JP2022075478A - Analysis system and analysis method - Google Patents

Abstract

To provide an analysis system and an analysis method with improved usability.SOLUTION: An analysis system is used with a sample supply unit 170 for supplying a sample, a detector for detecting the sample, and a display unit, and includes: a plurality of channel units 10 arranged in parallel; and a display control unit for causing the display unit to display a control screen regarding control of the plurality of channel units 10. Each channel unit 10 includes a mobile phase supply unit 50 for supplying a mobile phase, and an analysis column 40 for separating a sample supplied from the sample supply unit 170 for each component to guide it to the detector.SELECTED DRAWING: Figure 3

Description

The present invention relates to an analysis system and an analysis method.

A chromatograph is known as an analyzer that separates and measures substances contained in a sample for each of different components. For example, in a liquid chromatograph, the sample to be measured is introduced into the analysis column together with the mobile phase of the liquid. The sample eluted from the analysis column is separated by component due to the difference in chemical properties or composition, and is detected by the detector. Patent Document 1 describes a liquid chromatograph including six measurement blocks. Each measurement block includes an analysis column and the like. By selectively using the six measurement blocks, the sample is measured under a plurality of conditions.

Japanese Unexamined Patent Publication No. 2018-169350

According to the liquid chromatograph described in Patent Document 1, the time required for a series of measurements can be shortened and the throughput can be improved. However, the operation of the liquid chromatograph of Patent Document 1 is complicated as compared with the operation of the liquid chromatograph when the measurement block is single, so that the analysis conditions or various settings of the apparatus are complicated. In addition, when an abnormality occurs in the device, the cause may not be immediately confirmed, which is a burden on the user when performing analysis.

Therefore, an object of the present invention is to provide an analysis system and an analysis method with improved usability.

One aspect of the present invention is an analysis system used together with a sample supply unit for supplying a sample, a detector for detecting a sample, and a display unit, and is supplied by a plurality of channels arranged in parallel and the sample supply unit. A flow path switching unit that selectively guides the sample to be sampled to the plurality of channel units, and a display control unit that displays a control screen for controlling the plurality of channel units on the display unit. Each relates to an analytical system comprising a mobile phase supply unit that supplies a mobile phase and an analytical column that separates the sample supplied by the sample supply unit into components and guides them to the detector.

Another aspect of the present invention is an analysis system used together with a sample supply unit for supplying a sample, a detector for detecting a sample, and a display unit, wherein a plurality of channels arranged in parallel and the sample supply unit are used. A flow path switching unit that selectively guides the supplied sample to the plurality of channel units and an analysis control device are provided, and each of the plurality of channel units has a mobile phase supply unit that supplies a mobile phase and the sample. The analysis control device includes a data processing unit, a sample supply unit, or a plurality of channel units, including an analysis column that separates a sample supplied by a supply unit into each component and guides the sample to the detector. It is supplied by the channel unit, the input unit into which the operation timings of the detector and the data processing unit are input, the first control unit that controls the sample supply unit so as to supply the sample, and the sample supply unit. A second control unit that controls the flow path switching unit so that the sample is guided to any of the channel portions, and the detector is controlled so as to detect the sample guided from the one of the channel portions. The third control unit, the fourth control unit that controls the data processing unit so as to process the detection data of the sample by the detector, and the first control unit according to the operation timing input to the input unit. The present invention relates to an analysis system including a unit, a second control unit, a third control unit, and a main control unit that controls the fourth control unit.

Yet another aspect of the present invention is an analysis method used together with a sample supply unit for supplying a sample, a detector for detecting a sample, and a display unit, wherein the sample supplied by the sample supply unit is switched by a flow path switching unit. Each of the plurality of channel portions includes a mobile phase, including selectively guiding to a plurality of channels arranged in parallel and displaying a control screen relating to control of the plurality of channel portions on the display unit. The present invention relates to an analysis method including a mobile phase supply unit for supplying a sample, and an analysis column for separating a sample supplied by the sample supply unit for each component and guiding the sample to the detector.

According to the present invention, the usability of the analysis system can be improved.

It is a figure which shows the structure of the analysis system which concerns on one Embodiment of this invention. It is a figure which shows the structure of the chromatograph of FIG. It is a figure which shows the structure of the channel part of FIG. It is a figure for demonstrating the operation of a chromatograph at the time of a pretreatment. It is a figure for demonstrating operation of a chromatograph at the time of measurement. It is a figure for demonstrating operation of a chromatograph at the time of measurement. It is a figure for demonstrating operation of a chromatograph at the time of measurement. It is a time flow which shows the operation procedure by a chromatograph. It is a figure which shows the structure of the analysis control apparatus. It is a figure which shows the functional block of the analysis execution part of FIG. It is a figure which shows an example of the 1st control screen. It is a figure which shows an example of the 2nd control screen. It is a figure which shows an example of the 3rd control screen. It is a figure which shows an example of the 4th control screen. It is a figure which shows an example of the 5th control screen. It is a figure which shows an example of the sixth control screen. It is a figure which shows an example of the 7th control screen. It is a flowchart which shows the algorithm of the analysis processing performed by the analysis control program. It is a flowchart which shows the algorithm of the analysis processing performed by the analysis control program.

(1) Configuration of Analytical System Hereinafter, the analytical system and the analytical method according to the embodiment of the present invention will be described in detail with reference to the drawings. FIG. 1 is a diagram showing a configuration of an analysis system according to an embodiment of the present invention. As shown in FIG. 1, the analysis system 500 includes a chromatograph 100, a mass spectrometer 200, and a processing device 300. In this embodiment, the analysis system 500 is an LC-MS (Liquid Chromatograph Mass Spectrometer).

The chromatograph 100 includes an LC (liquid chromatograph). The configuration of the chromatograph 100 will be described later. The mass spectrometer 200 is used as a detector for the chromatograph 100. Instead of the mass spectrometer 200, an absorbance detector, a fluorescence detector, a differential refractometer detector, or the like may be used as the detector of the chromatograph 100.

The processing device 300 includes a control unit 310, a RAM (random access memory) 320, a ROM (read-only memory) 330, a storage unit 340, an operation unit 350, a display unit 360, and an input / output I / F (interface) 370. .. The control unit 310, RAM 320, ROM 330, storage unit 340, operation unit 350, display unit 360, and input / output I / F 370 are connected to the bus 380. The control unit 310, RAM 320, and ROM 330 constitute an analysis control device 400.

The control unit 310 includes, for example, a plurality of CPUs (central processing units). The RAM 320 is used as a working area of the control unit 310. The system program is stored in the ROM 330. The storage unit 340 includes a storage medium such as a hard disk or a semiconductor memory. The storage unit 340 stores an analysis control program for controlling the chromatograph 100 by the analysis control device 400.

The operation unit 350 is an input device such as a keyboard, a mouse, or a touch panel, and is operated by the user to make a predetermined input or selection to the analysis control device 400. The display unit 360 is a display device such as a liquid crystal display device, and displays a predetermined GUI (graphical user interface) or the like. The input / output I / F 370 is connected to the chromatograph 100 and the mass spectrometer 200.

