JP2022045179A - Cleaner composition for intraoral attachments - Google Patents

Abstract

To provide a cleaner composition for intraoral attachments containing a flavor, which can exhibit an excellent denture plaque removing effect, and can effectively inhibit an unpleasant odor from occurring from the residual flavor or the composition itself in the cleaned intraoral attachments.SOLUTION: A cleaner composition for intraoral attachments contains following components (A)-(B): (A) a C10-20 fatty acid salt or a salt thereof of 0.5 mass% or more and 20 mass% or less in terms of fatty acid, and (B) at least one flavor compound selected from ionone, cis-3-hexenol, geraniol, δ-undecalactone, pinene, and thymol. The mass ratio between the content of the component (A) and the content of the component (B) ((A)/(B)) is 0.8 or more and 500 or less. The pH at 25°C is 8 or more and 14 or less.SELECTED DRAWING: None

Description

The present invention relates to a detergent composition for an intraoral wearing device.

With the progress of super-aging in recent years, the number of people who are obliged to wear removable oral devices such as dentures is acceleratingly increasing. Such intraoral wearing devices, such as dentures and orthodontic devices, tend to have stains such as denture plaque and food residues adhering during wearing, and when the oral wearing device is worn, unpleasant odors such as bad breath are generated. It may be accompanied, and it may cause caries and periodontal disease.
In this way, since daily delicate cleaning is indispensable for intraoral wear devices that need to be kept clean in order to maintain physical health, various cleaning agents have been developed in the past, and further fragrances have been added. Studies have also been conducted to improve the generation of unpleasant odors by using it.

For example, Patent Document 1 discloses a tablet-shaped denture cleaning agent containing a fragrance with a fragrance tone other than mint note, and by imparting a scent to the denture after cleaning, the user can feel the cleaning effect. Attempts have been made to make it. Further, Patent Document 2 discloses a dental device cleaning prescription having one or a combination of a plurality of flavor oils, which enhances the effect of maintaining a continuous and refreshing breath.

Japanese Unexamined Patent Publication No. 2015-189724 JP-A-2007-254471A

That is, in the techniques described in these patent documents, unpleasant odors in dentures and oral cavity are masked with a large amount of fragrance.
However, in masking with such a large amount of fragrance, when the washed oral device is returned to the oral cavity and worn, the fragrance remaining excessively on the oral device and the denture plaque remaining on the oral device causes the fragrance. The present inventors have found that even if the aroma is excessively brought about and the unpleasant odor is masked, it can be a factor that causes unpleasant odor.

Therefore, the present invention exhibits an excellent denture plaque removing effect, and thus causes an unpleasant odor derived from the fragrance remaining in the denture plaque remaining in the oral wearing device or the oral wearing device after cleaning and the cleaning composition itself. The present invention relates to a cleaning agent composition for an intraoral wearing device, which can effectively suppress the occurrence.

Therefore, as a result of diligent studies to solve the above problems, the present inventor contains a specific fatty acid salt or a salt thereof and a specific fragrance compound in a specific amount and a specific mass ratio, and further, in a specific pH range. By doing so, it retains a good fragrance while exhibiting an excellent denture plaque removal effect, effectively avoiding excessive residual fragrance compounds in the oral cavity wearing device after washing, and effectively generating an unpleasant odor. We have found a cleaning agent composition for intraoral wearing devices that can be suppressed.

That is, in the present invention, the following components (A) to (B):
(A) Fatty acid salt having 10 or more and 20 or less carbon atoms or a salt thereof. 0.5% by mass or more and 20% by mass or less in terms of fatty acid. And one or more fragrance compounds selected from Timor,
The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.8 or more and 500 or less, and the pH at 25 ° C. is 8 or more and 14 or less. It is intended to provide a cleaning agent composition for an intraoral wearing device.

According to the detergent composition for an intraoral wear device of the present invention, a stable and good fragrance is maintained from immediately after production to after storage, and an unpleasant odor derived from the detergent composition for an intraoral wear device is suppressed. Can be done. In addition, by exhibiting an excellent denture plaque removing effect while providing an appropriate aroma during washing, excessive residual fragrance compounds in the denture plaque remaining in the oral cavity wearing device and the oral wearing device after washing are avoided. , The generation of unpleasant odor can be effectively suppressed. Therefore, it is possible to obtain a comfortable feeling of use when the intraoral wearing device is reattached after cleaning.

Hereinafter, the present invention will be described in detail.
In addition, in this specification, "intraoral wearing device" means all dentures, removable partial dentures, orthodontic appliances, retainers, mouthpieces, etc. (hereinafter, these are also collectively referred to as "dentures, etc."). It means a so-called dental attachment that needs to be attached and detached in the oral cavity. Specifically, for example, a full denture (total denture) is a denture to be attached to a toothless jaw, and is composed of an artificial tooth and a denture base. On the other hand, removable partial dentures (partial dentures) are dentures to be attached to jaws with partially lost teeth, and are composed of artificial teeth, denture bases, and abutment devices such as clasps, rests, and attachments. Orthodontic appliances, retainers and mouthpieces have similar configurations. Examples of the material of the denture base generally include a resin such as acrylic resin, and examples of the material of the artificial tooth and the abutment device include such resin, metal such as titanium, and ceramics.
Further, in the present specification, the "unpleasant odor" is generated by excessive residual of a fragrance compound that originally brings about a pleasant fragrance in the denture plaque remaining in the oral cavity wearing device or the oral wearing device after washing. On the contrary, it means an odor that is felt as unpleasant. It also means to include the unpleasant fatty acid odor caused by the fatty acid salt of the component (A) or the contained component such as the salt thereof.
Further, as used herein, the term "denture plaque" means an aggregate of bacteria attached to an intraoral wearing device and extracellular substances produced by the bacteria.

