JP2021522231A - チオエーテル環状ペプチドアミリン受容体調節因子 - Google Patents

チオエーテル環状ペプチドアミリン受容体調節因子 Download PDF

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Publication number
JP2021522231A
JP2021522231A JP2020558904A JP2020558904A JP2021522231A JP 2021522231 A JP2021522231 A JP 2021522231A JP 2020558904 A JP2020558904 A JP 2020558904A JP 2020558904 A JP2020558904 A JP 2020558904A JP 2021522231 A JP2021522231 A JP 2021522231A
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Japan
Prior art keywords
mab
formula
peptide
compound
seq
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JP2020558904A
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English (en)
Japanese (ja)
Inventor
ジャン,ウェンイン
パッチ,レイモンド
ジャン,ルイ
ジェン,ソンマオ
ヒンケ,シモン
Original Assignee
ヤンセン ファーマシューティカ エヌ.ベー.
ヤンセン ファーマシューティカ エヌ.ベー.
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Application filed by ヤンセン ファーマシューティカ エヌ.ベー., ヤンセン ファーマシューティカ エヌ.ベー. filed Critical ヤンセン ファーマシューティカ エヌ.ベー.
Publication of JP2021522231A publication Critical patent/JP2021522231A/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020558904A 2018-04-25 2019-04-17 チオエーテル環状ペプチドアミリン受容体調節因子 Pending JP2021522231A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862662492P 2018-04-25 2018-04-25
US62/662,492 2018-04-25
PCT/IB2019/053194 WO2019207427A2 (fr) 2018-04-25 2019-04-17 Modulateurs du récepteur de l'amyline de peptide cyclique thioéther

Publications (1)

Publication Number Publication Date
JP2021522231A true JP2021522231A (ja) 2021-08-30

Family

ID=68293854

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020558904A Pending JP2021522231A (ja) 2018-04-25 2019-04-17 チオエーテル環状ペプチドアミリン受容体調節因子

Country Status (5)

Country Link
EP (1) EP3784265A4 (fr)
JP (1) JP2021522231A (fr)
CN (1) CN112074289A (fr)
CA (1) CA3097812A1 (fr)
WO (1) WO2019207427A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022210988B9 (en) 2021-01-20 2024-02-22 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
CN114057862A (zh) * 2021-12-14 2022-02-18 安徽省国平药业有限公司 一种glp-1(1-37)多肽的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526656A (ja) * 1997-05-06 2001-12-18 アミリン・ファーマシューティカルズ,インコーポレイテッド アミリンまたはアミリン・アゴニストを用いる胃炎を予防する方法
JP2009530250A (ja) * 2006-03-15 2009-08-27 ノボ・ノルデイスク・エー/エス アミリン誘導体
JP2014516049A (ja) * 2011-05-25 2014-07-07 アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー アミリンペプチドおよび誘導体ならびにそれらの使用
JP2016531110A (ja) * 2013-07-25 2016-10-06 ノバルティス アーゲー 心不全治療のためのジスルフィド環状ポリペプチド
WO2017075505A2 (fr) * 2015-10-28 2017-05-04 Tufts University Nouveaux polypeptides présentant une meilleure stabilité et procédés de préparation et d'utilisation associés

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399744B2 (en) * 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
EP2036923A1 (fr) * 2007-09-11 2009-03-18 Novo Nordisk A/S Dérivés d'amyline améliorés
CA2764108A1 (fr) * 2009-06-08 2010-12-16 Amunix Operating Inc. Polypeptides de regulation du glucose et leurs procedes de production et d'utilisation
WO2011050008A2 (fr) * 2009-10-19 2011-04-28 Amylin Pharmaceuticals, Inc. Polythérapie comprenant l'administration d'un amylinomimétique et d'un peptidomimétique de pyy pour obtenir une perte de poids et pour traiter l'obésité et les états pathologiques et les troubles métaboliques associés
WO2011084808A2 (fr) * 2009-12-21 2011-07-14 Amunix Operating Inc. Compositions de polypeptides bifonctionnels et procédés pour le traitement de maladies métaboliques et cardiovasculaires
US20140249076A1 (en) * 2011-10-18 2014-09-04 Astrazeneca Pharmaceuticals Lp Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties
AR097701A1 (es) * 2013-09-19 2016-04-13 Zealand Pharma As Análogos de amilina
CN113563423A (zh) * 2014-07-17 2021-10-29 领导医疗有限公司 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526656A (ja) * 1997-05-06 2001-12-18 アミリン・ファーマシューティカルズ,インコーポレイテッド アミリンまたはアミリン・アゴニストを用いる胃炎を予防する方法
JP2009530250A (ja) * 2006-03-15 2009-08-27 ノボ・ノルデイスク・エー/エス アミリン誘導体
JP2014516049A (ja) * 2011-05-25 2014-07-07 アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー アミリンペプチドおよび誘導体ならびにそれらの使用
JP2016531110A (ja) * 2013-07-25 2016-10-06 ノバルティス アーゲー 心不全治療のためのジスルフィド環状ポリペプチド
WO2017075505A2 (fr) * 2015-10-28 2017-05-04 Tufts University Nouveaux polypeptides présentant une meilleure stabilité et procédés de préparation et d'utilisation associés

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MACK, C.M., ET AL.: ""Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over nati", INTERNATIONAL JOURNAL OF OBESITY, vol. 34, JPN6023011278, 24 November 2009 (2009-11-24), pages 385 - 395, ISSN: 0005022100 *
MOLL, G.N., ET AL.: ""A biological stabilization technology for peptide drugs: enzymatic introduction of thioether-bridge", DRUG DISCOVERY TODAY: TECHNOLOGIES, vol. Vol.6, No.1-4, JPN6023011277, 19 April 2009 (2009-04-19), pages 13 - 18, ISSN: 0005022101 *

Also Published As

Publication number Publication date
EP3784265A2 (fr) 2021-03-03
EP3784265A4 (fr) 2022-06-22
WO2019207427A3 (fr) 2020-01-02
CN112074289A (zh) 2020-12-11
WO2019207427A2 (fr) 2019-10-31
CA3097812A1 (fr) 2019-10-31

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