FIG. 2 is a diagram showing the configuration of the chromatograph 100 of FIG. As shown in FIG. 2, the chromatograph 100 includes a plurality of (six in this example) channel units 10, a low pressure valve 110, a measuring unit 120, a cleaning liquid supply unit 130, a flow path switching unit 140, 150, 160, and a sample supply. Includes part 170. Hereinafter, when the plurality of channel units 10 are distinguished, the plurality of channel units 10 are referred to as channel units 10A to 10F, respectively. The configuration of the channel unit 10 will be described later.

The low pressure valve 110 and the flow path switching portions 140, 150, 160 are, for example, multi-way switching valves. The low pressure valve 110 has three ports 111 to 113, and the ports 111 and 112 are configured to be selectively connectable to the port 113. The measuring unit 120 includes, for example, a syringe and a pump, and is connected to the port 111 of the low pressure valve 110. The measuring unit 120 sucks the specified amount of sample.

The cleaning liquid supply unit 130 includes, for example, a degassing device, a pump, an on / off valve, and the like, and is connected to the port 112 of the low pressure valve 110. The cleaning liquid supply unit 130 supplies the cleaning liquid contained in the cleaning liquid container 502 to each channel unit 10. In the present embodiment, the cleaning liquid supplied to each channel portion 10 is the same liquid as the mobile phase of the channel portion 10.

The flow path switching units 140 and 150 are examples of the flow path switching units. The flow path switching unit 140 has seven ports 141 to 147, and the ports 141 to 146 are configured to be selectively connectable to the port 147. The ports 141 to 146 are connected to the channel portions 10A to 10F, respectively. The flow path switching unit 150 has seven ports 151 to 157, and the ports 151 to 156 are configured to be selectively connectable to the port 157. The ports 151 to 156 are connected to the channel portions 10A to 10F, respectively. Port 157 is connected to port 113 of the low pressure valve 110.

The configuration of the flow path switching unit 160 is the same as the configuration of the flow path switching units 140 and 150. The flow path switching unit 160 has seven ports (not shown) connected to the channel units 10A to 10F and the mass spectrometer 200, respectively. The flow path switching unit 160 selectively guides the mobile phase containing the sample eluted from the plurality of channel units 10 to the mass spectrometer 200 by switching the connection between the ports. In FIG. 2, in order to facilitate the visual recognition of the connection relationship, the connection flow path between each channel portion 10 and the port of the flow path switching section 160 is shown by a alternate long and short dash line.

The sample supply unit 170 is, for example, an autosampler and includes a needle 171, a sample loop 172, and a drive device 173. The needle 171 sucks the sample from the sample container 501 and selectively injects the sucked sample into the plurality of channel portions 10. One end and the other end of the sample loop 172 are connected to the needle 171 and the port 147 of the flow path switching portion 140, respectively. The sample loop 172 holds a predetermined volume of sample sucked by the needle 171. The drive device 173 includes, for example, an actuator to drive the needle 171.

The mass spectrometer 200 detects a sample from each channel unit 10 guided by the flow path switching unit 160. In the present embodiment, a single mass spectrometer 200 commonly used for the plurality of channel units 10 is provided as a detector, but the embodiment is not limited to this. A plurality of detectors corresponding to each of the plurality of channel units 10 may be provided. In this case, since the plurality of detectors are connected to the corresponding channel units 10, the chromatograph 100 does not include the flow path switching unit 160.

Since the plurality of channel units 10A to 10F have similar configurations to each other, the configuration of one channel unit 10 will be described. FIG. 3 is a diagram showing the configuration of the channel portion 10 of FIG. As shown in FIG. 3, the channel section 10 includes a high pressure valve 20, an injection port 30, an analysis column 40, and a mobile phase supply section 50. The configurations of the analysis column 40 and the mobile phase supply unit 50 may differ for each channel unit 10. Further, measurement conditions such as the temperature of the analysis column 40 or the flow rate of the mobile phase supplied by the mobile phase supply unit 50 may differ for each channel unit 10.

The high-pressure valve 20 has six ports 21 to 26, and is configured to be switchable between a first connection state and a second connection state. In the first connection state, ports 21 and 22 are connected, ports 23 and 24 are connected, and ports 25 and 26 are connected. In the second connection state, the ports 22 and 23 are connected, the ports 24 and 25 are connected, and the ports 26 and 21 are connected. The port 21 is connected to the waste liquid device 504.

The injection port 30 is configured to allow the needle 171 of the sample supply unit 170 to be inserted, and is connected to the port 22 of the high pressure valve 20. The injection port 30 receives the injection of the sample from the inserted needle 171. The analytical column 40 is housed in a column oven (not shown). One end and the other end of the analysis column 40 are connected to the port 23 of the high pressure valve 20 and the flow path switching portion 160, respectively. The analysis column 40 separates the sample from the port 23 of the high-pressure valve 20 for each component according to the difference in chemical properties or composition, and elutes the sample into the flow path switching unit 160.

The mobile phase supply unit 50 includes a high-pressure pump and the like, and is connected to the port 24 of the high-pressure valve 20. The mobile phase supply unit 50 sucks the liquid mobile phase from the mobile phase container 503 and supplies the sucked mobile phase. The mobile phase supplied by the mobile phase supply unit 50 is pumped to the mass spectrometer 200 through the ports 24 and 23 of the high pressure valve 20, the analysis column 40 and the flow path switching unit 160.

The flow path switching portions 140 and 150 are connected to the ports 25 and 26 of the high pressure valve 20 of each channel portion 10, respectively. Specifically, the ports 141 to 146 (FIG. 2) of the flow path switching portion 140 of FIG. 2 are connected to the ports 25 of the high pressure valve 20 of the channel portions 10A to 10F, respectively. The ports 151 to 156 of the flow path switching portion 150 of FIG. 2 are connected to the ports 26 of the high pressure valves 20 of the channel portions 10A to 10F, respectively. Of the channel units 10A to 10F, the connection between the ports of the flow path switching units 140 and 150 is switched so that the selected channel unit 10 can be accessed.

For example, when the channel unit 10A is selected, the ports 141 and 147 of the flow path switching unit 140 are connected, and the ports 151 and 157 of the flow path switching unit 150 are connected. When the channel unit 10B is selected, the ports 142 and 147 of the flow path switching unit 140 are connected, and the ports 152 and 157 of the flow path switching unit 150 are connected. When the channel unit 10C is selected, the ports 143 and 147 of the flow path switching unit 140 are connected, and the ports 153 and 157 of the flow path switching unit 150 are connected.

When the channel unit 10D is selected, the ports 144 and 147 of the flow path switching unit 140 are connected, and the ports 154 and 157 of the flow path switching unit 150 are connected. When the channel unit 10E is selected, the ports 145 and 147 of the flow path switching unit 140 are connected, and the ports 155 and 157 of the flow path switching unit 150 are connected. When the channel section 10F is selected, the ports 146 and 147 of the flow path switching section 140 are connected, and the ports 156 and 157 of the flow path switching section 150 are connected.

