JP2022046689A - Metered-spray aerosol for disinfection, method for spraying metered-spray aerosol for disinfection, and method for improving efficacy of disinfecting/sterilizing component - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a metered-spray aerosol in which the efficacy of a chemical agent is increased and its effect is maintained over a prolonged period, so that the user can feel the effect during its use.

SOLUTION: This metered-spray aerosol for disinfection sprays a fixed amount of an aerosol composition in one spray operation. The aerosol composition comprises a stock solution containing disinfecting/sterilizing component, and a spraying agent. The aerosol composition is charged into a pressure-resistant container. The metered-spray aerosol for disinfection is sprayed by 1.0-3.0 mL per use, and the length of spray time is within 0.8 seconds per use.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to an aerosol for quantitative injection type sterilization, an injection method using the same, and a method for improving the efficacy of a sterilizing / sterilizing component discharged when the aerosol for quantitative injection type sterilization is injected.

A quantitative injection type aerosol is known in which a constant amount of an aerosol composition composed of a stock solution containing a drug as an active ingredient and an injection agent is injected in one injection operation. Since the fixed-quantity injection type aerosol discharges a predetermined amount of chemicals in one injection operation, it is difficult for the user to make a difference in the operation method (difference in the injection button pressing method and the injection amount depending on the pressing time), which is effective. It has the advantage of less variation.

As such a fixed-quantity spray-type aerosol, for example, Patent Document 1 discloses a pest control aerosol provided with a fixed-quantity spraying aerosol valve having a spray capacity of 0.35 to 0.9 mL per spray. There is.

Japanese Patent Application Laid-Open No. 2010-280633

As mentioned above, the quantitative injection type aerosol for use in spaces such as insecticide aerosols and aromatic agent aerosols has the advantage that the effect does not vary much, but if the injection amount per injection is small, the feeling of use is sufficient. It was not possible to obtain it, and even though an effective amount of the drug was discharged by one injection, it was sometimes injected multiple times and excessively consumed. Further, in the conventional fixed-quantity injection type aerosol, there is a limit to the duration of the effect of the drug, and in order to continue this effect, the injection operation must be repeated after a certain period of time has elapsed from the injection, and the frequency is high.
Therefore, an object of the present invention is to provide a quantitative injection type aerosol that improves the efficacy of a drug, enhances the sustainability of the effect, and gives a feeling of use.

As a result of diligent studies, the present inventors have made a quantitative injection type aerosol capable of mass injection of 1.0 mL or more, since the injection amount by one injection operation is large, the discharge amount of the drug is enhanced while enhancing the feeling of use. In addition, in the case of a quantitative injection type aerosol that injects a large amount, the sustainability of the effect of the drug changes depending on the injection time by one injection operation, and the aerosol composition is injected per one injection operation. We have found that there is an optimal balance between the amount and spray time to sustain the effect of the drug.

That is, the present invention is characterized by the following (1) to (7).
(1) A quantitative injection type aerosol for sterilization that injects a fixed amount of an aerosol composition with one injection operation. The aerosol composition comprises a stock solution containing a sterilizing / sterilizing component and a propellant. The quantitative injection type aerosol for sterilization, which is filled in a pressure-resistant container, has a single injection amount of 1.0 to 3.0 mL and a single injection time of 0.8 seconds or less. Aerosol for mold disinfection.
(2) The aerosol for quantitative injection type sterilization according to (1) above, wherein the one-time injection time is 0.20 to 0.75 seconds.
(3) The aerosol for quantitative injection type sterilization according to (1) or (2) above, wherein the undiluted solution further contains a solvent.
(4) The quantitative injection type sterilization according to any one of (1) to (3) above, wherein the content of the sterilizing / sterilizing component is 0.01 to 70% by mass / volume% in the stock solution. For aerosol.
(5) The quantitative injection type removal according to any one of (1) to (4) above, wherein the volume ratio of the undiluted solution to the propellant in the aerosol composition is 1:99 to 50:50. Aerosol for fungi.
(6) Using a quantitative injection type sterilization aerosol in which a pressure-resistant container is filled with an aerosol composition consisting of a stock solution containing a sterilizing / sterilizing component and an injection agent, the injection amount is 1.0 in one injection operation. A method for injecting a fixed-quantity injection-type sterilizing aerosol that injects up to 3.0 mL and an injection time of 0.8 seconds or less.
(7) A method for improving the efficacy of a sterilizing / sterilizing component in an aerosol composition injected using a quantitative injection type sterilizing aerosol, the aerosol composition in the range of 1.0 to 3.0 mL. A method for improving the efficacy of sterilizing and sterilizing components by spraying a certain amount of substances within 0.8 seconds.

According to the aerosol for quantitative injection type sterilization of the present invention, the aerosol composition can be ejected in a large amount in a predetermined amount in the range of 1.0 to 3.0 mL by one injection operation, and further, the aerosol composition. It is possible to enhance the sustainability of the effects of the sterilizing and bactericidal components inside. Therefore, since there is no difference in the operation method depending on the user, there is no variation in the effect, unnecessary overuse can be avoided, and the effect of the drug can be maintained by one injection operation.

