JP2022026218A - External composition - Google Patents
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- JP2022026218A JP2022026218A JP2020129579A JP2020129579A JP2022026218A JP 2022026218 A JP2022026218 A JP 2022026218A JP 2020129579 A JP2020129579 A JP 2020129579A JP 2020129579 A JP2020129579 A JP 2020129579A JP 2022026218 A JP2022026218 A JP 2022026218A
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- 239000000203 mixture Substances 0.000 title claims abstract description 87
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 16
- 239000000600 sorbitol Substances 0.000 claims abstract description 6
- 239000006260 foam Substances 0.000 claims description 104
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 229960002920 sorbitol Drugs 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 7
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 7
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 7
- 229920001499 Heparinoid Polymers 0.000 claims description 6
- 239000002554 heparinoid Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 abstract description 11
- 230000002688 persistence Effects 0.000 abstract description 7
- 239000002628 heparin derivative Substances 0.000 abstract description 3
- 229920001451 polypropylene glycol Polymers 0.000 abstract description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 238000005187 foaming Methods 0.000 description 32
- 238000011156 evaluation Methods 0.000 description 11
- 150000005846 sugar alcohols Chemical class 0.000 description 11
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 8
- 239000002736 nonionic surfactant Substances 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000004088 foaming agent Substances 0.000 description 5
- 235000010356 sorbitol Nutrition 0.000 description 5
- 229940058015 1,3-butylene glycol Drugs 0.000 description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 238000007599 discharging Methods 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 235000010724 Wisteria floribunda Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- GFMIDCCZJUXASS-UHFFFAOYSA-N hexane-1,1,6-triol Chemical compound OCCCCCC(O)O GFMIDCCZJUXASS-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 125000006353 oxyethylene group Chemical group 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- VIZORQUEIQEFRT-UHFFFAOYSA-N Diethyl adipate Chemical compound CCOC(=O)CCCCC(=O)OCC VIZORQUEIQEFRT-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- XWIHRGFIPXWGEF-UHFFFAOYSA-N propafenone hydrochloride Chemical compound Cl.CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 XWIHRGFIPXWGEF-UHFFFAOYSA-N 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、外用組成物等に関する。 The present invention relates to an external composition or the like.
外用剤の剤形として、例えば、軟膏剤、クリーム剤、ローション剤等がある。軟膏剤やクリーム剤は、半固形状であるので、広範囲に塗り広げ難い。また、ローション剤は、液状であるので、広範囲に塗り広げることには向いているが、使用時に液が垂れることがあり使い難い。 Dosage forms of external preparations include, for example, ointments, creams, lotions and the like. Since ointments and creams are semi-solid, it is difficult to spread them over a wide area. In addition, since the lotion is liquid, it is suitable for spreading over a wide area, but it is difficult to use because the liquid may drip during use.
一方、近年、簡便で広範囲に使用可能なフォーム剤が注目されている。フォーム剤は、吐出時は泡状態であるので液垂れが抑制されており、また液体であるので広範囲に塗り広げることにも適している。フォーム剤としては、皮膚への刺激を抑える目的で、非イオン性界面活性剤を用いた、ポンプ型泡吐出装置等の非ガス型泡吐出装置を用いたフォーム剤が望ましい。特許文献１には、非イオン性界面活性剤と一定量以上のアルコールを組合わせることにより、泡を長時間保持することが提案されている。 On the other hand, in recent years, a foaming agent that is simple and can be widely used has attracted attention. Since the foaming agent is in a foamy state at the time of ejection, dripping is suppressed, and since it is a liquid, it is also suitable for spreading over a wide area. As the foaming agent, a foaming agent using a non-gas type foam discharging device such as a pump type foam discharging device using a nonionic surfactant is desirable for the purpose of suppressing irritation to the skin. Patent Document 1 proposes that foam is retained for a long time by combining a nonionic surfactant and a certain amount or more of alcohol.
本発明者は、研究を進める中で、従来技術のフォーム剤は、泡の持続性は良く液垂れは抑制されているものの、塗り広げても泡がなかなか消失せず、塗り広げた部分が白化したように見えるという問題（泡切れが悪いという問題）を有することに着目した。 In the course of research by the present inventor, the foaming agent of the prior art has good foam durability and suppresses dripping, but the foam does not disappear easily even when spread, and the spread portion is whitened. I focused on having the problem that it looks like it was done (the problem that the bubbles are not broken).
そこで、本発明は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好である、外用組成物を提供することを課題とする。 Therefore, it is an object of the present invention to provide an external composition having good foaming and foam sustainability, but also good foam breaking.
本発明者は上記課題に鑑みて鋭意研究を進めた結果、（A1成分）ソルビトール、（B成分）ポリオキシエチレンポリオキシプロピレングリコール、及び（C成分）ヘパリン類似物質を含有する、外用組成物、であれば、上記課題を解決できることを見出した。本発明者はこの知見に基づいてさらに研究を進めた結果、本発明を完成させた。即ち、本発明は、下記の態様を包含する。 As a result of diligent research in view of the above problems, the present inventor has produced an external composition containing (A1 component) sorbitol, (B component) polyoxyethylene polyoxypropylene glycol, and (C component) heparinoid. If so, we have found that the above problems can be solved. The present inventor has completed the present invention as a result of further research based on this finding. That is, the present invention includes the following aspects.
