JP2022058962A - 抑制された酸素透過性を有するメディカルデリバリーデバイス - Google Patents
抑制された酸素透過性を有するメディカルデリバリーデバイス Download PDFInfo
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Images
Abstract
Description
本開示は、メディカルデリバリーデバイス、特に、メディカルデリバリーデバイス内に含まれる流体又は物質への酸素の透過を抑制するように構成されたシリンジ、自動インジェクタ及びペンに関する。
シリンジ、自動インジェクタ及びペンなどのメディカルデリバリーデバイスは、典型的に、バレル、前記バレル内に配置されたストッパー及び前記ストッパーを変位させるためのプランジャーロッド又は作動機構を含む。製薬業界が新しくより便利なドラッグデリバリー方法を模索するにつれて、事前充填シリンジ、自動インジェクタ及びペンが、単位用量の薬物デリバリーのための好ましい選択肢として浮上してきた。事前充填シリンジは、患者が注射可能な薬剤を自己投与できるようにしながら、薬剤の無駄を最小限に抑え、製品の寿命を延ばす。特に、事前充填シリンジ、自動インジェクタ及びペンは、投与エラーを排除し、過剰充填を防ぐ。長期間の経過に伴う薬物の不安定性は、事前充填シリンジで持続する問題の1つである。薬物の不安定性は、例えば、シリンジとそこに含まれる流体組成物との間の相互作用に起因しうる。
本開示は、少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端及び遠位端ならびに内面を有するシリコーン不含バレル、前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパー、及び、前記バレル内でストッパーを変位させるためのプランジャーロッド又は作動機構を含むメディカルデリバリーデバイス(例えば、シリンジ、自動インジェクタ及びペン)に関する。バレルは、エラストマーストッパーとバレルの内面との間の締まりばめを強化するために、バレルの近位端に位置する直径が減少した領域を有する。ストッパーは、前記ストッパーが押し込まれていない状態にある間に、直径が減少した領域と隣接接触する少なくとも1つのリブを含む。直径が減少した領域は、バレルの残りの部分の直径よりも小さい直径を有する。バレルは、近位端の直径が減少した領域と、遠位端の直径が大きい領域との間に配置された遷移セクション(例えば、フラスティコニカル又はテーパー遷移セクション)を含むことができ、それらの間の漸進的な遷移を提供する。
添付の図面は、開示のさらなる理解を提供するために含まれ、本明細書に取り込まれ、その一部を構成し、実施形態を示し、記載とともに、本開示の原理を説明するのに役立つ。
当業者は、本開示の様々な態様が、意図された機能を発揮するように構成された任意の数の方法及び装置によって実現できることを容易に理解するであろう。本明細書で参照される添付の描図は、必ずしも一定の縮尺で描かれているわけではなく、本開示の様々な態様を例示するために誇張されている場合があり、その点で、描図は限定として解釈されるべきではないことにも留意されたい。「シリコーン」及び「シリコーンオイル」という用語は、本明細書において互換的に使用されうる。
ン(Hardy-Zuckerman)4ネコ肉腫ウイルス癌遺伝子相同体、リンパ球特異性タンパク質チロシンキナーゼ(LCK)、LIMドメインキナーゼファミリー、セリン/トレオニンキナーゼファミリー、ロイシンリッチリピートキナーゼファミリー、v-yes-1ヤマグチ肉腫ウイルス関連癌遺伝子相同体(LYN)、オス生殖細胞関連キナーゼ(MAK)、MAP/微小管親和性調節キナーゼファミリー、微小管関連セリン/トレオニンキナーゼファミリー、母系胚性ロイシンジッパーキナーゼ、c-mer癌原遺伝子チロシンキナーゼ(MERTK)、met癌原遺伝子(肝細胞成長因子受容体)、MAPキナーゼ相互作用セリン/トレオニンキナーゼファミリー、ミオシン軽鎖キナーゼファミリー、混合系統キナーゼドメイン様タンパク質アイソフォーム、CDC42結合タンパク質キナーゼファミリー、セリン/トレオニンキナーゼファミリー、マクロファージ刺激1受容体(c-met関連チロシンキナーゼ)(MST1R)、ラパマイシンの機械的標的(セリン/トレオニンキナーゼ)(MTOR)、筋肉-骨格受容体チロシンキナーゼ(MUSK)、ミオシン軽鎖キナーゼファミリー、NIMA(有糸分裂遺伝子aにはない)関連キナーゼファミリー、セリン/トレオニン-タンパク質キナーゼNIM1(NIM1)、ネモ様キナーゼ(NLK)、酸化ストレス応答性1(OSR1)、p21タンパク質(Cdc42/Rac)活性化キナーゼファミリー、PASドメイン含有セリン/トレオニンキナーゼ、血小板由来成長因子受容体ファミリー、3-ホスホイノシチド依存タンパク質キナーゼ-1(PDPK1)、カルシウム依存タンパク質キナーゼ1、ホスホリラーゼキナーゼγファミリー、ホスファチジルイノシトール4,5-ビスホスファート3キナーゼ、ホスホイノシチド-3キナーゼファミリー、ホスファチジルイノシトール4キナーゼファミリー、ホスホイノシチドキナーゼ、FYVEフィンガー含有、Pim-1癌遺伝子(PIM1)、pim-2癌遺伝子(PIM2)、pim-3癌遺伝子(PIM3)、ホスファチジルイノシトール-4-ホスファート5キナーゼファミリー、ホスファチジルイノシトール-5-ホスファート4キナーゼファミリータンパク質キナーゼ、膜関連チロシン/トレオニン1(PKMYT1)、タンパク質キナーゼNファミリー、ポロ様キナーゼファミリー、タンパク質キナーゼCファミリー、タンパク質キナーゼDファミリー、cGMP依存タンパク質キナーゼファミリー、真核生物翻訳開始因子2-αキナーゼ2(PRKR)、X結合タンパク質キナーゼ(PRKX)、プロラクチン受容体(PRLR)、PRP4・mRNA前駆体処理因子4相同体B(酵母菌)(PRP4)、PTK2Bタンパク質チロシンキナーゼ2β(PTK2B)、SIKファミリーキナーゼ3(QSK)、v-raf-1マウス白血病ウイルス癌遺伝子相同体1(RAF1)、神経栄養チロシンキナーゼ受容体型ファミリー、受容体(TNFRSF)相互作用セリン-トレオニンキナーゼファミリー、二重セリン/トレオニン及びチロシンタンパク質キナーゼ(RIPK5)、Rho関連コイルドコイル含有タンパク質キナーゼファミリー、c-ros癌遺伝子1受容体チロシンキナーゼ(ROS1)、リボソームタンパク質S6キナーゼファミリー、SH3結合ドメインキナーゼ1(SBK1)、血清/グルココルチコイド調節キナーゼファミリー、性質不明で推定のセリン/トレオニンタンパク質キナーゼ(Sugenキナーゼ110)(SgK110)、塩誘導性キナーゼファミリー、SNF関連キナーゼ(SNRK)、src関連キナーゼ、SFRSタンパク質キナーゼファミリー、脾臓チロシンキナーゼ(SYK)、TAOキナーゼファミリー、TANK結合キナーゼ1(TBK1)、tecタンパク質チロシンキナーゼ(TEC)、睾丸特異性キナーゼ1(TESK1)、形質転換成長因子、β受容体ファミリー、免疫グロブリン様及びEGF様ドメイン1を有するチロシンキナーゼ(TIE1)、TEKチロシンキナーゼ、内皮(TIE2)、アンジオポイエチン-1受容体(Tie2)、tousled様キナーゼファミリー、TRAF2及びNCK相互作用キナーゼ(TNIK),非受容体チロシンキナーゼファミリー、TNNI3相互作用キナーゼ(TNNI3K)、過渡受容体電位陽イオンチャネル、睾丸特異性セリンキナーゼファミリー、TTKタンパク質キナーゼ(TTK)、TXKチロシンキナーゼ(TXK)、チロシンキナーゼ2(TYK2)、TYRO3タンパク質チロシンキナーゼ(TYRO3)、unc-51様キナーゼファミリー、ホスファチジルイノシトール3-キナーゼ、ワクチニア関連キナーゼ2(VRK2)、WEE1相同体ファミリー、WNKリシン欠損タンパク質キナーゼファミリー、v-yes-1ヤマグチ肉腫ウイルス癌遺伝子相同体1(YES)、殺菌αモチーフ及びロイシンジッパー含有キナーゼAZK(ZAK)、ζ鎖(TCR)関連タンパク質キナーゼ70kDa(ZAP70)が挙げられ、核ホルモン受容体の例としては、限定するわけではないが、アンドロゲン受容体(AR)、エストロゲン関連受容体α(ESRRA)、エストロゲン受容体1(ESR1)、核受容体サブファミリー1グループHメンバー4(NR1H4)、核受容体サブファミリー3グループCメンバー1(グルココルチコイド受容体)(NR3C1)、核受容体サブファミリー1グループHメンバー3(肝臓X受容体α)(NR1H3)、核受容体サブファミリー1グループHメンバー2(肝臓X受容体β)(NR1H2)、核受容体サブファミリー1グループHメンバー2(肝臓X受容体β)(NR1H2)、核受容体サブファミリー3グループCメンバー2(電解質コルチコイド受容体)(NR3C2)、ペルオキシソーム増殖因子活性化受容体α(PPARA)、ペルオキシソーム増殖因子活性化受容体γ(PPARG)、ペルオキシソーム増殖因子活性化受容体δ(PPARD)、プロゲステロン受容体α(PGR)、プロゲステロン受容体β(PGR)、レチノイン酸受容体α(RARA)、レチノイン酸受容体-β(RARB)、レチノイドX受容体α(RXRA)、レチノイドX受容体γ(RXRG)、甲状腺ホルモン受容体α(THRA)、甲状腺ホルモン受容体β(THRB)、レチノイン酸関連オーファン受容体、肝臓X受容体、ファルネソイドX受容体、ビタミンD受容体、プレグナンX受容体、構成的アンドロスタン受容体、肝細胞核因子4、エストロゲン受容体、エストロゲン関連受容体、糖質コルチコイド受容体、神経成長因子誘導遺伝子B、生殖細胞核因子が挙げられ、エピジェネティック標的の例としては、限定するわけではないが、ATPaseファミリーAAAドメイン含有タンパク質2(ATAD2A)、ATPaseファミリーAAAドメイン含有2B(ATAD2B)、ATPaseファミリーAAAドメイン含有2B(ATAD2B)、ジンクフィンガードメイン隣接ブロモドメイン1A(BAZ1A)、ジンクフィンガードメイン隣接ブロモドメイン1B(BAZ1B)、ジンクフィンガードメイン隣接ブロモドメイン2A(BAZ2A)、ジンクフィンガードメイン隣接ブロモドメイン2A(BAZ2A)、ジンクフィンガードメイン隣接ブロモドメイン2B(BAZ2B)、ブロモドメイン含有タンパク質1(BRD1)、ブロモドメイン含有タンパク質2第一ブロモドメイン(BRD2)、ブロモドメイン含有タンパク質2第一及び第二ブロモドメイン(BRD2)、ブロモドメイン含有タンパク質2アイソフォーム1ブロモドメイン2(BRD2(2))、ブロモドメイン含有タンパク質3ブロモドメイン1(BRD3(1))、ブロモドメイン含有タンパク質3第一ブロモドメイン(BRD3)、ブロモドメイン含有タンパク質3第一及び第二ブロモドメイン(BRD3)、ブロモドメイン含有タンパク質3ブロモドメイン2(BRD3(2))、ブロモドメイン含有タンパク質4第一ブロモドメイン(BRD4)、ブロモドメイン含有タンパク質4アイソフォームlong型ブロモドメイン1及び2(BRD4(1-2))、ブロモドメイン含有タンパク質4アイソフォームlong型ブロモドメイン2(BRD4(2))、ブロモドメイン含有タンパク質4アイソフォームshort型(BRD4(全長-short型アイソフォーム))、ブロモドメイン含有タンパク質7(BRD7)、ブロモドメイン含有8ブロモドメイン1(BRD8(1))、ブロモドメイン含有8ブロモドメイン2(BRD8(2))、ブロモドメイン含有タンパク質9アイソフォーム1(BRD9)、ブロモドメイン含有睾丸特異性第一ブロモドメイン(BRDT)、ブロモドメイン含有睾丸特異性第一及び第二ブロモドメイン(BRDT)、ブロモドメイン睾丸特異性タンパク質アイソフォームbブロモドメイン2(BRDT(2))、ブロモドメイン及びPHDフィンガー含有1(BRPF1)、ブロモドメイン及びPHDフィンガー含有3(BRPF3)、ブロモドメイン及びPHDフィンガー含有3(BRPF3)、ブロモドメイン及びWDリピート含有3第2ブロモドメイン(BRWD3(2))、猫眼症候群重要領域タンパク質2(CECR2)、CREB結合タンパク質(CREBBP)、E1A結合タンパク質p300(EP300)、EP300(EP300)、ヌクレオソームリモデリング因子サブユニットBPTFアイソフォーム1(FALZ)、ヌクレオソームリモデリング因子サブユニットBPT(FALZ)、真性染色質ヒストンリシンN-メチルトランスフェラーゼ2(EHMT2)、ヒストンアセチルトランスフェラーゼKAT2A(GCN5L2)、真性染色質ヒストンリシンN-メチルトランスフェラーゼ1(EHMT1)、ヒストンリシンN-メチルトランスフェラーゼMLL(MLL)、ポリブロモ1第一ブロモドメイン(PB1(1))、ポリブロモ1第二ブロモドメイン(PB1(2))、ポリブロモ1ブロモドメイン2(PBRM1(2))、ポリブロモ1ブロモドメイン5(PBRM1(5))、ヒストンアセチルトランスフェラーゼKAT2B(PCAF)、PH相互作用タンパク質第一ブロモドメイン(PHIP(1))、PH相互作用タンパク質第二ブロモドメイン(PHIP(2))、タンパク質キナーゼC結合タンパク質1(PRKCBP1)、タンパク質アルギニンN-メチルトランスフェラーゼ3(PRMT3)、クロマチンサブファミリーaメンバー2のSWI/SNF関連マトリックス関連アクチン依存調節因子(SMARCA2)、クロマチンサブファミリーaメンバー4のSWI/SNF関連マトリックス関連アクチン依存調節因子(SMARCA4)、核内構造体タンパク質SP110(SP110)、核内構造体タンパク質SP140(SP140)、転写開始因子TFIIDサブユニット1(TAF1(1-2))、TAF1・RNAポリメラーゼII-TATAボックス結合タンパク質(TBP)関連因子-250kDa-ブロモドメイン2(TAF1(2))、転写開始因子TFIIDサブユニット1様第一ブロモドメイン(TAF1L(1))、転写開始因子TFIIDサブユニット1様-第二ブロモドメイン(TAF1L(2))、三要素モチーフ含有24(TRIM24(ブロモ))、三要素モチーフ含有24(TRIM24(PHDブロモ))、E3ユビキチンタンパク質リガーゼTRIM33(TRIM33)、三要素モチーフ含有33(TRIM33(PHD-ブロモ))、WDリピート9第一ブロモドメイン(WDR9(1))、WDリピート9第二ブロモドメイン(WDR9(2))が挙げられ、膜輸送タンパク質としては、限定するわけではないが、ATP結合カセット(ABC)スーパーファミリー、溶質輸送体(SLC)スーパーファミリー、多剤耐性タンパク質1(P-グリコタンパク質)、有機陰イオン輸送体1、及びタンパク質、例えば、EAAT3、EAAC1、EAAT1、GLUT1、GLUT2、GLUT9、GLUT10、rBAT、AE1、NBC1、KNBC、CHED2、BTR1、NABC1、CDPD、SGLT1、SGLT2、NIS、CHT1、NET、DAT、GLYT2、CRTR
