JP2022046121A - Blood uric acid value-reducing agent - Google Patents
Blood uric acid value-reducing agent Download PDFInfo
- Publication number
- JP2022046121A JP2022046121A JP2020152010A JP2020152010A JP2022046121A JP 2022046121 A JP2022046121 A JP 2022046121A JP 2020152010 A JP2020152010 A JP 2020152010A JP 2020152010 A JP2020152010 A JP 2020152010A JP 2022046121 A JP2022046121 A JP 2022046121A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- acid
- oil
- uric acid
- blood uric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title claims abstract description 43
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 229940116269 uric acid Drugs 0.000 title claims abstract description 41
- 239000008280 blood Substances 0.000 title claims abstract description 35
- 210000004369 blood Anatomy 0.000 title claims abstract description 35
- 239000003638 chemical reducing agent Substances 0.000 title abstract 4
- 239000000284 extract Substances 0.000 claims abstract description 172
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Abstract
Description
本発明は、血中尿酸値低下剤に関する。 The present invention relates to a blood uric acid level lowering agent.
近年、高カロリー、高タンパク、高脂質食摂取の急激な増加や、ストレスの増加などにより、高尿酸血症やそれに由来する痛風症状を有する人が増加している。現在、成人男性の約2割が高尿酸血症の状態にあると言われている。 In recent years, the number of people with hyperuricemia and gout symptoms resulting from it is increasing due to a rapid increase in intake of high-calorie, high-protein, high-fat diets and an increase in stress. Currently, it is said that about 20% of adult men are in a state of hyperuricemia.
一般に、血中の尿酸値が7.0mg/dL以上となった状態を高尿酸血症と呼ぶ。通常、単なる高尿酸血症の状態では自覚症状はないが、その状態を長期間放置すると血中の尿酸塩が結晶化し、その尿酸塩が関節などに蓄積した場合は、激しい痛みを伴う痛風発作を引き起こす。さらに症状が進むと、皮下に痛風結節を生じたり、腎臓や尿路に尿酸結晶が蓄積し尿路結石を生じたりしやすくなり、長期にわたると腎不全などの腎疾患に繋がることが知られている。このため、血中の尿酸値を適切にコントロールすることは、痛風をはじめ高尿酸血症の予防、改善の基本である。重症の痛風患者も、血中尿酸値を適正な水準に低下させることにより、痛風発作の減少、慢性化への抑制、腎疾患への予防および改善に効果的であると考えられている(非特許文献1、特許文献1)。
Generally, a state in which the uric acid level in blood is 7.0 mg / dL or more is called hyperuricemia. Normally, there is no subjective symptom in the state of mere hyperuricemia, but if the state is left for a long time, the urate in the blood crystallizes, and if the urate accumulates in the joints, gout attack with severe pain. cause. It is known that as the symptoms progress further, gouty nodules under the skin and uric acid crystals that accumulate in the kidneys and urinary tract tend to cause urinary tract stones, leading to renal diseases such as renal failure over a long period of time. .. Therefore, appropriate control of blood uric acid level is the basis of prevention and improvement of hyperuricemia including gout. Patients with severe gout are also thought to be effective in reducing gout attacks, controlling chronicity, and preventing and ameliorating renal disease by lowering blood uric acid levels to appropriate levels (non-severe).
このような背景の菊の花抽出物及びルテオリンが血中尿酸値を低下させる作用を有することを見出し、本発明を完成させた。
即ち、本発明は、新規な成分の血中尿酸値低下剤を提供することを目的とする。
We have found that the chrysanthemum flower extract and luteolin in such a background have an action of lowering the blood uric acid level, and completed the present invention.
That is, an object of the present invention is to provide a blood uric acid level lowering agent having a novel component.
上記課題を解決するための本発明の特徴は以下の通りである。
(1)菊(学名:Chrysanthemum morifolium)の花(つぼみも含む)及び/またはその抽出物を有効成分とする血中尿酸値低下剤。
(2)ルテオリンを有効成分とする血中尿酸値低下剤。
The features of the present invention for solving the above problems are as follows.
(1) A blood uric acid level lowering agent containing chrysanthemum (scientific name: Chrysanthemum morifolium) flowers (including buds) and / or an extract thereof as an active ingredient.
(2) A blood uric acid level lowering agent containing luteolin as an active ingredient.
以下に本発明を詳細に説明する。
本発明は、菊(学名:Chrysanthemum morifolium)の花(つぼみも含む。以下同じ)及び/またはその抽出物を有効成分とすることを特徴とする。
菊は、キク科キク属の短日性植物である。前記菊は、日本で自生しており、容易に入手可能である。菊の花部は、中国で古くから薬用として利用されており、日本でもお茶やお酒として飲用され、更には食用として料理に利用されており、めまいや頭痛、眼の疲れなどに効果があると言われている。上記菊の花はつぼみを含んでもよい。なお、ここでの「つぼみを含む」とは、つぼみと花とが混じったものと使用しても良いし、つぼみのみ、花のみを用いての良いという意味である。
The present invention will be described in detail below.
The present invention is characterized in that a chrysanthemum (scientific name: Chrysanthemum morifolium) flower (including buds; the same applies hereinafter) and / or an extract thereof is used as an active ingredient.
Chrysanthemum is a short-day plant of the genus Chrysanthemum in the family Asteraceae. The chrysanthemum grows naturally in Japan and is easily available. Chrysanthemum flower part has been used for medicinal purposes in China for a long time, and is also used as tea and alcohol in Japan, and is also used for cooking as food, and is effective for dizziness, headache, eye fatigue, etc. Is said to be. The chrysanthemum flower may contain a bud. In addition, "including buds" here means that a mixture of buds and flowers may be used, or only buds or flowers may be used.
菊の花の抽出物を用いる場合、その抽出方法は特に限定されないが、たとえば、極性溶媒抽出、超臨界抽出等が挙げられる。尚、これらのうちの何れか一方のみを行っても良いし、これらの両方を行っても良い。 When the chrysanthemum flower extract is used, the extraction method is not particularly limited, and examples thereof include polar solvent extraction and supercritical extraction. In addition, only one of these may be performed, or both of them may be performed.
ここで、極性溶媒抽出にて抽出する場合、用いる極性溶媒は特に限定されないが、たとえば、水、メタノール、エタノール、イソプロパノール、アセトン、1,3-ブチレングリコール、エチレングリコール、プロピレングリコール、グリセリン、酢酸、酢酸エチル、エーテル、ヘキサン等が挙げられる。これらのうち、水、メタノール、エタノールが好ましい。特に、含水メタノールや含水エタノール等の含水アルコールを用いることが好ましい。有効成分を効率よく抽出できるからである。尚、これらは1種のみ用いても良いし、2種以上併用しても良い。 Here, in the case of extraction by polar solvent extraction, the polar solvent used is not particularly limited, but for example, water, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, acetic acid, etc. Examples thereof include ethyl acetate, ether, hexane and the like. Of these, water, methanol and ethanol are preferable. In particular, it is preferable to use a hydrous alcohol such as hydrous methanol or hydrous ethanol. This is because the active ingredient can be efficiently extracted. It should be noted that these may be used alone or in combination of two or more.
抽出溶媒として水を使用する場合には、抽出温度20~100℃、好ましくは80~100℃程度で行うとよい。これは、抽出温度が低すぎると、有効成分が抽出されにくいためである。抽出用の水の種類は、特に限定されず、水道水、蒸留水、ミネラル水、アルカリイオン水等を使用することができる。 When water is used as the extraction solvent, the extraction temperature is preferably 20 to 100 ° C, preferably about 80 to 100 ° C. This is because if the extraction temperature is too low, it is difficult to extract the active ingredient. The type of water for extraction is not particularly limited, and tap water, distilled water, mineral water, alkaline ionized water and the like can be used.
抽出溶媒として含水アルコールを使用する場合、アルコール濃度30~90wt%であることが好ましい。30wt%程度よりも少ないか、90wt%を超えると、有効成分の抽出量が低下しやすくなるからである。また、抽出温度は、20~95℃、好ましくは50~95℃程度で行うとよい。なお、含水エタノール抽出は、有効成分の含有率を向上させるため、種々の濃度で繰り返すとよい。 When hydrous alcohol is used as the extraction solvent, the alcohol concentration is preferably 30 to 90 wt%. This is because if it is less than about 30 wt% or more than 90 wt%, the amount of the active ingredient extracted tends to decrease. The extraction temperature is preferably about 20 to 95 ° C, preferably about 50 to 95 ° C. The water-containing ethanol extraction may be repeated at various concentrations in order to improve the content of the active ingredient.
また、極性溶媒にて抽出する場合、その抽出方法は特に限定されず、例えば、連続抽出、浸漬抽出、向流抽出等任意の方法を採用することができ、室温ないし還流加熱下において任意の装置を使用することができる。尚、上記方法にて抽出を行う場合、これらのうちの1つのみを行っても良いし、これらの方法を組み合わせても良い。 Further, when extracting with a polar solvent, the extraction method is not particularly limited, and for example, any method such as continuous extraction, immersion extraction, countercurrent extraction can be adopted, and any device can be used at room temperature or under reflux heating. Can be used. When the extraction is performed by the above method, only one of these methods may be performed, or these methods may be combined.