項１． （A1成分）ソルビトール、（B成分）ポリオキシエチレンポリオキシプロピレングリコール、及び（C成分）ヘパリン類似物質を含有する、外用組成物．
項２． 前記A1成分がD－ソルビトールを含む、項１に記載の外用組成物．
項３． 前記外用組成物中の前記A1成分の含有率が0.1～40質量％である、項１又は２に記載の外用組成物．
項４． さらに、（A2成分）グリセリンを含有する、項１～３のいずれかに記載の外用組成物．
項５． 前記外用組成物中の前記A2成分の含有率が0.5～45質量％である、項４に記載の外用組成物．
項６． 前記外用組成物中の前記B成分の含有率が0.05～10質量％である、項１～５のいずれかに記載の外用組成物．
項７． 前記外用組成物中の前記C成分の含有率が0.01～10質量％である、項１～６のいずれかに記載の外用組成物．
項８． 前記外用組成物中の水の含有率が25質量％以上である、項１～７のいずれかに記載の外用組成物．
項９． 皮膚への塗布に用いるための、項１～８のいずれかに記載の外用組成物．
項１０． 泡吐出装置用である、項１～９のいずれかに記載の外用組成物．
項１１． 前記泡吐出装置が非ガス型泡吐出装置である、項１０に記載の外用組成物．
項１２． 項１～１１のいずれかに記載の外用組成物を泡吐出装置を備える容器に充填してなる、外用剤．
Item 1. An external composition containing (A1 component) sorbitol, (B component) polyoxyethylene polyoxypropylene glycol, and (C component) heparinoid.
Item 2. Item 2. The external composition according to Item 1, wherein the A1 component contains D-sorbitol.
Item 3. Item 2. The external composition according to Item 1 or 2, wherein the content of the A1 component in the external composition is 0.1 to 40% by mass.
Item 4. Item 4. The external composition according to any one of Items 1 to 3, further comprising (A2 component) glycerin.
Item 5. Item 2. The external composition according to Item 4, wherein the content of the A2 component in the external composition is 0.5 to 45% by mass.
Item 6. Item 2. The external composition according to any one of Items 1 to 5, wherein the content of the component B in the external composition is 0.05 to 10% by mass.
Item 7. Item 6. The external composition according to any one of Items 1 to 6, wherein the content of the C component in the external composition is 0.01 to 10% by mass.
Item 8. Item 2. The external composition according to any one of Items 1 to 7, wherein the content of water in the external composition is 25% by mass or more.
Item 9. Item 6. The external composition according to any one of Items 1 to 8, which is used for application to the skin.
Item 10. Item 6. The external composition according to any one of Items 1 to 9, which is for a foam discharge device.
Item 11. Item 6. The external composition according to Item 10, wherein the foam discharging device is a non-gas type foam discharging device.
Item 12. An external preparation prepared by filling a container provided with a foam discharge device with the external composition according to any one of Items 1 to 11.
本発明によれば、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好である、外用組成物を提供することができる。 According to the present invention, it is possible to provide an external composition having good foaming and foam sustainability, but also good foam breakage.
本明細書中において、「含有」及び「含む」なる表現については、「含有」、「含む」、「実質的にからなる」及び「のみからなる」という概念を含む。 In the present specification, the expressions "contains" and "contains" include the concepts of "contains", "contains", "substantially consists" and "consists of only".
本発明は、その一態様において、（A1成分）ソルビトール、（B成分）ポリオキシエチレンポリオキシプロピレングリコール、及び（C成分）ヘパリン類似物質を含有する、外用組成物（本明細書において、「本発明の外用組成物」と示すこともある。）に関する。以下、これについて説明する。 The present invention, in one aspect thereof, is an external composition containing (A1 component) sorbitol, (B component) polyoxyethylene polyoxypropylene glycol, and (C component) heparinoid (in the present specification, "the present invention". It may be referred to as "external composition of the invention"). This will be described below.
ソルビトール（A1成分）は、糖アルコールであり、D－ソルビトール、及びL－ソルビトールのいずれも包含する。本発明の一態様において、これらの中でも、泡立ち、泡の持続性、泡切れ等の観点から、好ましくはD－ソルビトールが挙げられる。 Sorbitol (A1 component) is a sugar alcohol and includes both D-sorbitol and L-sorbitol. In one aspect of the present invention, among these, D-sorbitol is preferably mentioned from the viewpoint of foaming, foam sustainability, foam breakage and the like.
A1成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The A1 component can be used alone or in combination of any two or more.
本発明の一態様において、A1成分は、D－ソルビトールを含むことが好ましい。 In one aspect of the present invention, the A1 component preferably contains D-sorbitol.
本発明の外用組成物中のA1成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.1～40質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは0.2～40質量％、より好ましくは0.4～35質量％、さらに好ましくは0.5～30質量％である。泡立ち、泡の持続性、泡切れ等の観点から、本発明の好ましい一態様において、該含有率の下限は、例えば1質量％、2質量％、3質量％、4質量％、5質量％、6質量％、7質量％、8質量％、9質量％、10質量％であり得る。 The content of the A1 component in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.1 to 40% by mass. The content is preferably 0.2 to 40% by mass, more preferably 0.4 to 35% by mass, and further preferably 0.5 to 30% by mass from the viewpoints of foaming, foam sustainability, foam breakage and the like. From the viewpoint of foaming, foam sustainability, foam breakage, etc., in a preferred embodiment of the present invention, the lower limit of the content is, for example, 1% by mass, 2% by mass, 3% by mass, 4% by mass, 5% by mass, It can be 6% by weight, 7% by weight, 8% by weight, 9% by weight, 10% by weight.