FIG. 1 is a plan view for explaining the test room used in Test Example 1. FIG. 2 is a perspective view for explaining the test method of Test Example 2. FIG. 3 is a plan view for explaining the test room used in Test Example 4.

Hereinafter, embodiments of the present invention will be described in more detail.
In addition, in this specification, "mass" is synonymous with "weight".

The quantitative injection type aerosol of the present invention is formed by filling a pressure-resistant container with an aerosol composition containing a stock solution containing a drug and an propellant. Hereinafter, each component will be described.

(Undiluted solution)
The undiluted solution constituting the aerosol composition of the present invention contains at least a drug which is an active ingredient. The active ingredient refers to an aerosol that exerts some action when a quantitative injection type aerosol is used, and is not particularly limited, and examples thereof include a pest control component, an aromatic component, a deodorant component, a sterilization / sterilization component, and the like. ..

The pest control component is a component capable of killing, repelling, knocking down, etc. the target pest. The type of pest control component is not particularly limited, and known compounds can be used.
Examples of the pest control component include pyrethroid compounds such as permethrin, pyrethrin, alesulin, phthalthrin, resmethrin, flamethrin, phenothrin, empentrin, praretrin, ciphenothrin, imiprothrin, transfluthrin, metoflutrin, dimefluthrin, and mepafluthrin; Organic phosphorus compounds such as chlorpyriphosmethyl, diazinone and fenthion; carbamate compounds such as carbalyl and propoxul; compounds such as metoprene, pyriproxyfen, metoxadiazone, fipronil, amidoflumeth and brofuranilide; , Chouji oil, television oil, eucalyptus oil, hiba oil, jasmine oil, neroli oil, peppermint oil, bergamot oil, butygrain oil, lemon oil, lemongrass oil, cinnamon oil, citronella oil, geranium oil, citral, l-menthol, acetic acid Citroneryl, cinnamic aldehyde, terpineol, nonyl alcohol, cis-jasmon, limonene, linalol, 1,8-cineole, geraniol, α-pinene, p-menthan-3,8-diol, eugenol, menthyl acetate, timole, benzoic acid Various essential oil components such as benzyl and benzyl salicylate; propylene glycol monopropyl ether, propylene glycol monobutyl ether, dipropylene glycol monopropyl ether, dipropylene glycol monobutyl ether, dipropylene glycol dimethyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monoisobutyl ether, Glycol ethers such as diethylene glycol dibutyl ether, diethylene glycol dimethyl ether and triethylene glycol dimethyl ether; dibasic acid esters such as dibutyl adipate and the like can be mentioned. These may be used individually by 1 type and may be used in combination of 2 or more type.

The pest control component may be appropriately selected according to the type of the target pest. Target pests include, for example, mosquitoes, flies, moths, bees, clothes moths, cockroaches, ants, spiders, caterpillars, ticks, bookworms, mukade, caterpillars, yasude, spiders, abs, gnats, butterfly flies, termites, midges, chironomids, and chironomids. , Garbage beetle, fly beetle, stain, kamikirimushi, cuttlefish beetle, chatate beetle, case-bearing clothes moth, etc.
Transfluthrin, methfluthrin, profluthrin, phthalthrin, praretrin, monfluorotrin and the like are suitable for flying pests such as mosquitoes, flies, moths, bees, abs, gnats, chironomids, leafhoppers, butterfly flies, clothes moths and clothes moths. .. Also, for cockroaches, bark beetles, ants, spiders, pill bugs, mites, millipedes, centipedes, beetles, millipedes, spiders, termites, bark beetles, beetles, wasps, and spots, phthalthrin, praretrin, imiprothrin, permethrin, etc. Phenothrin and the like are suitable.

The aroma component is a component that emits aroma. Examples of the aromatic component include natural fragrances such as anis oil, lavender oil, rose oil, rosemary oil, and grapefruit oil, in addition to the above-mentioned essential oil components; kanfen, p-simene, citronellol, nerol, benzyl alcohol, n-. Examples thereof include synthetic fragrances such as butyraldehyde, isobutyraldehyde, coumarin and cineole. These may be used individually by 1 type and may be used in combination of 2 or more type.

The deodorant component is a component that can eliminate the odor. Examples of the deodorant component include green tea extract, persimmon tannin, methacrylate lauric acid, methyl benzoate, methyl phenylacetate, geranyl chloride, acetophenone myristate, benzyl acetate, benzyl propionate, and a component that adsorbs odorous components such as silver. Examples thereof include components that mask odorous components such as the above-mentioned aromatic components. These may be used individually by 1 type and may be used in combination of 2 or more type.

The sterilizing / sterilizing component is a component that removes or kills microorganisms, molds, and bacteria. Examples of the sterilizing / bactericidal component include ethanol, hinokithiol, 2-mercaptobenzothiazole, 2- (4-thiazolyl) benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, triphorin, and p-. Examples thereof include chloromethaxylenol, 3-methyl-4-isopropylphenol, ortho-phenylphenol, chlorhexidine gluconate, polylysine and chitosan, tetrahydrolinalol, and dialkyldimethylammonium chloride. These may be used individually by 1 type and may be used in combination of 2 or more type.