具体的な方法としては、抽出溶媒を満たした処理槽に抽出原料を投入し、攪拌しながら有効成分を溶出させる。例えば、抽出溶媒として水または含水アルコールを用いる場合には、抽出原料の5~100倍量程度(重量比)の極性溶媒を使用し、30分~5時間程度抽出を行う。溶媒中に有効成分を溶出させた後、ろ過して抽出残渣を除くことによって、抽出液を得る。その後、常法に従って抽出液に希釈、濃縮、乾燥、精製等の処理を施し、菊の花抽出物を得る。さらに必要に応じて、活性炭処理、樹脂吸着処理、イオン交換樹脂、液-液向流分配等の方法により、精製を行ってもよい。 As a specific method, the extraction raw material is put into a treatment tank filled with an extraction solvent, and the active ingredient is eluted while stirring. For example, when water or a hydrous alcohol is used as the extraction solvent, a polar solvent in an amount (weight ratio) of about 5 to 100 times that of the extraction raw material is used, and extraction is performed for about 30 minutes to 5 hours. An extract is obtained by eluting the active ingredient in a solvent and then filtering to remove the extraction residue. Then, the extract is subjected to treatments such as dilution, concentration, drying and purification according to a conventional method to obtain a chrysanthemum flower extract. Further, if necessary, purification may be carried out by a method such as activated carbon treatment, resin adsorption treatment, ion exchange resin, liquid-liquid countercurrent distribution, or the like.
更に、本発明で用いる菊の花抽出物は、ルテオリンを20wt%以上含有することが好ましい。
なお、精製方法としては、例えば、活性炭処理、樹脂吸着処理、イオン交換樹脂、液-液向流分配等の方法が挙げられる。
Further, the chrysanthemum flower extract used in the present invention preferably contains 20 wt% or more of luteolin.
Examples of the purification method include methods such as activated carbon treatment, resin adsorption treatment, ion exchange resin, and liquid-liquid countercurrent distribution.
具体的な精製方法としては、例えば、菊の花から極性溶媒にて抽出した菊の花抽出液を吸着剤にて吸着処理を行った後に溶出溶媒にて吸着成分を溶出させた後、溶媒を除去する方法等が挙げられる。 As a specific purification method, for example, a chrysanthemum flower extract extracted from a chrysanthemum flower with a polar solvent is adsorbed with an adsorbent, the adsorbed component is eluted with an elution solvent, and then the solvent is used. Examples include a method of removing.
吸着処理に用いる吸着剤としては、分岐多糖体、セルロース、珪藻土、活性炭、イオン交換樹脂、アルミナ、シリカゲル等を、単独又は2種類以上を任意に組み合わせて使用することができる。珪藻土、活性炭、イオン交換樹脂、アルミナ、シリカゲル等としては、シリカゲルBW-200、シリカゲルPSQ-60B、サイロピュート81、キョーワード700、キョーワード500、キョーワード200、トミタFA、トミタ-AD700、トミタ-AD600、トミタ-AD800、トミタ-AD400、トミタ-300、キューファイン2000,キューファイン3000、パーライト37、ラジオライトP-5、ラジオライトW-50、協力白鷺、HP2MG、HP20、SP70、SP825、モレクラシーブスなどを用いることができる。 As the adsorbent used for the adsorption treatment, branched polysaccharides, cellulose, diatomaceous earth, activated carbon, ion exchange resin, alumina, silica gel and the like can be used alone or in any combination of two or more. Examples of diatomaceous earth, activated carbon, ion exchange resin, alumina, silica gel, etc. include silica gel BW-200, silica gel PSQ-60B, silopute 81, Kyoward 700, Kyoward 500, Kyoward 200, Tomita FA, Tomita-AD700, Tomita-AD600. , Tomita-AD800, Tomita-AD400, Tomita-300, Cue Fine 2000, Cue Fine 3000, Perlite 37, Radio Light P-5, Radio Light W-50, Cooperative Shirasagi, HP2MG, HP20, SP70, SP825, Morecla Sives, etc. Can be used.
吸着処理は吸着剤を菊の花の抽出液に添加、混合するなどしてルテオリン等の有効成分を吸着させることにより行うことができる。有効成分の分離のための溶出溶媒としてはエタノール、水などの溶媒が挙げられるがこれらに限定されない。更に、この溶出溶媒は1種のみ用いても良いし、2種以上を混合して用いても良い。特に好ましくはエタノール水溶液を使用すると良い。 The adsorption treatment can be performed by adding and mixing an adsorbent to the extract of chrysanthemum flowers to adsorb an active ingredient such as luteolin. Examples of the elution solvent for separating the active ingredient include, but are not limited to, solvents such as ethanol and water. Further, only one kind of this elution solvent may be used, or two or more kinds may be mixed and used. Particularly preferably, an aqueous ethanol solution is used.
溶出後はろ過を行い、ろ液より吸着剤を除去することが好ましい。ろ過後、減圧,濃縮処理などにより溶剤を除去し、本発明に用いる菊の花抽出物を得る。更に乾燥して菊の花抽出物粉末を得ることもできる。
尚、吸着処理の回数は特に限定されず、1回だけ行っても良いし複数回行っても良い。更に複数回行う場合は、上記吸着剤として同じ吸着剤で複数回処理を行っても良いし、異なった吸着剤で複数回処理を行っても良い。異なる溶媒濃度で吸着処理を行った処理物をルテオリン濃度20wt%以上になるように適宜は混合してもよい。
After elution, it is preferable to perform filtration to remove the adsorbent from the filtrate. After filtration, the solvent is removed by decompression, concentration treatment, etc. to obtain the chrysanthemum flower extract used in the present invention. It can also be further dried to obtain chrysanthemum flower extract powder.
The number of times of the adsorption treatment is not particularly limited, and the adsorption treatment may be performed only once or a plurality of times. Further, when the treatment is performed a plurality of times, the same adsorbent may be used for the treatment a plurality of times, or different adsorbents may be used for the treatment a plurality of times. The treated products that have been adsorbed at different solvent concentrations may be appropriately mixed so that the luteolin concentration is 20 wt% or more.
また、本発明は、ルテオリンを有効成分とすることを特徴とする。上記ルテオリンを得る方法は特に限定されず、上記菊の花抽出物から濃縮生成してもよいし、合成品、市販品を使用することもできる。 Further, the present invention is characterized in that luteolin is used as an active ingredient. The method for obtaining the luteolin is not particularly limited, and a concentrated product may be produced from the chrysanthemum flower extract, or a synthetic product or a commercially available product may be used.
本発明は、各種飲食品の素材として使用することができる。飲食品としては、例えば、食用油(サラダ油)、菓子類(ガム、キャンディー、キャラメル、チョコレート、クッキー、スナック、ゼリー、グミ、錠菓等)、麺類(そば、うどん、ラーメン等)、乳製品(ミルク、アイスクリーム、ヨーグルト等)、佃煮類(昆布佃煮、のり佃煮、小魚佃煮等)、調味料(味噌、醤油等)、スープ類、飲料(ジュース、コーヒー、紅茶、茶、炭酸飲料、スポーツ飲料等)をはじめとする一般食品や、健康食品(錠剤、カプセル等)、栄養補助食品(栄養ドリンク等)が挙げられる。これらの飲食品に本発明の血中尿酸値低下剤を適宜配合するとよい。 The present invention can be used as a material for various foods and drinks. Food and beverages include, for example, edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookies, snacks, jelly, gummy, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), dairy products ( Milk, ice cream, yogurt, etc.), boiled noodles (kelp boiled, paste boiled, small fish boiled, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated beverages, sports Examples include general foods such as beverages), health foods (tablets, capsules, etc.), and nutritional supplements (nutrition drinks, etc.). The blood uric acid level lowering agent of the present invention may be appropriately added to these foods and drinks.