本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等（特に、泡の持続性）の観点から、グリセリン（A2成分）を含有することが好ましい。 The external composition of the present invention preferably contains glycerin (A2 component) from the viewpoint of foaming, foam persistence, foam breakage and the like (particularly, foam persistence).
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA2成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.5～45質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは1～45質量％、より好ましくは2～40質量％、さらに好ましくは4～35質量％、よりさらに好ましくは6～30質量％、とりわけ好ましくは6～25質量％、特に好ましくは8～25質量％である。 When the external composition of the present invention contains an A2 component, the content of the A2 component in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.5 to 45% by mass. The content is preferably 1 to 45% by mass, more preferably 2 to 40% by mass, still more preferably 4 to 35% by mass, still more preferably 6 from the viewpoint of foaming, foam sustainability, foam breakage and the like. It is -30% by mass, particularly preferably 6 to 25% by mass, and particularly preferably 8 to 25% by mass.
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA1成分とA2成分との合計含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは1～85質量％、より好ましくは2～75質量％、さらに好ましくは4～70質量％、よりさらに好ましくは5～65質量％、とりわけ好ましくは7～55質量％、とりわけさらに好ましくは9～50質量％である。本発明の一態様において、該含有率の下限は、例えば12質量％、14質量％、16質量％、18質量％、又は19質量％であり得る。 When the external composition of the present invention contains an A2 component, the total content of the A1 component and the A2 component in the external composition of the present invention is preferably from the viewpoint of foaming, foam sustainability, foam breakage and the like. 1 to 85% by mass, more preferably 2 to 75% by mass, still more preferably 4 to 70% by mass, still more preferably 5 to 65% by mass, particularly preferably 7 to 55% by mass, and even more preferably 9 to 50%. It is mass%. In one aspect of the invention, the lower limit of the content may be, for example, 12% by weight, 14% by weight, 16% by weight, 18% by weight, or 19% by weight.
本発明の外用組成物がA2成分を含有する場合、本発明の外用組成物中のA1成分とA2成分との含有比は、泡立ち、泡の持続性、泡切れ等の観点から、A1成分1質量部に対して、A2成分が、好ましくは0.05～45質量部、より好ましくは0.1～40質量部、さらに好ましくは0.2～35質量部、よりさらに好ましくは0.3～30質量部である。本発明のさらに好ましい態様において、A1成分1質量部に対して、A2成分は、好ましくは0.4～10質量部、0.5～5質量部、0.6～3質量部、0.8～2質量部である。 When the external composition of the present invention contains an A2 component, the content ratio of the A1 component to the A2 component in the external composition of the present invention is the A1 component 1 from the viewpoint of foaming, foam sustainability, foam breakage, etc. The A2 component is preferably 0.05 to 45 parts by mass, more preferably 0.1 to 40 parts by mass, still more preferably 0.2 to 35 parts by mass, and even more preferably 0.3 to 30 parts by mass with respect to parts by mass. In a more preferable embodiment of the present invention, the A2 component is preferably 0.4 to 10 parts by mass, 0.5 to 5 parts by mass, 0.6 to 3 parts by mass, and 0.8 to 2 parts by mass with respect to 1 part by mass of the A1 component.
本発明の一態様において、本発明の外用組成物は、A1成分及びA2成分以外の他の多価アルコールを含有することができる。他の多価アルコールとしては、例えばA1成分及びA2成分以外の糖アルコール、プロピレングリコール、ジプロピレングリコール、1,3－ブチレングリコール、1,2－ペンタンジオール、1,2－ヘキサンジオール、1,3,6－ヘキサントリオール、ポリエチレングリコール、ポリプロピレングリコール等が挙げられる。ただ、その場合、泡立ち、泡の持続性、泡切れ等の観点から、他の多価アルコールの含有量はより低いことが好ましい。 In one aspect of the present invention, the external composition of the present invention may contain a polyhydric alcohol other than the A1 component and the A2 component. Other polyhydric alcohols include, for example, sugar alcohols other than A1 component and A2 component, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,3. , 6-Hexanetriol, polyethylene glycol, polypropylene glycol and the like. However, in that case, it is preferable that the content of the other polyhydric alcohol is lower from the viewpoint of foaming, foam sustainability, foam breakage and the like.
他の多価アルコールは、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other polyhydric alcohols can be used alone or in combination of any two or more.