The above-mentioned drugs can be used in combination with components having different effects. For example, the pest control component and the fragrance component can be used in combination, or the fragrance component and the deodorant component other than the fragrance component can be used in combination.

The content of the drug is preferably 0.01 to 70% by mass / volume in the undiluted solution. When the amount of the drug in the stock solution is 0.01% by mass / volume or more, a sufficient effect of the drug can be obtained, and when the amount is 70% by mass / volume or less, the production aptitude is improved. The lower limit of the content of the drug is more preferably 0.1% by mass / volume% or more, further preferably 0.3% by mass / volume% or more, particularly preferably 0.5% by mass / volume% or more, and the upper limit is 65% by mass / volume or less is more preferable, 50% by mass / volume% or less is further preferable, and 25% by mass / volume% or less is particularly preferable.

The undiluted solution may contain a solvent for the purpose of adjusting the viscosity of the undiluted solution, improving the production aptitude, increasing the permeability of the drug to pests, and the like. Examples of such a solvent include the above-mentioned glycol ethers, hydrocarbon solvents, alcohol solvents, aromatic solvents, ester solvents and the like. In addition, water and a surfactant can be used.
Examples of the hydrocarbon-based solvent include aliphatic hydrocarbons such as paraffin-based hydrocarbons and naphthen-based hydrocarbons, and alicyclic hydrocarbons, and kerosene such as JIS No. 1 kerosene is preferable. Specific examples thereof include normal paraffin and isoparaffin. Typical examples of normal paraffin have 8 to 16 carbon atoms, and examples thereof include neothiosol manufactured by Chuo Kasei Co., Ltd. and normal paraffin MA manufactured by JXTG Energy Co., Ltd. Typical isoparaffins have 8 to 16 carbon atoms, and examples thereof include IP Clean LX and Supersol FP25 manufactured by Idemitsu Kosan Co., Ltd.
Examples of the alcohol solvent include lower alcohols such as ethanol and propanol (normal, iso), and polyhydric alcohols such as glycerin and ethylene glycol.
Examples of the aromatic solvent include toluene, xylene and the like.
Examples of the ester solvent include isopropyl myristate, hexyl laurate, isopropyl palmitate and the like.

The content of the solvent is preferably 30 to 99.99 mass / volume% in the undiluted solution. When the solvent is 30% by mass / volume% or more in the undiluted solution, the production aptitude can be improved, and when it is 99.99% by mass / volume% or less, a sufficient effect of the drug can be ensured, which is preferable. The lower limit of the solvent content is more preferably 35% by mass / volume% or more, further preferably 50% by mass / volume% or more, and the upper limit is more preferably 99.9% by mass / volume% or less, 99.5% by mass. / Volume% or less is more preferable.

The undiluted solution may contain other components as long as the effects of the present invention are not impaired. Examples of other components include preservatives, pH adjusters, ultraviolet absorbers, inorganic substances, surfactants, solubilizing agents and the like.

The content of the undiluted solution in the aerosol composition can be appropriately changed depending on the purpose of use of the quantitative injection type aerosol and the combination with the propellant, and is not particularly limited. For example, 1 to 50% by volume in the aerosol composition. Can be. When the undiluted solution is 1% by volume or more in the aerosol composition, a sufficient effect of the drug can be obtained, and when it is 50% by volume or less, the undiluted solution can be sprayed as spray particles, so that it can be used indoors, for example. If this is the case, the contamination of furniture, floors, walls, etc. by the undiluted solution can be reduced. In the aerosol composition, the lower limit of the content of the stock solution is more preferably 3% by volume or more, further preferably 5% by volume or more, and the upper limit is more preferably 40% by volume or less, more preferably 30% by volume. The following are more preferred.

(Spray agent)
The propellant is a medium for injecting the undiluted solution, and is pressure-filled in a pressure-resistant container together with the undiluted solution.
Examples of the propellant include liquefied petroleum gas (LPG) such as propane, propylene, n-butane and isobutane, liquefied gas such as dimethyl ether (DME), carbon dioxide gas, nitrogen gas, compressed gas such as compressed air, and HFC-152a. , HFC-134a, HFO-1234yf, HFO-1234ze and the like, and one or more kinds of halogenated carbon gas can be used. The propellant to be used may be appropriately selected according to the compatibility with the undiluted solution and the container member such as the aerosol valve.

The content of the propellant in the aerosol composition can be appropriately changed depending on the purpose of use of the quantitative injection type aerosol and the combination with the undiluted solution, and is not particularly limited. For example, 50 to 99% by volume in the aerosol composition. Can be. When the propellant is 50% by volume or more in the aerosol composition, the undiluted solution can be sprayed as spray particles, so that the drug is more easily diffused and the effect of the drug is more likely to be sustained. Further, when the propellant is 99% by volume or less, a sufficient effect of the drug can be obtained. The lower limit of the content of the propellant in the aerosol composition is more preferably 60% by volume or more, further preferably 70% by volume or more, and the upper limit is more preferably 97% by volume or less, and 95% by volume or less. More preferred.

The volume ratio of the undiluted solution to the propellant in the aerosol composition is preferably 1:99 to 50:50, more preferably 3:97 to 40:60, and even more preferably 5:95 to 30:70. .. With such a volume ratio, a sufficient effect of the drug can be obtained.

