CA3097812A1 - Modulateurs du recepteur de l'amyline de peptide cyclique thioether - Google Patents
Modulateurs du recepteur de l'amyline de peptide cyclique thioether Download PDFInfo
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- CA3097812A1 CA3097812A1 CA3097812A CA3097812A CA3097812A1 CA 3097812 A1 CA3097812 A1 CA 3097812A1 CA 3097812 A CA3097812 A CA 3097812A CA 3097812 A CA3097812 A CA 3097812A CA 3097812 A1 CA3097812 A1 CA 3097812A1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- SFVVQRJOGUKCEG-OPQSFPLASA-N β-MSH Chemical compound C1C[C@@H](O)[C@H]2C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)=CCN21 SFVVQRJOGUKCEG-OPQSFPLASA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des analogues peptidiques amylinomimétiques et leurs dérivés dans lesquels l'extrémité N-terminale de chaque peptide est liée de manière covalente à une fonctionnalité thiol à chaîne latérale d'acide aminé interne au moyen d'un élément de pontage de cyclisation non peptidyle. Les analogues d'amylinomimétiques cyclisés par thioéther et leurs dérivés peuvent comprendre une ou plusieurs modifications comportant des substitutions, des insertions, des délétions et des modifications et peuvent éventuellement comprendre un élément de liaison à l'albumine sérique, tel qu'une chaîne alkyle d'au moins 14 atomes de carbone portant éventuellement une fraction carboxylate pendante supplémentaire, ou une fraction biologique prolongeant la demi-vie, telle que la HSA, un AcM ou un Fc non ciblant. En outre, l'invention concerne des compositions correspondantes et des méthodes de traitement de pathologies réagissant à la modulation du récepteur de l'amyline.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862662492P | 2018-04-25 | 2018-04-25 | |
US62/662,492 | 2018-04-25 | ||
PCT/IB2019/053194 WO2019207427A2 (fr) | 2018-04-25 | 2019-04-17 | Modulateurs du récepteur de l'amyline de peptide cyclique thioéther |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3097812A1 true CA3097812A1 (fr) | 2019-10-31 |
Family
ID=68293854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3097812A Pending CA3097812A1 (fr) | 2018-04-25 | 2019-04-17 | Modulateurs du recepteur de l'amyline de peptide cyclique thioether |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3784265A4 (fr) |
JP (1) | JP2021522231A (fr) |
CN (1) | CN112074289A (fr) |
CA (1) | CA3097812A1 (fr) |
WO (1) | WO2019207427A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2022210988B9 (en) | 2021-01-20 | 2024-02-22 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
CN114057862A (zh) * | 2021-12-14 | 2022-02-18 | 安徽省国平药业有限公司 | 一种glp-1(1-37)多肽的合成方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7101853B2 (en) * | 1997-05-06 | 2006-09-05 | Amylin Pharmaceuticals, Inc. | Method for treating or preventing gastritis using amylin or amylin agonists |
US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
US8486890B2 (en) * | 2006-03-15 | 2013-07-16 | Novo Nordisk A/S | Amylin derivatives |
EP2036923A1 (fr) * | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Dérivés d'amyline améliorés |
CA2764108A1 (fr) * | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Polypeptides de regulation du glucose et leurs procedes de production et d'utilisation |
WO2011050008A2 (fr) * | 2009-10-19 | 2011-04-28 | Amylin Pharmaceuticals, Inc. | Polythérapie comprenant l'administration d'un amylinomimétique et d'un peptidomimétique de pyy pour obtenir une perte de poids et pour traiter l'obésité et les états pathologiques et les troubles métaboliques associés |
WO2011084808A2 (fr) * | 2009-12-21 | 2011-07-14 | Amunix Operating Inc. | Compositions de polypeptides bifonctionnels et procédés pour le traitement de maladies métaboliques et cardiovasculaires |
CA2837104A1 (fr) * | 2011-05-25 | 2012-11-29 | Amylin Pharmaceuticals, Llc | Peptides amylines et leurs derives et utilisations |
US20140249076A1 (en) * | 2011-10-18 | 2014-09-04 | Astrazeneca Pharmaceuticals Lp | Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties |
US9683018B2 (en) * | 2013-07-25 | 2017-06-20 | Novartis Ag | Disulfide cyclic polypeptides for the treatment of heart failure |
AR097701A1 (es) * | 2013-09-19 | 2016-04-13 | Zealand Pharma As | Análogos de amilina |
CN113563423A (zh) * | 2014-07-17 | 2021-10-29 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
WO2017075522A2 (fr) * | 2015-10-28 | 2017-05-04 | Tufts University | Polypeptides glp-2 présentant une meilleure stabilité protéolytique et leurs procédés de préparation et d'utilisation |
-
2019
- 2019-04-17 EP EP19791705.7A patent/EP3784265A4/fr not_active Withdrawn
- 2019-04-17 JP JP2020558904A patent/JP2021522231A/ja active Pending
- 2019-04-17 CN CN201980027903.XA patent/CN112074289A/zh active Pending
- 2019-04-17 WO PCT/IB2019/053194 patent/WO2019207427A2/fr unknown
- 2019-04-17 CA CA3097812A patent/CA3097812A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3784265A2 (fr) | 2021-03-03 |
JP2021522231A (ja) | 2021-08-30 |
EP3784265A4 (fr) | 2022-06-22 |
WO2019207427A3 (fr) | 2020-01-02 |
CN112074289A (zh) | 2020-12-11 |
WO2019207427A2 (fr) | 2019-10-31 |
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