JP2022037433A - Polydatin-containing stable composition - Google Patents

Abstract

To provide a composition that contains polydatin and is particularly stable to light.SOLUTION: A composition contains (a) polydatin, (b) at least one caffeoylquinic acid compound, (c) at least one vitamin B3 compound, and (d) water. The amount of the (b) caffeoylquinic acid compound is 0.5 mass% or more, preferably 1.0 mass% or more, more preferably 1.5 mass% or more relative to the total mass of the composition. The inventive composition is particularly stable to light.SELECTED DRAWING: None

Description

The present invention relates to compositions that include polydatine but are particularly light stable, preferably cosmetic or dermatological compositions.

The formation of free radicals is widely believed to play a crucial role in the mechanism of skin aging. Free radicals are highly reactive molecular species with unpaired electrons that can directly damage various cell membranes, lipids, proteins, RNA, and DNA. The damaging effects of such free radicals, often present in the form of reactive oxygen species, are induced inside tissues and cells during normal metabolism and externally through various oxidative stresses. UV exposure and environmental pollution can accelerate skin aging by producing free radicals in the skin. Antioxidants protect cells from oxidative stress damage by removing free radicals and suppressing oxidative reactions. Topical application of antioxidants is widely used in skin care products to prevent skin aging. It has been previously shown in the field of cosmetics that polyphenols act synergistically with other antioxidants such as vitamin E and carotenoids.

Lee J. et al., "Hydrotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property," Pharmaceutical Research, Vol. 20, No. 7, 2003. Lee S. et al., "Hydrotropic Polymers: Synthesis and characterization of Polymers Containing Picolylnicotinamide Moieties", Macromolecules, 36, 2248-2255, 2003 Walter Noll's Chemistry and Technology of Silicones (1968), Academic Press Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48-53

Polydatine (also known as piceid) is an antioxidant and can be used as a potent whitening active ingredient. However, it is difficult for a composition containing polydatine to be particularly stable to light.

It is an object of the present invention to provide a composition comprising polydatine, but particularly stable to light.

The above object of the present invention is
(a) Polydatine,
(b) At least one cafe oil quinic acid compound,
(c) At least one vitamin B3 compound, and
(d) A composition containing water,
(b) The amount of the caffe oil quinic acid compound is 0.5% by mass or more, preferably 1.0% by mass or more, more preferably 1.5% by mass or more, based on the total mass of the composition.
It can be achieved by the composition.

(a) Polydatine may be of plant origin.

The amount of (a) polydatine in the composition according to the present invention is 0.01% by mass to 3% by mass, preferably 0.05% by mass to 2% by mass, and more preferably 0.1% by mass to 1 with respect to the total mass of the composition. It may be in the range of mass%.

(b) The cafe oil quinic acid compound has the following formula (I).

(In the equation, R ₁ , R ₂ , R ₃ , and R ₄ are independently hydrogen atoms, or the following equation (II).

Represents a cafe oil group represented by
However, at least one of R ₁ , R ₂ , R ₃ , and R ₄ represents the cafe oil group of formula (II)).
Can be represented by.

(b) Café oil The quinic acid compound may be chlorogenic acid.

(b) Café oil The quinic acid compound may be derived from a plant.

The amount of the (b) café oil quinic acid compound in the composition according to the present invention is 0.5% by mass to 15% by mass, preferably 1.0% by mass to 10% by mass, more preferably 1.5% by mass, based on the total mass of the composition. It may be in the range of mass% to 5% by mass.

(c) The vitamin B3 compound has the following formula (III).

(In the formula, R represents -CONH ₂ , -COOH, CH ₂ OH, -CO-NH-CH ₂ -COOH, or -CO-NH-OH)
Can be represented by.

(c) The vitamin B3 compound may be niacinamide.

The amount of the (c) vitamin B3 compound in the composition according to the present invention is 0.1% by mass to 15% by mass, preferably 0.5% by mass to 10% by mass, and more preferably 1% by mass with respect to the total mass of the composition. It may be in the range of ~ 5% by mass.

The mass ratio of the amounts of the (a) polydatine / (b) caffe oil quinic acid compound may be 0.1 to 1, preferably 0.2 to 0.5, and more preferably 0.3 to 0.4.

The mass ratio of the amounts of (a) polydatine / (c) vitamin B3 compound may be 0.01 to 0.5, preferably 0.05 to 0.3, and more preferably 0.1 to 0.2.

The mass ratio of the amounts of the (c) vitamin B3 compound / (b) cafe oil quinic acid compound may be 1 to 8, preferably 1.5 to 4, and more preferably 2 to 3.

The composition according to the invention may be in the form of an O / W emulsion, preferably a nano or micro O / W emulsion, more preferably a nano or micro O / W gel emulsion.

The present invention also relates to a cosmetic method for treating a keratin substance such as skin, which comprises a step of applying the composition according to the present invention to the keratin substance.

As a result of diligent studies, the present inventor has found that it is possible to provide a composition containing polydatine, which is particularly stable to light.

Therefore, the composition according to the present invention is
(a) Polydatine,
(b) At least one cafe oil quinic acid compound,
(c) At least one vitamin B3 compound, and
(d) Contains water,
(b) The amount of the caffe oil quinic acid compound is 0.5% by mass or more, preferably 1.0% by mass or more, and more preferably 1.5% by mass or more with respect to the total mass of the composition.

The compositions according to the invention are stable to several factors, including cooling and light, in particular light such as visible light, UV light, and IR light. Therefore, the composition according to the present invention can have excellent thermal stability and photostability, especially photostability.

The term "excellent thermal stability" here refers to the composition according to the invention being visually uniform and in the form of crystalline particles after cooling to a certain period of time, such as one month, eg 4 ° C. It means that the precipitation of succulent polydatine does not occur.

The term "excellent photostability" here refers to that more than 50%, preferably more than 55%, more preferably more than 60% of polydatine before exposure to light remains after exposure to light. It means that you can do it.

Hereinafter, the composition according to the present invention will be described in more detail.

[Polydatine]
The composition according to the invention comprises (a) polydatine.

Polydatine, which can also be described as 3,4', 5-trihydroxystilbene-3-β-mono-D glucoside, is a stilbenoid. Stilbenoids have strong natural antioxidant properties, such as quenching free radicals and limiting oxidative stress. These properties can be used for skin care or sun care products, including the compositions according to the invention. Polydatin is active in the trans conformation, but when exposed to sunlight and other irradiation, it photoisomerizes to cispolydatin, which is less biologically active.

The amount of (a) polydatine in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more with respect to the total mass of the composition.

The amount of (a) polydatine in the composition according to the present invention may be 3% by mass or less, preferably 2% by mass or less, more preferably 1% by mass or less, based on the total mass of the composition. , (A) The amount of polydatine is not zero.

The amount of (a) polydatine in the composition according to the present invention is 0.01% by mass to 3% by mass, preferably 0.05% by mass to 2% by mass, and more preferably 0.1% by mass to 1 with respect to the total mass of the composition. It may be in the range of mass%.

[Cafe oil quinic acid compound]
The composition according to the invention comprises (b) at least one café oil quinic acid compound. If more than one caffe oil quinic acid compound is used, they may be the same or different.

(b) Café oil quinic acid compound here means a compound having a quinic acid structure having at least one caffe oil group (radical or group).

(b) The cafe oil quinic acid compound has the following formula (I).

(In the equation, R ₁ , R ₂ , R ₃ , and R ₄ are independently hydrogen atoms, or the following equation (II).

Represents a cafe oil group represented by
However, at least one of R ₁ , R ₂ , R ₃ , and R ₄ represents the cafe oil group of formula (II)).
Can be represented by.