本発明の外用組成物において、多価アルコール中のA1成分とA2成分との合計含有率（本発明の外用組成物がA2成分を含有しない場合は、A1成分の含有率を意味する）、或いは多価アルコール中の糖アルコールの合計含有率は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the total content of the A1 component and the A2 component in the polyhydric alcohol (when the external composition of the present invention does not contain the A2 component, it means the content of the A1 component), or. The total content of sugar alcohol in the polyhydric alcohol is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass or more, still more preferably 95% by mass or more. , Particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の一態様において、本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等の観点から、他の多価アルコール（例えば、1,3-ブチレングリコール、マクロゴール400、及び1,3,6－ヘキサントリオールからなる群より選択される少なくとも1種の多価アルコール）の含有量がより低いことが好ましい。本発明の外用組成物中の該多価アルコール（一例として、1,3-ブチレングリコール）の含有率は、例えば0質量％以上5質量％未満、好ましくは0質量％以上4質量％未満、より好ましくは0質量％以上3質量％未満、さらに好ましくは0質量％以上2質量％未満、よりさらに好ましくは0質量％以上1質量％未満、とりわけ好ましくは0質量％以上0.5質量％未満、とりわけさらに好ましくは0質量％以上0.1質量％未満、とりわけよりさらに好ましくは0質量％以上0.01質量％未満である。本発明の一態様において、該含有率は、0質量％であることができる。 In one aspect of the invention, the external composition of the invention comprises other polyhydric alcohols (eg, 1,3-butylene glycol, macrogol 400, and 1) in terms of foaming, foam persistence, foam breakage, and the like. , At least one polyhydric alcohol selected from the group consisting of 3,6-hexanetriol) is preferably lower in content. The content of the polyvalent alcohol (for example, 1,3-butylene glycol) in the external composition of the present invention is, for example, 0% by mass or more and less than 5% by mass, preferably 0% by mass or more and less than 4% by mass. It is preferably 0% by mass or more and less than 3% by mass, more preferably 0% by mass or more and less than 2% by mass, still more preferably 0% by mass or more and less than 1% by mass, particularly preferably 0% by mass or more and less than 0.5% by mass, and particularly further. It is preferably 0% by mass or more and less than 0.1% by mass, and more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the invention, the content can be 0% by weight.
ポリオキシエチレンポリオキシプロピレングリコール（B成分）は、オキシエチレン単位及びオキシプロピレン単位を含む非イオン性界面活性剤である。オキシエチレン単位におけるエチレンオキサイドの平均付加モル数は、特に制限されないが、例えば10～300、好ましくは50～250、より好ましくは100～200である。オキシプロピレン単位におけるプロピレンオキサイドの平均付加モル数は、特に制限されないが、例えば10～300、好ましくは20～150、より好ましくは25～70である。 Polyoxyethylene polyoxypropylene glycol (component B) is a nonionic surfactant containing oxyethylene units and oxypropylene units. The average number of moles of ethylene oxide added per oxyethylene unit is not particularly limited, but is, for example, 10 to 300, preferably 50 to 250, and more preferably 100 to 200. The average number of moles of propylene oxide added in an oxypropylene unit is not particularly limited, but is, for example, 10 to 300, preferably 20 to 150, and more preferably 25 to 70.
ポリオキシエチレンポリオキシプロピレングリコールのHLB値は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該HLB値は、例えば10～20、好ましくは12～18である。 The HLB value of polyoxyethylene polyoxypropylene glycol is not particularly limited as long as it can satisfactorily exhibit foaming, foam sustainability, and foam breakage. The HLB value is, for example, 10 to 20, preferably 12 to 18.
B成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The B component can be used alone or in combination of any two or more.
本発明の外用組成物中のB成分の含有率は、泡立ち、泡の持続性、及び泡切れを良好に発揮できる限り、特に制限されない。該含有率は、例えば0.02～15質量％である。該含有率は、泡立ち、泡の持続性、泡切れ等の観点から、好ましくは0.05～12質量％、より好ましくは0.05～10質量％、さらに好ましくは0.1～9質量％、よりさらに好ましくは0.2～9質量％、とりわけ好ましくは0.3～9質量％、とりわけさらに好ましくは0.4～9質量％である。泡立ち、泡の持続性、泡切れ等の観点から、本発明の好ましい一態様において、該含有率の上限は、例えば8質量％、7質量％、6質量％、5質量％、4質量％、3質量％、2質量％、1質量、0.8質量％であり得る。 The content of the component B in the external composition of the present invention is not particularly limited as long as foaming, foam sustainability, and foam breakage can be satisfactorily exhibited. The content is, for example, 0.02 to 15% by mass. The content is preferably 0.05 to 12% by mass, more preferably 0.05 to 10% by mass, still more preferably 0.1 to 9% by mass, still more preferably 0.2, from the viewpoints of foaming, foam sustainability, foam breakage and the like. It is -9% by mass, particularly preferably 0.3-9% by mass, and even more preferably 0.4-9% by mass. From the viewpoint of foaming, foam sustainability, foam breakage, etc., in a preferred embodiment of the present invention, the upper limit of the content is, for example, 8% by mass, 7% by mass, 6% by mass, 5% by mass, 4% by mass, It can be 3% by mass, 2% by mass, 1% by mass, or 0.8% by mass.
本発明の一態様において、本発明の外用組成物は、B成分以外の他の界面活性剤を含有することができる。他の界面活性剤としては、例えばポリオキシアルキレン単位を含む非イオン性界面活性剤（例えば、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、ポリオキシアルキレンアルキルエーテル等）、グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、脂肪族アルカノールアミド等の非イオン性界面活性剤； 陰イオン性界面活性剤； 陽イオン性界面活性剤； 両性界面活性剤等が挙げられる。ただ、その場合、皮膚への刺激性、泡立ち、泡の持続性、泡切れ等の観点から、他の界面活性剤の含有量はより低いことが好ましい。 In one aspect of the present invention, the external composition of the present invention may contain a surfactant other than the component B. Other surfactants include, for example, nonionic surfactants containing polyoxyalkylene units (eg, polyoxyalkylene fatty acid ester, polyoxyalkylene cured castor oil, polyoxyalkylene alkyl ether, etc.), glycerin fatty acid ester, sorbitan fatty acid. Nonionic surfactants such as esters and aliphatic alkanolamides; anionic surfactants; cationic surfactants; amphoteric surfactants and the like can be mentioned. However, in that case, the content of the other surfactant is preferably lower from the viewpoint of skin irritation, foaming, foam persistence, foam breakage and the like.