The cleaning agent composition for an intraoral wearing device of the present invention contains, as the component (A), a fatty acid salt having 10 or more and 20 or less carbon atoms or a salt thereof in an amount of 0.5% by mass or more and 20% by mass or less in terms of fatty acid. As a result, it is strongly adsorbed on the surface of the denture plaque firmly attached to the intraoral wearing device, disintegrates the aggregated structure of the denture plaque, and can be effectively uprooted and detached from the intraoral wearing device. Therefore, an excellent denture plaque removing effect can be exhibited, and the component (B) described later is effectively suppressed from remaining excessively in the oral cavity wearing device after cleaning, and the generation of unpleasant odor is effective. Can be prevented. In addition, it is considered that it also contributes to stably maintaining the aroma of the component (B) from the time of manufacture to the time of storage.

The fatty acid of the component (A) and the fatty acid constituting the fatty acid salt of the component (A) have 10 or more and 20 or less carbon atoms, preferably 12 or more and 20 or less, and more preferably 14 or more and 20 or less. Yes, more preferably 16 or more and 20 or less. Such fatty acids may have saturated or unsaturated straight chains or branched chains, and those having unsaturated straight chains are more preferable.

Specific examples of the fatty acid constituting the fatty acid of the component (A) and the fatty acid salt of the component (A) include capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, palmitoleic acid, oleic acid, and linoleic acid. , Linolenic acid, bacsenic acid, gadrain acid, eicosenoic acid, isostearic acid, and arachidic acid, and one or more selected from palm oil fatty acid, palm oil fatty acid, etc., which are mixed fatty acids thereof. Among them, palmitoleic acid and oleic acid are used from the viewpoint of fully exerting the effect of removing denture plaque and from the viewpoint of effectively avoiding the excessive residue of the component (B) while contributing to the retention of good aroma by the component (B). One or more selected from acid, linolenic acid, linolenic acid, vaccenic acid, gadoleic acid, and eicosenoic acid is preferable, and oleic acid is more preferable.
The salt of the component (A) is an inorganic salt selected from sodium salt, potassium salt, magnesium salt, and ammonium salt; organic amine salt such as monoethanolammonium salt, diethanolammonium salt, and triethanolammonium salt; arginine salt and the like. One or more selected from the basic amino acid salts of. Above all, from the viewpoint of fully exerting the effect of removing denture plaques and from the viewpoint of effectively avoiding excessive residual of the component (B) while contributing to the retention of good aroma by the component (B), sodium salts or Potassium salts are preferred, especially sodium salts.

The content of the component (A) is from the viewpoint of effectively exerting an excellent denture plaque removing effect and from the viewpoint of effectively avoiding excessive residue of the component (B) after washing while maintaining a good aroma. In the cleaning agent composition for an intraoral wearing device of the present invention, the amount in terms of fatty acid is 0.5% by mass or more, preferably 0.6% by mass or more, and more preferably 0.7% by mass or more. It is more preferably 0.8% by mass or more. Further, the content of the component (A) is the oral cavity of the present invention from the viewpoint of reducing the generation of the fatty acid odor derived from the component (A) and effectively reducing the unpleasant odor generated from the orally worn device after washing. In the cleaning agent composition for wearing equipment, the fatty acid equivalent amount is 20% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 2% by mass or less. be. The content of the component (A) is 0.5% by mass or more and 20% by mass or less in terms of fatty acid in the cleaning agent composition for an intraoral wearing device of the present invention, preferably 0.6. It is -10% by mass, more preferably 0.7 to 5% by mass, still more preferably 0.8 to 2% by mass.

The cleaning agent composition for an intraoral wearing device of the present invention has one or more selected from ionone, cis-3-hexenol, geraniol, δ-undecalactone, pinene, and thymol as the component (B). Contains fragrance compounds. This component (B), coupled with its excellent compatibility with the component (A), provides a pleasant fragrance in the oral cavity during washing and does not excessively remain in the oral cavity wearing device after washing. It is considered that it becomes possible to effectively reduce the generation of unpleasant odor while maintaining a good aroma.
Among them, it is selected from ionone, cis-3-hexenol, pinene, and thymol from the viewpoint of effectively avoiding excessive residue in the oral cavity wearing device after washing and effectively suppressing the generation of unpleasant odor. Species or two or more are preferred, especially ionone or cis-3-hexenol.

The content of the component (B) is preferably 0. It is 008% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.012% by mass or more, and even more preferably 0.014% by mass or more. Further, the content of the component (B) is preferably 0.8 in the cleaning agent composition for an orally-mounted device of the present invention from the viewpoint of effectively avoiding excessive residue in the orally-mounted device after cleaning. It is 0% by mass or less, more preferably 0.2% by mass or less, still more preferably 0.05% by mass or less, still more preferably 0.02% by mass or less. The content of the component (B) is preferably 0.008 to 0.8% by mass in terms of fatty acid in the cleaning agent composition for an intraoral wearing device of the present invention, and more preferably 0. It is 01 to 0.2% by mass, more preferably 0.012 to 0.05% by mass, and even more preferably 0.014 to 0.02% by mass.