(b) Examples of caffe oil quinic acid compounds are 3-cafe oil quinic acid (chlorogenic acid), 4,5-di-cafe oil quinic acid, 3,5-di-cafe oil quinic acid, 1,3-di. -Café oil quinic acid, 3,4-di-cafe oil quinic acid, 3,4,5-tri-cafe oil quinic acid, and mixtures thereof can be mentioned.

(b) Café oil The quinic acid compound is preferably chlorogenic acid.

The amount of the (b) cafe oil quinic acid compound in the composition according to the present invention is 0.5% by mass or more, preferably 1.0% by mass or more, and more preferably 1.5% by mass or more with respect to the total mass of the composition. There may be.

The amount of the (b) café oil quinic acid compound in the composition according to the present invention is 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition. However, (b) the amount of caffe oil quinic acid compound is not zero.

The amount of the (b) café oil quinic acid compound in the composition according to the present invention is 0.5% by mass to 15% by mass, preferably 1.0% by mass to 10% by mass, more preferably 1.5% by mass, based on the total mass of the composition. It may be in the range of mass% to 5% by mass.

[Vitamin B3 compound]
The composition according to the invention comprises (c) at least one vitamin B3 compound. If more than one vitamin B3 compound is used, they may be the same or different.

Vitamin B3 compound, here, means a compound in the group of vitamin B3, and a derivative thereof.

Vitamin B3 is also called vitamin PP, and here, the following equation (III)

(In the formula, R is -CONH ₂ (niacinamide), -COOH (nicotinic acid or niacin), or CH ₂ OH (nicotinyl alcohol), -CO-NH-CH ₂ -COOH (nicotin uric acid), or- It is a compound represented by CO-NH-OH (which can be nicotinylhydroxamic acid). Niacinamide is preferred.

Vitamin B3 derivatives that can be mentioned include, for example, nicotinic acid esters such as tocopherol nicotinate, amides derived from niacinamide by substitution of the hydrogen group of -CONH ₂ , products from the reaction of carboxylic acids with amino acids, nicoti. Examples include esters of nyl alcohols with carboxylic acids such as acetic acid, salicylic acid, glycolid acid, or palmitic acid.

The following derivatives can also be mentioned: 2-chloronicotinamide, 6-methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N, N-dimethylnicotinamide, N, N-diethylnicotinamide, N-picorylnicotinamide, N-allylnicotinamide, N- (hydroxymethyl) nicotinamide, quinophosphateimide, nicotinanilide, N-benzylnicotinamide, N-ethylnicotinamide, niphenazone, nicotinaldehyde, isonicotinic acid, Methylisonicotinic acid, thionicotinamide, nearramid, 2-mercaptonicotinic acid, nicomol and nearplazine, methyl nicotinamide, and sodium nicotinate.

Other vitamin B3 derivatives that can also be mentioned include inorganic salts such as chlorides, bromides, iodides, or carbonates, and organic salts such as salts obtained by reaction with carboxylic acids, such as acetates. Examples thereof include salicylate, glycolate, lactate, malate, citrate, mandelate, tartrate and the like.

The amount of the (c) vitamin B3 compound in the composition according to the present invention may be 0.1% by mass or more, preferably 0.5% by mass or more, more preferably 1% by mass or more, based on the total mass of the composition. ..

The amount of the (c) vitamin B3 compound in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition. However, (c) the amount of vitamin B3 compound is not zero.

The amount of the (c) vitamin B3 compound in the composition according to the present invention is 0.1% by mass to 15% by mass, preferably 0.5% by mass to 10% by mass, and more preferably 1% by mass with respect to the total mass of the composition. It may be in the range of ~ 5% by mass.

(Mass ratio)
The mass ratio of the amounts of the (a) polydatine / (b) cafe oil quinic acid compound may be 0.1 or more, preferably 0.2 or more, and more preferably 0.3 or more.

The mass ratio of the amount of (a) polydatine / (b) caffe oil quinic acid compound may be 1 or less, preferably 0.5 or less, and more preferably 0.4 or less.

The mass ratio of the amounts of the (a) polydatine / (b) caffe oil quinic acid compound may be 0.1 to 1, preferably 0.2 to 0.5, and more preferably 0.3 to 0.4.

The mass ratio of the amounts of (a) polydatine / (c) vitamin B3 compound may be 0.01 or more, preferably 0.05 or more, and more preferably 0.1 or more.

The mass ratio of the amounts of (a) polydatine / (c) vitamin B3 compound may be 0.5 or less, preferably 0.3 or less, and more preferably 0.2 or less.

The mass ratio of the amounts of (a) polydatine / (c) vitamin B3 compound may be 0.01 to 0.5, preferably 0.05 to 0.3, and more preferably 0.1 to 0.2.

The mass ratio of the amounts of the (c) vitamin B3 compound / (b) cafe oil quinic acid compound may be 1 or more, preferably 1.5 or more, and more preferably 2 or more.

The mass ratio of the amounts of the (c) vitamin B3 compound / (b) cafe oil quinic acid compound may be 8 or less, preferably 4 or less, and more preferably 3 or less.

The mass ratio of the amounts of the (c) vitamin B3 compound / (b) cafe oil quinic acid compound may be 1 to 8, preferably 1.5 to 4, and more preferably 2 to 3.

[water]
The composition according to the invention comprises (d) water.

The amount of (d) water in the composition according to the present invention may be 50% by mass or more, preferably 60% by mass or more, and more preferably 70% by mass or more with respect to the total mass of the composition.

On the other hand, the amount of (d) water in the composition according to the present invention may be 95% by mass or less, preferably 90% by mass or less, more preferably 85% by mass or less, based on the total mass of the composition. However, (d) the amount of water is not zero.

The amount of (d) water in the composition according to the present invention is 50% by mass to 95% by mass, preferably 60% by mass to 90% by mass, and more preferably 70% by mass to 85% with respect to the total mass of the composition. It may be in the range of mass%.

[Solubilizer]
The composition according to the invention may further contain at least one solubilizer. If more than one solubilizer is used, they may be the same or different.

The solubilizer can further dissolve (a) polydatine in (d) water.

The solubilizer may be hydrotropes, but the solubilizer is not required to be hydrotropes. Hydrotropes (or hydrotropes) are a diverse class of water-soluble compounds characterized by an amphipathic molecular structure and the ability to dramatically increase the solubility of less soluble organic molecules in water. be.

Many hydrotropes have aromatic structures with ionic moieties, some of which are linear alkyl chains. Hydrotropes are very similar to surfactants and have the ability to reduce surface tension, but due to their small hydrophobic units and their relatively short alkyl chains, they are another class of amphipathic substances. Distinguished. As a result, even at high concentrations, hydrophobicity is not sufficient to create well-organized self-association structures such as micelles.

Common hydrotrope molecules include sodium 1,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate, sodium salicylate, sodium benzenesulfonate, caffeine, sodium p-toluenesulfonate, butylmonoglycol. Sodium sulfate, 4-aminobenzoic acid HCl, sodium cumenesulfonate, 2-methacryloyloxyethyl phosphorylcholine, resorcinol, butylurea, pyrogallol, N-picorylacetamide 3.5, prokine HCl, proline HCl, pyridine, 3-picorylamine, ibprofen Examples thereof include sodium, sodium xylene sulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N, N-dimethylacetamide, N-methylacetamide, and isoniazide. Hydrotropes are described by Lee J. et al., "Hydrotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property," Pharmaceutical Research, Vol. 20, No. 7, 2003, and Lee S. et al., "Hydrotropic Polymers: Synthesis and characterization of." Polymers Containing Picolylnicotinamide Moieties, Macromolecules, 36, pp. 2248-2255, found in 2003. Preferred hydrotropes may include caffeine, sodium PCA, sodium salicylate, urea, and dihydroxyethylurea.

The amount of the solubilizer in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more with respect to the total mass of the composition.