(Quantitative injection aerosol)
The quantitative injection type aerosol of the present invention is configured by filling the pressure-resistant container for the aerosol with the above-mentioned undiluted solution and the propellant, and closing the opening of the pressure-resistant container with an aerosol valve.

The fixed-quantity injection type aerosol is an aerosol that injects a fixed amount of the aerosol composition in one injection operation. In the quantitative injection type aerosol, the aerosol composition (stock solution and propellant) in the pressure resistant container passes through the aerosol valve when the injection member (hereinafter, also referred to as an injection button) attached to the aerosol valve is operated by the user. ) Is sprayed, and the undiluted solution is atomized by the propellant and sprayed as spray particles.

(Aerosol valve)
The aerosol valve has an opening / closing member for switching communication and blocking between the inside and outside of the pressure-resistant container by operating the injection member by the user, a housing to which the opening / closing member is attached, and a housing in a predetermined position of the pressure-resistant container. A mounting member for holding is provided. Further, the opening / closing member includes a stem that slides up and down in conjunction with the injection member. The sliding of the stem switches between communication (injection state) and cutoff (non-injection state) of the aerosol composition. The aerosol valve is formed with a housing hole for taking in the aerosol composition from the pressure-resistant container and a stem hole for sending the taken-in aerosol composition to the injection member. The housing is formed with a housing hole for taking in the aerosol composition from the pressure resistant container. The stem is formed with a stem hole for sending the aerosol composition incorporated in the housing to the injection member. The path from the housing hole to the stem hole constitutes an internal passage through which the aerosol composition passes.

In the present invention, the aerosol valve is a quantitative aerosol valve that is quantitatively injected by operating the injection member once. The injection amount of the aerosol valve is set to a predetermined fixed amount in the range of 1.0 to 3.0 mL in one injection operation. By using an aerosol valve having a housing capable of storing an aerosol composition having a predetermined amount in the range of 1.0 to 3.0 mL per injection, 1.0 to 3.0 mL can be obtained by one injection operation. It is possible to inject a predetermined fixed amount in the range of the above, and it is possible to inject a large amount of the drug. The injection amount of the aerosol valve can be appropriately set to a predetermined injection amount as long as it is within the above range.

(Injection member)
The injection member (injection button) is a member attached to the pressure-resistant container via the aerosol valve. The injection button is formed with a passage in the operation unit through which the aerosol composition taken in from the pressure resistant container passes through the stem hole of the aerosol valve and a nozzle into which the aerosol composition is injected.

The inner diameter (injection hole diameter) of the injection port of the injection button is preferably φ0.45 to 3.0 mm, more preferably φ0.5 to 2.0 mm, and φ0. 6 to 1.6 mm is more preferable. Further, there is no problem even if a plurality of nozzles having the same area as these are provided.

(Injection pressure)
In the quantitative injection type aerosol of the present invention, as described above, the pressure-resistant container for aerosol is filled with the stock solution and the propellant, that is, the aerosol composition, and by pressing the injection button, a fixed amount of the aerosol composition is formed by pressing the injection button once. Is sprayed. The injection pressure of the aerosol composition at a position 20 cm away from the injection port is preferably 5 to 40 gf, more preferably 8 to 30 gf. When the injection pressure is in the above range, the injection time can be set in a desired range.
The injection pressure is a digital force gauge (for example, manufactured by Imada Co., Ltd., model number: DS2-2N) that is laid on its side at a distance of 20 cm from the injection port of the quantitative injection type aerosol under room temperature conditions of 25 ° C. It can be measured by calculating the average with the maximum value when the aerosol composition is injected toward the center of a circular flat plate having a diameter of 60 mm attached to the injection load.

(Injection time)
The quantitative injection type aerosol of the present invention has an injection time of 0.8 seconds or less per injection operation. The reason why the effect of the present invention can be obtained is not clear, but by injecting an aerosol composition having a predetermined amount in the range of 1.0 to 3.0 mL per injection within 0.8 seconds. Since the volatility of the drug can be efficiently increased, the efficacy of the drug can be improved, and it is considered that the sustainability of the effect is enhanced.
The injection time for one injection operation is preferably 0.75 seconds or less, more preferably 0.10 to 0.75 seconds, further preferably 0.20 to 0.75 seconds, and 0.25 to 0. .75 seconds is particularly preferred.

In the present invention, as a method of adjusting the injection time by one injection operation, for example, a method of adjusting the size of the injection port of the injection button, a method of adjusting the injection pressure of the quantitative injection type aerosol, and a stem hole diameter of the aerosol valve. A method of adjusting the pressure of the propellant, a method of adjusting the pressure of the propellant, a combination thereof, and the like.

By injecting a fixed amount of the aerosol composition in the range of 1.0 to 3.0 mL within 0.8 seconds using the quantitative injection type aerosol of the present invention, the agent of the injected aerosol composition can be used. The efficacy can be improved, and thus the sustainability of the effect of the drug can be enhanced.

Hereinafter, the present invention will be further described with reference to Examples and Comparative Examples, but the present invention is not limited to the following examples.