(2) Operation of chromatograph FIG. 4 is a diagram for explaining the operation of the chromatograph 100 at the time of pretreatment. As shown in FIG. 4, at the time of preprocessing, the channel portion 10 to be used is selected from the channel portions 10A to 10F. The connection of the flow path switching units 140 and 150 is switched so that the selected channel unit 10 can be accessed, and the high pressure valve 20 of the channel unit 10 is switched to the first connection state. Further, the ports 112 and 113 of the low pressure valve 110 are connected. Further, the needle 171 of the sample supply unit 170 is inserted into the injection port 30 of the selected channel unit 10.

In this case, as shown by a thick solid line in FIG. 4, the cleaning liquid supply unit 130 and the waste liquid device 504 are connected by a predetermined flow path (hereinafter referred to as a cleaning flow path 101). The cleaning flow path 101 includes a low pressure valve 110, a flow path switching unit 150, ports 26 and 25 of the high pressure valve 20, a flow path switching unit 140, a sample supply unit 170, and ports 22 and 21 of the high pressure valve 20. A part of the cleaning flow path 101 is also used as a measurement flow path 102, which will be described later.

In this connected state, the cleaning liquid contained in the cleaning liquid container 502 is supplied to the cleaning flow path 101 by the cleaning liquid supply unit 130. As a result, the pretreatment of filling the cleaning flow path 101 with a cleaning liquid which is the same liquid as the mobile phase used for measurement is executed. At the time of executing the pretreatment, the mobile phase housed in the mobile phase container 503 is supplied to the port 24 of the high pressure valve 20 by the mobile phase supply unit 50. In this case, a part of the measurement flow path 102 shown by the thick alternate long and short dash line in FIG. 4 is filled with the mobile phase.

5 to 7 are diagrams for explaining the operation of the chromatograph 100 at the time of measurement. As shown in FIG. 5, at the time of measuring the sample after the pretreatment, the needle 171 of the sample supply unit 170 is inserted into the sample container 501, and the ports 111 and 113 of the low pressure valve 110 are connected to each other. In this state, the measuring unit 120 is driven to hold a sample having a predetermined capacity in the sample loop 172. Next, as shown in FIG. 6, the needle 171 of the sample supply unit 170 is inserted into the injection port 30, and the high pressure valve 20 is switched to the second connection state. Further, the ports 112 and 113 of the low pressure valve 110 are connected.

In this case, as shown by a thick alternate long and short dash line in FIG. 6, the mobile phase supply unit 50 and the mass spectrometer 200 are connected by a predetermined flow path (hereinafter referred to as a measurement flow path 102). The measurement flow path 102 includes ports 24 and 25 of the high pressure valve 20, a flow path switching unit 140, a sample supply unit 170, an injection port 30, ports 22 and 23 of the high pressure valve 20, an analysis column 40 and a flow path switching unit 160. .. In this state, the mobile phase housed in the mobile phase container 503 is supplied to the measurement flow path 102 by the mobile phase supply unit 50. As a result, the sample is supplied to the mobile phase in the sample supply unit 170.

The sample supplied to the mobile phase is separated and eluted for each component in the analysis column 40. The sample eluted from the analysis column 40 is detected by the mass spectrometer 200. After a predetermined time, as shown in FIG. 7, the high pressure valve 20 is switched to the first connection state. In this case, the measurement of the sample is continued while the sample supply unit 170 is separated from the measurement flow path 102.

In this connected state, the cleaning liquid supply unit 130 and the waste liquid device 504 are connected by the cleaning flow path 101 as in the pretreatment of FIG. Here, the cleaning liquid contained in the cleaning liquid container 502 is supplied to the cleaning flow path 101 by the cleaning liquid supply unit 130. As a result, the inside of the cleaning flow path 101 is cleaned with the cleaning liquid while the measurement of the sample is continued. Further, it is possible to execute the pretreatment in another channel unit 10 while continuing the measurement of the sample in one channel unit 10. This further improves the efficiency of measurement.

In this way, the high pressure valve 20 is switched between the first connection state and the second connection state. In the first connection state, the mobile phase supplied by the mobile phase supply unit 50 is guided to the analysis column 40 through the sample supply unit 170. In the second connection state, the mobile phase supplied by the mobile phase supply unit 50 is guided to the analysis column 40 without passing through the sample supply unit 170, and the cleaning liquid supplied by the cleaning liquid supply unit 130 is sent to the sample supply unit 170. Be guided.

FIG. 8 is a time flow showing the operation procedure by the chromatograph 100. As shown in FIG. 8, the chromatograph 100 repeats the pretreatment of FIGS. 4 to 7 and the measurement of the sample by the plurality of channel portions 10 sequentially selected. The samples from the plurality of channel units 10 are detected by the mass spectrometer 200 at different periods from each other. Further, the pretreatment in each channel unit 10 is executed during the detection period of the sample in the previous channel unit 10. Therefore, the throughput is improved.

(3) Analytical control device FIG. 9 is a diagram showing the configuration of the analytical control device 400. As shown in FIG. 9, the analysis control device 400 has a display control unit 401, a selection unit 402, a timing setting unit 403, a calibration curve setting unit 404, a power supply control unit 405, a batch generation unit 406, and an analysis execution unit as functional units. 407 and data processing unit 408 are included. By executing the analysis control program stored in the storage unit 340 or the like by the control unit 310 of FIG. 1, the functional unit of the analysis control device 400 is realized. A part or all of the functional part of the analysis control device 400 may be realized by hardware such as an electronic circuit.

The display control unit 401 causes the display unit 360 to display various control screens relating to the control of the plurality of channel units 10 of the chromatograph 100. Some control screens function as a GUI that allows the user to make a predetermined input or selection using the operation unit 350. An example of the control screen will be described later. The selection unit 402 receives from the operation unit 350 the channel unit 10 designation to be used for measurement. The user can specify the channel unit 10 to be used for the measurement by operating the operation unit 350 through the GUI displayed on the display unit 360. The selection unit 402 selects the accepted channel unit 10.

The timing setting unit 403 receives the operation period of the sample supply unit 170, the channel unit 10, the mass spectrometer 200, and the data processing unit 408 selected by the selection unit 402. That is, the timing setting unit 403 functions as an input unit into which the above operation period is input. The operation period of the sample supply unit 170 includes the execution period of the pretreatment. The timing setting unit 403 can also receive the injection amount of the sample to be injected from the sample supply unit 170 into the injection port 30 of the channel unit 10 in FIG.

The user can input the above-mentioned operation period and sample injection amount by operating the operation unit 350 through the GUI displayed on the display unit 360. The timing setting unit 403 sets the operation timing of the sample supply unit 170, the plurality of channel units 10, the mass spectrometer 200, and the data processing unit 408 (hereinafter, referred to as timing setting) based on the received operation period. conduct. As a result, the sample injection timing by the sample supply unit 170, the timing of detecting the sample derived from any of the channel units 10 by the mass spectrometer 200, and the output from the mass spectrometer 200 by detecting the sample in the data processing unit 408. The period for processing the signal to be processed is set. Further, the timing setting unit 403 sets the injection amount of the accepted sample.