他の界面活性剤は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 Other surfactants may be used alone or in combination of any two or more.
本発明の外用組成物において、界面活性剤中のB成分の含有率、或いはポリオキシアルキレン単位を含む非イオン性界面活性剤（B成分を含む。好ましくはB成分と、ポリオキシアルキレン脂肪酸エステル、ポリオキシアルキレン硬化ひまし油、及びポリオキシアルキレンアルキルエーテルからなる群より選択される少なくとも1種と）の合計含有率は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the content of the B component in the surfactant or the nonionic surfactant containing the polyoxyalkylene unit (including the B component, preferably the B component and the polyoxyalkylene fatty acid ester, The total content of (with at least one selected from the group consisting of polyoxyalkylene cured castor oil and polyoxyalkylene alkyl ether) is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more. It is more preferably 90% by mass or more, still more preferably 95% by mass or more, particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物において、非イオン性界面活性剤中のB成分の含有率は、例えば70質量％以上、好ましくは80質量％以上、より好ましくは85質量％以上、さらに好ましくは90質量％以上、よりさらに好ましくは95質量％以上、とりわけ好ましくは97質量％以上、とりわけさらに好ましくは98質量％、特に好ましくは99質量％以上である。該含有率は、100質量％以下である。 In the external composition of the present invention, the content of the component B in the nonionic surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, still more preferably 90% by mass. As described above, it is more preferably 95% by mass or more, particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.
本発明の外用組成物中の他の界面活性剤（特に、陰イオン性界面活性剤、陽イオン性界面活性剤、及び両性界面活性剤）の含有率は、例えば0質量％以上5質量％未満、好ましくは0質量％以上4質量％未満、より好ましくは0質量％以上3質量％未満、さらに好ましくは0質量％以上2質量％未満、よりさらに好ましくは0質量％以上1質量％未満、とりわけ好ましくは0質量％以上0.5質量％未満、とりわけさらに好ましくは0質量％以上0.1質量％未満、とりわけよりさらに好ましくは0質量％以上0.01質量％未満である。本発明の一態様において、該含有率は、0質量％であることができる。 The content of other surfactants (particularly, anionic surfactants, cationic surfactants, and amphoteric surfactants) in the external composition of the present invention is, for example, 0% by mass or more and less than 5% by mass. , Preferably 0% by mass or more and less than 4% by mass, more preferably 0% by mass or more and less than 3% by mass, further preferably 0% by mass or more and less than 2% by mass, still more preferably 0% by mass or more and less than 1% by mass, in particular. It is preferably 0% by mass or more and less than 0.5% by mass, more preferably 0% by mass or more and less than 0.1% by mass, and even more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the invention, the content can be 0% by weight.
ヘパリン類似物質（C成分）は、コンドロイチン多硫酸等の多硫酸化ムコ多糖であり、保湿作用や血流量増加作用等を有することが知られている公知の薬剤である。ヘパリン類似物質の由来については、特に制限されないが、例えば、ムコ多糖類を多硫酸化することにより得られたもの、食用獣の組織（例えば、ウシの気管軟骨を含む肺臓）から抽出したもの等が挙げられる。ヘパリン類似物質としては、日本薬局方外医薬品規格に収戴されているヘパリン類似物質を好適に使用することができる。 The heparinoid (component C) is a polysulfated mucopolysaccharide such as chondroitin polysulfate, and is a known drug known to have a moisturizing effect, a blood flow increasing effect, and the like. The origin of the heparinoid is not particularly limited, but is, for example, one obtained by polysulfating mucopolysaccharide, one extracted from edible animal tissue (for example, lung containing bovine tracheal cartilage), and the like. Can be mentioned. As the heparin-like substance, a heparin-like substance contained in the Japanese Pharmacopoeia non-Japanese Pharmacopoeia drug standard can be preferably used.
C成分は、1種単独で用いることもできるし、任意の2種以上を組み合わせて用いることもできる。 The C component can be used alone or in combination of any two or more.
本発明の外用組成物中のC成分の含有率は、薬効を発揮することができ、且つ泡立ち、泡の持続性、泡切れ等を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば0.01～10質量％、0.05～3質量％、又は0.1～1質量％である。 The content of the C component in the external composition of the present invention is not particularly limited as long as it can exert a medicinal effect and does not significantly impair foaming, foam sustainability, foam breakage and the like. The content is, for example, 0.01 to 10% by mass, 0.05 to 3% by mass, or 0.1 to 1% by mass.