On the other hand, the amount of the solubilizer in the composition according to the present invention may be 4% by mass or less, preferably 3% by mass or less, more preferably 2% by mass or less, based on the total mass of the composition. However, the amount of solubilizer is not zero.

The amount of the solubilizer in the composition according to the present invention is 0.01% by mass to 4% by mass, preferably 0.05% by mass to 3% by mass, and more preferably 0.1% by mass to 2% by mass with respect to the total mass of the composition. It may be within the range of%.

[oil]
The composition according to the invention may further contain at least one oil. If more than one oil is used, they may be the same or different.

Here, "oil" means a fatty compound or fatty substance and is in the form of a liquid or paste (non-solid) at room temperature (25 ° C.) under atmospheric pressure (760 mmHg). Oils commonly used in cosmetics can be used alone or in combination thereof. These oils may be volatile or non-volatile.

The oil may be a non-polar oil such as a hydrocarbon oil or a silicone oil, a vegetable oil or an animal oil, and a polar oil such as an ester oil or an ether oil, or a mixture thereof.

The oil may be selected from the group consisting of plant or animal origin oils, synthetic oils, silicone oils, hydrocarbon oils, and fatty alcohols.

Examples of vegetable oils are, for example, flaxseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, southern ka oil, sunflower oil, benibana oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, Soybean oil, peanut oil, and mixtures thereof can be mentioned.

Examples of animal oils can be mentioned, for example, squalene and squalene.

Examples of synthetic oils can be referred to as alkane oils such as isododecane and isohexadecane, ester oils, ether oils, and artificial triglycerides.

Ester oils are preferably saturated or unsaturated, linear or branched C ₁ to C ₂₆ aliphatic monoacids or polyacids, and saturated or unsaturated, linear or branched C ₁ to It is a liquid ester with C ₂₆ aliphatic monoalcohol or polyhydric alcohol, and the total number of carbon atoms of these esters is 10 or more.

Preferably, in the case of an ester of monoalcohol, at least one of the alcohols and acids from which the ester of the present invention is derived is branched.

Among the monoesters of monoacid and monoalcohol, ethyl palmitate, ethylhexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristate, such as isopropyl myristate or ethyl myristate, isosetyl stearate, 2-ethylhexyl isononanoate, Isononyl isononanoate, isodesyl neopentate, and isostearyl neopentate can be mentioned.

C ₄ to C ₂₂ dicarboxylic acid or tricarboxylic acid and ester of C ₁ to C ₂₂ alcohol, and monocarboxylic acid, dicarboxylic acid, or tricarboxylic acid and non-sugar C ₄ to C ₂₆ dihydroxy, trihydroxy, tetrahydroxy, or Esters with pentahydroxy alcohols can also be used.

In particular, the following can be mentioned: diethyl sevacinate, isopropyl lauroyl sarcosin isopropyl, diisopropyl sevacinate, bis sevacinate (2-ethylhexyl), diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, bis adipate. (2-Ethylhexyl), diisostearyl adipate, bis maleate (2-ethylhexyl), triisopropyl citrate, triisocetyl citrate, triisostearyl citrate, glyceryl trilactic acid, glyceryl trioctanoate, trioctyldodecyl citrate, Trioleyl citrate, neopentyl glycol diheptate, diethylene glycol diisononanoate.

As the ester oil, sugar esters and diesters of C ₆ to C ₃₀ , preferably C ₁₂ to C ₂₂ fatty acids can be used. The term "sugar" means an oxygen-retaining hydrocarbon compound containing several alcohol functional groups, having or not having an aldehyde or ketone functional group, and containing at least 4 carbon atoms. Recall what to do. These sugars can be monosaccharides, oligosaccharides, or polysaccharides.

Examples of suitable sugars that can be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose, and lactose, as well as derivatives thereof, especially alkyl derivatives, such as. Methyl derivatives, examples include methyl glucose.

Fatty acid glycoesters include, among other things, esters or mixtures of the above-mentioned sugars with linear or branched, saturated or unsaturated C ₆ to C ₃₀ , preferably C ₁₂ to C ₂₂ fatty acids. You can choose from. These compounds can have 1 to 3 conjugated or unconjugated carbon-carbon double bonds when unsaturated.

Esters in this modified form may also be selected from monoesters, diesters, triesters, tetraesters, and polyesters, as well as mixtures thereof.

These esters include, for example, oleic acid ester, lauric acid ester, palmitic acid ester, myristic acid ester, behenic acid ester, coconut fatty acid ester, stearic acid ester, linoleic acid ester, linolenic acid ester, capric acid ester, and arachidonic acid. It may be an ester, or a mixture thereof, for example, a mixed ester of oleopalmitic acid, oleostearic acid, and palmitostearic acid, and pentaerythrityl tetraethylhexanoate.

More specifically, monoesters and diesters, especially monooleic or dioleic acids of sucrose, glucose, or methylgluco, stearic acid esters, behenic acid esters, oleopalmitic acid esters, linoleic acid esters, linolenic acid esters, and Oreostearate ester is used.

An example that can be mentioned is the product sold by Amerchol under the name Glucate® DO, which is methylglucose dioleate.

Examples of preferred ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanate, octyldodecyl octanate, isodecyl neopentate, myristyl propionate, 2-ethylhexanoic acid 2. -Ethylhexyl, 2-ethylhexyl octanoate, 2-ethylhexyl caprylic acid / caprylic acid, methyl palmitate, ethyl palmitate, isopropyl palmitate, dicaprilyl carbonate, lauroyl sarcosine isopropyl, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, laurin Hexyl acid, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, tri (2-ethylhexanoic acid) glyceryl, tetra (2-ethylhexanoic acid) pentaerythrityl, 2-ethylhexyl succinate, diethyl sebacate , And mixtures thereof can be mentioned.

Examples of artificial triglycerides include, for example, capril caprylyl glyceride, glyceryl trimyristate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, tri (capric acid / capric acid) glyceryl, And tri (capric acid / capric acid / linolenic acid) glyceryl can be mentioned.

Examples of silicone oils include linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic organopolysiloxanes such as cyclohexasiloxane, octamethylcyclotetrasiloxane. , Decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc., and mixtures thereof.

Preferably, the silicone oil is selected from liquid polydialkylsiloxanes, in particular liquid polydimethylsiloxane (PDMS), and liquid polyorganosiloxanes containing at least one aryl group.

These silicone oils may also be organically modified. The organically modified silicones that can be used in accordance with the present invention are the silicone oils defined above and include, in their structure, one or more organic functional groups attached via hydrocarbon-based groups.

Organopolysiloxane is defined in more detail in Walter Noll's Chemistry and Technology of Silicones (1968), Academic Press. The organopolysiloxane may be volatile or non-volatile.

If volatile, the silicone is more specifically selected from those having a boiling point between 60 ° C and 260 ° C, and even more specifically from the following.

(i) Cyclic polydialkylsiloxane containing 3-7, preferably 4-5 silicon atoms. These are, for example, octamethylcyclotetrasiloxanes sold under the name Volatile Silicone® 7207 by Union Carbide or under the name Silbione® 70045 V2 by Rhodia, Union Carbide. Sold by Rhodia under the name Volatile Silicone® 7158, Decamethylcyclopentasiloxane sold by Rhodia under the name Silbione® 70045 V5, and Momentive Performance Materials under the name Silsoft 1217. Dodecamethylcyclopentasiloxane, as well as mixtures thereof. It is also possible to refer to a cyclopolymer of the following type, such as dimethylsiloxane / methylalkylsiloxane, such as Silicone Volatile® FZ 3109 sold by Union Carbide.