The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B), coupled with the reduction of the fatty acid odor derived from the component (A), is a pleasant aroma in the oral cavity. It is 0.8 or more, preferably 4 or more, more preferably 10 or more, and further preferably 20 or more, from the viewpoint of bringing about the above and maintaining the aroma well. Further, the mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is effective for excessive residual of the component (B) in the intraoral wearing device after washing. From the viewpoint of avoiding the problem and effectively reducing the unpleasant odor, it is 500 or less, preferably 300 or less, more preferably 100 or less, and further preferably 50 or less. The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.8 or more and 500 or less, preferably 4 to 300. It is more preferably 10 to 100, still more preferably 20 to 50.

In the detergent composition for an intraoral wearing device of the present invention, it is preferable to limit the content of the fragrance compound of the following component (C) as a fragrance compound other than the component (B). This makes it possible to secure the retention of the aroma after storage. As the fragrance compound of the component (C), one or more selected from menthol, limonene, linalool, citral, isopulegol, mentyl lactate, and vanillin are preferable from the viewpoint of improving the retention of aroma.

The content of the component (C) may be less than 0.09% by mass, preferably 0.05% by mass or less, more preferably 0.01% by mass or less, and further. It may be preferably 0.005% by mass or less, further preferably 0.001% by mass or less, still more preferably 0.0005% by mass or less, or the present invention. The cleaning agent composition for an intraoral wearing device does not have to contain the component (C).

The detergent composition for an intraoral wearing device of the present invention further has an anionic surfactant (d1) and a nonionic surfactant (d2) other than the component (A) from the viewpoint of obtaining a more excellent denture plaque removing effect. , And one or more selected surfactants (D) selected from the amphoteric surfactant (d3) are preferably contained.

Specific examples of the anionic surfactant of the component (d1), which is an anionic surfactant other than the component (A), include lauryl sulfate, myristyl sulfate, palmityl sulfate, stearyl sulfate, and octyl sulfate. Alkyl sulfate esters such as salts and capryl sulfates; alkyl sulfonates such as alkylbenzene sulfonates, α-olefin sulfonates and hydroxyalkane sulfonates; acyl amino acid salts such as acylglutamates and acylsarcosine salts; lauryl N-methyl long-chain acyltaurine salt such as methyl taurine salt; alkyl phosphate such as alkyl phosphate; higher fatty acid sulfonated monoglyceride salt, fatty acid ester salt of isethionic acid; polyoxyethylene monoalkyl phosphate. One kind or two or more kinds are mentioned.
Of these, acylamino acid salts are preferable from the viewpoint of enhancing the effect of removing denture plaque while effectively preventing the generation of unpleasant odors.

Specific examples of the nonionic surfactant of the component (d2) include polyoxyethylene hydrogenated castor oil; sucrose fatty acid ester; sorbitan fatty acid ester; glycerin fatty acid ester such as monostearic glyceride; alkyl glucoside; monostearic acid. Polyglycerin fatty acid esters such as decaglyceride and monomyristic acid decaglyceride; polyoxyethylene alkyl phenyl ethers such as polyoxyethylene monoalkyl (or alkenyl) ethers, polyoxyethylene polyoxypropylene copolymers and polyoxyethylene nonylphenyl ethers. A fatty acid alkanolamide such as coconut oil fatty acid diethanolamide; and one or more selected from polyethylene glycol fatty acid esters.
Among them, polyoxyethylene monoalkyl (or alkenyl) ether or polyoxyethylene polyoxypropylene copolymer is preferable from the viewpoint of enhancing the effect of removing denture plaque while effectively preventing the generation of unpleasant odor.

Specific examples of the amphoteric surfactant of the component (d3) include alkylamine oxide; betaine acetate such as lauryldimethylaminoacetic acid betaine; 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazolium betaine. Imidazolinium betaine such as; alkyl sulfobetaine such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amide alkyl betaine such as coconut oil fatty acid amide propyl betaine; One or more selected from the chain alkyl imidazoline betaine salts can be mentioned.
Of these, coconut oil fatty acid amide alkyl betaine and alkyl amine oxide are preferable from the viewpoint of effectively preventing the generation of unpleasant odors and enhancing the effect of removing denture plaque.
Further, among the anionic surfactants (d1), nonionic surfactants (d2), and amphoteric surfactants (d3) other than these components (A), while effectively preventing the generation of unpleasant odors, From the viewpoint of maintaining a stable and good aroma, the component (d1) is preferable, and the acyl amino acid salt is more preferable.

The content of the component (D) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.1% by mass or more in the detergent composition for an intraoral wearing device of the present invention. 1% by mass or more. The content of the component (D) is preferably 20% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass in the detergent composition for an intraoral wearing device of the present invention. % Or less. The content of the component (D) is preferably 0.05% by mass or more and 20% by mass or less, more preferably 0.1 to 10% by mass, in the detergent composition for an intraoral wearing device of the present invention. %, More preferably 1 to 8% by mass.