これら飲食品には、その種類に応じて種々の成分を配合することができ、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、L-アスコルビン酸、dl-α-トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンB類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤等の食品素材を使用することができる。さらに、健康維持機能をもった本血中尿酸値低下剤には、他の抗酸化物質や健康食品素材などの配剤、(例えば、抗酸化物質、還元型アスコルビン酸(ビタミンC)、ビタミンE、還元型グルタチン、トコトリエノール、ビタミンA誘導体、リコピン、β-クリプトキサンチン、アスタキサンチン、ゼアキサンチン、フコキサンチン、尿酸、ユビキノン、コエンザイムQ10、葉酸、ニンニクエキス、アリシン、セザミン、リグナン類、カテキン、イソフラボン、カルコン、タンニン類、フラボノイド類、クマリン、イソクマリン類、ブルーベリーエキス、アルブチン、タンニン、アントシアニン、リンゴポリフェノール、ブドウ種子エキス、エラジ酸、コウジ酸、サージ抽出物健康食品素材、V.(ビタミン)A、V.B1、V.B2、V.B6、V.B12、V.C、V.D、V.E、V.P、コリン、ナイアシン、パントテン酸、葉酸カルシウム、EPA、オリゴ糖、食物繊維、スクアレン、大豆レシチン、タウリン、ドナリエラ、プロテイン、オクタコサノール、DHA、卵黄レシチン、リノール酸、ラクトフェリン、マグネシウム、亜鉛、クロム、セレン、カリウム、ヘム鉄、カキ肉エキス、キトサン、キチンオリゴ糖、コラーゲン、コンドロイチン、ウコン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、シジミエキス、スッポン、オオバコ、カミツレ、カモミール、セイヨウタンポポ、ハイビスカス、ハチミツ、ボーレン、ローヤルゼリー、ライム、ラベンダー、ローズヒップ、ローズマリー、セージ、ビフィズス菌、フェーカリス菌、ラクリス、小麦胚芽油、ゴマ油、シソ油、大豆油、中鎖脂肪酸、アガリクス、イチョウ葉エキス、ウコン、コンドロイチン、玄米胚芽エキス、レイシ、タマネギ、DHA、 EPA、 DPA、 甜茶、冬虫夏草、ニンニク、蜂の子、パパイヤ、プーアル、プロポリス、メグスリの木、ヤブシタケ、ロイヤルゼリー、ノコギリヤシ、ヒアルロン酸、コラーゲン、ギャバ、ハープシールオイル、サメ軟骨、グルコサミン、レシチン、ホスファチジルセリン、田七ニンジン、桑葉、大豆抽出物、エキナセア、エゾウコギ、大麦抽出物、オリーブ葉、オリーブ実、ギムネマ、バナバ、サラシア、ガルシニア、キトサン、セントジョーンズワート、ナツメ、ニンジン、パッションフラワー、ブロッコリー、プラセンタ、ハトムギ、ブドウ種子、ピーナッツ種皮、ビルベリー、ブラックコホシュ、マリアアザミ、月桂樹、セージ、ローズマリー、ラフマ、黒酢、ゴーヤー、マカ、紅花、亜麻、ウーロン茶、花棘、カフェイン、カプサイシン、キシロオリゴ糖、グルコサミン、ソバ、シトラス、食物繊維、プロテイン、プルーン、スピルリナ、大麦若葉、核酸、酵母、椎茸、梅肉、アミノ酸、深海鮫抽出物、ノニ、カキ肉、スッポン、シャンピニオン、オオバコ、アセロラ、パイナップル、バナナ、モモ、アンズ、メロン、イチゴ、ラズベリー、オレンジ、フコイダン、メシマコブ、クランベリー、コンドロイチン硫酸、亜鉛、鉄、セラミド、シルクペプチド、グリシン、ナイアシン、チェストツリー、セラミド、L-システイン、L-カルニチン、赤ワイン葉、ミレット、ホーステール、ビオチン、センテラアジアティカ、ハスカップ、ピクノジェノール、フキ、ルバーブ、クローブ、ローズマリー、カテキン、プーアル、クエン酸、ビール酵母、メリロート、ブラックジンガー、ショウガ、ガジュツ、ナットウキナーゼ、ベニコウジ、トコトリエノール、ラクトフェリン、シナモン、韃靼ソバ、ココア、ユズ種子エキス、シソの実エキス、ライチ種子エキス、月見草エキス、黒米エキス、α-リポ酸、ギャバ、生コーヒー豆エキス、フキエキス、キウイ種子エキス、温州みかんエキス、アカショウガエキス、アスタキサンチン、クルミエキス、カンカエキス、シロキクラゲ多糖体、フコキサンチン、レスベラトロール、イチゴ種子エキス)なども配合することができる。 Various components can be blended in these foods and drinks according to their types, for example, glucose, fructose, sucrose, maltose, sorbitol, stebioside, corn syrup, lactose, citric acid, tartrate acid, apple acid, and succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbicate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, Arabic gum, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amides, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. Furthermore, the main blood uric acid level lowering agent having a health maintenance function includes distributions such as other antioxidants and health food materials (for example, antioxidants, reduced ascorbic acid (vitamin C), vitamin E, etc. Reduced glutatin, tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, alicin, sezamine, lignans, catechin, isoflavone, calcon, tannin , Flavonoids, coumarin, isocoumarin, blueberry extract, arbutin, tannin, anthocyanin, apple polyphenol, grape seed extract, eladic acid, koji acid, surge extract health food material, V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid, calcium folic acid, EPA, oligosaccharides, dietary fiber, squalene, soybean lecithin, taurine, donariera, protein, octacosanol , DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, hem iron, oyster extract, chitosan, chitin oligosaccharide, collagen, chondroitin, corn, kanzo, kukoshi, keihi, sanzashi, ginger, Reishi, Shijimi extract, Suppon, Obako, Chamomile, Chamomile, Seiyodanpopo, Hibiscus, Honey, Bohlen, Royal jelly, Lime, Lavender, Rosehip, Rosemary, Sage, Bifizus, Faecalis, Lacris, Wheat germ oil, Sesame oil, Perilla oil, soybean oil, medium chain fatty acid, agarix, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, reishi, onion, DHA, EPA, DPA, vitamin tea, winter worm summer grass, garlic, bee cub, papaya, puer, propolis, Megusuri tree, Yabushitake, Royal jelly, Nokogiri palm, Hyaluronic acid, Collagen, GABA, Harpseal oil, Shark cartilage, Glucosamine, Recitin, Phosphatidylserine, Tanana carrot, Mulberry leaf, Soybean extract, Echinacea, Ezokogi, Barley extract , Olive leaf, olive fruit, gymnema, banaba, salasia, garsina, chitosan, St. Jones wort, nuts, carrots, passion flower, broccoli, placenta, honeybee, grape seeds, peanut seed coat, bilberry, Black kohosh, Maria thistle, laurel, sage, rosemary, rafma, black vinegar, bitter gourd, maca, red flower, flax, oolong tea, flower spine, caffeine, capsaicin, xylooligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein, prune , Spirulina, barley young leaves, nucleic acid, yeast, shiitake mushroom, plum meat, amino acid, deep sea shark extract, noni, oyster meat, suppon, champignon, obaco, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange , Fucoidan, Meshimakobu, Cranberry, Chondroitin Sulfate, Zinc, Iron, Ceramide, Silk Peptide, Glycine, Niacin, Chest Tree, Ceramide, L-Cysteine, L-Carnitine, Red Wine Leaf, Millet, Horsetail, Biotin, Centera Asiatica , Hascup, Pycnogenol, Fuki, Rubarb, Clove, Rosemary, Catechin, Poor, Citric acid, Beer yeast, Merilot, Blackzinger, Ginger, Gajutsu, Nattokinase, Benikouji, Tocotrienol, Lactoferrin, Cinnamon, Cucumber buckwheat, Cocoa, Yuzu seed Extract, perilla seed extract, lychee seed extract, evening primrose extract, black rice extract, α-lipoic acid, gaba, raw coffee bean extract, fuki extract, kiwi seed extract, Wenzhou orange extract, red ginger extract, astaxanthin, walnut extract, canca extract, White jellyfish polysaccharide, fucoxanthin, resveratrol, strawberry seed extract) and the like can also be blended.
具体的な製法としては、本発明をそのまま、抽出物の場合は粉末デキストリンとともにスプレードライまたは凍結乾燥し、これを粉末、顆粒、打錠または溶液にすることで容易に食品(インスタント食品等)に含有させることができる。また必要に応じてアラビアガム等のバインダーと混合して粉末状あるいは顆粒状にし、固形食品に添加することも可能である。また、エキスの場合はそのまま、もしくは例えば、水、エタノール、グリセリンあるいはこれらの混合物に分散溶解して、飲料に添加することも可能である。 As a specific manufacturing method, the present invention is used as it is, and in the case of an extract, it is spray-dried or freeze-dried together with powdered dextrin, and this is easily made into food (instant food, etc.) by making it into powder, granules, tableting or solution. Can be contained. It is also possible to mix it with a binder such as gum arabic to make it into powder or granules, and add it to solid foods, if necessary. Further, in the case of an extract, it can be added as it is or, for example, dispersed and dissolved in water, ethanol, glycerin or a mixture thereof and added to a beverage.
本発明は、薬品(医薬品および医薬部外品を含む。)の素材として用いてもよい。薬品製剤用の原料に、本発明を適宜配合して製造することができる。尚、上記薬品は、ヒトに用いても良いし、ヒト以外の哺乳類動物に用いても良い。本発明の血中尿酸値低下剤に配合しうる製剤原料としては、例えば、賦形剤(ブドウ糖、乳糖、白糖、塩化ナトリウム、デンプン、炭酸カルシウム、カオリン、結晶セルロース、カカオ脂、硬化植物油、カオリン、タルク等)、結合剤(蒸留水、生理食塩水、エタノール水、単シロップ、ブドウ糖液、デンプン液、ゼラチン溶液、カルボキシメチルセルロース、リン酸カリウム、ポリビニルピロリドン等)、崩壊剤(アルギン酸ナトリウム、カンテン、炭酸水素ナトリウム、炭酸カルシウム、ラウリル硫酸ナトリウム、ステアリン酸モノグリセリド、デンプン、乳糖、アラビアゴム末、ゼラチン、エタノール等)、崩壊抑制剤(白糖、ステアリン、カカオ脂、水素添加油等)、吸収促進剤(第四級アンモニウム塩基、ラウリル硫酸ナトリウム等)、吸着剤(グリセリン、デンプン、乳糖、カオリン、ベントナイト、硅酸等)、滑沢剤(精製タルク、ステアリン酸塩、ポリエチレングリコール等)などが挙げられる。 The present invention may be used as a material for pharmaceuticals (including pharmaceuticals and quasi-drugs). The present invention can be appropriately blended with a raw material for a pharmaceutical preparation to produce the product. The above chemicals may be used for humans or mammals other than humans. Examples of the preparation raw material that can be blended in the blood uric acid level lowering agent of the present invention include excipients (dextrose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cacao butter, hardened vegetable oil, kaolin). , Tarku, etc.), binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, canten, etc.) Sodium hydrogen carbonate, calcium carbonate, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitor (white sugar, stear, cacao butter, hydrogenated oil, etc.), absorption enhancer ( Examples include quaternary ammonium bases (sodium lauryl sulfate, etc.), excipients (glycerin, starch, lactose, kaolin, bentonite, silica acid, etc.), lubricants (purified talc, stearate, polyethylene glycol, etc.).