、B0AT1、SIT1、XT3、y+LAT1、BAT1、NHERF1、NHE6、ASBT、DMT1、DCT1、NRAMP2、NKCC2、NCC、KCC3、NACT、MCT1、MCT8、MCT12、SLD、VGLUT3、THTR1、THTR2、PIT2、GLVR2、OCTN2、URAT1、NCKX1、NCKX5、CIC、PiC、ANT1、ORNT1、AGC1、ARALAR、Citrin、STLN2、aralar2、TPC、MUP1、MCPHA、CACT、GC1、PHC、DTD、CLD、DRA、PDS、Prestin、TAT1、FATP4、ENT3、ZnT2、ZnT10、AT1、NPT2A、NPT2B、HHRH、CST、CDG2F、UGAT、UGTL、UGALT、UGT1、UGT2、FUCT1、CDG2C、NST、PAT2、G6PT1、SPX4、ZIP4、LIV4、ZIP13、LZT-Hs9、FPN1、MTP1、IREG1、RHAG、AIM1、PCFT、FLVCR1、FLVCR2、RFT1、RFT2、RFT3、OATP1B1、OATP1B3、OATP2A1が挙げられ、構造タンパク質としては、限定するわけではないが、熱ショックタンパク質、微小管安定化タンパク質、癌タンパク質18、スタスミン、キネシン8及びキネシン14ファミリー、Kip3、Kif18Aが挙げられ、プロテアーゼとしては、限定するわけではないが、ADAM(ジスインテグリン及び金属プロテアーゼ)ファミリーが挙げられる、シグナル伝達の他の分子標的としては、限定するわけではないが、細胞分裂周期遺伝子25相同体A(CDC25A)、フォークヘッドボックスO3(フォークヘッドボックスO3)、B細胞阻害因子のκ軽鎖ポリペプチド遺伝子転写促進因子の核因子、α(NFKBIA)、核因子(赤血球由来2)様2(NFE2L2)、ナトリウム排泄増加ペプチド受容体A(NPR1)、腫瘍壊死因子受容体スーパーファミリー、メンバー11a(TNFRSF11A)、v-rel細網内皮症ウイルス癌遺伝子相同体A(鳥類)(RELA)、ステロール調節因子元素結合転写因子2(SREBF2)、CREB調節転写共活性因子1(CRTC1)、CREB調節転写共活性因子2(CRTC2)、Xボックス結合タンパク質1(XBP1)、カテニン(カドヘリン関連タンパク質),β1(CTNNB1)及びこれらの組み合わせが挙げられる。
糖酸化鉄注射液(Venofer)、Istodax(注射用ロミデプシン)、イトラコナゾール注射液(Sporanox注射液)、Jevtana(カバジタキセル注射液)、Jonexa、Kalbitor(エカランチド注射液)、D5NS中KCL(5%ブドウ糖中塩化カリウム及び塩化ナトリウム注射液)、D5W中KCL、NS中KCL、Kenalog 10注射液(トリアムシノロンアセトニド注射可能懸濁液)、Kepivance(パリフェルミン)、Keppra注射液(レベチラセタム)、ケラチノサイト、KFG、キナーゼ阻害剤、Kineret(アナキンラ)、Kinlytic(ウロキナーゼ注射液)、Kinrix、Klonopin(クロナゼパム)、Kytril注射液(グラニセトロン塩酸塩)、ラコサミド錠剤及び注射液(Vimpat)、乳酸リンゲル液、Lanoxin注射液(ジゴキシン注射液)、注射用ランソプラゾール(Prevacid I.V.)、Lantus、Leucovorin Calcium(ロイコボリンカルシウム注射液)、Lente (L)、Leptin、Levemir、Leukine Sargramostim、Leuprolide Acetate、Levothyroxine、レベチラセタム(Keppra注射液)、Lovenox、Levocarnitine注射液(Carnitor注射液)、Lexiscan(レガデノソン注射液)、Lioresal Intrathecal(バクロフェン注射液)、リラグルチド[rDNA]注射液(Victoza)、Lovenox(エノキサパリンナトリウム注射液)、Lucentis(ラニビズマブ注射液)、Lumizyme、Lupron(酢酸ロイプロリド注射液)、Lusedra(ホスプロポフォール二ナトリウム注射液)、Maci、Magnesium Sulfate(硫酸マグネシウム注射液)、マンニトール注射液(Mannitol IV)、Marcaine(ブピバカイン塩酸塩及びエピネフリン注射液)、Maxipime(注射用セフェピム塩酸塩)、テクネチウム注射のMDP 多投与キット(テクネチウムTc99mメドロナート注射液)、メカセルミン[rDNA由来]注射液(Increlex)、メカセルミンリンファバート[rDNA由来]注射液(Iplex)、メルファラン塩酸塩注射液(Alkeran注射液)、メトトレキサート、Menactra、Menopur(メノトロピンス注射液)、注射用メノトロピンス(Repronex)、注射用メトヘキシタールナトリウム(Brevital Sodium)、メチルドーパート塩酸塩注射液、溶液(メチルドーパート塩酸塩)、Methylene Blue(メチレンブルー注射液)、酢酸メチルプレドニゾロン注射可能懸濁液(Depo Medrol)、MetMab、メトクロプラミド注射液(Reglan注射液)、Metrodin(注射用ウロフォリトロピン)、メトロニダゾール注射液(Flagyl注射液)、Miacalcin、Midazolam(ミダゾラム注射液)、Mimpara(シナカルセト)、Minocin注射液(ミノサイクリン注射液)、ミノサイクリン注射(Minocin注射液)、Mipomersen、注射濃縮物用ミトキサントロン(Novantrone)、モルヒネ注射液(Duramorph)、モルヒネ硫酸塩XRリポソーム注射液(DepoDur)、Morrhuate Sodium(モルイン酸ナトリウム注射液)、Motesanib、Mozobil(プレリキサホル注射液)、Multihance(ガドベン酸二メグルミン注射液)、複合電解質及びブドウ糖注射液、複合電解質注射液、Mylotarg(注射用ゲムツズマブオゾガマイシン)、Myozyme(アルグルコシダーゼα)、Nafcillin注射液(ナフシリンナトリウム)、ナフシリンナトリウム(Nafcillin注射液)、ナルトレキソンXR注射液(Vivitrol)、Naprosyn(ナプロキセン)、NeoProfen(イブプロフェンリシン注射液)、Nandrol Decanoate、Neostigmine Methylsulfate(メチル硫酸ネオスチグミン注射液)、NEO-GAA、NeoTect(テクネチウムTc99mデプレオチド注射液)、Nephramine(必須アミノ酸注射液)、Neulasta(ペグフィルグラスチム)、Neupogen(フィルグラスチム)、Novolin、Novolog、NeoRecormon、Neutrexin(グルクロン酸トリメトレキサート注射液)、NPH(N)、Nexterone(アミオダロン塩酸塩注射液)、Norditropin(ソマトロピン注射液)、Normal Saline(塩化ナトリウム注射液)、Novantrone(注射濃縮物用ミトキサントロン)、Novolin 70/30 Innolet (70% NPH、ヒトイソフェンインスリン懸濁液及び30%標準ヒトインスリン注射液)、NovoLog(インスリンアスパルト[rDNA由来]注射液)、Nplate(ロミプロスチム)、Nutropin(注射用ソマトロピン(rDNA由来))、Nutropin AQ、Nutropin Depot(注射用ソマトロピン(rDNA由来))、酢酸オクトレオチド注射液(Sandostatin LAR)、オクレリズマブ、オファツムマブ注射液(Arzerra)、オランザピン徐放性注射可能懸濁液(Zyprexa Relprevv)、Omnitarg、Omnitrope(ソマトロピン[rDNA由来]注射液)、オンダンセトロン塩酸塩注射液(Zofran注射液)、OptiMARK(ガドベルセタミド注射液)、Optiray注射液(イオベルソール注射液)、Orencia、Osmitrol注射液Aviva容器入り(マンニトール注射液Avivaプラスチック容器250入り)、Osmitrol注射液Viaflex入り(マンニトール注射液Viaflexプラスチック容器250入り)、Osteoprotegrin、Ovidrel(コリオゴナドトロピンα注射液)、Oxacillin(注射用オキサシリン)、オキサリプラチン注射液(Eloxatin)、オキシトシン注射液(Pitocin)、パリペリドンパルミチン酸エステル徐放性注射可能懸濁液(Invega Sustenna)、パミドロネート二ナトリウム注射液、静脈内投与用パニツムマブ注射液(Vectibix)、パパベリン(Papaverine)塩酸塩注射液(パパベリン注射液)、パパベリン(Papaverine)注射液(パパベリン塩酸塩注射液)副甲状腺ホルモン、パリカルシトール注射液、押し上げ式バイアル入り(Zemplar注射液)、PARP阻害剤、Pediarix、PEGlntron、ペグインターフェロン、ペグフィルグラスチム、ペニシリンGベンザチン及びペニシリンGプロカイン、ペンテト酸カルシウム三ナトリウム注射液(Ca-DTPA)、ペンテト酸亜鉛三ナトリウム注射液(Zn-DTPA)、Pepcid注射液(ファモチジン注射液)、Pergonal、ペルツズマブ、Phentolamine