The detergent composition for an intraoral wear device of the present invention further comprises an antioxidant (from the viewpoint of effectively suppressing the generation of fatty acid odor derived from the component (A) while preventing unnecessary oxidation of each component contained therein. It is preferable to contain E). Examples of such component (E) include sulfite, tocopherol, gallic acid ester, dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and its salt, and ascorbic acid higher fatty acid ester.
Among them, sodium sulfite, potassium sulfite, ammonium sulfite, sodium hydrogen sulfite, potassium hydrogen sulfite, ammonium hydrogen sulfite, from the viewpoint of exerting a good antioxidant effect and suppressing the generation of fatty acid odor derived from the component (A), One or more sulfites selected from sodium sulfite, potassium disulfite, and ammonium dissulfite are preferred, and sodium sulfite or sodium hydrogen sulfite is more preferred.

The content of the component (E) is preferably 0.0005% by mass or more in the detergent composition for an intraoral wearing device of the present invention from the viewpoint of effectively suppressing the generation of the fatty acid odor derived from the component (A). It is more preferably 0.005% by mass or more, further preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more. Further, the content of the component (E) is preferably 10% by mass or less in the cleaning agent composition for an intraoral wearing device of the present invention from the viewpoint of ensuring an excellent effect of removing denture plaque. It is preferably 5% by mass or less, more preferably 1% by mass or less, and even more preferably 0.5% by mass or less. The content of the component (E) is preferably 0.0005 to 10% by mass, more preferably 0.005 to 5% by mass in the cleaning agent composition for an intraoral wearing device of the present invention. It is more preferably 0.05 to 1% by mass, and even more preferably 0.1 to 0.5% by mass.

The cleaning agent composition for an intraoral wear device of the present invention further contains an anionic polymer or copolymer (F) having a mass average molecular weight of 2000 or more and 500,000 or less from the viewpoint of ensuring an excellent effect of removing denture plaque. Is preferable. Anionic homopolymers or copolymers are homopolymers or copolymers containing building blocks derived from anionic monomers.
The component (F) may be a homopolymer composed of a structural unit derived from only one anionic monomer, a copolymer composed of a structural unit derived from two or more anionic monomers, or an anion. It may be a copolymer composed of a structural unit derived from a sex monomer and a structural unit derived from a monomer other than an anionic monomer.

The mass average molecular weight of the component (F) is 2000 or more, preferably 5000 or more, more preferably 8000 or more, and further preferably 10000 or more, from the viewpoint of effectively enhancing the denture plaque removing effect. Further, the mass average molecular weight of the component (F) is 500,000 or less, preferably 350,000 or less, more preferably 200,000 or less, and further preferably 200,000 or less, from the viewpoint of ensuring good solubility or dispersibility of each component. It is preferably 100,000 or less. The mass average molecular weight of the component (F) is 2000 or more and 500,000 or less, preferably 5000 to 350,000, more preferably 8000 to 200,000, and further preferably 10,000 to 100,000.

The structural unit derived from the anionic monomer contained in the component (F) is a structural unit derived from the anionic monomer (f1) having a carboxyl group, a sulfo group, or a phosphoric acid group from the viewpoint of greatly contributing to the exertion of the denture plaque removing effect. Is preferable. Specific examples of the monomer (f1) constituting the component (F) include acrylic acid, methacrylic acid, itaconic acid, maleic acid, fumaric acid, sulfonic acid, styrene sulfonic acid, methacryloyloxyalkyl sulfonic acid, and methacryl. Derived from amidoalkyl sulfonic acid, acryloyloxyalkyl phosphate, a monomer in which an anhydride or a part thereof is substituted with an alkyl group or the like, and a sugar such as glycopyranose in which a carboxymethyl group is bonded to a part of the hydroxy group. One or more selected from the monomers of the above. Among them, it is preferable that the monomer does not contain an aromatic ring or an alicyclic ring in the molecular structure, and more preferably one or more selected from acrylic acid, methacrylic acid, maleic acid, and sulfonic acid.

The content of the constituent unit derived from the anionic monomer in 100% by mass of all the constituent units of the component (F) is preferably 15% by mass or more from the viewpoint of effectively ensuring the excellent denture plaque removing effect. It is more preferably 35% by mass or more, further preferably 50% by mass or more, and preferably 100% by mass or less.

Specific examples of the component (F) include acrylic acid homopolymer, methacrylic acid homopolymer, crosslinked acrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, and acrylic acid / sulfonic acid. Examples include one or more selected from copolymers, vinyl acetate / maleic acid copolymers, phosphinic acid / acrylic acid copolymers, carboxymethyl cellulose, xanthan gum, gellan gum, alginic acid, carrageenan, pectin, and hyaluronic acid. Among them, one or more selected from acrylic acid homopolymer, acrylic acid / maleic acid copolymer, acrylic acid / methacrylic acid copolymer, and acrylic acid / sulfonic acid copolymer from the viewpoint of exhibiting an excellent denture plaque removing effect. Is preferable, one or more selected from acrylic acid / maleic acid copolymer and acrylic acid / sulfonic acid copolymer is more preferable, and acrylic acid / maleic acid copolymer is further preferable.

