JP2021534398A5 - - Google Patents

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Publication number
JP2021534398A5
JP2021534398A5 JP2021507759A JP2021507759A JP2021534398A5 JP 2021534398 A5 JP2021534398 A5 JP 2021534398A5 JP 2021507759 A JP2021507759 A JP 2021507759A JP 2021507759 A JP2021507759 A JP 2021507759A JP 2021534398 A5 JP2021534398 A5 JP 2021534398A5
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JP
Japan
Prior art keywords
antibody
protein
matrix
conditions
affinity matrix
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JP2021507759A
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English (en)
Japanese (ja)
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JP7527273B2 (ja
JP2021534398A (ja
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Priority claimed from PCT/US2019/046769 external-priority patent/WO2020037182A1/en
Publication of JP2021534398A publication Critical patent/JP2021534398A/ja
Publication of JP2021534398A5 publication Critical patent/JP2021534398A5/ja
Priority to JP2024117397A priority Critical patent/JP2024156725A/ja
Application granted granted Critical
Publication of JP7527273B2 publication Critical patent/JP7527273B2/ja
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JP2021507759A 2018-08-17 2019-08-16 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム Active JP7527273B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024117397A JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862719323P 2018-08-17 2018-08-17
US62/719,323 2018-08-17
PCT/US2019/046769 WO2020037182A1 (en) 2018-08-17 2019-08-16 Method and chromatography system for determining amount and purity of a multimeric protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024117397A Division JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Publications (3)

Publication Number Publication Date
JP2021534398A JP2021534398A (ja) 2021-12-09
JP2021534398A5 true JP2021534398A5 (enExample) 2022-08-18
JP7527273B2 JP7527273B2 (ja) 2024-08-02

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ID=67851218

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021507759A Active JP7527273B2 (ja) 2018-08-17 2019-08-16 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム
JP2024117397A Pending JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Family Applications After (1)

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JP2024117397A Pending JP2024156725A (ja) 2018-08-17 2024-07-23 多量体タンパク質の量および純度を決定するための方法およびクロマトグラフィーシステム

Country Status (14)

Country Link
US (2) US12152056B2 (enExample)
EP (1) EP3837552A1 (enExample)
JP (2) JP7527273B2 (enExample)
KR (2) KR102795000B1 (enExample)
CN (2) CN118641770A (enExample)
AU (2) AU2019322895B2 (enExample)
BR (1) BR112021002724A2 (enExample)
CA (1) CA3109362A1 (enExample)
EA (1) EA202190459A1 (enExample)
IL (2) IL280764B2 (enExample)
MX (1) MX2021001915A (enExample)
MY (1) MY207066A (enExample)
SG (1) SG11202101369XA (enExample)
WO (1) WO2020037182A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202101369XA (en) * 2018-08-17 2021-03-30 Regeneron Pharma Method and chromatography system for determining amount and purity of a multimeric protein
AU2020293237A1 (en) * 2019-06-13 2022-01-06 Regeneron Pharmaceuticals, Inc. Methods for removing undesired components during multistage chromatographic processes
WO2022234412A1 (en) 2021-05-03 2022-11-10 Lupin Limited A process for purification of fc-fusion proteins
CN117761217A (zh) * 2023-12-22 2024-03-26 深圳市乐土生命科技投资有限公司 一种检测Fc轻链改造双抗或Fc融合蛋白表达量的方法
WO2026075981A1 (en) * 2024-10-01 2026-04-09 Regeneron Pharmaceuticals, Inc. Methods of analyzing heterodimeric proteins

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826696B1 (de) 1996-09-03 2002-05-29 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
WO2010030393A1 (en) * 2008-09-15 2010-03-18 Millipore Corporation Methods for quantifying protein leakage from protein based affinity chromatography resins
TWI507525B (zh) 2009-06-26 2015-11-11 Regeneron Pharma 具天然免疫球蛋白形式之易分離的雙專一性抗體
EP2633306B1 (en) 2010-10-27 2016-03-23 GE Healthcare Bio-Sciences AB Chromatography system with guard columns
WO2012074481A1 (en) * 2010-12-03 2012-06-07 Ge Healthcare Bio-Sciences Ab System and process for biopolymer chromatography
EP2500073A1 (en) 2011-03-17 2012-09-19 ChromaCon AG Method for identification and purification of multi-specific polypeptides
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
EP2847224A4 (en) 2012-05-10 2016-04-27 Zymeworks Inc SINGLE ARM MONOVALENT ANTIBODY CONSTRUCTS AND USES THEREOF
AU2014226126B2 (en) * 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
JP2015052533A (ja) 2013-09-06 2015-03-19 株式会社日立製作所 クロマトグラフィー装置およびクロマトグラフィー方法
AP2016009222A0 (en) 2013-11-04 2016-05-31 Glenmark Pharmaceuticals Sa Production of t cell retargeting hetero-dimeric immunoglobulins
AR101262A1 (es) * 2014-07-26 2016-12-07 Regeneron Pharma Plataforma de purificación para anticuerpos biespecíficos
BR112017018365A2 (pt) * 2015-03-13 2018-04-10 Bristol-Myers Squibb Company uso de lavagens alcalinas durante cromatografia para remoção de impurezas
EP3280444B1 (en) 2015-04-10 2024-05-08 Adimab, LLC Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species
GB201602156D0 (en) * 2016-02-05 2016-03-23 Jones Philip C And Boku University Of Natural Resources And Life Sciences Heterodimers and purification thereof
SG11202101369XA (en) * 2018-08-17 2021-03-30 Regeneron Pharma Method and chromatography system for determining amount and purity of a multimeric protein

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