<Test Example 1: Insecticidal efficacy confirmation test for Culex pipiens>
1. 1. Preparation of undiluted solution According to the formulation shown in Table 1, transfluthrin was measured, isopropanol (specific gravity 0.785 (20 ° C.)) was added, and the volumetric flask was adjusted to 100 mL to prepare undiluted solutions 1 to 3.

2. 2. Preparation of Quantitative Injection Aerosols According to Table 2, quantitative injection aerosols of Reference Examples 1 to 5 and Comparative Examples 1 to 5 were prepared.

(Reference example 1)
An aerosol pressure can (capacity 294 mL) was filled with 12.8 mL of the undiluted solution 1, and the aerosol pressure can was closed with an aerosol valve (single injection amount 1.0 mL, stem hole area 1.4 mm ² ). Subsequently, 187.2 mL of liquefied petroleum gas (0.49 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 1.0 mL per push and a transfluthrin discharge amount of 16 mg.

(Reference example 2)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and a transfluthrin discharge amount of 16 mg was obtained in the same manner as in Reference Example 1 except that the injection button was changed to one with a nozzle hole diameter of φ0.6 mm. ..

(Comparative Example 1)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and a transfluthrin discharge amount of 16 mg was obtained in the same manner as in Reference Example 1 except that the injection button was changed to one with a nozzle hole diameter of φ0.4 mm. ..

(Reference example 3)
Similar to Reference Example 1 except that the aerosol valve was changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.5 mm ² , the injection amount per push was 1.0 mL, and transfluthrin was discharged. A fixed-quantity injection aerosol having an amount of 16 mg was obtained.

(Reference example 4)
Similar to Reference Example 1 except that the aerosol valve was changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.28 mm ² , the injection amount per push was 1.0 mL, and transfluthrin was discharged. A fixed-quantity injection aerosol having an amount of 16 mg was obtained.

(Comparative Example 2)
Similar to Reference Example 1 except that the aerosol valve was changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.13 mm ² , the injection amount per push was 1.0 mL, and transfluthrin was discharged. A fixed-quantity injection aerosol having an amount of 16 mg was obtained.

(Reference example 5)
An aerosol pressure can (capacity 294 mL) was filled with 12.8 mL of undiluted solution 2, and the aerosol pressure can was closed with an aerosol valve (single injection amount 2.2 mL, stem hole area 1.4 mm ² ). Subsequently, 187.2 mL of liquefied petroleum gas (0.49 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 2.2 mL per push and a transfluthrin discharge amount of 16 mg.

(Comparative Example 3)
A fixed-quantity injection aerosol with an injection amount of 2.2 mL per push and a transfluthrin discharge amount of 16 mg was obtained in the same manner as in Reference Example 5 except that the injection button was changed to one with a nozzle hole diameter of φ0.6 mm. ..

(Comparative Example 4)
The aerosol pressure can (capacity 59 mL) was filled with 3.2 mL of the undiluted solution 3, and the aerosol pressure can was closed with an aerosol valve (single injection amount 0.2 mL, stem hole area 0.4 mm ² ). Subsequently, 16.8 mL of liquefied petroleum gas (0.49 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ0.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 0.2 mL per push and a transfluthrin discharge amount of 16 mg.

(Comparative Example 5)
A fixed-quantity injection aerosol with an injection amount of 0.2 mL per push and a transfluthrin discharge amount of 16 mg was obtained in the same manner as in Comparative Example 4 except that the injection button was changed to one having a nozzle hole diameter of φ0.23 mm. ..

3. 3. Measurement of injection time A laser light diffractive particle size measuring device (“LDSA-1400A” manufactured by Microtrac Bell Co., Ltd.) is installed at a position 5 cm away from the injection port of the quantitative injection type aerosol in a straight line in the injection direction (horizontal direction). Then, the laser beam was made to hit from the direction perpendicular to the injection direction. The injection button was operated once (1 push) to inject, and the moving image was shot. The moving image was played back, and the longest continuous time during which the lighting of the laser beam by the spray particles could be confirmed was measured in 0.01 second units. It should be noted that the interruption of the laser light lighting within 0.05 seconds is judged to be continuous, the measurement is terminated when the laser light is not lit for 0.06 seconds or more, and the final time when the laser light is lit. Was taken as the measurement time. The results are shown in Tables 3 and 4, respectively.

4. Insecticidal efficacy confirmation test for Culex pipiens (confirmation of insecticidal efficacy immediately after injection)
As a test insect, a cage containing 10 Culex pipiens (a 25 cm long x 25 cm wide 16 mesh gauge folded in half and stapled around it to form a cylinder) was prepared.
As shown in FIG. 1, Culex pipiens was placed on the floor (height 0 cm) at the four corners (corners B to E) of the test room 10 in an 8-mat space (volume 31.1 m ³ ) and at a height of 75 cm from the floor. A cage was installed. The injection button of the quantitative injection type aerosol was operated once (1 push) toward the central portion A at an angle of 45 degrees diagonally upward from the height of 1 m from the floor of the corner portion B. The time until the Culex pipiens was knocked down (falled down and could not move) was measured, and the KT50 (minutes) (the time required for 50% of the Culex pipiens to be knocked down) was calculated by the probit method. The test was performed 3 times and the average was calculated. The results are shown in Table 3.