The mass ratio (acrylic acid / maleic acid) of the structural unit derived from the acrylic acid monomer and the structural unit derived from the maleic acid monomer constituting the acrylic acid / maleic acid copolymer is preferably 0.01 to 99, and more. It is preferably 0.05 to 50, more preferably 0.1 to 10, and even more preferably 0.1 to 5.

The content of the component (F) is preferably 0.05% by mass or more, more preferably 0, in the cleaning agent composition for an intraoral wearing device of the present invention from the viewpoint of effectively enhancing the effect of removing denture plaque. It is .07% by mass or more, more preferably 0.1% by mass or more. Further, the content of the component (F) is preferably 8% by mass or less in the detergent composition for an intraoral wearing device of the present invention from the viewpoint of ensuring good solubility or dispersibility of each component. , More preferably 6% by mass or less, still more preferably 4% by mass or less. The content of the component (F) is preferably 0.05 to 8% by mass, more preferably 0.07 to 6% by mass in the detergent composition for an intraoral wearing device of the present invention. , More preferably 0.1 to 4% by mass.

The detergent composition for an intraoral wearing device of the present invention satisfactorily disperses or dissolves each of the above components, exerts an excellent denture plaque removing effect, effectively reduces unpleasant odors, and is stable. From the viewpoint of maintaining a good aroma, it is preferable to further contain water.

The content of water is preferably 70% by mass or more, more preferably 75% by mass or more, preferably 98% by mass or less, and more, in the detergent composition for an intraoral wearing device of the present invention. It is preferably 95% by mass or less.
The water in the present invention is not only purified water directly blended in the detergent composition for intraoral wear equipment, but also the water content contained in each of the blended components. It means the total water contained in it. Further, the water in the present invention includes water that is premixed in the cleaning composition for an intraoral wearing device, but if not, for example, it may be diluted with water or the like before use, or it may be diluted with water or the like. When it is in a state of being dissolved in water or the like, it means that the water used for its dilution or dissolution is also included.

The detergent composition for an intraoral wear device of the present invention can further contain a pH adjuster. As a result, it is possible to maintain an effective pH for reducing the generation of an unpleasant odor while promoting the exertion of the excellent denture plaque removing effect of the component (A).

Specific examples of the pH adjuster include carbonates and bicarbonates; hydroxides; organic acids such as citric acid, malic acid, lactic acid, tartaric acid, and succinic acid, or one selected from these salts. Two or more types can be mentioned. Among them, one or more selected from carbonates, bicarbonates, and hydroxides are preferable, and sodium carbonate, sodium hydrogencarbonate, sodium sesquicarbonate, sodium hydroxide, potassium carbonate, potassium hydrogencarbonate, and sesquicarbonate are preferable. One or more selected from potassium and potassium hydroxide are more preferred, and one or more selected from potassium carbonate, potassium hydrogencarbonate, sesquicarbonate, and potassium hydroxide are even more preferred. In this case, the content of the pH adjuster is preferably 0 in the cleaning agent composition for oral wearing equipment of the present invention from the viewpoint of stabilizing the pH of the cleaning agent composition for oral wearing equipment of the present invention. It is 1 to 60% by mass, more preferably 0.1 to 20% by mass, still more preferably 0.15 to 10% by mass, and even more preferably 0.2 to 5% by mass.

In addition to the above-mentioned components, for example, an anti-inflammatory agent or an antiseptic; other than the above-mentioned components (B) and (C) Perfume compounds; pigments; dyes; bleaching agents; enzymes and the like can be contained.
Specific examples of fragrances other than the above components (B) and (C) include, for example, "Perfume and Flavor Chemicals" Montclair, NJ (USA) (1969) edited by Steffen Arctander, Synthetic Fragrance Editorial Committee. Edited "Synthetic Fragrances-Chemicals and Product Knowledge" (Chemical Industry Daily, December 20, 2016, supplementary new edition), edited by Motoki Nakajima, "Basic Knowledge of Fragrances and Fragrances", Industrial Books (First Edition, 1995), etc. Examples include fragrance compounds.

The pH of the detergent composition for an intraoral wear device of the present invention at 25 ° C. is preferably 8 or more from the viewpoint of effectively reducing the generation of unpleasant odor while exhibiting an excellent denture plaque removing effect. 9 or more, more preferably 10 or more, still more preferably 10.5 or more, 14 or less, preferably 13 or less, more preferably 12 or less, still more preferably 11 or less. be.

The form of the detergent composition for an intraoral wearing device of the present invention may be liquid, foamy, paste-like, gel-like, concentrated, powdery, granular, or tablet-like, and further, the present invention in liquid form. A form in which a sheet is impregnated with the detergent composition for an intraoral wear device, a form in which the detergent composition for an intraoral wear device of the present invention is filled in a spray container, a form in which a foam discharge container is filled, or an aerosol container. It may be in the form of being filled in.
When cleaning an intraoral wear device using the detergent composition for an intraoral wear device of the present invention, if it is in the form of powder, granules, or tablets, it is diluted with water or the like, or dissolved in water or the like. It may be used as a cleaning agent for intraoral wearing devices. In this case, it is sufficient that the detergent composition for an orally-mounted device at the time of application to the cleaning agent for an orally-mounted device has a formulation that satisfies a predetermined requirement.

