JP2021534253A - 液体ベンダムスチン医薬組成物 - Google Patents

液体ベンダムスチン医薬組成物 Download PDF

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Publication number
JP2021534253A
JP2021534253A JP2021532537A JP2021532537A JP2021534253A JP 2021534253 A JP2021534253 A JP 2021534253A JP 2021532537 A JP2021532537 A JP 2021532537A JP 2021532537 A JP2021532537 A JP 2021532537A JP 2021534253 A JP2021534253 A JP 2021534253A
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JP
Japan
Prior art keywords
pharmaceutical composition
bendamustine
amount
water
solvent
Prior art date
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Application number
JP2021532537A
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English (en)
Japanese (ja)
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JP2021534253A5 (OSRAM
Inventor
マルコム ニール アンドリュー
ノリス ノエル
Original Assignee
ホスピーラ オーストラリア ピーティーワイ リミテッド
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Publication date
Application filed by ホスピーラ オーストラリア ピーティーワイ リミテッド filed Critical ホスピーラ オーストラリア ピーティーワイ リミテッド
Publication of JP2021534253A publication Critical patent/JP2021534253A/ja
Publication of JP2021534253A5 publication Critical patent/JP2021534253A5/ja
Priority to JP2024086001A priority Critical patent/JP2024109878A/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021532537A 2018-08-17 2019-08-14 液体ベンダムスチン医薬組成物 Withdrawn JP2021534253A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024086001A JP2024109878A (ja) 2018-08-17 2024-05-28 液体ベンダムスチン医薬組成物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862764975P 2018-08-17 2018-08-17
US62/764,975 2018-08-17
US201862723725P 2018-08-28 2018-08-28
US62/723,725 2018-08-28
US201962815376P 2019-03-08 2019-03-08
US62/815,376 2019-03-08
PCT/IB2019/056903 WO2020035806A1 (en) 2018-08-17 2019-08-14 Liquid bendamustine pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024086001A Division JP2024109878A (ja) 2018-08-17 2024-05-28 液体ベンダムスチン医薬組成物

Publications (2)

Publication Number Publication Date
JP2021534253A true JP2021534253A (ja) 2021-12-09
JP2021534253A5 JP2021534253A5 (OSRAM) 2022-08-10

Family

ID=69525233

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021532537A Withdrawn JP2021534253A (ja) 2018-08-17 2019-08-14 液体ベンダムスチン医薬組成物
JP2024086001A Withdrawn JP2024109878A (ja) 2018-08-17 2024-05-28 液体ベンダムスチン医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024086001A Withdrawn JP2024109878A (ja) 2018-08-17 2024-05-28 液体ベンダムスチン医薬組成物

Country Status (7)

Country Link
US (1) US12246007B2 (OSRAM)
EP (1) EP3836921B1 (OSRAM)
JP (2) JP2021534253A (OSRAM)
AU (1) AU2019321089A1 (OSRAM)
CA (1) CA3108321A1 (OSRAM)
ES (1) ES3055021T3 (OSRAM)
WO (1) WO2020035806A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081148A1 (en) 2018-10-16 2020-04-23 US Nano Food & Drug INC Intratumor injection formulation
US11730815B2 (en) 2018-11-26 2023-08-22 Good Health, Llc Stable liquid pharmaceutical compositions comprising bendamustine
CN114929213A (zh) * 2020-04-13 2022-08-19 美国纳米食品药品公司 碱性化疗药瘤内注射剂组合物
AU2021256189A1 (en) * 2020-04-15 2022-11-10 Kashiv Biosciences, Llc Stable ready to dilute formulations of carfilzomib
GB202118175D0 (en) 2021-12-15 2022-01-26 Arecor Ltd Novel composition
US11707450B1 (en) 2022-03-03 2023-07-25 Slayback Pharma Llc Stable pharmaceutical compositions of bendamustine
CN118415976A (zh) * 2024-05-09 2024-08-02 深圳开悦生命科技有限公司 多环化合物注射剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016005995A2 (en) * 2014-07-10 2016-01-14 Leiutis Pharmaceuticals Pvt. Ltd. Glycol free stable liquid compositions of bendamustine
CN105726472A (zh) * 2016-03-25 2016-07-06 南京康玻斯医药科技有限公司 苯达莫司汀药剂组合物及应用
WO2017175098A1 (en) * 2016-04-05 2017-10-12 Leiutis Pharmaceuticals Pvt Ltd Stable liquid pharmaceutical formulations of bendamustine
US20180055823A1 (en) * 2016-08-31 2018-03-01 Mahendra R. Patel Bendamustine Solution Formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
WO2010036702A1 (en) * 2008-09-25 2010-04-01 Cephalon, Inc. Liquid formulations of bendamustine
ES2609106T5 (es) 2010-01-28 2020-11-10 Eagle Pharmaceuticals Inc Formulaciones de bendamustina
US20130210878A1 (en) 2012-01-24 2013-08-15 Innopharma, Inc. Bendamustine compositions and methods therefore
DK3533447T3 (da) 2012-03-20 2023-04-24 Eagle Pharmaceuticals Inc Flydende bendamustinsammensætninger til anvendelse i fremgangsmåde til behandling af bendamustin-responsive tilstande hos patienter som kræver reducerede volumener til indgivelse
FI2827862T3 (fi) 2012-03-20 2024-02-13 Eagle Pharmaceuticals Inc Bendamustiinin formulaatioita
US20160235717A1 (en) * 2013-10-11 2016-08-18 Luitpold Pharmaceuticals, Inc. Bendamustine pharmaceutical compositions
WO2016059590A1 (en) 2014-10-16 2016-04-21 Piramal Enterprises Limited Stable injectable composition of small molecule drugs and process for its preparation
US9603930B2 (en) 2014-12-04 2017-03-28 Navinta, Llc Liquid bendamustine formulation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016005995A2 (en) * 2014-07-10 2016-01-14 Leiutis Pharmaceuticals Pvt. Ltd. Glycol free stable liquid compositions of bendamustine
CN105726472A (zh) * 2016-03-25 2016-07-06 南京康玻斯医药科技有限公司 苯达莫司汀药剂组合物及应用
WO2017175098A1 (en) * 2016-04-05 2017-10-12 Leiutis Pharmaceuticals Pvt Ltd Stable liquid pharmaceutical formulations of bendamustine
US20180055823A1 (en) * 2016-08-31 2018-03-01 Mahendra R. Patel Bendamustine Solution Formulations

Also Published As

Publication number Publication date
EP3836921A4 (en) 2022-04-20
ES3055021T3 (en) 2026-02-09
JP2024109878A (ja) 2024-08-14
US20210275500A1 (en) 2021-09-09
CA3108321A1 (en) 2020-02-20
EP3836921A1 (en) 2021-06-23
EP3836921B1 (en) 2025-10-08
EP3836921C0 (en) 2025-10-08
AU2019321089A1 (en) 2021-02-11
WO2020035806A1 (en) 2020-02-20
US12246007B2 (en) 2025-03-11

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