Mesylate(注射用フェントラミンメシル酸塩)、Physostigmine Salicylate(サリチル酸フィゾスチグミン(Physostigmine)(注射液))、ピペラシリン・タゾバクタム注射液(Zosyn)、Pitocin(オキシトシン注射液)、Plasma-Lyte 148(複合電解質注射液)、Plasma-Lyte 56及びブドウ糖(複合電解質及びブドウ糖注射液、Viaflexブラスチック容器250入り)、PlasmaLyte、プレリキサホル注射液(Mozobil)、ポリドカノール注射液(Asclera)、塩化カリウム、静脈内注射用プララトレキセート溶液(Folotyn)、酢酸プラムリンタイド注射液(Symlin)、Premarin注射液(注射用結合型エストロゲン)、注射用テクネチウムTc99セスタミビのプレップキット(Cardiolite)、Prevacid I.V.(注射用ランソプラゾール)、Primaxin I.V.(注射用イミペネム及びシラスタチン)、Prochymal、Procrit、プロゲステロン、ProHance(ガドテリドール注射液)、Prolia(デノスマブ注射液)、Promethazine HCl注射液(塩酸プロメタジン注射液)、プロプラノロール(Propranolol)塩酸塩注射液、グルコン酸キニジン注射液(Quinidine注射液)、Quinidine注射液(グルコン酸キニジン注射液)、R-Gene 10(塩酸アルギニン注射液)、ラニビズマブ注射液(Lucentis)、ラニチジン塩酸塩注射液(Zantac注射液)、Raptiva、Reclast(ゾレドロン酸注射液)、Recombivarix HB、レガデノソン注射液(Lexiscan)、Reglan注射液(メトクロプラミド注射液)、Remicade、Renagel、Renvela(炭酸セベラマー)、Repronex(注射用メノトロピンス)、Retrovir IV(ジドブジン注射液)、rhApo2L/TRAIL、リンゲル液及び5%ブドウ糖注射液(ブドウ糖中リンゲル)、リンゲル注射液、Rituxan、リツキシマブ、Rocephin(セフトリアキソン)、ロクロニウムブロミド注射液(Zemuron)、Roferon-A(インターフェロンα-2a)、Romazicon(フルマゼニル)、注射用ロミデプシン(Istodax)、Saizen(ソマトロピン注射液)、Sandostatin LAR(酢酸オクトレオチド注射液)、Sclerostin Ab、Sensipar(cinacalcet)、Sensorcaine(ブピバカイン塩酸塩注射液)、Septocaine(Articane HCl及びエピネフリン注射液)、Serostim LQ(ソマトロピン(rDNA由来)注射液)、Simponi注射液(ゴリムマブ注射液)、Sodium Acetate(酢酸ナトリウム注射液)、炭酸水素ナトリウム(炭酸水素ナトリウム5%注射液)、Sodium Lactate(乳酸ナトリウム注射液、AVIVA入り)、フェニル酢酸ナトリウム及び安息香酸ナトリウム注射液(Ammonul)、注射用ソマトロピン(rDNA由来)(Nutropin)、Sporanox注射液(イトラコナゾール注射液)、Stelara注射液(ウステキヌマブ)、Stemgen、Sufenta(クエン酸スフェンタニル注射液)、クエン酸スフェンタニル注射液(Sufenta)、Sumavel、スマトリプタン注射液(Alsuma)、Symlin、Symlin Pen、全身性ヘッジホッグ拮抗薬、Synvisc-One(Hylan G-F 20 Single関節内注射液)、Tarceva、Taxotere(注射用ドセタキセル)、テクネチウムTc99m、注射用テラバンシン(Vibativ)、テムシロリムス注射液(Torisel)、Tenormin I.V.注射液(アテノロール注射液)、テリパラチド(rDNA由来)注射液(Forteo)、シピオン酸テストステロン、エナント酸テストステロン、プロピオン酸テストステロン、Tev-Tropin(ソマトロピン、rDNA由来、注射用)、tgAAC94、塩化タリウム、テオフィリン、Thiotepa(チオテパ注射液)、Thymoglobulin(抗胸腺細胞グロブリン(ウサギ)、Thyrogen(注射用サイロトロピンα)、チカルシリン二ナトリウム及びクラブラン酸カリウムGalaxy(Timentin注射液)、Tigan注射液(注射可能な塩酸トリメトベンズアミド)、Timentin注射液(チカルシリン二ナトリウム及びクラブラン酸カリウムGalaxy)、TNKase、Tobramycin注射液(トブラマイシン注射液)、トシリズマブ注射液(Actemra)、Torisel(テムシロリムス注射液)、Totect(注射用デクスラゾキサン、静脈内注射のみ)、Trastuzumab-DM1、Travasol(アミノ酸(注射液))、Treanda(ベンダムスチン塩酸塩注射液)、Trelstar(注射可能懸濁液用トリプトレリンパモアート)、トリアムシノロンアセトニド、二酢酸トリアムシノロン、トリアムシノロンヘキサアセトニド注射可能懸濁液(Aristospan注射液20mg)、Triesence(トリアムシノロンアセトニド注射可能懸濁液)、塩酸トリメトベンズアミド注射可能液(Tigan注射液)、グルクロン酸トリメトレキサート注射液(Neutrexin)、注射可能懸濁液用トリプトレリンパモアート(Trelstar)、Twinject、Trivaris(トリアムシノロンアセトニド注射可能懸濁液)、Trisenox(三酸化ヒ素注射液)、Twinrix、Typhoid Vi、Ultravist(イオプロミド注射液)、注射用ウロフォリトロピン(Metrodin)、ウロキナーゼ注射液(Kinlytic)、ウステキヌマブ(Stelara注射液)、Ultralente (U)、Valium(ジアゼパム)、バルプロ酸ナトリウム注射液(Depacon)、Valtropin(ソマトロピン注射液)、Vancomycin Hydrochloride(バンコマイシン塩酸塩注射液)、バンコマイシン塩酸塩注射液(Vancomycin Hydrochloride)、Vaprisol(塩酸コニバプタン注射液)、VAQTA、Vasovist(静脈内投与用ガドホスベセット三ナトリウム注射液)、Vectibix(静脈内投与用パニツムマブ注射液)、Venofer(含糖酸化鉄注射液)、ベルテポルフィン注射液(Visudyne)、Vibativ(注射用テラバンシン)、Victoza(リラグルチド[rDNA]注射液)、Vimpat(ラコサミド錠剤及び注射液)、Vinblastine Sulfate(ビンブラスチン硫酸塩注射液)、Vincasar PFS(ビンクリスチン硫酸塩注射液)、Victoza、Vincristine Sulfate(ビンクリスチン硫酸塩注射液)、Visudyne(ベルテポルフィン注射液)、ビタミンB-12、Vivitrol(ナルトレキソンXR注射液)、Voluven(ヒドロキシエチル澱粉の塩化ナトリウム中の注射液)、Xeloda、Xenical(orlistat)、Xeomin(注射用インコボツリナムトキシンA)、Xolair、Zantac注射液(ラニチジン塩酸塩注射液)、Zemplar注射液(パリカルシトール注射液、押し上げ式バイアル入り)、Zemuron(ロクロニウムブロミド注射液)、Zenapax(ダクリズマブ)、Zevalin、ジドブジン注射液(Retrovir IV)、Zithromax注射液(アジスロマイシン)、Zn-DTPA(ペンテト酸亜鉛三ナトリウム注射液)、Zofran注射液(オンダンセトロン塩酸塩注射液)、Zingo、注射用ゾレドロン酸(Zometa)、ゾレドロン酸注射液(Reclast)、Zometa(注射用ゾレドロン酸)、