The calibration curve setting unit 404 creates a setting for individually creating a calibration curve corresponding to one or more channel units 10 among a plurality of channel units 10 and a calibration curve commonly corresponding to two or more channel units 10. Accepts selection with settings. By operating the operation unit 350, the user can select a setting for creating a calibration curve corresponding to the desired channel unit 10 (hereinafter, referred to as a calibration curve setting). The display control unit 401 causes the display unit 360 to display a screen showing the calibration curve setting selected by the calibration curve setting unit 404 as a control screen.

The processing device 300 is shut down when an abnormality occurs in the analysis system 500, or when a predetermined time has elapsed after the analysis based on the batch file (hereinafter referred to as batch analysis) is completed. The power supply control unit 405 sets a target for turning off the power at the end of batch analysis and a setting for target for turning off the power when the processing device 300 shuts down, among various components of the analysis system 500. And accept. The components of the analysis system 500 include, for example, a degassing device of the cleaning liquid supply unit 130, a high pressure pump of the mobile phase supply unit 50, a column oven accommodating the analysis column 40, a sample supply unit 170 or a mass spectrometer 200.

By operating the operation unit 350 through the GUI displayed on the display unit 360, the user selects the target to be turned off at the end of the batch analysis as the first target, and shuts down the analysis system 500. At this time, the target for turning off the power can be selected as the second target. The power control unit 405 turns off the power of the first target or the second target according to the accepted setting (hereinafter, referred to as a shutdown setting).

The batch generation unit 406 receives the sample information and analysis conditions used in each of the plurality of channel units 10 from the operation unit 350. By operating the operation unit 350 through the GUI displayed on the display unit 360, the user can input the information of the sample to be used in each of the plurality of channel units 10 and the analysis conditions. The batch generation unit 406 generates a batch file for controlling the analysis sequence based on the received sample information and analysis conditions. The batch file may be generated for each channel unit 10.

In the present embodiment, the sample to be measured and the timing setting performed by the timing setting unit 403 are associated with each other as a group, and a name is given to the group. Further, when the sample is a standard sample, the group may further include the calibration curve setting performed by the calibration curve setting unit 404. The batch generation unit 406 further generates a batch file using the group selected by the user.

The analysis execution unit 407 includes a chromatograph 100, a mass analyzer 200, and a data processing unit so that pretreatment, sample measurement, detection, and data processing are sequentially executed based on the batch file generated by the batch generation unit 406. Controls the operation of 408. This will perform a batch analysis. The configuration of the analysis execution unit 407 will be described later.

The data processing unit 408 acquires and processes the detection data of the sample from the mass spectrometer 200. As a result, an MS chromatogram is generated or a QC value is calculated. Further, the data processing unit 408 functions as a calibration curve creation unit, and is based on the calibration curve setting in the calibration curve setting unit 404 and the detection result when the standard sample is supplied to the channel unit 10 related to the setting. Create a calibration curve to be used in the channel unit 10. As a result, the detection data is quantified.

FIG. 10 is a diagram showing a functional block of the analysis execution unit 407 of FIG. As shown in FIG. 10, the analysis execution unit 407 includes a first control unit 1, a second control unit 2, a third control unit 3, a fourth control unit 4, and a main control unit 5. As described above, in the present embodiment, the control unit 310 of FIG. 1 includes, for example, a plurality of CPUs. Each of the first control unit 1, the second control unit 2, the third control unit 3, the fourth control unit 4, and the main control unit 5 is realized by executing an analysis control program by a separate CPU. To.

The first control unit 1 mainly controls the sample supply unit 170 so as to supply the sample. The second control unit 2 mainly controls the flow path switching units 140 and 150 so that the sample supplied by the sample supply unit 170 is guided to any one of the plurality of channel units 10. Further, the second control unit 2 controls the flow path switching unit 160 so that the sample from the channel unit 10 is guided to the mass spectrometer 200.

The third control unit 3 controls the mass spectrometer 200 so as to detect the sample derived from the channel unit 10. The fourth control unit 4 controls the data processing unit 408 so as to process the detection data of the sample by the mass spectrometer 200. The main control unit 5 controls the operations of the first control unit 1, the second control unit 2, the third control unit 3, and the fourth control unit 4 according to the timing setting by the timing setting unit 403 of FIG. ..

According to the above configuration, the first control unit 1, the second control unit 2, the third control unit 3, the fourth control unit 4, and the main control unit 5 are realized by separate CPUs. It can operate independently of each other. As a result, the sample supply unit 170, the plurality of channel units 10, the mass spectrometer 200, and the data processing unit 408 can be operated in parallel within a range in which the analysis does not interfere.

When the channel unit 10 is added, the second control unit 2 is updated by the CPU executing the control software installed so as to correspond to the channel unit 10 to be added. Further, when the authentication between the main control unit 5 and the updated second control unit 2 is completed, the channel unit 10 can be used. As described above, when the channel unit 10 is added, it can be handled only by adding the control software, and it is not necessary to expand the control unit 310. Therefore, the analysis system 500 can be operated easily and efficiently.

(4) Control screen An example of a control screen displayed on the display unit 360 by the display control unit 401 in FIG. 9 will be described. FIG. 11 is a diagram showing an example of the first control screen. As shown in FIG. 11, on the first control screen 410, a plurality of icons 411 corresponding to the plurality of channel units 10 are displayed. Further, on the first control screen 410, a plurality of buttons 412 corresponding to the plurality of channel units 10 are displayed.

One of the channel units 10 may be in an unusable state due to the occurrence of an error or the like. Whether or not each channel unit 10 is in a usable state can be determined by the selection unit 402 in FIG. 9 using a detection unit that detects the analysis status of each channel unit 10. The detection unit includes a sensor that detects a signal output during analysis, a sensor that detects the driving status of the high-pressure pump of the mobile phase supply unit 50, and the like.

On the first control screen 410, the icon 411 corresponding to the channel unit 10 in the usable situation and the icon 411 corresponding to the channel unit 10 in the unusable situation are displayed so as to be distinguishable. As a result, the user can easily recognize the channel unit 10 in a usable situation.

In the present embodiment, the icon 411 corresponding to the channel unit 10 in the unusable situation is displayed by graying out, but the embodiment is not limited to this. The icon 411 corresponding to the channel unit 10 in an unusable situation may not be displayed on the first control screen 410. The user can specify the channel unit 10 to be used for the measurement by turning on the button 412 corresponding to the desired channel unit 10. The selection unit 402 in FIG. 9 selects the channel unit 10 to be used for measurement based on the user's designation.

FIG. 12 is a diagram showing an example of the second control screen. As shown in FIG. 12, the pull-down menus 421, 422, 423 and the like are displayed on the second control screen 420. By operating the pull-down menus 421 to 423 and the like, analysis conditions such as a sample supply unit 170, a mass spectrometer 200, and an analysis method used for analysis are input.

FIG. 13 is a diagram showing an example of the third control screen. As shown in FIG. 13, the pull-down menus 431, 432 and the like are displayed on the third control screen 430. By operating the pull-down menu 431, any rack is selected from a plurality of racks each holding a plurality of sample containers (vials), and an image 433 showing the selected rack is displayed on the third control screen 430. Is displayed. In the example of FIG. 13, the selected rack holds 54 sample containers 501.