Among them, the cleaning agent composition for an intraoral wear device of the present invention is preferably in the form of a foam, and by covering the intraoral wear device with foam, an effective and excellent denture plaque removing effect is exhibited. It is possible to avoid excessive residual fragrance compound in the denture plaque remaining in the oral cavity wearing device or the oral cavity wearing device after washing, and effectively suppress the generation of unpleasant odor.

In particular, the detergent composition for an intraoral wearing device of the present invention is in a foamy form, and by covering the intraoral wearing device with this, the cleaning agent composition is applied to every corner of the intraoral wearing device having a complicated shape. Is sufficiently reached and is retained as it is without dripping, and by exhibiting an excellent denture plaque removing effect, a fragrance compound in the denture plaque that remains in the oral cavity wearing device or the oral wearing device after cleaning. It is possible to avoid the excessive residue of the detergent and effectively suppress the generation of unpleasant odor.
As a result, the orally-attached device after applying the composition is simply rinsed with water or the like, and an excellent denture plaque removing effect with high rapid effect is exhibited without applying any physical additional force such as brushing. By doing so, it is possible to avoid excessive residual of the fragrance compound in the denture plaque remaining in the oral cavity wearing device or the oral cavity wearing device after washing, and it is possible to effectively suppress the generation of unpleasant odor.

In the usage mode of the detergent composition for an intraoral wearing device of the present invention, first, the oral wearing device such as a denture after use is immersed in the cleaning agent composition for the oral wearing device, or the cleaning for the oral wearing device is performed. After applying the agent composition to an intraoral wearing device by foam ejection, application, dropping, spraying, etc., the agent composition is left to stand for a certain period of time. The leaving time may be usually 3 to 30 minutes, preferably 4 to 20 minutes, and more preferably 5 to 10 minutes.
Next, after leaving it to stand, the intraoral wearing device is rinsed with water or the like to wash away the cleaning agent composition for the intraoral wearing device. The cleaning agent composition for an intraoral wearing device of the present invention is more preferably just washed away, and it is not necessary to apply a physical additional force such as brushing.

In this way, it exhibits an excellent denture plaque removing effect even though it is applied for a very short time without requiring any special physical additional force, and remains in the oral cavity wearing device and the oral wearing device after cleaning. Excessive residue of the fragrance compound in the denture plaque can be avoided, and the generation of an unpleasant odor can be effectively suppressed. With the cleaning agent composition for an intraoral wearing device of the present invention, even users such as the elderly do not feel an unpleasant odor when reattached after cleaning, and the good fragrance that is brought about gives a comfortable feeling of use. It can be obtained, and the frequency of use can be easily increased.

When the detergent composition for an intraoral wearing device of the present invention is in the form of a foam, the usage mode thereof is after the oral wearing device such as a denture is coated with the foam-shaped detergent composition for the oral wearing device. , Leave it for a certain period of time.
The time for covering the oral cavity wearing device with foam is preferably 1 minute or more, more preferably 2 minutes, from the viewpoint of fully enjoying the excellent effect of removing denture plaque and the effect of effectively suppressing the generation of unpleasant odor. The above is more, and more preferably 3 minutes or more. Further, the time for covering the oral cavity wearing device with foam is preferably 30 minutes or less, more preferably 20 minutes or less, and further preferably 10 minutes or less from the viewpoint of fully exerting the effect of foam. .. The time for covering the intraoral wearing device with foam is preferably 1 minute or more and 30 minutes or less, more preferably 2 to 20 minutes, and further preferably 3 to 10 minutes.

The amount of foam that covers the intraoral wearing device is such that the surface area of the intraoral wearing device is 1 cm ² from the viewpoint of fully exerting the effect of foam and fully enjoying the excellent denture plaque removing effect and formation suppressing effect. It is preferably 0.05 g or more, more preferably 0.07 g or more, still more preferably 0.1 g or more, preferably 3.5 g or less, still more preferably 3.2 g or less, still more preferable. Is 3 g or less.

After covering the intraoral wearing device with the formed foam, it is preferable to wash the cleaning agent composition by rinsing the intraoral wearing device with water. As described above, when the cleaning agent composition for an intraoral wearing device of the present invention is in the form of foam, the coated foam is washed away by simply rinsing the intraoral wearing device with water without requiring any special physical additional force. However, since it can exert an excellent effect of removing denture plaque with high rapid effect and an effect of effectively suppressing the generation of unpleasant odor, the burden on users such as elderly people is reduced and the frequency of use can be easily increased. You can also.
Further, it is preferable to cover the intraoral wearing device with the formed foam and then rinse the intraoral wearing device after applying the composition with water without applying physical additional force. This makes it possible to easily and effectively clean the intraoral wearing device.

From the viewpoint of fully exerting the effect of foam, the detergent composition for an intraoral wear device of the present invention is filled in a container provided with a foam forming mechanism, and foam is formed by injecting or discharging from the container. Is preferable.
A container provided with a foam forming mechanism is a container capable of forming bubbles by injecting or discharging the contents filled in the container from the injection port or the discharge port to the outside of the container via the foam forming mechanism. Is. Examples of the container provided with such a foam forming mechanism include a trigger type injection container and a pump type dispenser container.

