JP2021530475A - タンパク質スイッチの新規設計 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
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| US201962788398P | 2019-01-04 | 2019-01-04 | |
| US62/788,398 | 2019-01-04 | ||
| PCT/US2019/042651 WO2020018935A2 (fr) | 2018-07-19 | 2019-07-19 | Conception de novo de commutateurs protéiques |
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| AU (1) | AU2019308317A1 (fr) |
| CA (1) | CA3106279A1 (fr) |
| WO (1) | WO2020018935A2 (fr) |
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| US11820800B2 (en) * | 2018-11-02 | 2023-11-21 | University Of Washington | Orthogonal protein heterodimers |
| CN113853384A (zh) * | 2019-01-07 | 2021-12-28 | 华盛顿大学 | 用于蛋白质降解的可调整控制的蛋白质开关的全新设计 |
| WO2020146254A1 (fr) * | 2019-01-07 | 2020-07-16 | The Regents Of The University Of California | Circuits de rétroaction moléculaires à base de dégrons en cage et leurs procédés d'utilisation |
| US20220226485A1 (en) * | 2019-06-17 | 2022-07-21 | University Of Washington | De novo design of phosphorylation inducible protein switches (phospho-switches) |
| EP4093751A1 (fr) * | 2020-01-22 | 2022-11-30 | Outpace Bio, Inc. | Polypeptides chimères |
| CN115515972A (zh) * | 2020-04-07 | 2022-12-23 | 尼尔路金治疗公司 | 血管紧张素转换酶2(ace2)的从头蛋白诱饵 |
| KR20230017215A (ko) | 2020-05-27 | 2023-02-03 | 유니버시티 오브 워싱턴 | 드 노보 설계한 단백질 스위치에 기반한 모듈형의 일반화 가능한 바이오센서 플랫폼 |
| CN116075524A (zh) * | 2020-07-30 | 2023-05-05 | 华盛顿大学 | 转铁蛋白受体结合蛋白 |
| CA3199940A1 (fr) * | 2020-11-30 | 2022-06-02 | Andrew Tsourkas | Marquage precis d'echafaudages proteiques par une charge destine a etre utilise dans des applications biomedicales |
| WO2022120423A1 (fr) * | 2020-12-08 | 2022-06-16 | James Cook University | Peptides et leurs utilisations |
| WO2023044494A2 (fr) * | 2021-09-17 | 2023-03-23 | Kotlyar David | Vaccin buccal par l'intermédiaire de bactéries dentaires et de peptides émis pour prévenir une infection par covid-19 |
| CN116041442B (zh) * | 2023-02-03 | 2023-12-01 | 西湖大学 | 一种d型多肽，其l型配体及应用 |
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| US6217864B1 (en) | 1996-02-23 | 2001-04-17 | The Regents Of The University Of California | Method for targeted degradation of intracellular proteins in vivo or ex vivo |
| WO1999013077A2 (fr) | 1997-09-10 | 1999-03-18 | President And Fellows Of Harvard College | Procedes inductibles de repression de la fonction genique |
| AU1203000A (en) | 1998-10-09 | 2000-05-01 | President And Fellows Of Harvard College | Targeted proteolysis by recruitment to ubiquitin protein ligases |
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| CA2411515A1 (fr) * | 2000-06-23 | 2002-01-03 | Genetastix Corporation | Generation et criblage a haut rendement d'un repertoire d'anticorps entierement humains dans la levure |
| WO2011156356A1 (fr) * | 2010-06-09 | 2011-12-15 | Zymogenetics, Inc. | Protéines de fusion vstm3 dimères et compositions et procédés connexes |
| EP2588129A4 (fr) | 2010-06-30 | 2014-07-09 | Univ Brandeis | Dégradation des protéines ciblées par de petites molécules |
| WO2015138711A1 (fr) * | 2014-03-12 | 2015-09-17 | University Of Wahington | Polypeptides visant à inhiber la protéine du virus d'epstein-barr bhrf1 et des protéines de la famille du lymphome à cellules b |
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2019
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| US20210115090A1 (en) | 2021-04-22 |
| AU2019308317A1 (en) | 2021-01-28 |
| WO2020018935A3 (fr) | 2020-02-20 |
| WO2020018935A2 (fr) | 2020-01-23 |
| US10851135B2 (en) | 2020-12-01 |
| CN112512544A (zh) | 2021-03-16 |
| US20200239524A1 (en) | 2020-07-30 |
| EP3823656A2 (fr) | 2021-05-26 |
| CA3106279A1 (fr) | 2020-01-23 |
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