By manipulating any portion of the sample container on image 433, the sample container is selected as the sample container to be used for measurement. Further, by selecting the pull-down menu 432, the type of the sample contained in the selected sample container is selected. Sample types include standard samples, unknown samples, control samples and QA / QC (quality assurance / quality control) samples.

The batch generation unit 406 of FIG. 9 generates a batch file based on the analysis conditions input to the second control screen 420 and the sample information input to the third control screen 430. The batch file has a table format. The generated batch file may include the unique number of the rack, the unique number of the sample container, the name of the group, and the like (see FIG. 17 described later).

FIG. 14 is a diagram showing an example of the fourth control screen. As shown in FIG. 14, a plurality of input fields 441 are displayed on the fourth control screen 440. A preprocessing period, a data collection period, a detection period, a data processing period, and the like are input to a plurality of input fields 441. The timing setting unit 403 of FIG. 9 sets the operation period of the sample supply unit 170, the plurality of channel units 10, the mass spectrometer 200, and the data processing unit 408 based on the input period.

Further, on the third control screen 430, a graph of the operating period of the sample supply unit 170, the plurality of channel units 10, the mass spectrometer 200, and the data processing unit 408 is displayed based on the input period. In the example of FIG. 14, the operation period of the two channel units 10 selected by the selection unit 402 is displayed instead of the entire channel unit 10. By visually recognizing the graph displayed on the fourth control screen 440, the user can easily input each period so that the measurements by the plurality of channel units 10 do not interfere with each other.

FIG. 15 is a diagram showing an example of a fifth control screen. The fifth control screen 450 is a screen for accepting a shutdown setting. As shown in FIG. 15, the fifth control screen 450 is provided with display areas 451 and 452. A plurality of check boxes 453 are displayed in the display area 451. The plurality of check boxes 453 correspond to a deaerator, a high-pressure pump, a column oven, a sample supply unit 170, and a mass spectrometer 200, respectively. When one or more check boxes 453 are checked, the component corresponding to the check box 453 is selected as the second target.

A plurality of check boxes 454 and input fields 455 are displayed in the display area 452. The plurality of check boxes 454 correspond to a deaerator, a high-pressure pump, a column oven, a sample supply unit 170, and a mass spectrometer 200, respectively. When one or more check boxes 454 are checked, the component corresponding to the check box 454 is selected as the first target. In the input field 455, the time from the end of batch analysis to the shutdown of the analysis system 500 is input.

It should be noted that some components such as high-pressure pumps require a relatively long time to become stable after the power is turned on. Further, in a high-pressure pump, the life may be longer if the pump is constantly pulsating. Therefore, in the display area 452 of the present embodiment, the check box 454 corresponding to the high pressure pump is displayed in gray out so that the high pressure pump cannot be selected as the first target.

FIG. 16 is a diagram showing an example of the sixth control screen. As shown in FIG. 16, on the sixth control screen 460, it is set that the calibration curve setting unit 404 of FIG. 9 individually creates a calibration curve corresponding to one or more channel units 10, or two or more. It is shown whether it is set to create a calibration curve commonly corresponding to the channel portion 10 of the above. In the example of FIG. 16, highlighting indicates that it is set to create a calibration curve individually corresponding to the channel portion 10 of 2.

FIG. 17 is a diagram showing an example of the seventh control screen. As shown in FIG. 17, the seventh control screen 470 is provided with display areas 471, 472, 473. In the display area 471, a flow path diagram showing the current connection state of the channel unit 10 is shown. As the measurement progresses, the display is updated so that any of the channel portions 10 used can be known.

In the example of FIG. 17, the connection between the currently used channel unit 10 and the mass spectrometer 200 is shown by a thick solid line. Further, the connection between the channel unit 10 and the mass spectrometer 200 used in the next measurement is shown by a thin solid line. In the display area 471, the ports of the flow path switching units 140 and 150 to which the channel units 10 are connected may be displayed.

The display area 472 shows a table of batch files generated by the batch generation unit 406 of FIG. The display area 472 may display a cursor on the line corresponding to the current progress stage in the analysis sequence. The display area 473 shows the pressure change of the high pressure pump of the channel portion 10 used. The display area 473 may show the pressure change of the high pressure pump for each channel portion 10.

As an example of another control screen, the control screen may be a screen for accepting a gradient condition in each channel unit 10. Alternatively, the control screen may be a screen that displays the details of the error of the channel unit 10. Details of the error include an abnormality in the high-pressure pump or the arrival of a replacement time for consumables. The control screen may show the distribution of QC values for each sample. Further, the generated MS chromatogram may be displayed in real time for each channel unit 10 on the control screen. Alternatively, a plurality of MS chromatograms may be superimposed and displayed on the control screen.

(5) Analysis processing FIGS. 18 and 19 are flowcharts showing an algorithm of analysis processing performed by an analysis control program. Hereinafter, the analysis process will be described with reference to the analysis control device 400 of FIG. 9 and the flowcharts of FIGS. 18 and 19. First, the selection unit 402 determines whether or not the designation of one or more channel units 10 has been accepted (step S1). This designation can be accepted from the first control screen 410 of FIG. If the designation of the channel unit 10 is not accepted, the selection unit 402 proceeds to step S3.

When the designation of the channel unit 10 is accepted, the selection unit 402 selects the channel unit 10 as the channel unit 10 to be used for the measurement (step S2), and proceeds to step S3. The selection unit 402 is selected as the channel unit 10 to be used for the measurement when the designation of the channel unit 10 is accepted, but the embodiment is not limited to this. The selection unit 402 may determine whether or not each channel unit 10 is in a usable state by using the above detection unit, and preferentially select the determined channel unit 10. In this case, step S1 is omitted.

In step S3, the timing setting unit 403 determines whether or not the operation period of the sample supply unit 170, the channel unit 10, the mass spectrometer 200, and the data processing unit 408 selected in step S1 has been accepted (step S3). These operating periods can be accepted from the fourth control screen 440 of FIG. If the operation period is not accepted, the timing setting unit 403 proceeds to step S5. When the operation period is accepted, the timing setting unit 403 executes the timing setting based on the operation period (step S4), and proceeds to step S5.

In step S5, the calibration curve setting unit 404 determines whether or not the selection of the setting for creating the calibration curve has been accepted (step S5). If the selection is not accepted, the calibration curve setting unit 404 proceeds to step S7. When the selection is accepted, the calibration curve setting unit 404 executes the calibration curve setting based on the selection (step S6), and proceeds to step S7. After step S6, the display control unit 401 may display the sixth control screen 460 of FIG. 16 showing the executed calibration curve setting on the display unit 360.

In step S7, the power supply control unit 405 determines whether or not the selection of the first target and the second target has been accepted (step S7). This selection is acceptable from the fifth control screen 450 of FIG. If the selection is not accepted, the power supply control unit 405 proceeds to step S9. If the selection is accepted, the power supply control unit 405 executes the shutdown setting based on the selection (step S8), and proceeds to step S9.

