JP2021535395A - アッセイ精度向上 - Google Patents

アッセイ精度向上 Download PDF

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JP2021535395A
JP2021535395A JP2021511663A JP2021511663A JP2021535395A JP 2021535395 A JP2021535395 A JP 2021535395A JP 2021511663 A JP2021511663 A JP 2021511663A JP 2021511663 A JP2021511663 A JP 2021511663A JP 2021535395 A JP2021535395 A JP 2021535395A
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sample
assay
image
aoi
area
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JP2021535395A5 (https=
JPWO2020047177A5 (https=
Inventor
スティーブン ワイ． チョウ
ウェイ ディン
ウー チョウ
ジュン ティアン
ユエチェン チャン
ミンカン ウー
シン リ
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エッセンリックス コーポレーション
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2413—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
    • G06F18/24133—Distances to prototypes
    • G06F18/24143—Distances to neighbourhood prototypes, e.g. restricted Coulomb energy networks [RCEN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/34—Smoothing or thinning of the pattern; Morphological operations; Skeletonisation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G06V10/443—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components by matching or filtering
    • G06V10/449—Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters
    • G06V10/451—Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters with interaction between the filter responses, e.g. cortical complex cells
    • G06V10/454—Integrating the filters into a hierarchical structure, e.g. convolutional neural networks [CNN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/764—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Medical Informatics (AREA)
  • Artificial Intelligence (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Software Systems (AREA)
  • Computing Systems (AREA)
  • Databases & Information Systems (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Data Mining & Analysis (AREA)
  • Optics & Photonics (AREA)
  • Quality & Reliability (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pathology (AREA)
  • Signal Processing (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2021511663A 2018-08-28 2019-08-28 アッセイ精度向上 Pending JP2021535395A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862724025P 2018-08-28 2018-08-28
US62/724,025 2018-08-28
US201862742247P 2018-10-05 2018-10-05
US62/742,247 2018-10-05
PCT/US2019/048678 WO2020047177A1 (en) 2018-08-28 2019-08-28 Assay accuracy improvement

Publications (3)

Publication Number Publication Date
JP2021535395A true JP2021535395A (ja) 2021-12-16
JP2021535395A5 JP2021535395A5 (https=) 2022-09-01
JPWO2020047177A5 JPWO2020047177A5 (https=) 2022-09-01

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JP2021511663A Pending JP2021535395A (ja) 2018-08-28 2019-08-28 アッセイ精度向上

Country Status (5)

Country Link
US (2) US11719618B2 (https=)
EP (1) EP3844477A4 (https=)
JP (1) JP2021535395A (https=)
CN (2) CN113227755B (https=)
WO (1) WO2020047177A1 (https=)

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WO2019023376A1 (en) * 2017-07-28 2019-01-31 Siemens Healthcare Diagnostics Inc. METHODS AND APPARATUS FOR QUANTIFYING DEEP LEARNING VOLUME
CN114341619B (zh) * 2019-04-05 2025-04-11 上海宜晟生物科技有限公司 测定准确度以及可靠性提高
JP7363384B2 (ja) * 2019-11-05 2023-10-18 富士通株式会社 解析装置、解析プログラム及び解析方法
US20230408534A1 (en) * 2020-10-08 2023-12-21 Essenlix Corporation Assay Error Reduction
CN112102411B (zh) * 2020-11-02 2021-02-12 中国人民解放军国防科技大学 一种基于语义误差图像的视觉定位方法及装置
CA3200162A1 (en) * 2020-12-15 2022-06-23 Mark Justin Parkinson Systems and methods for identifying cancer in pets
US20240085304A1 (en) * 2021-01-15 2024-03-14 Essenlix Corporation Imaging Based Assay Accuracy Improvement Through Guided Training
JP7697794B2 (ja) * 2021-01-29 2025-06-24 富士フイルム株式会社 情報処理装置、情報処理方法及び情報処理プログラム
CN117043867B (zh) * 2021-04-02 2025-11-28 因美纳有限公司 用于检测用于测序的核苷酸样品玻片内的气泡的机器学习模型
MX2023012736A (es) 2021-04-30 2023-11-09 Root Applied Sciences Inc Dispositivo para recoger material del aire.
JPWO2022270606A1 (https=) * 2021-06-25 2022-12-29
CN118140146A (zh) * 2021-07-12 2024-06-04 Essenlix 公司 多样品分析装置
US12354261B2 (en) * 2021-11-30 2025-07-08 Duke University Smart phone platforms for mobile health
US11940451B2 (en) 2021-12-20 2024-03-26 Instrumentation Laboratory Co. Microfluidic image analysis system
CN114648494B (zh) * 2022-02-28 2022-12-06 扬州市苏灵农药化工有限公司 基于工厂数字化的农药悬浮剂生产控制系统
CN115953330B (zh) * 2023-03-13 2023-05-26 腾讯科技（深圳）有限公司 虚拟场景图像的纹理优化方法、装置、设备和存储介质
CN117953067B (zh) * 2024-03-27 2024-06-18 华中科技大学 一种结合动平台惯测信息的事件相机动目标检测方法

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JP2018517209A (ja) * 2015-05-28 2018-06-28 トキタエ エルエルシー 画像分析システムおよび関連する方法
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WO2018148471A2 (en) * 2017-02-08 2018-08-16 Essenlix Corporation Optics, device, and system for assaying

Also Published As

Publication number Publication date
CN113227755A (zh) 2021-08-06
CN121324657A (zh) 2026-01-13
EP3844477A1 (en) 2021-07-07
CN113227755B (zh) 2025-06-27
EP3844477A4 (en) 2023-01-04
US20210270722A1 (en) 2021-09-02
WO2020047177A1 (en) 2020-03-05
US11719618B2 (en) 2023-08-08
US20230324278A1 (en) 2023-10-12

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