Mixtures of cyclic polydialkylsiloxanes and organosilicon compounds, such as mixtures of octamethylcyclotetrasiloxane and tetratrimethylsilylpentaerythritol (50/50), and octamethylcyclotetrasiloxane and oxy-1,1'-bis (2). , 2,2', 2', 3,3'-hexatrimethylsilyloxy) A mixture with neopentane can also be mentioned.

(ii) A linear volatile polydialkylsiloxane containing 2-9 silicon atoms and having a viscosity of 5 × 10 ^-6 m ² / s or less at 25 ° C. An example is the decamethyltetrasiloxane sold under the name SH 200, especially by Toray Silicone. Silicones in this category are also described in the papers published in Cosmetics and Toiletries, Vol. 91, January 1976, pp. 27-32, Todd & Byers, Volatile Silicone Fluids for Cosmetics. Silicone viscosities are measured at 25 ° C. according to ASTM Standard 445 Annex C.

Non-volatile polydialkylsiloxane may be used. These non-volatile silicones are selected from polydialkylsiloxanes in more detail, and among them, polydimethylsiloxanes containing a trimethylsilyl terminal group can be mainly referred to.

Among these polydialkylsiloxanes, the following commercial products can be referred to in a non-limiting manner:
--Silbione® 47 and 70 047 series or Mirasil® oils sold by Rhodia, eg 70 047 V 500 000 oils,
--Mirasil® series oils sold by Rhodia,
--Dow Corning 200 series oils, such as DC200 with a viscosity of 60000 mm ² / s;
--General Electric's Viscasil® oil and General Electric's SF series certain oils (SF 96, SF 18).

Polydimethylsiloxane containing a dimethylsilanol end group, known by the name Dimethiconol (CTFA), such as Rhodia's 48 Series oils can also be mentioned.

Among the silicones containing an aryl group, polydiarylsiloxane, particularly polydiphenylsiloxane and polyalkylarylsiloxane, for example, phenylsilicone oil can be mentioned.

Phenyl silicone oil has the following formula

(During the ceremony,
R ₁ to R ₁₀ are independent of each other, saturated or unsaturated, linear, cyclic or branched C ₁ to C ₃₀ hydrocarbon groups, preferably C ₁ to C ₁₂ hydrocarbon groups. More preferably, it is a C ₁ to C ₆ hydrocarbon group, particularly a methyl, ethyl, propyl or butyl group.
m, n, p, and q are integers of 0 to 900 including both ends, preferably 0 to 500 including both ends, and more preferably 0 to 100 including both ends, independently of each other.
However, the sum of n + m + q is other than 0)
You can choose from phenyl silicone.

Examples that can be mentioned include products sold under the following names:
--70 641 series of Silbione® oils from Rhodia,
--Rhodia Rhodorsil® 70 633 and 763 series oils,
--Dow Corning 556 Cosmetic Grade Fluid, an oil manufactured by Dow Corning
--Bayer PK series silicones, such as PK20 products,
--Constant oils in the SF series from General Electric, such as SF 1023, SF 1154, SF 1250, and SF 1265.

As the phenylsilicone oil, phenyltrimethicone (in the above formula, R ₁ to R ₁₀ are methyl, p, q, and n = 0, and m = 1) is preferable.

The organically modified liquid silicone may contain, among other things, polyethyleneoxy and / or polypropyleneoxy groups. Therefore, it is possible to refer to the silicone KF-6017 proposed by Shin-Etsu Chemical Co., Ltd. and the oils Silwet® L722 and L77 manufactured by Union Carbide.

Hydrocarbon oils can be selected from:
--C ₆ to C ₁₆ lower alkanes that are linear or branched, and optionally cyclic. Examples that can be mentioned include hexane, undecane, dodecane, tridecane, and isoparaffin, such as isohexadecane, isododecane, and isodecane; and
—— Linear or branched hydrocarbons containing more than 16 carbon atoms, such as liquid paraffin, liquid petroleum jelly, polydecene, and hydrogenated polyisobutene, such as Parleam®, and squalane.

Preferred examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as isohexadecane, isododecane, squalane, mineral oils (eg liquid paraffin), paraffin, petrolatum or petrolatum, and naphthalene; Polyisobutene, isoeikosan, and decene / butene copolymers; as well as mixtures thereof can be mentioned.

The term "fat" in fatty alcohols means that it contains a relatively large number of carbon atoms. Therefore, alcohols having 4 or more, preferably 6 or more, more preferably 12 or more carbon atoms are included in the range of fatty alcohols. Fatty alcohols may be saturated or unsaturated. The fatty alcohol may be linear or branched.

Fatty alcohols are saturated and unsaturated in structure R-OH (in the formula, R contains 4-40 carbon atoms, preferably 6-30 carbon atoms, more preferably 12-20 carbon atoms. Saturated, can have (chosen from linear and branched groups). In at least one embodiment, R can be selected from C ₁₂ to C ₂₀ alkyl groups and C ₁₂ to C ₂₀ alkenyl groups. R may or may not be substituted with at least one hydroxyl group.

Examples of fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, linoleyl alcohol, palmitrail alcohol, arachidnyl alcohol, Elsyl alcohol, and mixtures thereof, can be mentioned.

The fatty alcohol is preferably saturated fatty alcohol.

Thus, the fatty alcohols are linear or branched, saturated or unsaturated C ₆ to C ₃₀ alcohols, preferably linear or branched, saturated C ₆ to C ₃₀ alcohols, more preferably straight. You can choose from chained or branched, saturated C ₁₂ to C ₂₀ alcohols.

The term "saturated fatty alcohol" here means an alcohol having a long aliphatic saturated carbon chain. The saturated fatty alcohol is preferably selected from any linear or branched saturated C ₆ to C ₃₀ fatty alcohol. Among the linear or branched saturated C ₆ to C ₃₀ fatty alcohols, the linear or branched saturated C ₁₂ to C ₂₀ fatty alcohols may be preferably used. Any linear or branched saturated C ₁₆ -C ₂₀ fatty alcohol may be more preferably used. Branched C ₁₆ -C ₂₀ fatty alcohols may be used even more preferably.

Examples of saturated fatty alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, undecylenyl alcohol, myristyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, octyldodecanol, hexyldecanol, or mixtures thereof (eg, cetearyl alcohol), and behenyl alcohol can be used as saturated fatty alcohols.

According to at least one embodiment, the fatty alcohol used in the composition according to the invention is preferably selected from cetyl alcohol, octyldodecanol, hexyldecanol, and mixtures thereof.

It is also preferred that the oil be selected from oils having a molecular weight of less than 600 g / mol.

Preferably, the oil has a low molecular weight, such as less than 600 g / mol, and an ester oil having a short hydrocarbon chain (C ₁ to C ₁₂ ) (eg, lauroyl sarcosine isopropyl, isopropyl myristate, isopropyl palmitate, isononanoic acid). Isononyl and ethylhexyl palmitate), silicone oils (eg, volatile silicones such as cyclohexasiloxane), hydrocarbon oils (eg, isododecane, isohexadecan, and squalane), branched and / or unsaturated fatty alcohols (eg, isoddecane, isohexadecane, and squalane). It is selected from C ₁₂ to C ₃₀ ) type oils, such as octyldodecanol and oleyl alcohol, and ether oils such as dicaprylyl ether.

The oil is preferably selected from polar oils, more preferably ester oils.

The amount of oil in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more with respect to the total mass of the composition.

The amount of oil in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, more preferably 1% by mass or less, based on the total mass of the composition, but of the oil. The quantity is not zero.

The amount of oil in the composition according to the present invention is 0.01% by mass to 10% by mass, preferably 0.05% by mass to 5% by mass, and more preferably 0.1% by mass to 1% by mass with respect to the total mass of the composition. There may be.

[emulsifier]
The composition according to the invention may further contain at least one emulsifier. If more than one emulsifier is used, they may be the same or different.