(Confirmation of insecticidal efficacy 3 hours after injection)
As a test insect, a cage containing 10 Culex pipiens (a 25 cm long x 25 cm wide 16 mesh gauge folded in half and stapled around it to form a cylinder) was prepared.
As shown in FIG. 1, a quantitative injection type aerosol is directed toward the central portion A at an angle of 45 degrees diagonally upward from the floor of the corner B of the test chamber 10 in an 8 tatami space (volume 31.1 m ³ ). The injection button of was operated once (1 push). The test chamber 10 was left in a sealed state, and after 3 hours, cages containing Culex pipiens were placed on the floor (height 0 cm) at the four corners (corners B to E) of the test chamber 10 and at a height of 75 cm from the floor. did. The time until the Culex pipiens was knocked down was measured, and KT50 (minutes) was obtained by the probit method. The test was performed 3 times and the average was calculated. The results are shown in Table 4.

As shown in Table 3, immediately after the injection, the average of KT50 was about 3 minutes in all the quantitative injection type aerosols. On the other hand, as shown in Table 4, a difference was observed in the average of KT50 3 hours after the injection. Reference Examples 1 to 4 and Comparative Examples 1 and 2 are examples in which the injection amount per push is 1 mL and the nozzle hole diameter or the stem hole area of the injection button is changed. The average of KT50 was remarkably short, and the average of KT50 was remarkably short in Reference Examples 3 and 4 as compared with Comparative Example 2. Reference Example 5 and Comparative Example 3 are examples in which the injection amount per push is 2.2 mL and the nozzle hole diameter of the injection button is changed, but in Reference Example 5, the average of KT50 is significantly shorter than that of Comparative Example 3. rice field. In Comparative Examples 4 to 5, the injection amount per push is 0.2 mL, but in Comparative Examples 4 and 5, the average of KT50 is about the same even after 3 hours of injection regardless of the injection time. Met. From these results, it was found that the sustainability of the drug changes depending on the injection time in the fixed-quantity injection aerosol capable of mass injection of 1.0 mL or more.

<Test Example 2: Insecticidal efficacy confirmation test against cockroach>
1. 1. Preparation of undiluted solution Weigh 0.5 g of imiprothrin and 10 g of isopropyl myristate, and add No. 1 kerosene (normal paraffin, "neothiozole" manufactured by Chuo Kasei Co., Ltd., carbon number 11 to 15, specific density 0.761 (15 ° C)). The stock solution 4 was prepared by measuring up to 100 mL.

2. 2. Preparation of fixed-quantity injection aerosol According to Table 5, the fixed-quantity injection aerosols of Reference Examples 6 to 9 and Comparative Examples 6 to 7 were prepared.

(Reference example 6)
The aerosol pressure can (capacity 294 mL) was filled with 46 mL of the undiluted solution 4, and the aerosol pressure can was closed with an aerosol valve (single injection amount 1.0 mL, stem hole area 1.4 mm ² ). Subsequently, 154 mL of dimethyl ether (DME) was pressure-filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 1.0 mL per push and an imiprothrin discharge amount of 1.2 mg.

(Reference example 7)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and an imiprothrin discharge amount of 1.2 mg was obtained in the same manner as in Reference Example 6 except that the injection button was changed to one with a nozzle hole diameter of φ0.6 mm. ..

(Comparative Example 6)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and an imiprothrin discharge amount of 1.2 mg was obtained in the same manner as in Reference Example 6 except that the injection button was changed to one with a nozzle hole diameter of φ0.4 mm. ..

(Reference example 8)
The aerosol valve was changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.5 mm ² , but the injection amount per push was 1.0 mL and the imiprothrin discharge amount was the same as in Reference Example 6. A 1.2 mg metered dose aerosol was obtained.

(Reference example 9)
The aerosol valve was changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.28 mm ² , but the injection amount per push was 1.0 mL and the imiprothrin discharge amount was the same as in Reference Example 6. A 1.2 mg metered dose aerosol was obtained.

(Comparative Example 7)
The aerosol valve is the same as in Reference Example 6 except that the aerosol valve is changed to one with a single injection amount of 1.0 mL and a stem hole area of 0.13 mm ² , and the injection amount per push is 1.0 mL and the imiprothrin discharge amount is A 1.2 mg metered dose aerosol was obtained.

3. 3. Measurement of injection time The injection time of the quantitative injection type aerosol was measured by the same method as in Test Example 1. The results are shown in Table 6.

4. Insecticidal efficacy confirmation test against Smokybrown cockroach As shown in FIG. 2, a vinyl chloride cylinder 2 (diameter φ50 cm, height 15 cm) was installed on the floor on which the filter paper 1 was laid, and the inside thereof was used as a test plot. Calcium carbonate was applied to the inner side wall of the cylinder 2 so that the test insects would not crawl up. A position close to the inner side wall of the cylinder 2 on the filter paper 1 in the test plot was marked as a target point 3 for injection.
After releasing one female cockroach 5 as a test insect in the test area and letting it acclimatize for a while, when the cockroach 5 comes to the target point 3, it is aimed at the cockroach 5 from a distance of 50 cm. The injection button of the quantitative injection type aerosol was operated once (1 push). We measured the time it took for the Smokybrown cockroach to knock down (turn over and get stuck). The test was performed 3 times and the average was calculated. The results are shown in Table 6.