Zosyn(ピペラシリン・タゾバクタム注射液)、Zyprexa Relprevv(オランザピン徐放性注射可能懸濁液)及びこれらの組み合わせが挙げられる。
(態様)
(態様1)
少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有する潤滑剤不含バレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに接続されたプランジャーロッドと、
を含む、メディカルデリバリーデバイスであって、
前記バレルは少なくともその近位端に位置する直径が減少した領域を有し、前記エラストマーストッパーと前記バレルの内面との間の締まりばめを強化し、そして、
前記エラストマーストッパーは、前記エラストマーストッパーが押し込まれていない状態にある間に、直径が減少した領域内で隣接接触する少なくとも1つのリブを含む、メディカルデリバリーデバイス。
(態様2)
前記バレルは、直径が減少した領域、バレルの遠位端に配置された、より大きな直径の領域、及び、それらの間に配置された、直径が減少した領域とより大きな直径の領域との間の漸進的な遷移を提供するための遷移セクションを含む、態様1記載のメディカルデリバリーデバイス。
(態様3)
前記エラストマーストッパーが押し込まれていない状態にある間に、2つ以上のリブは、前記直径が減少した領域と隣接接触している、態様1又は態様2記載のメディカルデリバリーデバイス。
(態様4)
前記バレルの内面の一部の上にコーティング材料が設けられて、前記直径が減少した領域を形成する、態様1~3のいずれか1項記載のメディカルデリバリーデバイス。
(態様5)
前記コーティング材料はフッ素化エチレンプロピレン、延伸フッ素化エチレンプロピレン、エポキシ樹脂及びアクリルからなる群より選ばれる少なくとも1つの部材を含む、態様4記載のメディカルデリバリーデバイス。
(態様6)
シリンジが押し込まれていない状態にあるときに、少なくとも1つのリブは前記コーティング材料と接触している、態様4記載のメディカルデリバリーデバイス。
(態様7)
前記コーティング材料は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせをさらに含む、態様4記載のメディカルデリバリーデバイス。
(態様8)
前記エラストマーストッパーは延伸ポリテトラフルオロエチレン膜又は高密度化延伸ポリテトラフルオロエチレン膜で少なくとも部分的に覆われている、態様1~7のいずれか1項記載のメディカルデリバリーデバイス。
(態様9)
少なくとも1つのインサートはバレルの内面と接触して、直径が減少した領域を形成し、前記少なくとも1つのインサートは前記バレル内への酸素の透過を抑制するガスバリアである、態様1~8のいずれか1項記載のメディカルデリバリーデバイス。
(態様10)
前記インサートは接着剤を介して前記バレルの内面に取り付けられている、態様9記載のメディカルデリバリーデバイス。
(態様11)
前記インサートは前記バレルの内面上に一体的に形成されている、態様9又は態様10記載のメディカルデリバリーデバイス。
(態様12)
前記インサートは前記バレルの内面に結合された中実ポリマーチューブを含む、態様9~11のいずれか1項記載のメディカルデリバリーデバイス。
(態様13)
前記インサートは前記バレルの内面に取り付けられた1つ以上のフルオロポリマー膜を含むラミネートを含む、態様9~12のいずれか1項記載のメディカルデリバリーデバイス。
(態様14)
前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、態様1~13のいずれか1項記載のメディカルデリバリーデバイス。
(態様15)
前記少なくとも1つの治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、態様1~14のいずれか1項記載のメディカルデリバリーデバイス。
(態様16)
前記治療薬は第VII因子である、態様1~15のいずれか1項記載のメディカルデリバリーデバイス。
(態様17)
眼疾患の治療に使用される、態様1~16のいずれか1項記載のメディカルデリバリーデバイス。
(態様18)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様1~17のいずれか1項記載のメディカルデリバリーデバイス。
(態様19)
少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有する潤滑剤不含バレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーであって、複数のリブを含み、リブの各対がそれらの間に谷を有するエラストマーストッパーと、
少なくとも1つの谷の内部に配置された少なくとも1つのリング部材と、
を含み、
前記少なくとも1つのリング部材は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、メディカルデリバリーデバイス。
(態様20)
2つ以上の谷は前記少なくとも1つのリング部材を含む、態様19記載のメディカルデリバリーデバイス。
(態様21)
前記バレルの近位端に隣接する前記バレルの内面の一部の上に配置されたコーティング材料をさらに含み、直径が減少した領域を形成して、前記エラストマーストッパーと前記バレルの内面との間に締まりばめを強化する、態様19又は態様20記載のメディカルデリバリーデバイス。
(態様22)
前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、態様19~21のいずれか1項記載のメディカルデリバリーデバイス。
(態様23)
前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、態様19~22のいずれか1項記載のメディカルデリバリーデバイス。
(態様24)
前記治療薬は第VII因子である、態様19~23のいずれか1項記載のメディカルデリバリーデバイス。
(態様25)
眼疾患の治療に使用される、態様19~24のいずれか1項記載のメディカルデリバリーデバイス。
(態様26)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様19~25のいずれか1項記載のメディカルデリバリーデバイス。
(態様27)
少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有するシリコーン不含バレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記ストッパーに取り付けられ、そして前記バレル内でストッパーを遠位に移動させるために前記バレル内に取り付けられたプランジャーロッドと、
前記エラストマーストッパーの少なくとも一部の上に配置されたバリアコーティングであって、酸素バリア材料を含むバリアコーティングと、
を含む、メディカルデリバリーデバイス。
(態様28)
前記バリアコーティングは、前記流体チャンバに曝されていないエラストマーストッパーの部分を包囲している、態様27記載のメディカルデリバリーデバイス。
(態様29)
前記バリアコーティングは前記エラストマーストッパー全体を包囲している、態様27又は態様28記載のメディカルデリバリーデバイス。
(態様30)
前記バリアコーティングは前記プランジャーロッド上に配置されている、態様27~29のいずれか1項記載のメディカルデリバリーデバイス。
(態様31)
前記エラストマーストッパーは延伸ポリテトラフルオロエチレン層又は高密度化延伸ポリテトラフルオロエチレン層で少なくとも部分的に覆われている、態様27~30のいずれか1項記載のメディカルデリバリーデバイス。
(態様32)