The emulsifier can be a surfactant. The surfactant may be selected from cationic, anionic, amphoteric and nonionic surfactants. The composition according to the invention may preferably contain at least one anionic surfactant and at least one nonionic surfactant.

The anionic surfactant may be preferably selected from amino acid type surfactants.

Non-limiting examples of amino acid type surfactants include cocoyl taurine potassium, methyl cocoyl taurine potassium, caproyl methyl taurine sodium, cocoyl taurine sodium, lauroyl taurine sodium, methyl cocoyl taurine sodium, methyl lauroyl taurine sodium, and methyl myritoyl taurine sodium. , Methyloleoyl taurine sodium, Methylpalmitil taurine sodium, Methylstearoyl taurine sodium, Capriloleoyl glutamate dipotassium, Undecylenoyl glutamate dipotassium, Capriloyl glutamate disodium, Cocoyl glutamate disodium, Lauroyl glutamate disodium, stearoyl glutamate disodium , Undecilenoyl glutamate disodium, capilloyl glutamate potassium, cocoyl glutamate potassium, lauroyl glutamate potassium, myristoyl glutamate potassium, stearoyl glutamate potassium, undecylenoyl glutamate potassium, capriloyl glutamate sodium, cocoyl glutamate sodium lauroyl glutamate Sodium, olive oil fatty acid sodium glutamate, sodium palmitoyl glutamate, sodium stearoyl glutamate, sodium undecylenoyl glutamate, cocoylmethyl β-alanine, lauroyl β-alanine, lauroylmethyl β-alanine, myristol β-alanine, lauroylmethyl β-alanine potassium, Cocoyl alanine sodium, cocoyl methyl β-alanine sodium and myristylmethyl β-alanine palmitoyl glycine sodium, lauroyl glycine sodium, cocoyl glycine sodium, myristyl glycine sodium, lauroyl glycine potassium, cocoyl glycine potassium, lauroyl sarcosin potassium, cocoyl sarcosin potassium, cocoyl sarcosin. Included are sodium, lauroyl sarcosin sodium, myristoyl sarcosin sodium, and palmitoyl sarcosin sodium, and mixtures thereof.

Lauroyl sarcocin potassium, cocoyl sarcosin potassium, cocoyl sarcosin sodium, lauroyl sarcosin sodium, lauroyl aspartate sodium, myristoyl aspartate sodium, cocoyl aspartate sodium, caproyl aspartate sodium, lauroyl aspartate disodium, myristoyl aspartate dissodium, cocoyl Disodium aspartate, disoyl aspartate, disodium lauroyl aspartate, potassium myritoyl aspartate, potassium cocoyl aspartate, potassium caproyl aspartate, dipotassium lauroyl aspartate, dipotassium myritoyl aspartate, dipotassium cocoyl aspartate , Caproyl aspartate dipotassium, and mixtures thereof can also be mentioned.

The amount of the amino acid type surfactant in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, more preferably 0.01% by mass or more, based on the total mass of the composition. ..

On the other hand, the amount of the amino acid type surfactant in the composition according to the present invention is 1% by mass or less, preferably 0.5% by mass or less, more preferably 0.1% by mass or less, based on the total mass of the composition. However, the amount of amino acid type surfactant is not zero.

The amount of the amino acid type surfactant in the composition according to the present invention is 0.001% by mass to 1% by mass, preferably 0.005% by mass to 0.5% by mass, and more preferably 0.01% by mass with respect to the total mass of the composition. It may be in the range of ~ 0.1% by mass.

When the composition according to the present invention preferably contains at least one nonionic surfactant, more preferably at least one polyglyceryl fatty acid ester, and even more preferably a combination of first and second polyglyceryl fatty acid esters. There is also.

(1st polyglyceryl fatty acid ester)
The composition according to the invention may comprise at least one first polyglyceryl fatty acid ester having an HLB value of 12.0 or higher, preferably 12.5 or higher, more preferably 13.0 or higher. A single type of first polyglyceryl fatty acid ester may be used, or two or more different types of first polyglyceryl fatty acid esters may be used in combination.

The first polyglyceryl fatty acid ester can function as a surfactant, in particular a nonionic surfactant.

The first polyglyceryl fatty acid can have an HLB value of 12.0 to 17.0, preferably 12.5 to 16.0, more preferably 13.5 to 15.0.

The term HLB ("hydrophilic-lipophilic balance") is well known to those of skill in the art and refers to the ratio between the hydrophilic and lipophilic moieties in the molecule.

When two or more first polyglyceryl fatty acid esters are used, the HLB value is determined by the mass average of the HLB values of all the first polyglyceryl fatty acid esters.

The first polyglyceryl fatty acid ester may be selected from saturated or unsaturated fatty acid mono, di, avian, and higher esters.

The first polyglyceryl fatty acid ester preferably contains 2 to 4 glycerol units, preferably 3 or 4 glycerol units, more preferably 4 glycerol units.

The fatty acid or fatty acid moiety for the fatty acid moiety of the first polyglyceryl fatty acid ester may contain 12 or less carbon atoms, preferably 11 or less carbon atoms, more preferably 10 or less carbon atoms. The fatty acid or fatty acid moiety for the fatty acid moiety of the first polyglyceryl fatty acid ester may contain 4 or more carbon atoms, preferably 6 or more carbon atoms, more preferably 8 or more carbon atoms. The fatty acid or fatty acid moiety for the fatty acid moiety of the first polyglyceryl fatty acid ester may have 4-12 carbon atoms, preferably 6-11, more preferably 8-10 carbon atoms.

The fatty acid for the fatty acid portion of the first polyglyceryl fatty acid ester may be saturated or unsaturated and may be selected from caprylic acid, capric acid, and lauric acid.

The first polyglyceryl fatty acid ester is capric acid PG3 (HLB: about 14), capric acid PG4 (HLB: 14), lauric acid PG4 (HLB: about 14), capric acid PG4 (HLB: 14), myristic acid PG5 ( HLB: 15.4), stearic acid PG5 (HLB: 15), capric acid PG6 (HLB: 14.6), capric acid PG6 (HLB: 13.1), lauric acid PG6 (HLB: 14.1), lauric acid PG10 (HLB: 15.2), From myristic acid PG10 (HLB: 14.9), stearic acid PG10 (HLB: 14.1), isostearic acid PG10 (HLB: 13.7), oleic acid PG10 (HLB: 13.0), palm fatty acid PG10 (HLB: 16), and mixtures thereof. You may choose from the group of

The first polyglyceryl fatty acid ester is capric acid PG3 (HLB: about 14), caprylic acid PG4 (HLB: 14), lauric acid PG4 (HLB: about 14), capric acid PG4 (HLB: 14), and mixtures thereof. It may be preferable to be selected from the group consisting of.

The amount of the first polyglyceryl fatty acid ester in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, based on the total mass of the composition. ..

On the other hand, the amount of the first polyglyceryl fatty acid ester in the composition according to the present invention is 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition. Well, however, the amount of the first polyglyceryl fatty acid ester is not zero.

The amount of the first polyglyceryl fatty acid ester in the composition according to the present invention is 0.01% by mass to 15% by mass, preferably 0.05% by mass to 10% by mass, and more preferably 0.1% by mass with respect to the total mass of the composition. It may be in the range of ~ 5% by mass.

(Second polyglyceryl fatty acid ester)
The composition according to the invention may comprise at least one second polyglyceryl fatty acid ester having an HLB value of 10.0 or less, preferably 9.5 or less, more preferably 9.0 or less. A single type of second polyglyceryl fatty acid ester may be used, or two or more different types of second polyglyceryl fatty acid esters may be used in combination.

The second polyglyceryl fatty acid ester can function as a surfactant, especially a nonionic surfactant.