本発明の一態様において、本発明の外用組成物は、上記以外の他の成分を含有することができる。他の成分としては、例えば、エステル油類（例えば、トリアセチン、クエン酸トリエチル、トリ（カプリル、カプリン酸）グリセリン、アジピン酸ジイソプロピル、アジピン酸ジエチル、セバシン酸ジエチル等の二塩基酸、ミリスチン酸イソプロピル、パルミチン酸セチル、ラウリン酸ヘキシル、酢酸ベンジル等の一塩基酸等）、炭化水素類（例えば、流動パラフィン、スクワラン等）、溶剤（例えば、ベンジルアルコール、メチルエチルケトン、N－アルキルピロリドン、アルキレンカーボネート、アセトン、エタノール、イソプロパノール、プロピレングリコール、1,3－ブチレングリコール等）、水溶性高分子（例えば、カルボキシビニルポリマー、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース、キトサン、ポビドン、ポリビニルアルコール等）、防腐剤、保存剤、安定化剤等が挙げられる。 In one aspect of the present invention, the external composition of the present invention may contain other components other than the above. Other components include, for example, ester oils (eg, triacetin, triethyl citrate, tri (capryl, capric acid) glycerin, diisopropyl adipate, diethyl adipate, diethyl dibasic acid such as diethyl sebacate, isopropyl myristate, etc. Cetyl palmitate, hexyl laurate, monobasic acids such as benzyl acetate, etc.), hydrocarbons (eg, liquid paraffin, squalane, etc.), solvents (eg, benzyl alcohol, methyl ethyl ketone, N-alkylpyrrolidone, alkylene carbonate, acetone, etc.) Ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, etc.), water-soluble polymers (eg, carboxyvinyl polymer, hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, chitosan, povidone, polyvinyl alcohol, etc.), preservatives, preservatives , Stabilizers and the like.
本発明の外用組成物中の他の成分の含有率は、泡立ち、泡の持続性、泡切れ等を著しく阻害しない限りにおいて、特に制限されない。該含有率は、例えば、0～10質量％、0～5質量％、0～2質量％、0～1質量％、又は0～0.1質量％である。 The content of other components in the external composition of the present invention is not particularly limited as long as it does not significantly impair foaming, foam persistence, foam breakage and the like. The content is, for example, 0 to 10% by mass, 0 to 5% by mass, 0 to 2% by mass, 0 to 1% by mass, or 0 to 0.1% by mass.
本発明の外用組成物は、泡立ち、泡の持続性、泡切れ等の観点から、通常、水を含有する。本発明の組成物中の水の含有率は、例えば15質量％以上、好ましくは20質量％以上、より好ましくは25質量％以上、さらに好ましくは30質量％以上、よりさらに好ましくは35質量％以上、とりわけ好ましくは40質量％以上、とりわけさらに好ましくは50質量％以上、とりわけよりさらに好ましくは60質量％以上である。該含有率の上限は、例えば95質量％、90質量％、85質量％、又は80質量％であることができる。上記下限及び上限は、任意に組合わせることができる。 The external composition of the present invention usually contains water from the viewpoints of foaming, foam sustainability, foam breakage and the like. The content of water in the composition of the present invention is, for example, 15% by mass or more, preferably 20% by mass or more, more preferably 25% by mass or more, still more preferably 30% by mass or more, still more preferably 35% by mass or more. , Particularly preferably 40% by mass or more, particularly preferably 50% by mass or more, and even more preferably 60% by mass or more. The upper limit of the content can be, for example, 95% by mass, 90% by mass, 85% by mass, or 80% by mass. The above lower limit and upper limit can be arbitrarily combined.
本発明の外用組成物は、皮膚への塗布に用いることができる。本発明の外用組成物は、泡の持続性が良好であるので、泡状で吐出した際の液垂れを抑制しつつ、泡切れも良好であるので、容易に塗り広げることができる。本発明の外用組成物は、皮膚外用医薬、化粧料等の皮膚外用組成物の形態であることが好ましい。本発明の外用組成物は、塗布後に除去しない態様で用いられるものであり、泡立て使用した後に水で除去（例えば洗い流す）ことを目的とした洗浄剤とは区別されるものである。 The external composition of the present invention can be used for application to the skin. Since the composition for external use of the present invention has good foam durability, it can be easily spread because it suppresses dripping when discharged in the form of foam and also has good foam breakage. The external composition of the present invention is preferably in the form of an external composition for skin such as a medicine for external skin and cosmetics. The external composition of the present invention is used in such a manner that it is not removed after application, and is distinguished from a cleaning agent intended to be removed (for example, washed away) with water after being used by whipping.
本発明の外用組成物は、各成分を溶媒と共に混合することにより調製することができる。本発明の組成物は、好ましくは可溶化状態である。可溶化状態とは、界面活性剤がミセルを形成し、溶媒に溶解しない物質が透明かつ均一に溶解し、一相の溶液となっている状態をいう。また、可溶化状態は、マイクロエマルションの状態を含む。マイクロエマルションは、100nm以下の微細な粒子径の乳化粒からなり、熱力学的に安定なミセル溶液である。可溶化状態であることは、外観が透明であることをもって確認できる。また、常法により、粒子サイズを測定することにより可溶化状態を確認することもできる。可溶化状態の組成物は、必要に応じて各成分を加温下で溶解して、その後冷却することにより得ることが可能である。 The external composition of the present invention can be prepared by mixing each component with a solvent. The composition of the present invention is preferably in a solubilized state. The solubilized state means a state in which the surfactant forms micelles and the substance insoluble in the solvent is transparently and uniformly dissolved to form a one-phase solution. The solubilized state includes the state of a microemulsion. The microemulsion is a thermodynamically stable micelle solution composed of emulsified particles having a fine particle size of 100 nm or less. The solubilized state can be confirmed by the transparent appearance. In addition, the solubilized state can be confirmed by measuring the particle size by a conventional method. The solubilized composition can be obtained by dissolving each component under heating, if necessary, and then cooling.