Reference Examples 6 to 7 and Comparative Example 6 are examples in which the nozzle hole diameter of the injection button is changed in a quantitative injection type aerosol having an injection amount of 1 mL per push, and Reference Examples 8 to 9 and Comparative Example 7 are stem holes. This is an example of changing the area. From the results in Table 6, Reference Examples 6 and 7 having an injection time of 0.3 seconds and 0.73 seconds have a significantly knockdown time of kurogokiburi as compared with Comparative Example 6 having an injection time of 1.36 seconds. It was found that Reference Examples 8 and 9, which are short and have injection times of 0.58 seconds and 0.73 seconds, have a significantly shorter knockdown time of kurogokiburi than Comparative Example 7 having an injection time of 1.2 seconds. rice field.

<Test Example 3: Insecticidal efficacy confirmation test against houseflies>
1. 1. Preparation of undiluted solution Measure 1.4 g of phthalthrin, add No. 1 kerosene (normal paraffin, "Neothiozole" manufactured by Chuo Kasei Co., Ltd., carbon number 11 to 15, specific density 0.761 (15 ° C)), and increase the volume to 100 mL. To prepare the stock solution 5.

2. 2. Preparation of fixed-quantity injection aerosol According to Table 7, the fixed-quantity injection aerosols of Reference Examples 10 to 11 and Comparative Example 8 were prepared.

(Reference example 10)
An aerosol pressure can (capacity 294 mL) was filled with 40 mL of the undiluted solution 5, and the aerosol pressure can was closed with an aerosol valve (single injection amount 1.0 mL, stem hole area 1.4 mm ² ). Subsequently, 160 mL of liquefied petroleum gas (0.29 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 1.0 mL per push and a phthalthrin discharge amount of 2.8 mg.

(Reference example 11)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and a phthalthrin discharge amount of 2.8 mg was obtained in the same manner as in Reference Example 10 except that the injection button was changed to one with a nozzle hole diameter of φ0.6 mm. ..

(Comparative Example 8)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and a phthalthrin discharge amount of 2.8 mg was obtained in the same manner as in Reference Example 10 except that the injection button was changed to one with a nozzle hole diameter of φ0.4 mm. ..

3. 3. Measurement of injection time The injection time of the quantitative injection type aerosol was measured by the same method as in Test Example 1. The results are shown in Table 8.

4. Insecticidal efficacy confirmation test against houseflies One female housefly was released as a test insect in a test room of 8 tatami mat space (volume 31.1 m ³ ). At the timing when the housefly stopped on the wall, the injection button of the quantitative injection type aerosol was operated once (1 push) toward the housefly from a distance of about 50 cm. The time until the housefly fell and was knocked down was measured. The test was performed 3 times and the average was calculated. The results are shown in Table 8.

From the results in Table 8, Reference Examples 10 and 11 having an injection time of 0.32 seconds and 0.74 seconds have a significantly shorter knockdown time of houseflies than Comparative Example 8 having an injection time of 1.36 seconds. It turned out.

<Test Example 4: Fragrance efficacy confirmation test>
1. 1. Preparation of undiluted solution The undiluted solution 6 was prepared by measuring 0.5 g of linalool, adding absolute ethanol (specific gravity 0.785 (25 ° C.)), and measuring up to 100 mL.

2. 2. Preparation of fixed-quantity injection aerosol According to Table 9, the fixed-quantity injection aerosols of Reference Example 12 and Comparative Example 9 were prepared.

(Reference example 12)
An aerosol pressure can (capacity 294 mL) was filled with 40 mL of the undiluted solution 6, and the aerosol pressure can was closed with an aerosol valve (single injection amount 1.0 mL, stem hole area 1.4 mm ² ). Subsequently, 160 mL of liquefied petroleum gas (0.29 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 1.0 mL per push and a linalool discharge amount of 1.0 mg.

(Comparative Example 9)
A fixed-quantity injection aerosol with an injection amount of 1.0 mL per push and a linalool discharge amount of 1.0 mg was obtained in the same manner as in Reference Example 12, except that the injection button was changed to one with a nozzle hole diameter of φ0.4 mm. rice field.

3. 3. Measurement of injection time The injection time of the quantitative injection type aerosol was measured by the same method as in Test Example 1. The results are shown in Table 10.

4. Aroma sensory test (sensory evaluation 10 seconds after injection)
As shown in FIG. 3, a height of 100 cm from the floor at the center position F of the first wall 21 of the test room 20 in a 6 tatami space (volume 25 m ³ ) faces the first wall 21 almost horizontally to the floor surface. The injection button of the quantitative injection type aerosol was operated once (1 push) toward the third wall 23. After 10 seconds of injection, the central position F of the first wall 21 which is the injection position, the central position G of the second wall 22 orthogonal to the first wall 21, and the third wall facing the first wall 21. Standing at the center position H of 23, the intensity of the scent was evaluated according to the evaluation criteria of the 6-step odor intensity display method. The test was performed three times, and the average value was rounded off to obtain a value in six stages. The results are shown in Table 10.
〔Evaluation criteria〕
0: Odorless (a state in which the owner of a normal sense of smell does not smell)
1: Smell that can be finally detected (detection threshold concentration)
2: Weak odor that tells you what the odor is (cognitive threshold concentration)
3: Easily perceptible odor 4: Strong odor 5: Strong odor

(Sensory evaluation 30 minutes after injection)
After confirming the intensity of the scent 10 seconds after the injection, the test chamber 20 was left in a sealed state, and after 30 minutes, the intensity of the scent when standing at the center positions F to H of each wall was similarly evaluated. The test was performed three times, and the average value was rounded off to obtain a value in six stages. The results are shown in Table 10.