The second polyglyceryl fatty acid can have an HLB value of 5.0 to 10.0, preferably 6.0 to 9.5, more preferably 7.0 to 9.0.

When two or more second polyglyceryl fatty acid esters are used, the HLB value is determined by the mass average of the HLB values of all the second polyglyceryl fatty acid esters.

The second polyglyceryl fatty acid ester may be selected from saturated or unsaturated fatty acid mono, di, avian, and higher esters.

The second polyglyceryl fatty acid ester preferably contains 2 to 4 glycerol units, preferably 2 or 3 glycerol units, more preferably 2 glycerol units.

The fatty acid or fatty acid moiety for the fatty acid moiety of the second polyglyceryl fatty acid ester may contain 14 or more carbon atoms, preferably 16 or more carbon atoms, more preferably 18 or more carbon atoms. The fatty acid or fatty acid moiety for the fatty acid moiety of the second polyglyceryl fatty acid ester may contain 30 or less carbon atoms, preferably 24 or less carbon atoms, more preferably 20 or less carbon atoms. The fatty acid or fatty acid moiety for the fatty acid moiety of the second polyglyceryl fatty acid ester may have 14-30, preferably 16-24, more preferably 18-20 carbon atoms.

The fatty acid for the fatty acid portion of the second polyglyceryl fatty acid ester may be saturated or unsaturated and may be selected from myristic acid, stearic acid, isostearic acid, and oleic acid.

The second polyglyceryl fatty acid ester is stearate PG2 (HLB: 5.0), distearate PG2 (HLB: 4), isostearate PG2 (HLB: 8), diisostearic acid PG2 (HLB: 3.2), triisostearic acid PG2 (HLB). : 3), sesquiisostearic acid PG2 (HLB: about 4), oleic acid PG2 (HLB: 8), sesquioleic acid PG2 (HLB: 5.3), distearate PG3 (HLB: 5), diisostearate PG3 (HLB: 5) ), Diyashi fatty acid PG3 (HLB: 7), hexastearic acid PG5 (HLB: 4.0), trioleic acid PG5 (HLB: 7.0), pentaoleic acid PG10 (HLB: 6.4), sesquicaprylic acid PG2 (HLB: about 8) ), Capric acid PG2 (HLB: 9.5), Lauric acid PG2 (HLB: 8.5), Myristic acid PG2 (HLB: 10), Isopalmitic acid PG2 (HLB: 9), Oleic acid PG4 (HLB: 10), Stealic acid PG4 (HLB: 9), Isostearate PG4 (HLB: 8.2), Distearate PG6 (HLB: 8), Distearate PG10 (HLB: Approx. 9), Tristearate PG10 (HLB: 8), Diisostearate PG10 (HLB: 8) You may choose from the group consisting of 10), triisostearic acid PG10 (HLB: 8), tricoco fatty acid PG10 (HLB: 9), and mixtures thereof.

The second polyglyceryl fatty acid is stearate PG2 (HLB: 5.0), distearate PG2 (HLB: 4), isostearate PG2 (HLB: 8), diisostearate PG2 (HLB: 3.2), triisostearate PG2 (HLB: 4). 3), sesquiisostearic acid PG2 (HLB: about 4), oleic acid PG2 (HLB: 8), sesquioleic acid PG2 (HLB: 5.3), distearate PG3 (HLB: 5), diisostearate PG3 (HLB: 5) , Diyashi fatty acid PG3 (HLB: 7), sesquicaprylic acid PG2 (HLB: about 8), capric acid PG2 (HLB: 9.5), laurate PG2 (HLB: 8.5), myristic acid PG2 (HLB: 10), isopalmitin When preferably selected from the group consisting of acid PG2 (HLB: 9), oleic acid PG4 (HLB: 10), stearate PG4 (HLB: 9), isostearate PG4 (HLB: 8.2), and mixtures thereof. There is also.

The amount of the second polyglyceryl fatty acid ester in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, based on the total mass of the composition. ..

On the other hand, the amount of the second polyglyceryl fatty acid ester in the composition according to the present invention is 10% by mass or less, preferably 5% by mass or less, more preferably 1% by mass or less, based on the total mass of the composition. Well, however, the amount of second polyglyceryl fatty acid ester is not zero.

The amount of the second polyglyceryl fatty acid ester in the composition according to the present invention is 0.01% by mass to 10% by mass, preferably 0.05% by mass to 5% by mass, and more preferably 0.1% by mass with respect to the total mass of the composition. It may be in the range of ~ 1% by mass.

(Mass ratio for polyglyceryl fatty acid ester)
According to the present invention, the mass ratio of the amount of (total amount of the first polyglyceryl fatty acid ester and the second polyglyceryl fatty acid ester) / oil is 4.0 or less, preferably 3.0 or less, more preferably 2.0 or less. good.

Traditionally, the mass ratio of glyceryl fatty acid ester / oil amount is much higher, for example 6.0.

Therefore, the composition according to the present invention can reduce or limit the total amount of polyglyceryl fatty acid ester.

Since the present invention can reduce the total amount of polyglyceryl fatty acid ester, the composition according to the present invention can not give a sticky feeling when touched, or can further reduce the sticky feeling. ..

(Total amount of first polyglyceryl fatty acid ester and second polyglyceryl fatty acid ester) / The mass ratio of the amount of oil may be more than 0.5, preferably more than 1.0, more preferably more than 1.5.

On the other hand, according to the present invention, the mass ratio of the amount of the first polyglyceryl fatty acid ester / the second polyglyceryl fatty acid ester may be 1 or more, preferably 1.5 or more, more preferably 2 or more, and 5 or less. It may be preferably 4 or less, more preferably 3 or less, 1 to 5, preferably 1.5 to 4, and more preferably 2 to 3.

(Average HLB of polyglyceryl fatty acid ester)
The average HLB value of the first polyglyceryl fatty acid ester and the second polyglyceryl fatty acid ester can be calculated as the mass average of all the first and second polyglyceryl fatty acid esters.

The average HLB of the first polyglyceryl fatty acid ester and the second polyglyceryl fatty acid ester in the composition according to the present invention may be 11.0 or more, preferably 11.5 or more, and more preferably 12.0 or more.

The average HLB of the first polyglyceryl fatty acid ester and the second polyglyceryl fatty acid ester in the composition according to the present invention may be 14.0 or less, preferably 13.5 or less, and more preferably 13.0 or less.

Therefore, in one embodiment of the present invention, the average HLB of the first polyglyceryl fatty acid ester and the second polyglyceryl fatty acid ester in the composition according to the present invention is 11.0 to 14.0, preferably 11.5-13.5, more preferably 12.0. It may be in the range of ~ 13.0.

[Polyol]
The composition according to the invention may further comprise at least one polyol. A single type of polyol may be used, or two or more different types of polyols may be used in combination.

The term "polyol" here means an alcohol having two or more hydroxy groups and does not include sugars or derivatives thereof. As a sugar derivative, a sugar alcohol obtained by reducing one or more carbonyl groups of a sugar, and a hydrogen atom in one or more hydroxy groups are an alkyl group, a hydroxyalkyl group, an alkoxy group, or an acyl group. Examples thereof include sugars or sugar alcohols that have been replaced with at least one substituent such as a group or a carbonyl group.

The polyol may be a C ₂ to C ₁₂ polyol, preferably a C ₂ to C ₉ polyol, containing at least 2 hydroxy groups, preferably 2 to 5 hydroxy groups.

The polyol may be a natural polyol or a synthetic polyol. The polyol can have a linear, branched, or cyclic molecular structure.

The polyol may be selected from glycerin and its derivatives, and glycols and its derivatives. The polyols are glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,3-propanediol, 1,5-pentanediol, and caprylyl. It may be selected from the group consisting of sugars such as glycols, polyethylene glycols (5 to 50 ethylene oxide groups), and sorbitol.