前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、態様27~31のいずれか1項記載のメディカルデリバリーデバイス。
(態様33)
前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、態様27~32のいずれか1項記載のメディカルデリバリーデバイス。
(態様34)
前記治療薬は第VII因子である、態様27~33のいずれか1項記載のメディカルデリバリーデバイス。
(態様35)
眼疾患の治療に使用される、態様27~34のいずれか1項記載のメディカルデリバリーデバイス。
(態様36)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様27~35のいずれか1項記載のメディカルデリバリーデバイス。
(態様37)
少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端及び遠位端ならびに内面を有する潤滑剤不含バレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに取り付けられ、前記エラストマーストッパーをバレル内で遠位に移動させるためにシリンジバレル内に取り付けられたプランジャーロッドと、
前記バレルの近位端に隣接するバレルの内面の一部の上に配置されて、直径が減少した領域を形成するコーティング材料であって、前記直径が減少した領域は、前記バレルのコーティングされていない領域の直径よりも小さい直径を有する、コーティング材料と、
第一の面及び第二の面を有し、前記第一の面は前記エラストマーストッパーの前記外面に固定されている、延伸ポリテトラフルオロエチレンフィルムと、
を含み、
前記ストッパーは、前記ストッパーが押し込まれていない状態にある間に、前記コーティング材料内で隣接接触する少なくとも1つのリブを含み、そして、
前記ストッパーが押し込まれた状態にある間に、少なくとも1つのリブは前記内面のコーティングされていない領域と接触している、メディカルデリバリーデバイス。
(態様38)
前記エラストマーストッパーは複数のリブを含み、リブの各対はそれらの間に谷を有する、態様37記載のメディカルデリバリーデバイス。
(態様39)
少なくとも1つの谷の内部に配置された少なくとも1つのリング部材をさらに含み、前記リング部材は酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、態様38記載のメディカルデリバリーデバイス。
(態様40)
前記谷の各々は少なくとも1つの前記リング部材を含む、態様38又は態様39記載のメディカルデリバリーデバイス。
(態様41)
前記流体チャンバに曝されていない前記エラストマーストッパーの部分の上にバリアコーティングをさらに含み、前記バリアコーティングは酸素バリア材料を含む、態様37~40のいずれか1項記載のメディカルデリバリーデバイス。
(態様42)
前記エラストマーストッパー全体をコーティングするバリアをさらに含み、前記バリアコーティングは酸素バリア材料を含む、態様37~41のいずれか1項記載のメディカルデリバリーデバイス。
(態様43)
前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、態様37~42のいずれか1項記載のメディカルデリバリーデバイス。
(態様44)
前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、態様37~43のいずれか1項記載のメディカルデリバリーデバイス。
(態様45)
前記治療薬は第VII因子である、態様37~44のいずれか1項記載のメディカルデリバリーデバイス。
(態様46)
眼疾患の治療に使用される、態様37~45のいずれか1項記載のメディカルデリバリーデバイス。
(態様47)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様37~46のいずれか1項記載のメディカルデリバリーデバイス。
(態様48)
近位端、遠位端及び上に潤滑剤を有する内面を有するバレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに接続されたプランジャーロッドと、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記バレルは少なくともその近位端に配置された直径が減少した領域を有し、前記エラストマーストッパーと前記バレルの内面との間の締まりばめを強化し、そして、
前記エラストマーストッパーは、前記エラストマーストッパーが押し込まれていない状態にある間に、直径が減少した領域内で隣接接触する少なくとも1つのリブを含む、メディカルデリバリーデバイス。
(態様49)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様48記載のメディカルデリバリーデバイス。
(態様50)
近位端、遠位端及び上に潤滑剤を有する内面を有するバレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
少なくとも1つの谷の内部に配置された少なくとも1つのリング部材と、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記エラストマーストッパーは複数のリブを含み、リブの各対はそれらの間に谷を有し、そして、
前記少なくとも1つのリング部材は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、
メディカルデリバリーデバイス。
(態様51)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様50記載のメディカルデリバリーデバイス。
(態様52)
近位端及び遠位端ならびに上に潤滑剤を有する内面を有するバレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに取り付けられ、そして前記エラストマーストッパーを前記バレル内で遠位に移動させるためにシリンジバレル内に取り付けられたプランジャーロッドと、
前記バレルの近位端に隣接する前記バレルの内面の部分の上に配置されて、直径が減少した領域を形成するコーティング材料と、
第一の面及び第二の面を有し、前記第一の面は前記エラストマーストッパーの前記外面に固定されている、延伸ポリテトラフルオロエチレンフィルムと、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記直径が減少した領域は、前記バレルのコーティングされていない領域の直径よりも小さい直径を有し、
前記ストッパーは、前記ストッパーが押し込まれていない状態にある間に、前記コーティング材料内で隣接接触する少なくとも1つのリブを含み、そして、
前記ストッパーが押し込まれた状態にある間に、前記少なくとも1つのリブは前記内面のコーティングされていない領域と接触している、メディカルデリバリーデバイス。
(態様53)
前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、態様52記載のメディカルデリバリーデバイス。
Claims (53)
- 少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有する潤滑剤不含バレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに接続されたプランジャーロッドと、
を含む、メディカルデリバリーデバイスであって、
前記バレルは少なくともその近位端に位置する直径が減少した領域を有し、前記エラストマーストッパーと前記バレルの内面との間の締まりばめを強化し、そして、