本発明の外用組成物は、泡吐出装置用とすることができる。ここで、泡吐出装置とは、発泡させる機構を備えるものを意味する。すなわち、本発明の外用組成物は、泡吐出装置により発泡して用いるためのものである。泡吐出装置としては、皮膚への刺激の観点から、非ガス型泡吐出装置であることが好ましい。非ガス型泡吐出装置としては、例えばスクリーン型泡吐出装置が挙げられる。スクリーン型泡吐出装置とは、液体を加圧し、ネット状のスクリーンを通過させることにより、空気と混合せしめ、発泡させる機構のものを意味する。スクリーン型泡吐出装置としては、例えばポンプ型泡吐出装置、チューブ型泡吐出装置、スクイズ型泡吐出装置等が挙げられる。これらの中でも、ポンプ型泡吐出装置が好適である。 The external composition of the present invention can be used for a foam discharge device. Here, the foam discharge device means a device provided with a mechanism for foaming. That is, the external composition of the present invention is intended to be foamed and used by a foam ejection device. The foam ejection device is preferably a non-gas type foam ejection device from the viewpoint of irritation to the skin. Examples of the non-gas type foam discharge device include a screen type foam discharge device. The screen-type foam ejection device means a mechanism that pressurizes a liquid, passes it through a net-like screen, mixes it with air, and foams it. Examples of the screen type foam discharge device include a pump type foam discharge device, a tube type foam discharge device, a squeeze type foam discharge device, and the like. Among these, the pump type foam discharge device is preferable.
泡吐出装置としては、公知のもの、市販されているもの等を採用することができる。例えばポンプ型泡吐出装置であれば、特開2012－45525号公報、特開2008－307478号公報等に記載のものを使用することができる。 As the foam discharge device, a known one, a commercially available one, or the like can be adopted. For example, in the case of a pump-type foam discharge device, those described in JP-A-2012-45525, JP-A-2008-307478 and the like can be used.
本発明の外用組成物は、泡吐出装置を備える容器に充填して用いることができる。この観点から、本発明は、その一態様において、本発明の外用組成物を泡吐出装置を備える容器に充填してなる、外用剤、にも関する。「外用剤」については、上記した本発明の外用組成物と同様である。 The external composition of the present invention can be used by filling a container equipped with a foam ejection device. From this point of view, the present invention also relates to, in one aspect, an external preparation, which comprises filling a container provided with a foam ejection device with the external composition of the present invention. The “external agent” is the same as the above-mentioned external composition of the present invention.
以下に、実施例に基づいて本発明を詳細に説明するが、本発明はこれらの実施例によって限定されるものではない。 Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited to these examples.
試験例1．泡の評価試験1
表１（数字の単位は質量部）に示す処方に従って、泡吐出装置を備える容器への充填用の組成物1～10を調製した。具体的には、各成分をそれぞれ秤量し、80℃で加熱溶解して攪拌下で可溶化させた後、室温まで攪拌しながら冷却して組成物1～16を得た。これらの組成物をポンプ型泡吐出装置容器に充填し、試験に供した。
Test example 1. Foam evaluation test 1
Compositions 1 to 10 for filling a container equipped with a foam discharge device were prepared according to the formulation shown in Table 1 (the unit of the number is parts by mass). Specifically, each component was weighed, dissolved by heating at 80 ° C., solubilized under stirring, and then cooled to room temperature with stirring to obtain compositions 1 to 16. These compositions were filled in a pump-type foam discharger container and subjected to a test.
使用した材料の詳細は以下の通りである。
・70％Dソルビトール液（D-ソルビトール（富士フィルム和光純薬社製、商品名：D-ソルビトール（和光一級））を精製水に溶かして製造した）
・グリセリン（富士フィルム和光純薬社製、商品名：グリセリン（試薬特級））
・ポリオキシエチレンポリオキシプロピレングリコール（日油社製、商品名：プロノン188P）
The details of the materials used are as follows.
・ 70% D-sorbitol solution (manufactured by dissolving D-sorbitol (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., trade name: D-sorbitol (Wako first grade)) in purified water)
・ Glycerin (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd., product name: glycerin (special grade reagent))
-Polyoxyethylene polyoxypropylene glycol (manufactured by NOF Corporation, trade name: Pronon 188P)
ポンプ型泡吐出装置容器から組成物1～10それぞれをスライドガラス上に一定量吐出させた。吐出直後の泡立ちを、目視により観察し、以下の評価基準に従って4段階で評価した。また、泡の持続性を、吐出から5分間静置させた後の泡の状態の変化を目視により観察して、以下の評価基準に従って4段階で評価した。吐出直後の泡立ちについては、○以上の評価を泡立ち良好と判断し、泡の持続性については△以上の評価を持続性良好と判断した。 A fixed amount of each of the compositions 1 to 10 was discharged onto the slide glass from the pump-type foam discharge device container. Foaming immediately after discharge was visually observed and evaluated on a 4-point scale according to the following evaluation criteria. In addition, the sustainability of the foam was evaluated on a 4-point scale according to the following evaluation criteria by visually observing the change in the state of the foam after allowing it to stand for 5 minutes from the discharge. Regarding the foaming immediately after discharge, the evaluation of ◯ or higher was judged to be good foaming, and the evaluation of foam sustainability of Δ or higher was judged to be good sustainability.