In step S9, the batch generation unit 406 determines whether or not the sample information and analysis conditions have been accepted (step S9). The sample information can be accepted from the third control screen 430 of FIG. 13, and the analysis conditions can be accepted from the second control screen 420 of FIG. If the sample information and analysis conditions are not accepted, batch generator 406 proceeds to step S11.

When the sample information and analysis conditions are accepted, the batch generation unit 406 generates a batch file based on the sample information and analysis conditions (step S10), and proceeds to step S11. In the present embodiment, the timing setting executed in step S4 and the calibration curve setting executed in step S6 are also used to generate the batch file.

In step S11, the analysis execution unit 407 determines whether or not the start of batch analysis is instructed (step S11). After the steps S2, S4, S6, S8, and S10 are completed, the user can instruct the start of batch analysis by performing a predetermined operation using the operation unit 350. If the start of batch analysis is not instructed, the analysis execution unit 407 returns to step S1. Steps S1 to S11 are repeated until the start of batch analysis is instructed. Therefore, the user can make various designations or selections again.

When the start of the batch analysis is instructed, the analysis execution unit 407 analyzes the batch analysis according to the batch file generated in step S10 (step S12). Here, the display control unit 401 has a seventh control screen 470 of FIG. 17, which shows a table of batch files generated in step S10 and a flow path diagram showing a connection state of the channel unit 10 currently in use. Is displayed on the display unit 360 (step S13).

After that, the analysis execution unit 407 determines whether or not the batch analysis is completed (step S14). If the batch analysis has not been completed, the analysis execution unit 407 returns to step S12. As a result, the batch analysis is continued in step S12, and the display content of the seventh control screen 470 is updated in step S13. Steps S12 to S14 are repeated until the batch analysis is completed. The analysis execution unit 407 may receive an instruction to suspend the analysis for each channel unit 10. This time, it may be set whether or not to continue the analysis for the channel unit 10 different from the channel unit 10 in which the interruption is instructed.

When the batch analysis is completed, the power supply control unit 405 turns off the power supply of the first target according to the shutdown setting executed in step S8 (step S15). Next, the power supply control unit 405 determines whether or not the time set in the shutdown setting has elapsed (step S16). If the set time has not elapsed, the power supply control unit 405 determines whether or not the next use of the analysis system 500 is planned (step S17). If the next use of the analysis system 500 is not planned, the power supply control unit 405 returns to step S16.

Steps S16 and S17 are repeated until the set time elapses or the next use of the analysis system 500 is scheduled. When the set time has elapsed in step S16, the power supply control unit 405 turns off the power supply of the second target according to the shutdown setting (step S18), and ends the analysis process.

On the other hand, when the analysis system 500 is scheduled to be used next time in step S17, the power supply control unit 405 ends the analysis process without turning off the power supply of the second target. In this case, the next analysis using the analysis system 500 can be started in a relatively short period of time. The power supply control unit 405 may detect whether or not an abnormality has occurred in the analysis system 500, and if the abnormality is detected during the execution of the batch analysis, the power supply control unit 405 may execute step S18 as an interrupt process.

(6) Effect In the analysis system 500 according to the present embodiment, the sample is efficiently measured by the plurality of channel units 10. Further, even when a plurality of channel units 10 are provided, the control screen relating to the control of the plurality of channel units 10 is displayed on the display unit 360, so that the operation of the analysis system 500 can be easily recognized. This can improve usability.

For example, the user can easily recognize which sample is being measured in which channel unit 10 by visually recognizing the seventh control screen 470. Further, even when an abnormality occurs in the analysis system 500, it is possible to easily confirm which channel unit 10 the abnormality has occurred in. Furthermore, since the user can check the batch file at the same time, if an abnormality occurs in the analysis system 500, the cause can be identified and a series of samples that may be affected by the measurement result can be easily selected. Can be specified in.

The user can easily recognize the channel unit 10 in a usable state by visually recognizing the first control screen 410 without actually confirming the state of the actual channel unit 10. Thereby, the user can easily select the channel unit 10 to be used for the measurement.

By visually recognizing the fourth control screen 440, the user can easily recognize the operating period of the sample supply unit 170, the channel unit 10, the mass spectrometer 200, and the data processing unit 408. As a result, the user can intuitively set appropriate operation timings of the sample supply unit 170, the channel unit 10, the mass spectrometer 200, and the data processing unit 408.

Further, the user can easily set the target to be turned off at the end of execution of the batch file or the shutdown of the processing device 300 while confirming on the fifth control screen 450. Further, the user can easily create an appropriate calibration curve even when a plurality of channel units 10 are provided, and can easily recognize the calibration curve setting by visually recognizing the sixth control screen 460. Can be done.

Further, in the present embodiment, even when a plurality of channel units 10 are provided, the first control unit 1, the second control unit 2, the third control unit 3, the fourth control unit 4, and the main control are provided. The sample supply unit 170, the channel unit 10, the mass spectrometer, and the data processing unit 408 can be operated in parallel by the unit 5 within a range in which the analysis does not interfere. This can improve throughput and usability.

(7) Other Embodiments In the above embodiment, the analysis system 500 includes a cleaning liquid supply unit 130, a sample supply unit 170, a mass spectrometer 200, and a display unit 360, but the embodiment is not limited thereto. The analysis system 500 includes a cleaning liquid supply unit 130, a sample supply unit 170, a mass spectrometer 200, and a part or all of the display unit 360 as long as it can be connected to the cleaning liquid supply unit, the sample supply unit, the detector, and the display unit. It does not have to be.

Further, the cleaning liquid supply unit 130 may not be connected to the analysis system 500. Even in this case, when the high pressure valve 20 is in the first connected state, the sample supplied by the sample supply unit 170 is guided to the analysis column 40 together with the mobile phase supplied by the mobile phase supply unit 50. Further, when the high pressure valve 20 is in the second connected state, the sample trapped in the analysis column 40 by the mobile phase supplied by the mobile phase supply unit 50 is separated for each component and guided to the mass spectrometer 200.

Therefore, in each channel section 10, the high pressure valve 20 is switched between the first connection state and the second connection state, so that the sample supply section 170 is disconnected from the measurement flow path 102 while the sample measurement is continued. Therefore, the measurement of the sample in any of the channel units 10 and the supply of the sample in the other channel unit 10 can be executed in parallel. This further improves the efficiency of measurement.

(8) Aspects It will be understood by those skilled in the art that the plurality of exemplary embodiments described above are specific examples of the following embodiments.

(Section 1) The analysis system according to one aspect is
An analytical system used with a sample supply unit that supplies samples, a detector that detects samples, and a display unit.
With multiple channels arranged in parallel,
When the sample supplied by the sample supply unit is selectively guided to the plurality of channel units,
A display control unit for displaying a control screen related to control of the plurality of channel units on the display unit is provided.
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
It may include an analysis column that separates the sample supplied by the sample supply unit into each component and guides the sample to the detector.

In this analysis system, the sample is efficiently measured by a plurality of channels. Further, even when a plurality of channel units are provided, the control screen relating to the control of the plurality of channel units is displayed on the display unit, so that the operation of the analysis system can be easily recognized. This can improve usability.