The amount of the polyol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, and more preferably 0.1% by mass or more with respect to the total mass of the composition.

On the other hand, the amount of the polyol in the composition according to the present invention may be 25% by mass or less, preferably 20% by mass or less, more preferably 15% by mass or less, based on the total mass of the composition. The amount of polyol is not zero.

Therefore, the polyol is according to the present invention in an amount in the range of 0.01% by mass to 25% by mass, preferably 0.05% by mass to 20% by mass, for example, 0.1% by mass to 15% by mass, based on the total mass of the composition. It may be present in the composition.

[Other ingredients]
The composition according to the invention comprises one or more monoalcohols in liquid form at room temperature (25 ° C.), such as linear or branched monoalcohols containing 1 to 6 carbon atoms, for example. It may further contain ethanol, propanol, butanol, isopropanol, isobutanol, pentanol, and hexanol.

The amount of monoalcohol in the composition according to the present invention may be 0.01% by mass or more, preferably 0.1% by mass or more, and more preferably 1% by mass or more, based on the total mass of the composition.

On the other hand, the amount of monoalcohol in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition.

Therefore, the amount of monoalcohol in the composition according to the present invention is 0.01% by mass to 15% by mass, preferably 0.1% by mass to 10% by mass, and more preferably 1% by mass to 5 with respect to the total mass of the composition. It may be in the range of mass%.

In addition to the ingredients described above, the compositions according to the invention also include various adjuvants conventionally used in cosmetic and dermatological compositions, such as thickeners, anionic, nonionic, cationic, and. Includes amphoteric or zwitterionic polymers, additional antioxidants, colorants, chelating agents, sequestrants, fragrances, dispersants, conditioning agents, film-forming agents, preservatives, co-preservatives, and mixtures thereof. But it may be.

The composition according to the present invention may further contain baicalin. When the composition according to the present invention contains baicalin, it may be preferable that the amount of baicalin is limited to 0.5% by mass or less with respect to the total mass of the composition. The composition according to the present invention does not have to contain baicalin.

In one embodiment, the composition according to the invention is stable to light and may not include any UV filter. The term "not included" here means that the composition according to the invention may contain a limited amount of at least one UV filter. However, the amount of UV filter is preferably limited to less than 1% by weight, more preferably less than 0.1% by weight, even more preferably less than 0.01% by weight, based on the total mass of the composition. In some cases, the composition according to the invention is most preferably free of UV filters.

In another embodiment, the composition according to the invention may be free of polyoxyethylene-based nonionic surfactants. The term "free" here means that the composition according to the invention may contain a limited amount of polyoxyethylene-based nonionic surfactant. However, the amount of the polyoxyethylene nonionic surfactant is less than 1% by weight, more preferably less than 0.1% by weight, even more preferably less than 0.01% by weight, based on the total mass of the composition. It is preferable to be limited. In some cases, the composition according to the present invention is most preferably free of polyoxyethylene-based nonionic surfactants.

(Preparation)
The compositions of the present invention can be prepared by mixing the essential ingredients described above and, if necessary, the optional components described above.

(a) Polydatine may be of plant origin. Therefore, as (a) polydatin, for example, a plant extract containing (a) polydatin may be used. For example, (a) Polygonium Cuspidatum Root Extract commercially available from Guilin Layn Natural Ingredients may be used as the polydatine.

(b) Café oil The quinic acid compound may be derived from a plant. Therefore, as the (b) cafe oil quinic acid compound, for example, a plant extract containing (b) the cafe oil quinic acid compound may be used. For example, (b) Eucommia Leaves Extract Chlorogenic Acid 98% commercially available by Guilin Layn Natural Ingredients may be used as the cafe oil quinic acid compound.

Therefore, the composition according to the present invention comprises, for example, (a) polydatin and / or (a) a first plant extract containing polydatin, and (b) a caffeoyl quinic acid compound and / or (b) caffeoyl quinic acid. It can be prepared by mixing a second plant extract containing the compound with the above components (c) and (d) and, if necessary, the optional component described above.

The method and means for mixing the above essential components and optional components are not limited. Any conventional method and means can be used to prepare the composition according to the invention by mixing the above essential ingredients and optional ingredients.

The compositions according to the invention can be prepared without the use of large amounts of energy as required by homogenizers. Therefore, the composition according to the invention can be prepared by using a small amount of energy, for example by gently stirring the components of the composition. Therefore, the composition according to the present invention is environmentally friendly in consideration of its preparation method.

[form]
The composition according to the present invention is not limited. For example, the composition according to the present invention may be in the form of an aqueous solution.

When the composition according to the present invention contains at least one oil, the composition according to the present invention is preferably in the form of an O / W type emulsion containing an oil phase dispersed in a continuous aqueous phase. The dispersed oil phase can be oil droplets in the aqueous phase. In this case, the composition according to the present invention preferably contains at least one emulsifier described above.

Since the O / W type configuration or structure consists of an oil phase dispersed in the aqueous phase, it has an aqueous phase on the outside, so if the composition according to the invention has an O / W type configuration or structure. Due to the immediate freshness feel that the aqueous phase can give, a pleasing feel can be given.

The composition according to the invention may be in the form of nano or microemulsion.

"Microemulsion" can be defined in two ways: broad and narrow. That is, in one case, the microemulsion refers to a thermodynamically stable isotropic single liquid phase containing a three-component system having three components: an oily component, an aqueous component, and a surfactant ( There is a "microemulsion in the narrow sense"), and the second is that in a typical emulsion system that is thermodynamically unstable, the microemulsion has a transparent or translucent appearance due to its smaller particle size. There are cases where the indicated emulsions are further included (“microemulsions in a broad sense”) (Satoshi Tomomasa et al., Oil Chemistry, Vol. 37, No. 11 (1988), pp. 48-53). As used herein, "microemulsion" refers to a "microemulsion in the narrow sense", i.e., a thermodynamically stable isotropic single liquid phase.

Microemulsions are O / W (oil-in-water) type microemulsions in which oil is solubilized by micelles, W / O (water in oil) type microemulsions in which water is solubilized by reverse micelles, or surfactants. The number of associations of activator molecules becomes infinite, and as a result, refers to any one state of both continuous microemulsions having a continuous structure in both the aqueous phase and the oily phase.

The microemulsion may have a dispersed phase having a particle size of 100 nm or less, preferably 50 nm or less, more preferably 20 nm or less, as measured by laser particle size analysis.

"Nanoemulsion" here means an emulsion characterized by a dispersed phase having a size less than 350 nm, which optionally forms a lamellar type liquid crystal phase at the dispersed phase / continuous phase interface. It is stabilized by the crown of nonionic surfactants of (b) and (c) that can be. In the absence of a particular opacifier, the transparency of the nanoemulsion results from the small size of the dispersed phase, which is obtained by the use of mechanical energy.

Nanoemulsions can be distinguished from microemulsions by their structure. Specifically, the microemulsion is, for example, a thermodynamically stable dispersion formed from oil-swelled micelles formed by an emulsifier. Moreover, microemulsions do not require substantial mechanical energy to prepare.

The nanoemulsion may have a dispersed phase having a particle size of 300 nm or less, preferably 200 nm or less, more preferably 100 nm or less, as measured by laser particle size analysis.

(a) The particle size of the oil is 35 nm or less, preferably 30 nm or less, more preferably 25 nm or less, even more preferably when the composition according to the present invention is in the form of an O / W type emulsion. The particle size can be measured by a dynamic light scattering method. The particle size measurement can be performed by, for example, the ELSZ-2000 series of particle size analyzers commercially available by Otsuka Electronics Co., Ltd.

The particle size can be volume average particle diameter or number average particle diameter, preferably volume average particle diameter.

The composition according to the present invention may be transparent.