From the results in Table 10, Reference Example 12 having an injection time of 0.31 seconds is superior in scent spread and intensity after 30 minutes as compared with Comparative Example 9 having an injection time of 1.35 seconds, which is 30 minutes. It was found that the scent was excellent in sustainability even after the lapse of time.

<Test Example 5: Sterilization efficacy confirmation test>
1. 1. Preparation of undiluted solution 7 was prepared by measuring 20 g of isopropylmethylphenol (IPMP), adding 99.5% ethanol (specific gravity 0.785 (25 ° C.)), and measuring up to 100 mL.

2. 2. Preparation of quantitative injection type aerosol (Example 1)
An aerosol pressure can (capacity 294 mL) was filled with 60 mL of the undiluted solution 7, and the aerosol pressure can was closed with an aerosol valve (single injection amount 1.0 mL, stem hole area 1.4 mm ² ). Subsequently, 140 mL of liquefied petroleum gas (0.49 MPa (25 ° C.)) was pressurized and filled as a propellant.
An injection button (injection hole diameter φ1.6 mm) was attached to the aerosol valve to obtain a quantitative injection type aerosol with an injection amount of 1.0 mL per push and an IPMP discharge amount of 60 mg.

3. 3. Measurement of injection time The injection time of the quantitative injection type aerosol was measured by the same method as in Test Example 1. The results are shown in Table 11.

4. Efficacy confirmation test In the bathrooms of 10 ordinary households, the bathrooms are cleaned to remove pink slime (mainly caused by Rhodotorula (yeast) or Methylobacterium (bacteria)) and black mold (mainly caused by Cladosporium (fungus)). rice field. After that, two places where pink slime and black mold frequently occur were selected. The injection button of the quantitative injection type aerosol was operated once (1 push) toward one of them, and the treated place was designated as a treatment area. For the other place, the drug was prevented from adhering, and the place was designated as an untreated area. It was confirmed for each household how many days after the bathroom cleaning and sample processing the pink slime or black mold occurred.
The test period was conducted during the period when pink slime and black mold were likely to occur (June-September, Japan).
The results are shown in Table 11.

From the results in Table 11, pink slime or black mold was generated in the untreated group within one week, whereas in the treated group in which the quantitative injection type aerosol of Example 1 was injected, sterilization / prevention was performed for 10 days or more. It was found that a mold effect was obtained.

Although the present invention has been described in detail and with reference to specific embodiments, it will be apparent to those skilled in the art that various changes and modifications can be made without departing from the spirit and scope of the invention. This application is based on a Japanese patent application filed on December 12, 2017 (Japanese Patent Application No. 2017-238160), the contents of which are incorporated herein by reference.

1 Filter paper 2 Cylinder 3 Target point 5 Smokybrown cockroach 10, 20 Test room 21 First wall 22 Second wall 23 Third wall A Central part B to E Corner part F to H Central position

Claims (7)

A quantitative injection type sterilization aerosol that injects a fixed amount of aerosol composition with a single injection operation.
The aerosol composition is composed of a stock solution containing a sterilizing / sterilizing component and a propellant, and is filled in a pressure-resistant container.
The quantitative injection type sterilization aerosol is a quantitative injection type sterilization aerosol in which the amount of one injection is 1.0 to 3.0 mL and the one injection time is within 0.8 seconds. The aerosol for quantitative injection type sterilization according to claim 1, wherein the one-time injection time is 0.20 to 0.75 seconds. The aerosol for quantitative injection type sterilization according to claim 1 or 2, wherein the undiluted solution further contains a solvent. The aerosol for quantitative injection type sterilization according to any one of claims 1 to 3, wherein the content of the sterilizing / sterilizing component is 0.01 to 70% by mass / volume% in the undiluted solution. The aerosol for quantitative injection type sterilization according to any one of claims 1 to 4, wherein the volume ratio of the undiluted solution to the propellant in the aerosol composition is 1:99 to 50:50. Using a quantitative injection type sterilization aerosol in which a pressure-resistant container is filled with an aerosol composition consisting of a stock solution containing a sterilizing / sterilizing component and a spraying agent, the injection amount can be 1.0 to 3. A method for injecting a quantitative injection type sterilizing aerosol that injects 0 mL so that the injection time is within 0.8 seconds. A method for improving the efficacy of sterilizing / sterilizing components in an aerosol composition sprayed using a quantitative injection type sterilizing aerosol.
A method for improving the efficacy of a sterilizing / sterilizing component by injecting a certain amount of the aerosol composition in the range of 1.0 to 3.0 mL within 0.8 seconds.

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