＜吐出直後の泡立ちの評価基準＞
◎：泡質の良い（きめが細かい、泡が立つ）泡立ち。
○：泡立つ。
△：泡立ちが弱い。
×：泡にならない。
<Evaluation criteria for foaming immediately after ejection>
◎: Foaming with good foam quality (fine texture, foaming).
◯: Foams.
Δ: Weak foaming.
×: Does not form bubbles.
＜泡の持続性の評価基準＞
◎：泡に変化が認められない。
○：泡高さが低くなる。
△：スライドガラス上で泡が占める面積が小さくなる。
×：泡がなくなる。
<Evaluation criteria for foam sustainability>
⊚: No change is observed in the bubbles.
◯: The bubble height becomes low.
Δ: The area occupied by bubbles on the slide glass becomes smaller.
X: There are no bubbles.
一方で、ポンプ型泡吐出装置容器から組成物1～10それぞれを被検者の片方の腕に一定量吐出させ、指先に向けて塗り広げた。ただし、塗り広げる動作は1回のみとした。泡切れを、以下の評価基準に従って3段階で評価した。△以上の評価を泡切れ良好と判断した。 On the other hand, a certain amount of each of the compositions 1 to 10 was discharged from the pump-type foam discharger container to one arm of the subject and spread toward the fingertips. However, the spreading operation was performed only once. Foam breakage was evaluated on a three-point scale according to the following evaluation criteria. Δ The above evaluation was judged to be good for foam breakage.
＜泡切れの評価基準＞
○：1回塗り広げた後、腕に泡残りが認められたが、泡は1分以内に消失した。
△：1回塗り広げた後、腕に泡残りが認められ、泡は1分経過後も残っていた。ただ、何度も塗り広げることにより、泡は消え、白化も認められなかった。
×：1回塗り広げた後、腕に泡残りが認められ、それから何度も塗り広げたが泡が残り、腕に白化が認められた。
<Evaluation criteria for bubble breakage>
◯: After spreading once, foam remained on the arm, but the foam disappeared within 1 minute.
Δ: After spreading once, foam remained on the arm, and the foam remained even after 1 minute had passed. However, by spreading it many times, the bubbles disappeared and no whitening was observed.
X: After spreading once, foam remained on the arm, and then after spreading many times, foam remained and whitening was observed on the arm.
結果を表１に示す。 The results are shown in Table 1.
表１の通り、組成物1～10から得られる泡は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好であった。 As shown in Table 1, the foams obtained from the compositions 1 to 10 had good foaming and foam sustainability, but also had good foam breakage.
試験例2．泡の評価試験2
表２（数字の単位は質量部）に示す処方に従って、泡吐出装置を備える容器への充填用の組成物11を、試験例1と同様にして調製した。吐出直後の泡立ち、泡の持続性、及び泡切れを、試験例1と同様にして評価した。
Test example 2. Foam evaluation test 2
The composition 11 for filling a container equipped with a foam ejection device was prepared in the same manner as in Test Example 1 according to the formulation shown in Table 2 (the unit of the number is parts by mass). Foaming immediately after ejection, foam persistence, and foam breakage were evaluated in the same manner as in Test Example 1.
結果を表２に示す。 The results are shown in Table 2.
表２の通り、組成物11から得られる泡は、泡立ち及び泡の持続性が良好でありながらも、泡切れも良好であった。 As shown in Table 2, the foam obtained from the composition 11 had good foaming and foam sustainability, but also had good foam breakage.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001309986A (en) * | 2000-05-01 | 2001-11-06 | Lion Corp | Skin care composition in application container |
| JP2012214422A (en) * | 2011-04-01 | 2012-11-08 | Maruho Co Ltd | Non-aerosol composition for foaming agent |
| JP2015221783A (en) * | 2014-04-30 | 2015-12-10 | マルホ株式会社 | Foaming composition |
| JP2019172703A (en) * | 2016-06-16 | 2019-10-10 | 株式会社ポーラファルマ | Foam, composition for screen foamer, and method for evaluating the same |
| JP2020105091A (en) * | 2018-12-27 | 2020-07-09 | 小林製薬株式会社 | External emulsion composition |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001309986A (en) * | 2000-05-01 | 2001-11-06 | Lion Corp | Skin care composition in application container |
| JP2012214422A (en) * | 2011-04-01 | 2012-11-08 | Maruho Co Ltd | Non-aerosol composition for foaming agent |
| JP2015221783A (en) * | 2014-04-30 | 2015-12-10 | マルホ株式会社 | Foaming composition |
| JP2016180012A (en) * | 2014-04-30 | 2016-10-13 | マルホ株式会社 | Foaming composition |
| JP2019172703A (en) * | 2016-06-16 | 2019-10-10 | 株式会社ポーラファルマ | Foam, composition for screen foamer, and method for evaluating the same |
| JP2020059756A (en) * | 2016-06-16 | 2020-04-16 | 株式会社ポーラファルマ | Foam, screen foamer composition, and evaluation method for the same |
| JP2020105091A (en) * | 2018-12-27 | 2020-07-09 | 小林製薬株式会社 | External emulsion composition |
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