本発明の投与方法は、一般的には、錠剤、丸剤、軟・硬カプセル剤、細粒剤、散剤、顆粒剤等の形態で経口投与することができる。また、水溶性製剤は、液剤として経口的に投与することができる。さらに非経口投与であってもよい。非経口剤として投与する場合は、本発明の血中尿酸値低下剤をエタノールや水など適当な可溶化剤に分散させた後、パップ剤、ローション剤、軟膏剤、チンキ剤、クリーム剤などの剤形で適用することができる。また本血中尿酸値低下剤の水溶性製剤は、そのままで、あるいは分散剤、懸濁剤、安定剤などを添加した状態で、パップ剤、ローション剤、軟膏剤、チンキ剤、クリーム剤などの剤形で適用することができる。 The administration method of the present invention can generally be orally administered in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules and the like. In addition, the water-soluble preparation can be orally administered as a liquid preparation. Further, it may be administered parenterally. When administered as a parenteral agent, the blood uric acid level lowering agent of the present invention is dispersed in an appropriate solubilizer such as ethanol or water, and then a poultice, lotion, ointment, tincture, cream, etc. It can be applied in dosage form. In addition, the water-soluble preparation of this blood uric acid level lowering agent can be used as a poultice, lotion, ointment, tincture, cream, etc. as it is or with a dispersant, suspension, stabilizer, etc. added. It can be applied in dosage form.
投与量は、投与方法、病状、患者の年齢等によって変化し得るが、大人では、通常、1日当たり有効成分として5~200mg、子供では通常0.5~100mg程度投与することができる。 The dose may vary depending on the administration method, medical condition, age of the patient, etc., but for adults, usually 5 to 200 mg of the active ingredient per day can be administered, and for children, usually about 0.5 to 100 mg can be administered.
本発明を薬品として使用する際の配合比は、剤型によって適宜変更することが可能であるが、通常、経口または粘膜吸収により投与される場合は約0.0001~30wt%、非経口投与による場合は、0.0001~30wt%程度にするとよい。
なお、投与量は種々の条件で異なるので、前記投与量より少ない量で十分な場合もあるし、また、範囲を超えて投与する必要のある場合もある。医薬組成物は、前記血中尿酸値低下剤以外に、医薬分野において常用される既知の他の化合物、および経口投与に適した形態に成型するのに必要な化合物を包含していてもよい。そのような化合物としては、例えば、乳糖、デンプン、ヒドロキシプロピルセルロース、カオリン、タルク、炭酸カルシウムなどが挙げられる。
The compounding ratio when the present invention is used as a drug can be appropriately changed depending on the dosage form, but usually about 0.0001 to 30 wt% when administered orally or by mucosal absorption, by parenteral administration. In that case, it is preferable to set it to about 0.0001 to 30 wt%.
Since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range. In addition to the blood uric acid level lowering agent, the pharmaceutical composition may contain other known compounds commonly used in the pharmaceutical field and compounds necessary for molding into a form suitable for oral administration. Examples of such compounds include lactose, starch, hydroxypropyl cellulose, kaolin, talc, calcium carbonate and the like.
本発明は、皮膚外用剤(化粧品、医薬品および医薬部外品を含む。)として用いても、血中尿酸値低下作用を期待することができる。尚、上記皮膚外用剤は人間に用いても良いし、人間以外の哺乳類動物に用いても良い。
本発明の血中尿酸値低下剤を配合しうる皮膚外用剤の形態としては、例えば、乳液、石鹸、洗顔料、入浴剤、クリーム、乳液、化粧水、オーデコロン、ひげ剃り用クリーム、ひげ剃り用ローション、化粧油、日焼け・日焼け止めローション、おしろいパウダー、ファンデーション、香水、パック、爪クリーム、エナメル、エナメル除去液、眉墨、ほお紅、アイクリーム、アイシャドー、マスカラ、アイライナー、口紅、リップクリーム、シャンプー、リンス、染毛料、分散液、洗浄料等が挙げられる。
また、本発明血中尿酸値低下剤を配合しうる医薬品または医薬部外品の形態としては、軟膏剤、クリーム剤、外用液剤等が挙げられる。
The present invention can be expected to have an effect of lowering blood uric acid level even when used as a skin external preparation (including cosmetics, pharmaceuticals and quasi-drugs). The above-mentioned external skin preparation may be used for humans or for mammals other than humans.
Examples of the form of the external skin preparation containing the blood uric acid level lowering agent of the present invention include milky lotion, soap, face wash, bathing agent, cream, milky lotion, lotion, odecolon, shaving cream, and shaving. Lotion, cosmetic oil, sunscreen / sunscreen lotion, white powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blush, eye cream, eye shadow, mascara, eyeliner, lipstick, lip cream, shampoo , Rinsing, hair dye, dispersion, cleaning agent and the like.
In addition, examples of the pharmaceutical products or quasi-drugs to which the blood uric acid level lowering agent of the present invention can be added include ointments, creams, and external liquids.
上記形態の皮膚外用剤には、本発明による血中尿酸値低下剤の他に、その血中尿酸値低下作用を損なわない範囲で化粧品、医薬部外品などの皮膚外用剤に配合される成分、油分、高級アルコール、脂肪酸、紫外線吸収剤、粉体、顔料、界面活性剤、多価アルコール・糖、高分子、生理活性成分、溶媒、酸化防止剤、香料、防腐剤等を配合することができる。
例を以下に羅列するが、本発明はこれらの例に限定されるものではない。
In addition to the blood uric acid level lowering agent according to the present invention, the above-mentioned form of the skin external preparation is a component to be added to skin external preparations such as cosmetics and quasi-drugs as long as the blood uric acid level lowering effect is not impaired. , Oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. can.
Examples are listed below, but the invention is not limited to these examples.
(1)油分の例
エステル系の油相成分:トリ2-エチルヘキサン酸グリセリル、2-エチルヘキサン酸セチル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、パルミチン酸オクチル、イソステアリン酸イソセチル、ステアリン酸ブチル、ミリスチン酸ブチル、リノール酸エチル、リノール酸イソプロピル、オレイン酸エチル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソステアリル、ミリスチン酸オクチルドデシル、イソステアリン酸イソセチル、セバシン酸ジエチル、アジピン酸ジイソプロピル、ネオペンタン酸イソアラキル、トリ(カプリル・カプリン酸)グリセリル、トリ2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2-エチルヘキサン酸ペンタエリスリトール、カプリル酸セチル、ラウリン酸デシル、ラウリン酸ヘキシル、ミリスチン酸デシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、リシノレイン酸セチル、ラウリン酸イソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸オクチル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、リノール酸オクチルドデシル、イソステアリン酸イソプロピル、2-エチルヘキサン酸セトステアリル、2-エチルヘキサン酸ステアリル、イソステアリン酸ヘキシル、ジオクタン酸エチレングリコール、ジオレイン酸エチレングリコール、ジカプリン酸プロピレングリコール、ジ(カプリル・カプリン酸)プロピレングリコール、ジカプリル酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸ネオペンチルグリコール、トリカプリル酸グリセリル、トリウンデシル酸グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸グリセリル、ネオペンタン酸オクチルドデシル、オクタン酸イソステアリル、イソノナン酸オクチル、ネオデカン酸ヘキシルデシル、ネオデカン酸オクチルドデシル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸オクチルデシル、ポリグリセリンオレイン酸エステル、ポリグリセリンイソステアリン酸エステル、炭酸ジプロピル、炭酸ジアルキル(C12-18)、クエン酸トリイソセチル、クエン酸トリイソアラキル、クエン酸トリイソオクチル、乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸オクチルデシル、クエン酸トリエチル、クエン酸アセチルトリエチル、クエン酸アセチルトリブチル、クエン酸トリオクチル、リンゴ酸ジイソステアリル、ヒドロキシステアリン酸2-エチルヘキシル、コハク酸ジ2-エチルヘキシル、アジピン酸ジイソブチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、ステアリン酸コレステリル、イソステアリン酸コレステリル、ヒドロキシステアリン酸コレステリル、オレイン酸コレステリル、オレイン酸ジヒドロコレステリル、イソステアリン酸フィトステリル、オレイン酸フィトステリル、12-ステアロイルヒドロキシステアリン酸イソセチル、12-ステアロイルヒドロキシステアリン酸ステアリル、12-ステアロイルヒドロキシステアリン酸イソステアリル等が挙げられる。
炭化水素系の油相成分:スクワラン、流動パラフィン、α-オレフィンオリゴマー、イソパラフィン、セレシン、パラフィン、流動イソパラフィン、ポリブテン、マイクロクリスタリンワックス、ワセリン等が挙げられる。
動植物油とその硬化油、および天然由来のロウ:牛脂、硬化牛脂、豚脂、硬化豚脂、馬油、硬化馬油、ミンク油、オレンジラフィー油、魚油、硬化魚油、卵黄油等の動物油およびその硬化油、アボカド油、アルモンド油、オリーブ油、カカオ脂、キウイ種子油、杏仁油、ククイナッツ油、ゴマ油、小麦胚芽油、コメ胚芽油、コメヌカ油、サフラワー油、シアバター、大豆油、月見草油、シソ油、茶実油、ツバキ油、トウモロコシ油、ナタネ油、硬化ナタネ油、パーム核油、硬化パーム核油、パーム油、硬化パーム油、ピーナッツ油、硬化ピーナッツ油、ヒマシ油、硬化ヒマシ油、ヒマワリ油、ブドウ種子油、ホホバ油、硬化ホホバ油、マカデミアナッツ油、メドホーム油、綿実油、硬化綿実油、ヤシ油、硬化ヤシ油等の植物油およびその硬化油、ミツロウ、高酸価ミツロウ、ラノリン、還元ラノリン、硬化ラノリン、液状ラノリン、カルナバロウ、モンタンロウ等のロウ等が挙げられる。
シリコーン系の油相成分:ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルシクロポリシロキサン、オクタメチルポリシロキサン、デカメチルポリシロキサン、ドデカメチルシクロシロキサン、メチルハイドロジェンポリシロキサン、ポリエーテル変性オルガノポリシロキサン、ジメチルシロキサン・メチルセチルオキシシロキサン共重合体、ジメチルシロキサン・メチルステアロキシシロキサン共重合体、アルキル変性オルガノポリシロキサン、末端変性オルガノポリシロキサン、アミノ変性シリコーン油、アミノ変性オルガノポリシロキサン、ジメチコノール、シリコーンゲル、アクリルシリコーン、トリメチルシロキシケイ酸、シリコーンRTVゴム等が挙げられる。
フッ素系の油相成分:パーフルオロポリエーテル、フッ素変性オルガノポリシロキサン、フッ化ピッチ、フルオロカーボン、フルオロアルコール、フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン等が挙げられる。
(1) Examples of oil content Ester-based oil phase components: glyceryl tri2-ethylhexanate, cetyl 2-ethylhexanate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linate, isopropyl linoleate, ethyl oleate, isosetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isosetyl isostearate, diethyl sevacinate, adipine Diisopropyl acid, isoaraquil neopentanoate, glyceryl tri (capril capric acid), trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra2-ethylhexanoate, cetyl caprylate, decyl laurate, Hexyl laurate, decyl myristate, myristyl myristyl, cetyl myristate, stearyl stearate, decyl oleate, cetyl lysinoreate, isostearyl laurate, isotorideyl myristate, isosetyl myristate, isosteyl myristate, isosetyl palmitate, Isostearyl palmitate, octyl stearate, isosetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexarate, hexyl isostearate, Ethylene glycol dioctarate, ethylene glycol diolaneate, propylene glycol dicaprate, propylene glycol di (capril capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctarate, glyceryl tricaprylate, glyceryl triundecyl, Glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentaate, isostearyl octanoate, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isosetyl isostearate, isostearyl isostearate, octyldecyl isostearate, poly Glycerin oleic acid ester, polyglycerin isostearic acid ester, charcoal Dipropyl acid, dialkyl carbonate (C12-18), triisocetyl citrate, triisoaraquil citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyltriethyl citrate, citrate Acetyltributyl acid, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sevacinate, cholesteryl stearate, cholesteryl isostearite, hydroxysteer Examples thereof include cholesteryl acid, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, isocetyl 12-stearoyl hydroxystearate, stearyl 12-stearoyl hydroxystearate, and isostearyl 12-stearoyl hydroxystearate.
