nippi Co., Ltd.), "Nippi Peptide FCP-EX" (Nippi Peptide FCP-EX). Nippi Co., Ltd.), "HACP-CF" (manufactured by Zerice), "HACP-TF" (Zerais Co., Ltd.), "Korapep PU" (Nitta Gelatin Co., Ltd.), "Korapep JB" (Nitta Gelatin Co., Ltd.), Examples thereof include "HDL-50SP" (Nitta Gelatin Co., Ltd.), "SCP-3100" (Nitta Gelatin Co., Ltd.), "peptan P2000HD" (Rusuro Co., Ltd.) and the like.

The content of the collagen peptide (C) is preferably 1 to 95 wt%, more preferably 1.5 to 90 wt%, still more preferably 2 to 85 wt%, and 3 to 80 wt% in the oral solid composition of the present invention. Is particularly preferable.

The oral solid composition in the present invention is not particularly limited as long as it is a solid that can be orally ingested. Also included).

Examples of the form of the oral solid composition in the present invention include tablets such as chewable tablets, capsules, granules, fine granules, powders, etc., which are particularly effective for the problem of solidification over time. Capsules, granules, fine granules, and powders are preferable, and granules, fine granules, and powders are more preferable.

The oral solid composition of the present invention can be produced by a conventional method, and the method is not particularly limited. Usually, each component is weighed and obtained by a process such as mixing, granulation, and tablet making. As the granulation method, a commonly used method can be used without particular limitation, and examples thereof include a wet granulation method and a dry granulation method. Examples of the wet granulation method include a fluidized bed granulation method, a stirring granulation method, a kneading granulation method, an extrusion granulation method, a rolling granulation method, and a melt solvent method, and examples of the dry granulation method include a melt granulation method. Examples thereof include a direct tableting method, a slag method in which a slag tablet is produced by tableting, and granules are obtained by crushing the slag tablet, and a roller compactor method. Examples of the granulation solvent include alcohols such as water and ethanol or mixed solvents thereof, and the granulation solvents are appropriately viscous raw materials such as dextrin, indigestible dextrin, guar gum, starch and thickening polysaccharides. May be added. As the method for drying the granulated product, the usual method can be used without particular limitation. Locking refers to a granular tablet made by compression molding powder or granulated material. If you are concerned about the powder or odor adhering to the surface, you can also apply a surface coating or sugar coating. Each component may be mixed and then tableted, or granulated and then tableted. In the case of tablets, the operation of tableting is indispensable.

Further, in the oral solid composition of the present invention, as other components, vitamins, minerals, amino acids, sugars, sugar alcohols, starches, celluloses and the like are appropriately added as long as the effects of the present invention are not impaired. Can be blended. Further, if necessary, additives such as colorants, flavors, flavoring agents, preservatives, sweeteners, and acidulants can be appropriately blended as long as the effects of the present invention are not impaired. The oral solid composition of the present invention can be taken as it is without being dissolved in a beverage such as water or hot water when eating.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples and the like.

(Comparative Examples 1 to 10, Examples 1 to 10)
Each component was weighed and mixed according to the formulation shown in Table 1 below to obtain an oral solid composition. As a comparative example, an oral solid composition to which ferric pyrophosphate was not added was used. These oral solid compositions were filled in glass bottles and sealed.
The oral solid composition filled in a glass bottle and sealed was stored at 5 ° C. or 65 ° C. for 7 days, the properties (powder state) were observed and evaluated, and the odor was evaluated by a sensory test.
Based on the criteria in Table 2, the degree of change in the 65 ° C storage product with respect to the 5 ° C storage product was evaluated. The properties were evaluated by observing the degree of change from the powder state to, for example, solidification, agglomeration, stickiness, exudation, and the like. Both properties and odors were evaluated by three specialized panelists, and the degree of change agreed upon was described.
Artichoke leaf extract is bio-benefity (Ichimaru Falcos), Benibana extract is Benibana extract (Japanese powder), Dokudami extract is Dokudami extract powder (Japanese powder), Kiwi extract is Kiwi fruit juice powder (Nichiyu), and St. John's wort extract is Seiyo. Dried St. John's wort extract (Indena Japan) was used.
Nippi and Nippi Peptide PRA-P were used as collagen peptides.

