JP2021532818A - ハプテン標識細胞によりキメラ抗原受容体t細胞を刺激する方法およびそのための組成物 - Google Patents

ハプテン標識細胞によりキメラ抗原受容体t細胞を刺激する方法およびそのための組成物 Download PDF

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JP2021532818A
JP2021532818A JP2021506562A JP2021506562A JP2021532818A JP 2021532818 A JP2021532818 A JP 2021532818A JP 2021506562 A JP2021506562 A JP 2021506562A JP 2021506562 A JP2021506562 A JP 2021506562A JP 2021532818 A JP2021532818 A JP 2021532818A
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cells
car
hapten
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antibody
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シー. ジェンセン,マイケル
エフ. マッセイ,ジェイムズ
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シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート)
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    • C07K2319/00—Fusion polypeptide
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JP2021506562A 2018-08-06 2019-08-02 ハプテン標識細胞によりキメラ抗原受容体t細胞を刺激する方法およびそのための組成物 Pending JP2021532818A (ja)

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US201862714928P 2018-08-06 2018-08-06
US62/714,928 2018-08-06
PCT/US2019/044981 WO2020033272A1 (en) 2018-08-06 2019-08-02 Methods and compositions for stimulation of chimeric antigen receptor t cells with hapten labelled cells

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JP2024108743A Pending JP2024138364A (ja) 2018-08-06 2024-07-05 ハプテン標識細胞によりキメラ抗原受容体t細胞を刺激する方法およびそのための組成物

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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
SG10201808811QA (en) 2014-04-10 2018-11-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Method and compositions for cellular immunotherapy
EP3234120B1 (en) 2014-12-15 2025-09-03 The Regents of the University of California Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
WO2016100232A1 (en) 2014-12-15 2016-06-23 The Regents Of The University Of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
EP3368571B1 (en) 2015-10-30 2022-12-07 The Regents of The University of California Transforming growth factor-beta-responsive polypeptides and their methods for use
CA3019835A1 (en) 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy
AU2018219226B2 (en) 2017-02-07 2024-12-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
CN110582288B (zh) 2017-02-28 2024-09-20 恩多塞特公司 用于car t细胞疗法的组合物和方法
WO2019144095A1 (en) 2018-01-22 2019-07-25 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for car t cells
AU2019218729B2 (en) * 2018-02-06 2025-12-04 Seattle Children's Hospital (dba Seattle Children's Research Institute) Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors
JP7568224B2 (ja) 2018-02-23 2024-10-16 エンドサイト・インコーポレイテッド Car t細胞療法のための配列決定法
SG11202009975TA (en) 2018-04-12 2020-11-27 Umoja Biopharma Inc Viral vectors and packaging cell lines
WO2021158534A1 (en) * 2020-02-04 2021-08-12 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods and compositions for stimulation of chimeric antigen receptor t cells with hapten labelled cells
IL295063A (en) * 2020-02-04 2022-09-01 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Chimeric antigen receptors (car) against dinitrophenol
EP4121447A1 (en) 2020-03-20 2023-01-25 Lyell Immunopharma, Inc. Novel recombinant cell surface markers
WO2021223359A1 (en) * 2020-05-06 2021-11-11 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
CN111735952B (zh) * 2020-06-04 2023-07-11 北京勤邦科技股份有限公司 一种检测六氯苯的试纸条及方法
WO2021252358A1 (en) * 2020-06-08 2021-12-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-cd171 chimeric antigen receptors
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
CN114019166B (zh) * 2021-09-27 2024-02-27 浙江省食品药品检验研究院 一种检测龙葵素的试纸条及其应用
US20250011399A1 (en) * 2021-11-10 2025-01-09 Outpace Bio, Inc. Chimeric antigen receptors
CN116622640A (zh) * 2023-05-08 2023-08-22 湖南大学 一种分子响应型car-t细胞体系及其制备方法和应用
CN119775406B (zh) * 2025-01-22 2025-11-25 北京赛科希德科技股份有限公司 纤溶酶降解产物d-二聚体抗体及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004113062A (ja) * 2002-09-25 2004-04-15 Teruyuki Nagamune キメラ受容体を有する動物細胞とその利用
JP2020535128A (ja) * 2017-09-19 2020-12-03 マサチューセッツ インスティテュート オブ テクノロジー キメラ抗原受容体t細胞治療のための組成物およびその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016168766A1 (en) * 2015-04-15 2016-10-20 The California Institute For Biomedical Research Optimized chimeric receptor t cell switches and uses thereof
AU2017295704B2 (en) * 2016-07-13 2023-07-13 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
JP7078937B2 (ja) * 2016-12-21 2022-06-01 ダンマークス テクニスク ユニバーシテット 免疫細胞を操作するための抗原提示足場

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004113062A (ja) * 2002-09-25 2004-04-15 Teruyuki Nagamune キメラ受容体を有する動物細胞とその利用
JP2020535128A (ja) * 2017-09-19 2020-12-03 マサチューセッツ インスティテュート オブ テクノロジー キメラ抗原受容体t細胞治療のための組成物およびその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOMATERIALS, vol. 33, no. 3, JPN6023027311, 2012, pages 821 - 828, ISSN: 0005099143 *
BLOOD, vol. 122, no. 21, JPN6023027310, 2013, pages 4204, ISSN: 0005099144 *

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AU2019319674B2 (en) 2026-06-04
AU2019319674A1 (en) 2021-03-11
WO2020033272A1 (en) 2020-02-13
CN112789051A (zh) 2021-05-11
EP3833363A1 (en) 2021-06-16
JP2024138364A (ja) 2024-10-08
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