Hydrocarbon-based oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like can be mentioned.
Animal and vegetable oils and their hardened oils, and naturally occurring waxes: beef oils, hardened beef fats, pork fats, hardened pork fats, horse oils, hardened horse oils, mink oils, orange raffy oils, fish oils, hardened fish oils, egg yolk oils and other animal oils. Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, brown seed oil, camellia oil, corn oil, rapeseed oil, hardened rapeseed oil, palm kernel oil, hardened palm kernel oil, palm oil, hardened palm oil, peanut oil, hardened peanut oil, castor oil, hardened castor oil , Sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, palm oil, hardened palm oil and other vegetable oils and their hardened oils, beeswax, high acidity beeswax, lanolin, reduction. Examples thereof include waxes such as lanorin, hardened lanorin, liquid lanorin, carnauba wax and montan wax.
Silicone-based oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstealoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples thereof include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine-based oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluoride pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like can be mentioned.
(2)高級アルコールの例
ラウリルアルコール、ミリスチルアルコール、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、ベヘニルアルコール、2-エチルヘキサノール、ヘキサデシルアルコール、オクチルドデカノール等が挙げられる。
(2) Examples of higher alcohols Examples of higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like.
(3)脂肪酸の例
カプリル酸、カプリン酸、ウンデシレン酸、ラウリン酸、ミリスチン酸、パルミチン酸、パルミトレイン酸、ステアリン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸、アラキン酸、アラキドン酸、ベヘン酸、エルカ酸、2-エチルヘキサン酸等が挙げられる。
(3) Examples of fatty acids Caprylic acid, capric acid, undecylic acid, lauric acid, myristic acid, palmitoleic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, araquinic acid, arachidonic acid, behenic acid , Elcaic acid, 2-ethylhexanoic acid and the like.
(4)紫外線吸収剤の例
パラアミノ安息香酸、パラアミノ安息香酸アミル、パラアミノ安息香酸エチルジヒドロキシプロピル、パラアミノ安息香酸グリセリル、パラアミノ安息香酸エチル、パラアミノ安息香酸オクチル、パラアミノ安息香酸オクチルジメチル、サリチル酸エチレングリコール、サリチル酸オクチル、サリチル酸トリエタノールアミン、サリチル酸フェニル、サリチル酸ブチルフェニル、サリチル酸ベンジル、サリチル酸ホモメンチル、ケイ皮酸ベンジル、パラメトキシケイ皮酸オクチル、パラメトキシケイ皮酸2-エチルヘキシル、ジパラメトキシケイ皮酸モノ2-エチルヘキサン酸グリセリル、パラメトキシケイ皮酸イソプロピル、パラメトキシヒドロケイ皮酸ジエタノールアミン塩、ジイソプロピル・ジイソプロピルケイ皮酸エステル混合物、ウロカニン酸、ウロカニン酸エチル、ヒドロキシメトキシベンゾフェノン、ヒドロキシメトキシベンゾフェノンスルホン酸及びその塩、ジヒドロキシメトキシベンゾフェノン、ジヒドロキシメトキシベンゾフェノンジスルホン酸ナトリウム、ジヒドロキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン、ヒドロキシオクトキシベンゾフェノン、テトラヒドロキシベンゾフェノン、ブチルメトキシジベンゾイルメタン、2、4、6-トリアニリノ-p-(カルボ-2-エチルヘキシル-1-オキシ)-1、3、5-トリアジン、2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール、メチル-O-アミノベンゾエート、2-エチルヘキシル-2-シアノ-3、3-ジフェニルアクリレート、フェニルベンゾイミダゾール硫酸、3-(4-メチルベンジリデン)カンフル、イソプロピルジベンゾイルメタン、4-(3、4-ジメトキシフェニルメチレン)-2、5-ジオキソ-1-イミダゾリジンプロピオン酸2-エチルヘキシル等、およびこれらの高分子誘導体やシラン誘導体等が挙げられる。
(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octylparaaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylate Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomentyl salicylate, benzyl silicate, octyl paramethoxycinerate, 2-ethylhexyl paramethoxycinerate, mono 2-ethylhexyl diparamethoxycinerate Glyceryl ethylhexanate, isopropyl paramethoxycinerate, diethanolamine paramethoxyhydrosilicate diethanolamine salt, diisopropyl diisopropyl silicate ester mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, Dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-) 1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, Phenylbenzoimidazole sulfate, 3- (4-methylbenziliden) camphor, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, etc., and Examples thereof include these polymer derivatives and silane derivatives.
(5)粉体・顔料の例
赤色104号、赤色201号、黄色4号、青色1号、黒色401号等の色素、黄色4号ALレーキ、黄色203号BAレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、ウレタンパウダー、テフロン(登録商標)パウダー、シリコーンパウダー、ポリメタクリル酸メチルパウダー、セルロースパウダー、デンプン、シリコーンエラストマー球状粉体、ポリエチレン末等の高分子、黄酸化鉄、赤色酸化鉄、黒酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン、酸化セリウム等の白色顔料、タルク、マイカ、セリサイト、カオリン、板状硫酸バリウム等の体質顔料、雲母チタン等のパール顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸アルミニウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ステアリン酸アルミニウム、ステアリン酸マグネシウム、パルミチン酸亜鉛、ミリスチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛等の金属セッケン、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状(球状、棒状、針状、板状、不定形状、燐片状、紡錘状等)および粒子径に特に制限はない。なおこれらの粉体は、従来公知の表面処理、例えばフッ素化合物処理、シリコーン処理、シリコーン樹脂処理、ペンダント処理、シランカップリング剤処理、チタンカップリング剤処理、油剤処理、N-アシル化リジン処理、ポリアクリル酸処理、金属セッケン処理、アミノ酸処理、レシチン処理、無機化合物処理、プラズマ処理、メカノケミカル処理等によって事前に表面処理されていてもいなくても構わない。
(5) Examples of powders and pigments Red No. 104, Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, etc., Yellow No. 4 AL Lake, Yellow No. 203 BA Lake, etc., Nylon powder , Silk powder, Urethane powder, Teflon (registered trademark) powder, Silicone powder, Polymethylmethacrylate powder, Cellulose powder, Steel, Silicone elastomer spherical powder, Polymers such as polyethylene powder, Yellow iron oxide, Red iron oxide, Black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine blue and dark blue, white pigments such as zinc oxide, titanium oxide and cerium oxide, constitutional pigments such as talc, mica, sericite, kaolin and barium plate sulfate, mica titanium Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, inorganic powders such as silica and alumina, aluminum stearate, magnesium stearate, zinc palmitate, zinc myristine, myristin. Examples thereof include metal powders such as magnesium acid, zinc laurate, zinc undesylene and the like, bentonite, smectite, boron nitride and the like. There are no particular restrictions on the shape (spherical, rod-shaped, needle-shaped, plate-shaped, indefinite-shaped, flaky, spindle-shaped, etc.) and particle size of these powders. These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, and the like. It may or may not be surface-treated in advance by polyacrylic acid treatment, metal silane treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.