The trigger type injection container is equipped with a container body for filling the contents, a trigger and a sprayer as a foam forming mechanism, and by pulling the trigger at the time of use, the contents move from the injection port of the sprayer to the outside. It is sprayed and bubbles are formed. The trigger type injection container may be a direct pressure type or an accumulator type.
The pump-type dispenser container is equipped with a container body for filling the contents, a tube and a nozzle, and a foam forming mechanism such as a mesh inside these, and the contents are tubed by pressing a part of the container during use. Bubbles are formed by being discharged to the outside from the discharge port of the nozzle or nozzle.
When cleaning an orally-mounted device using the cleaning agent composition for an orally-mounted device of the present invention, it is preferable to use a trigger-type injection container among these containers from the viewpoint of fully exerting the effect of foam. ..

When a trigger type injection container is used, the injection diameter at an injection distance of 20 cm is preferably set to 2 cm or more, more preferably 3 cm or more, preferably 10 cm or less, and more preferably 8 cm or less from the viewpoint of fully exerting the effect of bubbles. Is desirable.
Further, in the trigger type injection container, the injection force of the detergent composition as the content is preferably 1 g · f or more, more preferably 3 g · f at an injection distance of 20 cm from the viewpoint of effectively forming bubbles. As mentioned above, it is preferable to set it to 10 g · f or less, and more preferably 8 g · f or less.

As described above, the cleaning agent composition for an intraoral wear device of the present invention can sufficiently remove the denture plaque of the intraoral wear device by applying it in a short time without requiring any special physical additional force, and after cleaning. Can avoid excessive residue of the fragrance compound in the denture plaque remaining in the intraoral wearing device or the oral wearing device, and can effectively suppress the generation of unpleasant odor. As a result, the burden on users such as the elderly is reduced, and the frequency of use can be easily increased.

Hereinafter, the present invention will be specifically described based on examples. Unless otherwise specified in the table, the content of each component indicates mass%.

[Examples 1 to 6, Comparative Examples 1 to 11]
According to the formulation shown in Table 1, 0.2% by mass of each of the fragrance compounds (B) or (C) shown in Table 2 was blended, and the cleaning agent compositions for each intraoral wear device were compared with Examples 1 to 6. Examples 1 to 11 (pH 10) were prepared.
Then, the retention of aroma was evaluated according to the following method.

<< Evaluation of aroma retention >>
25 mL of the prepared detergent composition for intraoral wear was placed in a glass screw tube (FS media vial, 50 mL, manufactured by Maruem), and the aroma generated from the composition immediately after preparation was put into a trained professional panel by one person. Evaluation was made according to the following criteria. Then, using a constant temperature storage device, each detergent composition for an intraoral wear device was stored at 50 ° C. for 30 days and then returned to room temperature, and the degree of aroma generated from the composition was evaluated in the same manner.
The results are shown in Table 2.
If the evaluation result immediately after preparation is 2 or more and the evaluation result after storage is 1 or more, it is judged that the detergent composition for an intraoral wearing device of the present invention is excellent in aroma retention. The higher the value, the stronger the aroma is felt (the better the aroma retention).
0: No fragrance is felt 1: The fragrance is faintly felt 2: The fragrance is weak but felt 3: The fragrance is slightly weakened but clearly felt 4: The fragrance is well maintained Can be felt clearly

[Examples 7 to 10, Comparative Examples 12 to 13]
According to the formulation shown in Table 3, the perfume compositions 1 and 2 shown in Table 4 were blended as the perfume compound (B) or (C) to prepare a detergent composition for each intraoral wear device.
Then, the evaluation was performed according to the following method.

<< Evaluation of fatty acid odor >>
25 mL of the prepared detergent composition for intraoral wear was placed in a glass screw tube (FS media vial, 50 mL, manufactured by Maruem), and the fatty acid odor of the composition immediately after preparation was carried out by one trained professional panel. Was evaluated according to the following criteria. Then, after storing at 25 ° C. for 30 days using a constant temperature storage device, the fatty acid odor of the composition was evaluated in the same manner.
The results are shown in Table 4.
0: No fatty acid odor is felt 1: Fatty acid odor is faintly felt 2: Fatty acid odor is weakly felt 3: Fatty acid odor is clearly felt 4: Fatty acid odor is slightly strongly felt 5: Fatty acid odor is strongly felt Be

<< Evaluation of odor remaining on dentures after cleaning >>
After storing 25 mL of the prepared detergent composition for intraoral wear equipment at 50 ° C. for 3 days using a constant temperature storage device, a denture substrate (manufactured by Kyouyu Co., Ltd., material: polymethylmethacrylate resin, 1 cm) was used. Was immersed for 5 minutes. Next, the denture substrate was rinsed with water to wash away the composition, and the unpleasant odor remaining on the denture substrate was evaluated by one trained professional panelist according to the following criteria. The higher the value, the stronger the unpleasant odor (the odor remaining on the denture).
The results are shown in Table 4.
0: No unpleasant odor is felt 1: Unpleasant odor is faintly felt 2: Unpleasant odor is weakly felt 3: Unpleasant odor is clearly felt 4: Unpleasant odor is slightly strongly felt 5: Unpleasant odor is strongly felt Be

<< Evaluation in foam application >>
The detergent composition for an intraoral wear device obtained in Examples 7 to 10 is filled in a foam discharge container (a trigger type injection container set to an injection diameter of 5 cm and an injection force of 5 g · f at an injection distance of 20 cm). The foam-like detergent composition for an intraoral wearing device discharged from the discharge port was applied to a used denture, left for 5 minutes, and then the denture was rinsed with water to wash away the composition.
From the time when the composition was applied to the denture to the time when the denture was rinsed with water, no offensive odor such as fatty acid odor or unpleasant odor derived from the composition was felt. Further, in the denture after washing, despite the application of the composition for a short time, the adhered denture plaque was sufficiently removed and no unpleasant odor due to the residual fragrance was felt.
Then, when the denture was returned to the oral cavity and attached, it was possible to realize high cleaning performance without any offensive odor and sliminess.