(Section 2) In the analysis system described in Clause 1,
Each of the plurality of channel units is supplied by the mobile phase supply unit and a first connection state in which the sample supplied by the sample supply unit is guided to the analysis column together with the mobile phase supplied by the mobile phase supply unit. It may further include a high pressure valve capable of switching to a second connection state in which the sample trapped in the analysis column is separated into components by the mobile phase and led to the detector.

In this case, in each channel section, the high-pressure valve is switched between the first connection state and the second connection state, so that the sample supply section is disconnected from the measurement flow path while the sample measurement is continued. Therefore, it becomes possible to perform the measurement of the sample in one of the channel portions and the supply of the sample in the other channel portion in parallel. This further improves the efficiency of measurement.

(Section 3) The analysis system described in paragraph 1 is
It is also used together with the cleaning liquid supply unit that supplies the cleaning liquid.
The flow path switching unit selectively guides the sample supplied by the sample supply unit or the cleaning liquid supplied by the cleaning liquid supply unit to the plurality of channel units.
Each of the plurality of channel portions has a first connection state in which the mobile phase supplied by the mobile phase supply unit is guided to the analysis column through the sample supply unit, and a mobile phase supplied by the mobile phase supply unit. It may further include a high pressure valve capable of switching to a second connection state in which the cleaning liquid supplied by the cleaning liquid supply unit is guided to the sample supply unit while being guided to the analysis column without passing through the sample supply unit.

In this case, in each channel section, the high pressure valve is switched between the first connection state and the second connection state, so that the sample supply section is washed while the measurement of the sample is continued. This further improves the efficiency of measurement.

(Clause 4) The analysis system according to any one of paragraphs 1 to 3 is
A batch generation unit that generates a batch file for controlling the analysis sequence based on the sample information and analysis conditions used in any of the channel units.
An analysis execution unit that controls the operation of the flow path switching unit and the sample supply unit based on the batch file generated by the batch generation unit may be further provided.

According to this configuration, even when a plurality of channel portions are provided, the analysis of the sample is efficiently performed by any of the channel portions according to the batch file. This further improves usability.

(Section 5) In the analysis system described in Section 4,
The display control unit may display a screen showing a table of batch files generated by the batch generation unit and a flow path diagram showing a connection state of the current channel unit on the display unit as the control screen. ..

In this case, the user can easily recognize which sample is being measured in which channel portion by visually recognizing the control screen. Further, even if an abnormality occurs in the analysis system, it is possible to easily confirm in which channel the abnormality has occurred. In addition, the user can check the batch file at the same time, so if an abnormality occurs in the analysis system, the cause can be identified and a series of samples that may be affected by the measurement results can be easily identified. Can be identified.

(Section 6) The analysis system according to paragraph 4 or 5 is
Equipped with a power control unit
The display control unit sets a target for turning off the power of the sample supply unit, the detector, and the mobile phase supply unit when the execution of the batch file generated by the batch generation unit ends. A screen for accepting the setting of the target for turning off the power when the analysis execution unit is shut down is displayed on the display unit as the control screen.
The power supply control unit may turn off the power of the sample supply unit, the detector, or the mobile phase supply unit according to the setting accepted on the control screen.

In this case, the user can easily set the target to be turned off at the end of execution of the batch file or the shutdown of the analysis execution unit while confirming on the control screen.

(Section 7) In the analysis system according to any one of paragraphs 1 to 6.
The display control unit may display a screen on the display unit as the control screen so as to be able to distinguish between the channel unit in the usable situation and the channel unit in the unusable situation.

In this case, the user can easily recognize the channel portion in a usable state by visually recognizing the control screen without actually confirming the state of the actual channel portion. This allows the user to easily select the channel portion to be used for the measurement.

(Section 8) The analysis system according to any one of paragraphs 1 to 7 is
A data processing unit that processes the detection data of the sample by the detector,
Further equipped with a timing setting unit
The display control unit causes the display unit to display a screen showing a graph of the operation period of the sample supply unit, any channel unit, the detector, and the data processing unit as the control screen.
The timing setting unit detects the sample from the detector by detecting the sample in the data processing unit together with the sample injection timing by the sample supply unit and the timing to detect the sample derived from any of the channel units by the detector. The period for processing the output signal may be set.

In this case, the user can easily recognize the operation period of the sample supply unit, the channel unit, the detector, and the data processing unit by visually recognizing the control screen. As a result, the user can intuitively set the appropriate operation timing of the sample supply unit, the channel unit, the detector, and the data processing unit.

(Section 9) The analysis system according to any one of paragraphs 1 to 8 is
A calibration curve setting that accepts the selection of a setting for creating a calibration curve individually corresponding to one or more channel portions and a setting for creating a calibration curve commonly corresponding to two or more channel portions among the plurality of channel portions. Department and
Further provided with a calibration curve creating unit that creates a calibration curve used in the channel unit based on the setting selected in the calibration curve setting unit and the sample guided to the channel unit related to the setting.
The display control unit may display a screen showing the settings selected in the calibration curve setting unit on the display unit as the control screen.

According to this configuration, an appropriate calibration curve can be easily created even when a plurality of channel portions are provided. In addition, the user can easily recognize the setting for creating the selected calibration curve by visually recognizing the control screen.

(Section 10) The analysis system according to another aspect is
An analytical system used with a sample supply unit that supplies samples, a detector that detects samples, and a display unit.
With multiple channels arranged in parallel,
A flow path switching unit that selectively guides the sample supplied by the sample supply unit to the plurality of channel units, and a flow path switching unit.
Equipped with an analysis control device
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
It includes an analysis column that separates the sample supplied by the sample supply unit for each component and guides it to the detector.
The analysis control device is
Data processing unit and
The sample supply unit, one of the plurality of channel units, an input unit for inputting the operation timing of the detector and the data processing unit, and the input unit.
A first control unit that controls the sample supply unit so as to supply a sample,
A second control unit that controls the flow path switching unit so that the sample supplied by the sample supply unit is guided to any of the channel units.
A third control unit that controls the detector so as to detect a sample derived from any of the channel units.
A fourth control unit that controls the data processing unit so as to process the detection data of the sample by the detector,
The first control unit, the second control unit, the third control unit, and the main control unit that controls the fourth control unit may be included according to the operation timing input to the input unit.

In this analysis system, the sample is efficiently measured by a plurality of channels. Further, even when a plurality of channel units are provided, the sample supply unit can be used as long as the analysis does not interfere with the first control unit, the second control unit, the third control unit, the fourth control unit, and the main control unit. The channel unit, mass spectrometer and data processing unit can be operated in parallel. This can improve throughput and usability.

(Section 11) The analysis method according to still another aspect is
An analytical method used in conjunction with a sample supply unit that supplies a sample, a detector that detects a sample, and a display unit.
The sample supplied by the sample supply unit is selectively guided to a plurality of channel units arranged in parallel by the flow path switching unit.
Including displaying a control screen relating to the control of the plurality of channel units on the display unit.
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
It may include an analysis column that separates the sample supplied by the sample supply unit into each component and guides the sample to the detector.