(6)界面活性剤の例
アニオン性界面活性剤:脂肪酸セッケン、α-アシルスルホン酸塩、アルキルスルホン酸塩、アルキルアリルスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキル硫酸塩、POEアルキルエーテル硫酸塩、アルキルアミド硫酸塩、アルキルリン酸塩、POEアルキルリン酸塩、アルキルアミドリン酸塩、アルキロイルアルキルタウリン塩、N-アシルアミノ酸塩、POEアルキルエーテルカルボン酸塩、アルキルスルホコハク酸塩、アルキルスルホ酢酸ナトリウム、アシル化加水分解コラーゲンペプチド塩、パーフルオロアルキルリン酸エステル等が挙げられる。
カチオン性界面活性剤:塩化アルキルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、塩化セトステアリルトリメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、臭化ベヘニルトリメチルアンモニウム、塩化ベンザルコニウム、塩化ベヘニン酸アミドプロピルジメチルヒドロキシプロピルアンモニウム、ステアリン酸ジエチルアミノエチルアミド、ステアリン酸ジメチルアミノプロピルアミド、ラノリン誘導体第四級アンモニウム塩等が挙げられる。
両性界面活性剤:カルボキシベタイン型、アミドベタイン型、スルホベタイン型、ヒドロキシスルホベタイン型、アミドスルホベタイン型、ホスホベタイン型、アミノカルボン酸塩型、イミダゾリン誘導体型、アミドアミン型等が挙げられる。
ノニオン性界面活性剤:プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、POEソルビタン脂肪酸エステル、POEソルビット脂肪酸エステル、POEグリセリン脂肪酸エステル、POEアルキルエーテル、POE脂肪酸エステル、POE硬化ヒマシ油、POEヒマシ油、POE・POP共重合体、POE・POPアルキルエーテル、ポリエーテル変性シリコーンラウリン酸アルカノールアミド、アルキルアミンオキシド、水素添加大豆リン脂質等が挙げられる。
天然系界面活性剤:レシチン、サポニン、糖系界面活性剤等が挙げられる。
(6) Examples of surfactants Anionic surfactants: fatty acid salts, α-acyl sulfonates, alkyl sulfonates, alkylallyl sulfonates, alkylnaphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates , Alkylamide Sulfate, Alkyl Phosphate, POE Alkylphosphate, Alkylamide Phosphate, Alkyylalkyl Taurine Salt, N-Acyl Amino Acid Salt, POE Alkyl Aether carboxylate, Alkyl Sulfonuccinate, Alkyl Sulfo Acetate Examples thereof include sodium, an acylated hydrolyzed collagen peptide salt, and a perfluoroalkyl phosphate ester.
Cationic surfactants: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, disstearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalconium chloride , Behenic chloride amidopropyldimethylhydroxypropylammonium, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salt of lanolin derivative and the like.
Amphoteric tensides: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like can be mentioned.
Nonionic surfactants: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured sunflower Examples thereof include oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid and the like.
Natural surfactants: lecithin, saponin, sugar-based surfactants and the like can be mentioned.
(7)多価アルコール、糖の例
エチレングリコール、ジエチレングリコール、ポリエチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン、ジグリセリン、ポリグリセリン、3-メチル-1、3-ブタンジオール、1、3-ブチレングリコール、ソルビトール、マンニトール、ラフィノース、エリスリトール、グルコース、ショ糖、果糖、キシリトール、ラクトース、マルトース、マルチトール、トレハロース、アルキル化トレハロース、混合異性化糖、硫酸化トレハロース、プルラン等が挙げられる。またこれらの化学修飾体等も使用可能である。
(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, martitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, purulan and the like. Further, these chemically modified products and the like can also be used.
(8)高分子の例
アクリル酸エステル/メタクリル酸エステル共重合体(プラスサイズ、互応化学社製)、酢酸ビニル/クロトン酸共重合体(レジン28-1310、NSC社製)、酢酸ビニル/クロトン酸/ビニルネオデカネート共重合体(28-2930、NSC社製)、メチルビニルエーテルマレイン酸ハーフエステル(ガントレッツES、ISP社製)、T-ブチルアクリレート/アクリル酸エチル/メタクリル酸共重合体(ルビマー、BASF社製)、ビニルピロリドン/ビニルアセテート/ビニルプロピオネート共重合体(ルビスコールVAP、BASF社製)、ビニルアセテート/クロトン酸共重合体(ルビセットCA、BASF社製)、ビニルアセテート/クロトン酸/ビニルピロリドン共重合体(ルビセットCAP、BASF社製)、ビニルピロリドン/アクリレート共重合体(ルビフレックス、BASF社製)、アクリレート/アクリルアミド共重合体(ウルトラホールド、BASF社製)、ビニルアセテート/ブチルマレエート/イソボルニルアクリラート共重合体(アドバンテージ、ISP社製)、カルボキシビニルポリマー(カーボポール、BFGoodrich社製)、アクリル酸・メタクリル酸アルキル共重合体(ペミュレン、BF Goodrich社製)等のアニオン性高分子化合物や、ジアルキルアミノエチルメタクリレート重合体の酢酸両性化物(ユカフォーマー、三菱化学社製)、アクリル酸オクチルアクリルアミド/アクリル酸ヒドロキシプロピル/メタクリル酸ブチルアミノエチル共重合体(AMPHOMER、NSC社製)等の両性高分子化合物、ビニルピロリドン/ジメチルアミノエチルメタクリレートの4級化物(GAFQUAT、ISP社製)、メチルビニルイミダゾリウムクロリド/ビニルピロリドン共重合体(ルビコート、BASF社製)等のカチオン性高分子化合物、ポリビニルピロリドン(ルビスコールK、BASF社製)、ビニルピロリドン/酢酸ビニル共重合体(ルビスコールVA、BASF社製)、ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマー937、ISP社製)、ビニルカプロラクタム/ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマーVC713、ISP社製)等のノニオン性高分子化合物等がある。また、セルロースまたはその誘導体、ケラチン及びコラーゲンまたはその誘導体、アルギン酸カルシウム、プルラン、寒天、ゼラチン、タマリンド種子多糖類、キサンタンガム、カラギーナン、ハイメトキシルペクチン、ローメトキシルペクチン、グアーガム、アラビアゴム、結晶セルロース、アラビノガラクタン、カラヤガム、トラガカントガム、アルギン酸、アルブミン、カゼイン、カードラン、ジェランガム、デキストラン等の天然由来高分子化合物も好適に用いることができる。
(8) Examples of polymers Acrylic acid ester / methacrylic acid ester copolymer (plus size, manufactured by Reciprocal Chemical Co., Ltd.), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecaneate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubimer) , BASF), Vinylpyrrolidone / Vinylacetate / Vinylpropionate copolymer (Rubiscol VAP, BASF), Vinylacetate / Crotonic acid copolymer (Rubiset CA, BASF), Vinylacetate / Croton Acid / vinylpyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinylpyrrolidone / acrylate copolymer (Rubiflex, manufactured by BASF), acrylate / acrylamide copolymer (Ultrahold, manufactured by BASF), vinyl acetate / Butylmaleate / isobornylacryllate copolymer (Advantage, manufactured by ISP), carboxyvinyl polymer (Carbopol, manufactured by BFGoodrich), acrylic acid / alkyl methacrylate copolymer (Pemulene, manufactured by BF Goodrich), etc. Anionic polymer compound, dialkylaminoethyl methacrylate polymer acetic acid amphoteric (Yukaformer, manufactured by Mitsubishi Chemical Corporation), octylacrylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC) ) And other amphoteric polymer compounds, vinylpyrrolidone / dimethylaminoethylmethacrylate quaternary product (GAFQUAT, manufactured by ISP), methylvinylimidazolium chloride / vinylpyrrolidone copolymer (rubicote, manufactured by BASF), etc. Polymer compound, polyvinylpyrrolidone (Rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF), vinylpyrrolidone / dimethylaminoethyl methacrylate polymer (copolymer 937, manufactured by ISP) ), Nonionic polymer compounds such as vinyl caprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP). In addition, cellulose or its derivatives, keratin and collagen or its derivatives, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, arabic rubber, crystalline cellulose, arabino. Naturally-derived high molecular compounds such as galactan, carrageenan, tragacanth gum, alginic acid, albumin, casein, curdlan, gellan gum, and dextran can also be preferably used.