Transparency can be measured by measuring turbidity. For example, the turbidity is by 2100Q (Hach Company) with a round cell (diameter 25 mm and height 60 mm) and a tungsten filament bulb capable of emitting visible light (between 400 and 800 nm, preferably between 400 and 500 nm). It can be measured using (commercially available). Measurements can be performed on undiluted compositions. The blank may be determined using distilled water.

The composition according to the invention has a turbidity of 150 NTU or less, preferably 130 NTU or less, more preferably 110 NTU or less.

The composition according to the invention may be more preferably in the form of a nano or micro O / W emulsion.

It may be even more preferred that the composition according to the invention is in the form of a nano or micro O / W gel emulsion. For example, the aqueous phase of a nano or micro O / W gel emulsion may contain at least one thickener, such as xanthan gum.

[Method and use]
The composition according to the present invention is preferably a cosmetic or dermatological composition, preferably a cosmetic composition, more preferably a skin cosmetic composition. The composition according to the invention may be in the form of lotions, creams, serums and the like.

The compositions according to the invention can be used for non-therapeutic methods such as cosmetological methods to treat keratin substances such as skin, especially the face, by applying to the keratin substances.

Therefore, the present invention also relates to a cosmetic method for treating a keratin substance such as skin, which comprises a step of applying the composition according to the present invention to the keratin substance.

The present invention may also relate to the use of the compositions according to the invention as cosmetics such as skin care products or in cosmetics. Skin care products may be lotions, creams, serums and the like.

In other words, the composition according to the present invention can be used as it is as a cosmetic. Alternatively, the composition according to the present invention can be used as an element of cosmetics. For example, the compositions according to the invention can be added to or combined with any other element to form a cosmetic.

Another aspect of the invention is
(d) In a composition containing water
Especially against light
(a) To stabilize polydatine,
(b) At least one cafe oil quinic acid compound, and
(c) may relate to the use of at least one vitamin B3 compound.

Another aspect of the invention is also.
(d) In a composition containing water
Especially for light
(a) As a stabilizer for polydatine,
(b) At least one cafe oil quinic acid compound, and
(c) may relate to the use of at least one vitamin B3 compound.

The above description of the components (a)-(d) for the composition according to the invention and the optional components can be applied to those components for use and method according to the invention. The description of the preparation and form of the composition according to the invention can also be applied to the preparation and form of the composition described in the above uses and methods.

The present invention will be described in more detail by way of examples, but this should not be construed as limiting the scope of the invention.

(Examples 1 to 3 and Comparative Examples 1 to 5)
The following compositions in the form of microemulsions according to Examples 1 to 3 and Comparative Examples 1 to 5 shown in Table 1 were prepared by mixing the components shown in Table 1 below. All figures for the amount of ingredients shown in Table 1 are based on "% by mass" as an active ingredient.

[evaluation]
(Thermal stability)
Each of the compositions according to Examples 1 to 3 and Comparative Examples 1 to 5 was put into a transparent glass bottle, and the glass bottle was stored at a temperature of 4 ° C. for 1 month. One month later, the sides of the glass bottle were visually observed and evaluated according to the following criteria.
Good: No crystal particles were observed Poor: Crystal particles were observed

The results are shown in the "Thermal Stability" row in Table 1.

The compositions according to Examples 1 to 3 and Comparative Examples 1, 4, and 5 were stable for a long period of time without forming crystal particles even at a cold temperature.

The compositions according to Comparative Examples 2 and 3 were unstable because crystal particles were formed at a cold temperature. Therefore, it has been found that the use of baicalin in an amount of 1.0% by weight or more is not preferable for preparing a thermally stable composition.

(Light stability)
Each of the compositions according to Examples 1-3 and Comparative Examples 1, 4, and 5 was spread on two glass plates in an amount of 2 mg / cm ² . One of the two glass plates was placed under xenon light and the other under no light. These were left at a temperature of 25 ° C. for 30 minutes. The two glass plates were then immersed in 25 g of methanol and stirred with a stirrer tip for 30 minutes to extract polydatine. The methanol solution was measured by HPLC (reverse phase) to quantify polydatin. The photostability of polydatine was calculated by the following formula.

Photostability (%) = (Xe Polydatin with light (%)) / (Xe Polydatin without light (%))

The results are shown in the "Light Stability" row in Table 1. "NA" in Table 1 means unavailable.

The compositions according to Examples 1-3 were more stable under light, with 50% of polydatine remaining, even after exposure to light.

The compositions according to Comparative Examples 1, 4, and 5 had less than 50% photostability and were less stable under light.

Claims (15)

(a) Polydatine,
(b) At least one cafe oil quinic acid compound,
(c) At least one vitamin B3 compound, and
(d) A composition containing water,
(b) A composition in which the amount of the caffe oil quinic acid compound is 0.5% by mass or more, preferably 1.0% by mass or more, more preferably 1.5% by mass or more, based on the total mass of the composition. (a) The composition according to claim 1, wherein the polydatine is derived from a plant. The amount of (a) polydatine in the composition is 0.01% by mass to 3% by mass, preferably 0.05% by mass to 2% by mass, and more preferably 0.1% by mass to 1% by mass with respect to the total mass of the composition. The composition according to claim 1 or 2, which is within the range. (b) The cafe oil quinic acid compound has the following formula (I).

(In the equation, R ₁ , R ₂ , R ₃ , and R ₄ are independently hydrogen atoms, or the following equation (II).

Represents a cafe oil group represented by
However, at least one of R ₁ , R ₂ , R ₃ , and R ₄ represents the cafe oil group of formula (II)).
The composition according to any one of claims 1 to 3, represented by. (b) The composition according to any one of claims 1 to 4, wherein the cafe oil quinic acid compound is chlorogenic acid. (b) The composition according to any one of claims 1 to 5, wherein the cafe oil quinic acid compound is derived from a plant. The amount of the (b) cafe oil quinic acid compound in the composition is 0.5% by mass to 15% by mass, preferably 1.0% by mass to 10% by mass, and more preferably 1.5% by mass to the total mass of the composition. The composition according to any one of claims 1 to 6, which is in the range of 5% by mass. (c) Vitamin B3 compound has the following formula (III)

(In the formula, R represents -CONH ₂ , -COOH, CH ₂ OH, -CO-NH-CH ₂ -COOH, or -CO-NH-OH)
The composition according to any one of claims 1 to 7, represented by. (c) The composition according to any one of claims 1 to 8, wherein the vitamin B3 compound is niacinamide. The amount of the (c) vitamin B3 compound in the composition is 0.1% by mass to 15% by mass, preferably 0.5% by mass to 10% by mass, more preferably 1% by mass to 5% by mass, based on the total mass of the composition. The composition according to any one of claims 1 to 9, which is within the range of%. The mass ratio of the amounts of (a) polydatine / (b) cafe oil quinic acid compound is 0.1 to 1, preferably 0.2 to 0.5, and more preferably 0.3 to 0.4, according to any one of claims 1 to 10. The composition described. The invention according to any one of claims 1 to 11, wherein the mass ratio of the amounts of (a) polydatine / (c) vitamin B3 compound is 0.01 to 0.5, preferably 0.05 to 0.3, and more preferably 0.1 to 0.2. Composition. Any one of claims 1 to 12, wherein the mass ratio of the amounts of (c) vitamin B3 compound / (b) cafe oil quinic acid compound is 1 to 8, preferably 1.5 to 4, more preferably 2 to 3. The composition according to the section. The composition according to any one of claims 1 to 13, which is in the form of an O / W type emulsion, preferably a nano or micro O / W type emulsion, and more preferably a nano or micro O / W type gel emulsion. A cosmetic method for treating a keratin substance such as skin, which comprises a step of applying the composition according to any one of claims 1 to 14 to the keratin substance.