As shown in Table 1, changes occurred in the plant extract alone or in the combination of the plant extract and the collagen peptide as compared with the product stored at 5 ° C. (Comparative Examples 1 to 10). On the other hand, by blending ferric pyrophosphate, changes to the product stored at 5 ° C are suppressed (Examples 1 to 10), and the product stored at 65 ° C is compared with the same plant extract alone or a combination example of the plant extract and collagen peptide. (For example, Example 1 suppressed the change in the 65 ° C. storage product with respect to Comparative Example 1 or Example 6 with respect to Comparative Example 6). Even when the change over time was large due to the inclusion of collagen peptide, the effect of ferric pyrophosphate compounding was equivalent to that without collagen peptide.

(Comparative Examples 11 to 28, Examples 11 to 28)
Each component was weighed and mixed according to the formulations shown in Tables 3 and 4 below to obtain an oral solid composition. As a comparative example, an oral solid composition to which ferric pyrophosphate or ammonium ferric citrate was not added was used. These oral solid compositions were filled in glass bottles and sealed.
The oral solid composition filled in a glass bottle and sealed was stored at 5 ° C. or 65 ° C. for 7 days, the properties (powder state) were observed and evaluated, and the odor was evaluated by a sensory test.
Based on the criteria in Table 2, the degree of change in the 65 ° C storage product with respect to the 5 ° C storage product was evaluated. The properties were evaluated by observing the degree of change from the powder state to, for example, solidification, agglomeration, stickiness, exudation, and the like. Both properties and odors were evaluated by one specialized panelist.
Rosehip extract is Rosehip extract powder-N (Nippon powder chemicals), White peach blossom extract is White peach blossom extract powder-N (Nippon powder chemicals), Touki extract is Touki extract S (Koshiro Pharmaceutical), and Strawberry seed extract is strawberry seed extract. -P (Oryza oil conversion), lemon balm extract used lemon balm extract powder MF (Nippon Powder Chemicals), yomogi extract used yomogi dried extract F (Maruzen Pharmaceutical Co., Ltd.), and rosemary extract rosemary extract (Bioactives Japan). For safflower extract and Houttuynia cordata extract, the same raw materials as in Table 1 were used.
Ferric pyrophosphate has an iron content of 29.98%, and ammonium ferric citrate has an iron content of 17.8%.

As shown in Tables 3 and 4, changes occurred in the plant extract alone or in the combination of the plant extract and the collagen peptide as compared with the products stored at 5 ° C. (Comparative Examples 11 to 23). On the other hand, by blending ferric pyrophosphate or ammonium ferric citrate, the change with respect to the product stored at 5 ° C. was suppressed (Examples 11 to 28), and the same plant extract alone or the compounding example of the plant extract and the collagen peptide was compared. , The change in the 65 ° C. storage product was suppressed (for example, the change in the 65 ° C. storage product was suppressed in Example 11 with respect to Comparative Example 11 or in Example 18 with respect to Comparative Example 18). When lactose hydrate was added to the plant extract alone or the combination of the plant extract and the collagen peptide, almost no effect of suppressing the change was observed in the product stored at 65 ° C. (Comparative Examples 24-28).

A solid composition such as a powder mixed with the formulations shown in Table 5 or an appropriately granulated granule can be produced.

INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to suppress changes in properties and odors during storage in an oral solid composition containing a plant extract in the oral solid composition. Therefore, in the fields of pharmaceuticals, quasi-drugs and foods, it is expected to provide an oral solid composition containing a plant extract, which is excellent in commerciality and ingestibility, and also in excellent manufacturability for processing.

Claims (5)

(A) Artichoke leaf extract powder, Benibana extract powder, Dokudami extract powder, Kiwi extract powder, Seiyootogirisou extract powder, Rosehip extract powder, White peach blossom extract powder, Touki extract powder, Strawberry seed extract powder, Lemon balm extract powder, Yomogi extract An oral solid composition comprising at least one plant extract selected from the group consisting of powder and rosemary extract powder, and (B) an iron compound. (C) The oral solid composition according to claim 1, which contains a collagen peptide. The oral solid composition according to claim 1 or 2, wherein the content of the (B) iron compound is 0.04 parts by mass or more with respect to 1 part by mass of the (A) plant extract in terms of iron. (B) The iron compound is ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, sodium iron citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferrous pyrophosphate. The oral solid composition according to any one of claims 1 to 3, which is at least one selected from the group consisting of ferrous iron and ferrous sulfate. (C) The oral solid composition according to any one of claims 2 to 4, wherein the collagen peptide has an average molecular weight of 500 to 50,000.