(9)生理活性成分の例
生理活性成分としては、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば、美白成分、免疫賦活剤、老化防止剤、紫外線防御剤、スリミング剤、ひきしめ剤、抗酸化剤、発毛剤、育毛剤、保湿剤、血行促進剤、抗菌剤、殺菌剤、乾燥剤、冷感剤、温感剤、ビタミン類、アミノ酸、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、酵素成分等が挙げられる。これらの好適な配合成分の例としては、例えばアシタバエキス、アボカドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エイジツエキス、エチナシ葉エキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オトギリソウエキス、オドリコソウエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、甘草エキス、カルカデエキス、カキョクエキス、キナエキス、キューカンバ-エキス、グアノシン、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、クロレラエキス、クワエキス、ゲンチアナエキス、紅茶エキス、酵母エキス、ゴボウエキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、シャクヤクエキス、ショウブ根エキス、シラカバエキス、スギナエキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セ-ジエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ダイズエキス、タイソウエキス、タイムエキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、リンゴエキス、レタスエキス、レモンエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス等を挙げることができる。
また、デオキシリボ核酸、ムコ多糖類、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、キチン、キトサン、加水分解卵殻膜などの生体高分子、アミノ酸、加水分解ペプチド、乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム、ベタイン、ホエイ、トリメチルグリシンなどの保湿成分、スフィンゴ脂質、セラミド、フィトスフィンゴシン、コレステロール、コレステロール誘導体、リン脂質などの油性成分、ε-アミノカプロン酸、グリチルリチン酸、β-グリチルレチン酸、塩化リゾチーム、グアイアズレン、ヒドロコールチゾン等の免疫賦活剤、ビタミンA、ビタミンB2、ビタミンB6、ビタミンC、ビタミンD、ビタミンE、パントテン酸カルシウム、ビオチン、ニコチン酸アミド、ビタミンCエステル等のビタミン類、アラントイン、ジイソプロピルアミンジクロロアセテート、4-アミノメチルシクロヘキサンカルボン酸等の活性成分、トコフェロール、カロチノイド、フラボノイド、タンニン、リグナン、サポニン等の抗酸化剤、α-ヒドロキシ酸、β-ヒドロキシ酸などの細胞賦活剤、γ-オリザノール、ビタミンE誘導体などの血行促進剤、レチノール、レチノール誘導体等の創傷治癒剤、アルブチン、コウジ酸、プラセンタエキス、イオウ、エラグ酸、リノール酸、トラネキサム酸、グルタチオン等の美白剤、セファランチン、カンゾウ抽出物、トウガラシチンキ、ヒノキチオール、ヨウ化ニンニクエキス、塩酸ピリドキシン、DL-α-トコフェロール、酢酸DL-α-トコフェロール、ニコチン酸、ニコチン酸誘導体、パントテン酸カルシウム、D-パントテニルアルコール、アセチルパントテニルエチルエーテル、ビオチン、アラントイン、イソプロピルメチルフェノール、エストラジオール、エチニルエストラジオール、塩化カプロニウム、塩化ベンザルコニウム、塩酸ジフェンヒドラミン、タカナール、カンフル、サリチル酸、ノニル酸バニリルアミド、ノナン酸バニリルアミド、ピロクトンオラミン、ペンタデカン酸グリセリル、L-メントール、モノニトログアヤコール、レゾルシン、γ-アミノ酪酸、塩化ベンゼトニウム、塩酸メキシレチン、オーキシン、女性ホルモン、カンタリスチンキ、シクロスポリン、ジンクピリチオン、ヒドロコールチゾン、ミノキシジル、モノステアリン酸ポリオキシエチレンソルビタン、ハッカ油、ササニシキエキス等の育毛剤などが挙げられる。
(9) Examples of bioactive ingredients Examples of the bioactive ingredients include substances that give some bioactivity to the skin when applied to the skin. For example, whitening ingredients, immunostimulators, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair growth agents, moisturizers, blood circulation promoters, antibacterial agents, bactericidal agents, desiccants, Examples thereof include cooling sensitizers, warming sensitizers, vitamins, amino acids, wound healing promoters, stimulant relievers, painkillers, cell activators, enzyme components and the like. Examples of these suitable compounding ingredients include, for example, Ashitaba extract, Avocado extract, Amacha extract, Artea extract, Arnica extract, Aloe extract, Anzu extract, Anzu kernel extract, Ginkgo extract, Wikyo extract, Ukon extract, Oolong tea extract, Agetsu. Extract, Echinashi leaf extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otogirisou extract, Odorikosou extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Camomila extract, carrot extract, kawarayomogi extract, licorice extract, karukade extract, kakyoku extract, kina extract, cucumber extract, guanosine, kuchinashi extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, clematis extract, chlorella extract, quail extract, Gentiana extract, tea extract, yeast extract, gobo extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract , Sansho extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Shakuyaku extract, Shobu root extract, Shirakaba extract, Sugina extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract Hakka extract, sage extract, zegna oyster extract, senkyu extract, senburi extract, soybean extract, taiso extract, thyme extract, tea extract, chowji extract, chigaya extract, chimpi extract, touki extract, tokinsenka extract, tounin extract, towhi extract, dokudami extract, tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Visabolol, Biwa extract, Fukitanpopo extract, Fukinoto extract, Bukuryo extract, Butcher Bloom extract, grape extract, propolis, hechima extract, benibana extract, peppermint extract, bodaiju extract, button extract, hop extract, pine extract, malonie extract, mizubasho Cucumber extract, Mukuroji extract, Melissa extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Yomogi extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Rengesou extract, Rose extract, Rosemary extract, Roman chamomile extract , Royal jelly extract and the like.
In addition, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidone carboxylate. , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipids, ceramides, phytosphingosin, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizinic acid, β-glycyrrhetinic acid, lysoteam chloride, guaiazulene, Immunostimulators such as hydrocortisone, vitamins such as vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinic acid amide, vitamin C ester, allantin, diisopropylamine dichloro Active ingredients such as acetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotinoid, flavonoid, tannin, lignan, saponin, cell activators such as α-hydroxy acid and β-hydroxy acid, γ-orizanol, Blood circulation promoters such as vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, whitening agents such as arbutine, kodiic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid and glutathione, cepharanthin, canzo extract, Togarashi tinki, hinokithiol, garlic iodide extract, pyridoxin hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pantothenyl alcohol, acetylpantothenyl ethyl ether, biotin , Allantin, isopropylmethylphenol, estradiol, ethynyl estradiol, capronium chloride, benzalconium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyrocton olamine, glyceryl pentadecanoate, L-menthol, Mononitroguayacole, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletin hydrochloride, auxin, female hormone, cantalistinki, cyclosporin, zincpyrythion, hydrocorthizone, minoxidyl, polyoxyethylene sorbitan monostearate, peppermint oil, sasani Hair growth agents such as shiki extract can be mentioned.
(10)酸化防止剤の例
亜硫酸水素ナトリウム、亜硫酸ナトリウム、エリソルビン酸、エリソルビン酸ナトリウム、チオジプロピオン酸ジラウリル、トコフェロール、トリルビグアナイド、ノルジヒドログアヤレチン酸、パラヒドロキシアニソール、ブチルヒドロキシアニソール、ジブチルヒドロキシトルエン、ステアリン酸アスコルビル、パルミチン酸アスコルビル、没食子酸オクチル、没食子酸プロピル、カロチノイド、フラボノイド、タンニン、リグナン、サポニン、リンゴエキスやチョウジエキスなどの酸化防止効果の認められる植物エキス等が挙げられる。
(10) Examples of Antioxidants Sodium Hydrogen Sulfite, Sodium Sulfite, Erythorbic Acid, Sodium Erythorbic Acid, Dilauryl Thiodipropionate, Tocopherol, Trirubiguanide, Nordihydroguayaletinic Acid, Parahydroxyanisole, Butylatedhydroxyanisole, Dibutylhydroxy Examples thereof include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotinoid, flavonoid, tannin, lignan, saponin, apple extract and chowdi extract.
(11)溶媒の例
精製水、エタノール、低級アルコール、エーテル類、LPG、フルオロカーボン、N-メチルピロリドン、フルオロアルコール、揮発性直鎖状シリコーン、次世代フロン等が挙げられる。
(11) Examples of solvents Purified water, ethanol, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, volatile linear silicones, next-generation freons and the like can be mentioned.
実施例:ルテオリン含有菊の花抽出物の調製及びルテオリン純品について
菊(学名:Chrysanthemum morifolium)の花を75wt%含水エタノールで抽出し、この抽出液に樹脂カラムクロマトグラフィーを用いて、エタノール30wt%、75wt%、100wt%の画分を得た。それぞれの画分にプレードライを行い、その後それぞれの画分粉末を得た。そして、それぞれの画分粉末をルテオリンの含有量20wt%になるように混合し、本実施例のルテオリン含有菊の花抽出物を得た。
さらに、本実施例のルテオリン純品は、市販品(和光純薬株式会社製)を用いた。
Example: Preparation of chrysanthemum flower extract containing luteolin and pure luteolin product Chrysanthemum (scientific name: Chrysanthemum morifolium) flowers are extracted with 75 wt% hydrous ethanol, and the extract is used for resin column chromatography to 30 wt% ethanol. , 75 wt% and 100 wt% fractions were obtained. Each fraction was play-dried and then each fraction powder was obtained. Then, each fraction powder was mixed so as to have a luteolin content of 20 wt% to obtain a luteolin-containing chrysanthemum flower extract of this example.
Further, as the pure luteolin product of this example, a commercially available product (manufactured by Wako Pure Chemical Industries, Ltd.) was used.
試験例:オキソン酸カリウム誘発血中尿酸上昇モデルを使った菊の花抽出物及びルテオリンの血中尿酸値の評価
方法
6週齢のBalb/c雌性マウスにサンプルを経口投与するとともに,オキソン酸カリウム(500 mg/kg)を皮下投与した。2,4時間後に眼窩静脈嚢より採血を行って血清を分離し,尿酸値を測定した。なお、ポジティブコントロールとして、アロプリノールを用いた。その結果を図1に示す。
Test example: Evaluation method of blood uric acid level of chrysanthemum flower extract and luteolin using potassium oxonate-induced blood uric acid elevation model
The sample was orally administered to 6-week-old Balb / c female mice, and potassium oxonate (500 mg / kg) was subcutaneously administered. Two or four hours later, blood was collected from the orbital venous sac, serum was separated, and the uric acid level was measured. Allopurinol was used as a positive control. The results are shown in Fig. 1.
結果及び実施例の効果
図1に示すように、ルテオリン(100 mg/kg)はオキソン酸カリウム投与4時間後において,血中尿酸値を有意に低下させた。菊の花エキス(100 mg/kg)には,尿酸値を下げる傾向が見られた。アロプリノール(10 mg/kg)は,尿酸値を投与2,4時間後において低下させた。
以上により、菊の花抽出物及びルテオリンに血中の尿酸値を低下させる作用を有することが確認された。また、これにより、菊の花抽出物及びルテオリンは血中尿酸値低下剤として有用であることが確認された。さらに、キサンチンオキシダーゼ阻害剤であるアロプリノールは尿酸値を投与2,4時間後において低下させているのに対し、ルテオリンは、4時間後のみに尿酸値を下げることが確認されていることから、生成された尿酸を体外に排出する、あるいは何らかの形で分解することにより、血中の尿酸値を低下させていることが分かった。
Results and Effects of Examples As shown in Fig. 1, luteolin (100 mg / kg) significantly reduced blood uric acid levels 4 hours after potassium oxoate administration. Chrysanthemum flower extract (100 mg / kg) tended to lower uric acid levels. Allopurinol (10 mg / kg) decreased uric acid levels 2 to 4 hours after administration.