According to this analysis method, even when a plurality of channel units are provided, a control screen relating to the control of the plurality of channel units is displayed on the display unit, so that the user can easily recognize the operation of the analysis system. It is possible. This can improve usability.

1 ... 1st control unit, 2 ... 2nd control unit, 3 ... 3rd control unit, 4 ... 4th control unit, 5 ... main control unit, 10, 10A-10F ... channel unit, 20 ... high pressure Valve, 21-26, 111-113, 141-147, 151-157 ... Port, 30 ... Injection port, 40 ... Analytical column, 50 ... Mobile phase supply unit, 100 ... Chromatograph, 101 ... Cleaning flow path, 102 ... Measurement flow path, 110 ... Low pressure valve, 120 ... Measuring section, 130 ... Cleaning liquid supply section, 140, 150, 160 ... Flow path switching section, 170 ... Sample supply section, 171 ... Needle, 172 ... Sample loop, 173 ... Drive device , 200 ... mass analyzer, 300 ... processing device, 310 ... control unit, 320 ... RAM, 330 ... ROM, 340 ... storage unit, 350 ... operation unit, 360 ... display unit, 370 ... input / output I / F, 380 ... Bus, 400 ... analysis control device, 401 ... display control unit, 402 ... selection unit, 403 ... timing setting unit, 404 ... calibration line setting unit, 405 ... power supply control unit, 406 ... batch generation unit, 407 ... analysis execution unit, 408 ... Data processing unit, 410 ... First control screen, 411 ... Icon, 412 ... Button, 420 ... Second control screen, 421-423, 431,432 ... Pull-down menu, 430 ... Third control screen, 433 ... image, 440 ... fourth control screen, 441,455 ... input field, 450 ... fifth control screen, 451, 452,471-473 ... display area, 453,454 ... check box, 460 ... sixth control Screen, 470 ... 7th control screen, 500 ... Analytical system, 501 ... Sample container, 502 ... Cleaning liquid container, 503 ... Mobile phase container, 504 ... Waste liquid device

Claims (11)

An analytical system used with a sample supply unit that supplies samples, a detector that detects samples, and a display unit.
With multiple channels arranged in parallel,
A flow path switching unit that selectively guides the sample supplied by the sample supply unit to the plurality of channel units, and a flow path switching unit.
A display control unit for displaying a control screen related to control of the plurality of channel units on the display unit is provided.
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
An analysis system including an analysis column that separates a sample supplied by the sample supply unit for each component and guides the sample to the detector. Each of the plurality of channel units is supplied by the mobile phase supply unit and a first connection state in which the sample supplied by the sample supply unit is guided to the analysis column together with the mobile phase supplied by the mobile phase supply unit. The analysis system according to claim 1, further comprising a high pressure valve capable of switching to a second connection state in which the sample trapped in the analysis column by the mobile phase is separated into components and guided to the detector. The analysis system is further used together with a cleaning liquid supply unit that supplies cleaning liquid.
The flow path switching unit selectively guides the sample supplied by the sample supply unit or the cleaning liquid supplied by the cleaning liquid supply unit to the plurality of channel units.
Each of the plurality of channel units has a first connection state in which the mobile phase supplied by the mobile phase supply unit is guided to the analysis column through the sample supply unit, and a mobile phase supplied by the mobile phase supply unit. The first aspect of claim 1, further comprising a high-pressure valve capable of switching to a second connection state in which the cleaning liquid supplied by the cleaning liquid supply unit is guided to the sample supply unit while being guided to the analysis column without passing through the sample supply unit. Analysis system. A batch generation unit that generates a batch file for controlling the analysis sequence based on the sample information and analysis conditions used in any of the channel units.
The analysis according to any one of claims 1 to 3, further comprising an analysis execution unit that controls the operation of the flow path switching unit and the sample supply unit based on the batch file generated by the batch generation unit. system. The display control unit causes the display unit to display a screen showing a table of batch files generated by the batch generation unit and a flow path diagram showing a connection state of the current channel unit as the control screen. 4. The analysis system described. Further equipped with a power control unit,
The display control unit sets a target for turning off the power of the sample supply unit, the detector, and the mobile phase supply unit when the execution of the batch file generated by the batch generation unit ends. A screen for accepting the setting of the target for turning off the power when the analysis execution unit is shut down is displayed on the display unit as the control screen.
The analysis system according to claim 4 or 5, wherein the power supply control unit turns off the power of the sample supply unit, the detector, or the mobile phase supply unit according to the setting accepted on the control screen. Any of claims 1 to 6, wherein the display control unit causes the display unit to display a screen that can distinguish between a channel unit in a usable situation and a channel unit in an unusable situation as the control screen. The analysis system described in one paragraph. A data processing unit that processes the detection data of the sample by the detector,
Further equipped with a timing setting unit
The display control unit causes the display unit to display a screen showing a graph of the operation period of the sample supply unit, any channel unit, the detector, and the data processing unit as the control screen.
The timing setting unit detects the sample from the detector by detecting the sample in the data processing unit together with the sample injection timing by the sample supply unit and the timing to detect the sample derived from any of the channel units by the detector. The analysis system according to any one of claims 1 to 7, wherein the period for processing the output signal is set. A calibration curve setting that accepts the selection of a setting for creating a calibration curve individually corresponding to one or more channel portions and a setting for creating a calibration curve commonly corresponding to two or more channel portions among the plurality of channel portions. Department and
Further provided with a calibration curve creating unit that creates a calibration curve used in the channel unit based on the setting selected in the calibration curve setting unit and the sample guided to the channel unit related to the setting.
The analysis system according to any one of claims 1 to 8, wherein the display control unit displays a screen showing a setting selected in the calibration curve setting unit on the display unit as the control screen. An analytical system used with a sample supply unit that supplies samples, a detector that detects samples, and a display unit.
With multiple channels arranged in parallel,
A flow path switching unit that selectively guides the sample supplied by the sample supply unit to the plurality of channel units, and a flow path switching unit.
Equipped with an analysis control device
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
It includes an analysis column that separates the sample supplied by the sample supply unit for each component and guides it to the detector.
The analysis control device is
Data processing unit and
The sample supply unit, one of the plurality of channel units, an input unit for inputting the operation timing of the detector and the data processing unit, and the input unit.
A first control unit that controls the sample supply unit so as to supply a sample,
A second control unit that controls the flow path switching unit so that the sample supplied by the sample supply unit is guided to any of the channel units.
A third control unit that controls the detector so as to detect a sample derived from any of the channel units.
A fourth control unit that controls the data processing unit so as to process the detection data of the sample by the detector,
An analysis system including a first control unit, a second control unit, a third control unit, and a main control unit that controls the fourth control unit according to an operation timing input to the input unit. .. An analytical method used in conjunction with a sample supply unit that supplies a sample, a detector that detects a sample, and a display unit.
The sample supplied by the sample supply unit is selectively guided to a plurality of channel units arranged in parallel by the flow path switching unit.
Including displaying a control screen relating to the control of the plurality of channel units on the display unit.
Each of the plurality of channel portions
The mobile phase supply unit that supplies the mobile phase and
An analysis method including an analysis column that separates a sample supplied by the sample supply unit into each component and guides the sample to the detector.

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