<< Evaluation of denture plaque removal effect >>
1) Preparation of denture plaque model test solution Streptococcus mutans JCM5705 and Candida albicans JCM1542 glycerol stocks are drawn on an agar plate (Anaero Columbia Agar with RSB, Nippon Becton Dickinson) and stored in a plastic case together with a CO ₂ pack. Under anaerobic conditions, the cells were cultured at 37 ° C. for 48 to 72 hours. Cells in which a single colony was picked up from the agar plate after culturing and 20 mL of liquid medium A (SCD medium Daigo (manufactured by Nippon Pharmaceutical Co., Ltd.) 3% by mass, Bacto Yeast Extract (manufactured by Becton Dickinson) 0.5% by mass) was dispensed. After placing in a culture flask and stirring, the cells were stored in a plastic case together with a CO ₂ pack under anaerobic conditions and cultured at 37 ° C. for 24 hours.

After culturing, this culture broth was diluted with liquid medium A so that OD = 0.5. Liquid medium B (SCD medium Daigo 3wt%, Bacto Yeast Extract 0.5wt%, D (+)-glucose (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) 1% by mass, sucrose (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) 2% by mass) was diluted to S. mutans OD = 0.01 and C. albicans OD = 0.00001. Further, a sterilized aqueous solution of calcium chloride (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) was mixed so as to have a final calcium ion concentration of 40 ppm to prepare a denture plaque model test solution.

2) Preparation of denture plaque model Put the denture substrate (manufactured by Kyouyu Co., Ltd., material: polymethylmethacrylate resin, 1 cm) in a 24-well plate, add 1 mL each of the denture plaque model test solution prepared in 1) above, and then add this. Was stored in a plastic case together with a CO ₂ pack under anaerobic conditions and cultured at 37 ° C. for 16 hours.

3) Evaluation of denture plaque removal effect The above-mentioned denture plaque model test solution in the plate was sucked up using a decompression pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. Next, ion-exchanged water was sucked up using a pump, and 1 mL of each composition obtained in Examples and Comparative Examples was separately prepared in a 24-well plate. Then, the denture substrate on which the denture plaque model was formed was dipped in the prepared solution, applied, and allowed to stand for 5 minutes.
The shaking was performed using a shaking machine (BioShake iQ (manufactured by Waken Betec)) at room temperature (25 ° C.) and 550 rpm.

Then, each composition was sucked up, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. The operation of adding 1 mL of ion-exchanged water and shaking for 5 minutes was repeated a total of 3 times. Then, the ion-exchanged water was sucked up, 750 μL of 0.1% by mass crystal violet (CV) solution was added, and the mixture was shaken for 15 minutes.
Further, the CV staining solution was sucked up by a pump, 1 mL of ion-exchanged water was added, and the mixture was shaken for 5 minutes. The operation of adding 1 mL of ion-exchanged water and shaking for 5 minutes was repeated twice. Next, the ion-exchanged water was sucked up with a pump, 500 μL of ethanol was added and pipetting was performed, and then the extract was diluted 10-fold with ion-exchanged water. ), The absorbance OD _{595 nm} was measured.

Further, the denture plaque removal rate (%) was calculated according to the following formula based on the absorbance OD _{595 nm} (initial value) when ion-exchanged water was used instead of the obtained composition.
Denture plaque removal rate (%) = 100-
{OD _595nm when the above obtained composition is used / OD _595nm when ion-exchanged water is used instead of the above obtained composition} × 100
The results are shown in Table 5.
The larger the value of the obtained denture plaque removal rate, the higher the denture plaque removal effect.

Claims (4)

The following components (A) to (B):
(A) Fatty acid salt having 10 or more and 20 or less carbon atoms or a salt thereof. 0.5% by mass or more and 20% by mass or less in terms of fatty acid. And one or more fragrance compounds selected from Timor,
The mass ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.8 or more and 500 or less, and the pH at 25 ° C. is 8 or more and 14 or less. Detergent composition for intraoral wearing equipment. The content of one or more perfume compounds (C) selected from menthol, limonene, linalool, citral, isopulegol, mentyl lactate, and vanillin is less than 0.09% by mass, or the component (C). The cleaning agent composition for an intraoral wearing device according to claim 1, which does not contain. Further, one or more surfactants (D) selected from anionic surfactants (d1) other than the component (A), nonionic surfactants (d2), and amphoteric surfactants (d3). The detergent composition for an intraoral wearing device according to claim 1 or 2, which contains 0.05% by mass or more and 20% by mass or less. The detergent composition for an intraoral wearing device according to claim 3, wherein the component (d1) is an acyl amino acid salt.