From the above, it was confirmed that the chrysanthemum flower extract and luteolin have an effect of lowering the uric acid level in blood. It was also confirmed that the chrysanthemum flower extract and luteolin are useful as blood uric acid level lowering agents. Furthermore, allopurinol, a xanthine oxidase inhibitor, lowered the uric acid level 2 to 4 hours after administration, whereas luteolin was confirmed to lower the uric acid level only 4 hours after administration. It was found that the uric acid level in the blood was lowered by excreting the uric acid from the body or decomposing it in some way.
以下に本発明の配合例を挙げるが、下記配合例は本発明を限定するものではない。
配合例1:チューインガム
砂糖 53.0wt%
ガムベース 20.0
グルコース 10.0
水飴 16.0
香料 0.5
菊の花抽出物 0.5
100.0wt%
Examples of the formulation of the present invention are given below, but the following formulation examples do not limit the present invention.
Formulation example 1: Chewing gum sugar 53.0 wt%
Gum base 20.0
Glucose 10.0
Syrup 16.0
Fragrance 0.5
Chrysanthemum flower extract 0.5
100.0 wt%
配合例2:グミ
還元水飴 40.0wt%
グラニュー糖 20.0
ブドウ糖 20.0
ゼラチン 4.7
水 9.68
イチゴ果汁 4.0
ブドウフレーバー 0.6
色素 0.02
菊の花抽出物 1.0
100.0wt%
Formulation example 2: Gummy
Reduced starch syrup 40.0 wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Strawberry juice 4.0
Grape flavor 0.6
Dye 0.02
Chrysanthemum flower extract 1.0
100.0 wt%
配合例3:キャンディー
砂糖 50.0wt%
水飴 33.0
水 14.4
有機酸 2.0
香料 0.2
菊の花抽出物 0.4
100.0wt%
Formulation example 3: Candy
Sugar 50.0 wt%
Syrup 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Chrysanthemum flower extract 0.4
100.0 wt%
配合例4:ヨーグルト(ハード・ソフト)
牛乳 41.5wt%
脱脂粉乳 5.8
砂糖 8.0
寒天 0.15
ゼラチン 0.1
乳酸菌 0.005
菊の花抽出物 0.4
香料 微量
水 残余
100.0wt%
Formulation example 4: Yogurt (hard / soft)
Milk 41.5 wt%
Skim milk powder 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Chrysanthemum flower extract 0.4
Fragrance trace amount
Water residue
100.0 wt%
配合例5:清涼飲料
果糖ブドウ糖液糖 30.0wt%
乳化剤 0.5
菊の花抽出物 0.05
香料 適量
精製水 残余
100.0wt%
Formulation example 5: Soft drink
Fructose-glucose liquid sugar 30.0 wt%
Emulsifier 0.5
Chrysanthemum flower extract 0.05
Appropriate amount of fragrance
Purified water residue
100.0 wt%
配合例6:錠菓
砂糖 76.4wt%
グルコース 19.0
ショ糖脂肪酸エステル 0.2
菊の花抽出物 0.5
精製水 3.9
100.0wt%
Formulation example 6: Tablet confectionery
Sugar 76.4 wt%
Glucose 19.0
Sucrose fatty acid ester 0.2
Chrysanthemum flower extract 0.5
Purified water 3.9
100.0 wt%
配合例7:ソフトカプセル
イチゴ種子油 87.0wt%
乳化剤 12.0
菊の花抽出物 1.0
100.0wt%
Formulation example 7: Soft capsule
Strawberry seed oil 87.0 wt%
Emulsifier 12.0
Chrysanthemum flower extract 1.0
100.0 wt%
配合例8:錠剤
乳糖 54.0wt%
結晶セルロース 30.0
澱粉分解物 10.0
グリセリン脂肪酸エステル 5.0
菊の花抽出物 1.0
100.0wt%
Formulation Example 8: Tablets
Lactose 54.0 wt%
Crystalline cellulose 30.0
Starch decomposition product 10.0
Glycerin fatty acid ester 5.0
Chrysanthemum flower extract 1.0
100.0 wt%
配合例9:顆粒内服剤(医薬品)
菊の花抽出物 1.0wt%
乳糖 30.0
コーンスターチ 60.0
結晶セルロース 8.0
ポリビニルピロリドン 1.0
100.0wt%
Formulation example 9: Oral granules (pharmaceutical products)
Chrysanthemum flower extract 1.0 wt%
Lactose 30.0
Cornstarch 60.0
Crystalline cellulose 8.0
Polyvinylpyrrolidone 1.0
100.0 wt%
配合例10:キャットフード
とうもろこし 34.0wt%
小麦粉 35.0
ミートミール 15.0
牛脂 8.9
食塩 1.0
かつおエキス 4.0
菊の花抽出物 1.0
タウリン 0.1
ビタミン類 0.5
ミネラル類 0.5
100.0wt%
Formulation example 10: Cat food
Corn 34.0 wt%
Flour 35.0
Meat meal 15.0
Beef tallow 8.9
Salt 1.0
Skipjack extract 4.0
Chrysanthemum flower extract 1.0
Taurine 0.1
Vitamins 0.5
Minerals 0.5
100.0 wt%
配合例11:ドッグフード
とうもろこし 30.0wt%
肉類(チキン) 15.0
脱脂大豆 10.0
小麦粉 25.0
糟糠類 5.0
菊の花抽出物 5.0
動物性油脂 8.9
オリゴ糖 0.1
ビタミン 0.5
ミネラル 0.5
100.0wt%
配合例12:化粧クリーム
スクワラン 20.0wt%
ミツロウ 5.0
精製ホホバ油 5.0
グリセリン 5.0
グリセリンモノステアレート 2.0
ポリオキシエチレン(20)ソルビタン-
モノステアレート 2.0
菊の花抽出物 2.0
防腐剤 適量
香料 適量
精製水 残余
100.0wt%
Formulation example 11: Dog food
Corn 30.0 wt%
Meat (chicken) 15.0
Solvent degreased soybean 10.0
Flour 25.0
Rice bran 5.0
Chrysanthemum flower extract 5.0
Animal fats and oils 8.9
Oligosaccharide 0.1
Vitamin 0.5
Mineral 0.5
100.0 wt%
Formulation example 12: Cosmetic cream
Squalene 20.0 wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerin monostearate 2.0
Polyoxyethylene (20) Sorbitan-
Monostearate 2.0
Chrysanthemum flower extract 2.0
Preservatives Appropriate amount
Appropriate amount of fragrance
Purified water residue
100.0 wt%
配合例13:化粧水
エタノール 5.0wt%
グリセリン 2.0
1,3-ブチレングリコール 2.0
ポリエチレンオレイルエーテル 0.5
クエン酸ナトリウム 0.1
クエン酸 0.1
菊の花抽出物 0.1
精製水 残余
100.0wt%
Formulation example 13: Toner
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Chrysanthemum flower extract 0.1
Purified water residue
100.0 wt%
配合例14:ボディージェル
マカデミアナッツ油 2.0wt%
ミリスチン酸オクチルドデシル 10.0
メチルフェニルポリシロキサン 5.0
ベヘニルアルコール 3.0
ステアリン酸 3.0
バチルアルコール 1.0
モノステアリン酸グリセリル 1.0
テトラオレイン酸ポリオキシエチレンソルビット 2.0
水素添加大豆リン脂質 1.0
セラミド 0.1
パルミチン酸レチノール 0.1
防腐剤 適量
ツボクサ抽出物 1.0
菊の花抽出物 1.0
1、3-ブチレングリコール 5.0
精製水 残余
100.0wt%
Formulation example 14: Body gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methyl Phenyl Polysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Bacil alcohol 1.0
Glyceryl monostearate 1.0
Polyoxyethylene sorbitol with tetraoleate 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinyl palmitate 0.1
Preservatives Appropriate amount
Centella asiatica extract 1.0
Chrysanthemum flower extract 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0 wt%
配合例15:乳液
スクワラン 4.0wt%
ワセリン 2.5
セタノール 2.0
グリセリン 2.0
親油型モノステアリン酸グリセリン 1.0
ステアリン酸 1.0
L-アルギニン 1.0
菊の花抽出物 0.5
水酸化カリウム 0.1
香料 微量
精製水 残余
100.0wt%
Formulation example 15: Emulsion
Squalene 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Oil-based glycerin monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Chrysanthemum flower extract 0.5
Potassium hydroxide 0.1
Fragrance trace amount
Purified water residue
100.0wt%
配合例16:浴用剤(液状)
プロピレングリコール 50.0wt%
エタノール 20.0
硫酸ナトリウム 5.0
菊の花抽出物 0.5
ラノリン 0.5
アボガド油 0.5
色素 1.5
香料 22.0
100.0wt%
Formulation Example 16: Bathing agent (liquid)
Propylene glycol 50.0 wt%
Ethanol 20.0
Sodium sulfate 5.0
Chrysanthemum flower extract 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%
以上により、本発明は、新規な成分を有効成分とする血中尿酸値低下剤を提供することができる。 As described above, the present invention can provide a blood uric acid level lowering agent containing a novel ingredient as an active ingredient.
Claims (2)
A blood uric acid level lowering agent containing luteolin as an active ingredient.
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