前記エラストマーストッパーは、前記エラストマーストッパーが押し込まれていない状態にある間に、直径が減少した領域内で隣接接触する少なくとも1つのリブを含む、メディカルデリバリーデバイス。 - 前記バレルは、直径が減少した領域、バレルの遠位端に配置された、より大きな直径の領域、及び、それらの間に配置された、直径が減少した領域とより大きな直径の領域との間の漸進的な遷移を提供するための遷移セクションを含む、請求項1記載のメディカルデリバリーデバイス。
- 前記エラストマーストッパーが押し込まれていない状態にある間に、2つ以上のリブは、前記直径が減少した領域と隣接接触している、請求項1又は請求項2記載のメディカルデリバリーデバイス。
- 前記バレルの内面の一部の上にコーティング材料が設けられて、前記直径が減少した領域を形成する、請求項1~3のいずれか1項記載のメディカルデリバリーデバイス。
- 前記コーティング材料はフッ素化エチレンプロピレン、延伸フッ素化エチレンプロピレン、エポキシ樹脂及びアクリルからなる群より選ばれる少なくとも1つの部材を含む、請求項4記載のメディカルデリバリーデバイス。
- シリンジが押し込まれていない状態にあるときに、少なくとも1つのリブは前記コーティング材料と接触している、請求項4記載のメディカルデリバリーデバイス。
- 前記コーティング材料は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせをさらに含む、請求項4記載のメディカルデリバリーデバイス。
- 前記エラストマーストッパーは延伸ポリテトラフルオロエチレン膜又は高密度化延伸ポリテトラフルオロエチレン膜で少なくとも部分的に覆われている、請求項1~7のいずれか1項記載のメディカルデリバリーデバイス。
- 少なくとも1つのインサートはバレルの内面と接触して、直径が減少した領域を形成し、前記少なくとも1つのインサートは前記バレル内への酸素の透過を抑制するガスバリアである、請求項1~8のいずれか1項記載のメディカルデリバリーデバイス。
- 前記インサートは接着剤を介して前記バレルの内面に取り付けられている、請求項9記載のメディカルデリバリーデバイス。
- 前記インサートは前記バレルの内面上に一体的に形成されている、請求項9又は請求項10記載のメディカルデリバリーデバイス。
- 前記インサートは前記バレルの内面に結合された中実ポリマーチューブを含む、請求項9~11のいずれか1項記載のメディカルデリバリーデバイス。
- 前記インサートは前記バレルの内面に取り付けられた1つ以上のフルオロポリマー膜を含むラミネートを含む、請求項9~12のいずれか1項記載のメディカルデリバリーデバイス。
- 前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、請求項1~13のいずれか1項記載のメディカルデリバリーデバイス。
- 前記少なくとも1つの治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、請求項1~14のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は第VII因子である、請求項1~15のいずれか1項記載のメディカルデリバリーデバイス。
- 眼疾患の治療に使用される、請求項1~16のいずれか1項記載のメディカルデリバリーデバイス。
- 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項1~17のいずれか1項記載のメディカルデリバリーデバイス。
- 少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有する潤滑剤不含バレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーであって、複数のリブを含み、リブの各対がそれらの間に谷を有するエラストマーストッパーと、
少なくとも1つの谷の内部に配置された少なくとも1つのリング部材と、
を含み、
前記少なくとも1つのリング部材は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、メディカルデリバリーデバイス。 - 2つ以上の谷は前記少なくとも1つのリング部材を含む、請求項19記載のメディカルデリバリーデバイス。
- 前記バレルの近位端に隣接する前記バレルの内面の一部の上に配置されたコーティング材料をさらに含み、直径が減少した領域を形成して、前記エラストマーストッパーと前記バレルの内面との間に締まりばめを強化する、請求項19又は請求項20記載のメディカルデリバリーデバイス。
- 前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、請求項19~21のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、請求項19~22のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は第VII因子である、請求項19~23のいずれか1項記載のメディカルデリバリーデバイス。
- 眼疾患の治療に使用される、請求項19~24のいずれか1項記載のメディカルデリバリーデバイス。
- 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項19~25のいずれか1項記載のメディカルデリバリーデバイス。
- 少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端、遠位端及び内面を有するシリコーン不含バレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記ストッパーに取り付けられ、そして前記バレル内でストッパーを遠位に移動させるために前記バレル内に取り付けられたプランジャーロッドと、
前記エラストマーストッパーの少なくとも一部の上に配置されたバリアコーティングであって、酸素バリア材料を含むバリアコーティングと、
を含む、メディカルデリバリーデバイス。 - 前記バリアコーティングは、前記流体チャンバに曝されていないエラストマーストッパーの部分を包囲している、請求項27記載のメディカルデリバリーデバイス。
- 前記バリアコーティングは前記エラストマーストッパー全体を包囲している、請求項27又は請求項28記載のメディカルデリバリーデバイス。
- 前記バリアコーティングは前記プランジャーロッド上に配置されている、請求項27~29のいずれか1項記載のメディカルデリバリーデバイス。
- 前記エラストマーストッパーは延伸ポリテトラフルオロエチレン層又は高密度化延伸ポリテトラフルオロエチレン層で少なくとも部分的に覆われている、請求項27~30のいずれか1項記載のメディカルデリバリーデバイス。
- 前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、請求項27~31のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、請求項27~32のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は第VII因子である、請求項27~33のいずれか1項記載のメディカルデリバリーデバイス。
- 眼疾患の治療に使用される、請求項27~34のいずれか1項記載のメディカルデリバリーデバイス。
- 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項27~35のいずれか1項記載のメディカルデリバリーデバイス。
- 少なくとも1つの治療薬を収容するための流体チャンバを画定する近位端及び遠位端ならびに内面を有する潤滑剤不含バレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに取り付けられ、前記エラストマーストッパーをバレル内で遠位に移動させるためにシリンジバレル内に取り付けられたプランジャーロッドと、
前記バレルの近位端に隣接するバレルの内面の一部の上に配置されて、直径が減少した領域を形成するコーティング材料であって、前記直径が減少した領域は、前記バレルのコーティングされていない領域の直径よりも小さい直径を有する、コーティング材料と、
第一の面及び第二の面を有し、前記第一の面は前記エラストマーストッパーの前記外面に固定されている、延伸ポリテトラフルオロエチレンフィルムと、
を含み、
前記ストッパーは、前記ストッパーが押し込まれていない状態にある間に、前記コーティング材料内で隣接接触する少なくとも1つのリブを含み、そして、
前記ストッパーが押し込まれた状態にある間に、少なくとも1つのリブは前記内面のコーティングされていない領域と接触している、メディカルデリバリーデバイス。 - 前記エラストマーストッパーは複数のリブを含み、リブの各対はそれらの間に谷を有する、請求項37記載のメディカルデリバリーデバイス。
- 少なくとも1つの谷の内部に配置された少なくとも1つのリング部材をさらに含み、前記リング部材は酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、請求項38記載のメディカルデリバリーデバイス。
- 前記谷の各々は少なくとも1つの前記リング部材を含む、請求項38又は請求項39記載のメディカルデリバリーデバイス。
- 前記流体チャンバに曝されていない前記エラストマーストッパーの部分の上にバリアコーティングをさらに含み、前記バリアコーティングは酸素バリア材料を含む、請求項37~40のいずれか1項記載のメディカルデリバリーデバイス。
- 前記エラストマーストッパー全体をコーティングするバリアをさらに含み、前記バリアコーティングは酸素バリア材料を含む、請求項37~41のいずれか1項記載のメディカルデリバリーデバイス。
- 前記少なくとも1つの治療薬は遺伝子凝固因子、サイトカイン、エピジェネティックタンパク質ファミリー、成長因子、ホルモン、ペプチド、シグナル伝達分子、ワクチン及びそれらの組み合わせからなる群のDNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントから選ばれる、請求項37~42のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は、DNA標的受容体遺伝子又は標的遺伝子のDNAフラグメントの突然変異から選ばれる、請求項37~43のいずれか1項記載のメディカルデリバリーデバイス。
- 前記治療薬は第VII因子である、請求項37~44のいずれか1項記載のメディカルデリバリーデバイス。
- 眼疾患の治療に使用される、請求項37~45のいずれか1項記載のメディカルデリバリーデバイス。
- 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項37~46のいずれか1項記載のメディカルデリバリーデバイス。
- 近位端、遠位端及び上に潤滑剤を有する内面を有するバレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに接続されたプランジャーロッドと、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記バレルは少なくともその近位端に配置された直径が減少した領域を有し、前記エラストマーストッパーと前記バレルの内面との間の締まりばめを強化し、そして、
前記エラストマーストッパーは、前記エラストマーストッパーが押し込まれていない状態にある間に、直径が減少した領域内で隣接接触する少なくとも1つのリブを含む、メディカルデリバリーデバイス。 - 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項48記載のメディカルデリバリーデバイス。
- 近位端、遠位端及び上に潤滑剤を有する内面を有するバレルと、
前記バレルの内面と液密シールを形成する外面を有するエラストマーストッパーと、
少なくとも1つの谷の内部に配置された少なくとも1つのリング部材と、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記エラストマーストッパーは複数のリブを含み、リブの各対はそれらの間に谷を有し、そして、
前記少なくとも1つのリング部材は、酸素吸収材料、酸素吸着材料又はそれらの組み合わせを含む、
メディカルデリバリーデバイス。 - 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項50記載のメディカルデリバリーデバイス。
- 近位端及び遠位端ならびに上に潤滑剤を有する内面を有するバレルと、
前記内面と液密シールを形成する外面を有するエラストマーストッパーと、
前記エラストマーストッパーに取り付けられ、そして前記エラストマーストッパーを前記バレル内で遠位に移動させるためにシリンジバレル内に取り付けられたプランジャーロッドと、
前記バレルの近位端に隣接する前記バレルの内面の部分の上に配置されて、直径が減少した領域を形成するコーティング材料と、
第一の面及び第二の面を有し、前記第一の面は前記エラストマーストッパーの前記外面に固定されている、延伸ポリテトラフルオロエチレンフィルムと、
を含み、
前記バレルは、少なくとも1つの治療薬を収容するための流体チャンバを画定し、
前記直径が減少した領域は、前記バレルのコーティングされていない領域の直径よりも小さい直径を有し、
前記ストッパーは、前記ストッパーが押し込まれていない状態にある間に、前記コーティング材料内で隣接接触する少なくとも1つのリブを含み、そして、
前記ストッパーが押し込まれた状態にある間に、前記少なくとも1つのリブは前記内面のコーティングされていない領域と接触している、メディカルデリバリーデバイス。 - 前記メディカルデリバリーデバイスはシリンジ、自動インジェクタ又はペンである、請求項52記載のメディカルデリバリーデバイス。
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JPH1133114A (ja) * | 1997-07-17 | 1999-02-09 | Terumo Corp | 薬液注入器具 |
EP2500052A1 (en) * | 2011-03-18 | 2012-09-19 | Becton Dickinson France | Container for improved injection |
WO2015033951A1 (ja) * | 2013-09-06 | 2015-03-12 | テルモ株式会社 | シリンジ用外筒及び射出成形用金型 |
JP2016504496A (ja) * | 2012-11-30 | 2016-02-12 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 医療シリンジ、カートリッジ等上でのpecvd堆積の均一性制御 |
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JPH1133114A (ja) * | 1997-07-17 | 1999-02-09 | Terumo Corp | 薬液注入器具 |
EP2500052A1 (en) * | 2011-03-18 | 2012-09-19 | Becton Dickinson France | Container for improved injection |
JP2016504496A (ja) * | 2012-11-30 | 2016-02-12 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 医療シリンジ、カートリッジ等上でのpecvd堆積の均一性制御 |
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