JP2021520942A - 閾値下強度における電気パルスによる神経ブロック - Google Patents

閾値下強度における電気パルスによる神経ブロック Download PDF

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Publication number
JP2021520942A
JP2021520942A JP2020556963A JP2020556963A JP2021520942A JP 2021520942 A JP2021520942 A JP 2021520942A JP 2020556963 A JP2020556963 A JP 2020556963A JP 2020556963 A JP2020556963 A JP 2020556963A JP 2021520942 A JP2021520942 A JP 2021520942A
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Japan
Prior art keywords
nerve
intensity
neuron
excitement
increased
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JP2020556963A
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English (en)
Japanese (ja)
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JP2021520942A5 (enExample
Inventor
チャンフェン、タイ
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University of Pittsburgh
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University of Pittsburgh
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Publication of JP2021520942A publication Critical patent/JP2021520942A/ja
Publication of JP2021520942A5 publication Critical patent/JP2021520942A5/ja
Priority to JP2024187316A priority Critical patent/JP2025013960A/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071Pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/3615Intensity
    • A61N1/36153Voltage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/3615Intensity
    • A61N1/36157Current
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/3615Intensity
    • A61N1/36164Sub-threshold or non-excitatory signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/36167Timing, e.g. stimulation onset
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062Spinal stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/36167Timing, e.g. stimulation onset
    • A61N1/36171Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
JP2020556963A 2018-04-16 2019-04-15 閾値下強度における電気パルスによる神経ブロック Pending JP2021520942A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024187316A JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862658147P 2018-04-16 2018-04-16
US62/658,147 2018-04-16
PCT/US2019/027471 WO2019204198A1 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Related Child Applications (1)

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JP2024187316A Division JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

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JP2021520942A true JP2021520942A (ja) 2021-08-26
JP2021520942A5 JP2021520942A5 (enExample) 2022-04-15

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JP2020556963A Pending JP2021520942A (ja) 2018-04-16 2019-04-15 閾値下強度における電気パルスによる神経ブロック
JP2024187316A Pending JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

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Country Link
US (3) US11865346B2 (enExample)
EP (1) EP3781252B1 (enExample)
JP (2) JP2021520942A (enExample)
KR (1) KR102873485B1 (enExample)
CN (1) CN112368047A (enExample)
AU (1) AU2019255603B2 (enExample)
CA (1) CA3097142A1 (enExample)
WO (1) WO2019204198A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
AU2018385603B2 (en) 2017-12-13 2024-05-02 Neuros Medical, Inc. Nerve cuff deployment devices
WO2019199558A1 (en) 2018-04-09 2019-10-17 Neuros Medical, Inc. Apparatuses and methods for setting an electrical dose
CA3097142A1 (en) * 2018-04-16 2019-10-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nerve block by electrical pulses at sub-threshold intensity
US12370079B2 (en) 2018-06-19 2025-07-29 Thermaquil, Inc. Apparatus and method for thermal blockade of nerves
US11878172B2 (en) 2020-02-11 2024-01-23 Neuros Medical, Inc. System and method for quantifying qualitative patient-reported data sets
CN115040230B (zh) * 2022-07-12 2024-04-23 上海宏桐实业有限公司 一种脉冲电场消融系统及电子设备
KR102682382B1 (ko) * 2023-11-28 2024-07-08 (주)리솔 통증 완화 장치 및 그 제어방법
CN118105624B (zh) * 2024-01-30 2024-09-13 上海诺诚电气股份有限公司 神经电刺激监测方法和系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
JP2011502586A (ja) * 2007-11-05 2011-01-27 ネヴロ コーポレイション マルチ周波数神経治療、および関連するシステムおよび方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6421566B1 (en) * 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US8626302B2 (en) 1998-06-03 2014-01-07 Spr Therapeutics, Llc Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US20070025608A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Enhancing intrinsic neural activity using a medical device to treat a patient
US20070173908A1 (en) * 2006-01-20 2007-07-26 Cyberonics, Inc. Transcutaneous trigeminal nerve stimulation to treat motion sickness
US9020597B2 (en) * 2008-11-12 2015-04-28 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
WO2009018518A1 (en) 2007-08-02 2009-02-05 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and systems for achieving a physiological response by pudendal nerve stimulation and bockade
US20090105786A1 (en) * 2007-10-22 2009-04-23 University Of Washington Method and device for strengthening synaptic connections
US8918178B2 (en) * 2009-03-20 2014-12-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US9878154B2 (en) 2009-10-01 2018-01-30 University of Pittsburgh—of the Commonwealth System of Higher Education Non-invasive method to treat urological and gastrointestinal disorders
US10173048B2 (en) 2011-03-10 2019-01-08 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
CN104168951B (zh) * 2011-11-15 2017-07-11 神经系统检测公司 用于使用经皮电神经刺激减轻疼痛的设备和方法
US20140243943A1 (en) * 2013-02-25 2014-08-28 Boston Scientific Neuromodulation Corporation System and method for stimulating intraosseous nerve fibers
WO2015013398A1 (en) * 2013-07-26 2015-01-29 Boston Scientific Neuromodulation Corporation Systems of providing modulation therapy without perception
US10335596B2 (en) * 2014-03-14 2019-07-02 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
US20160158551A1 (en) * 2014-12-05 2016-06-09 Pacesstter, Inc. System and method for dorsal root block during spinal cord stimulation
EP3237057B1 (en) 2014-12-23 2022-08-24 University of Pittsburgh - Of the Commonwealth System of Higher Education Devices and systems for treating urological and gastrointestinal disorders by electrical stimulation of the foot
US9962547B2 (en) * 2015-02-05 2018-05-08 Stimgenics, Llc Method and apparatus for multimodal electrical modulation of pain
US10765863B2 (en) * 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
US9872985B2 (en) * 2015-03-03 2018-01-23 Georgia Tech Research Corporation Glucose regulation via electrical stimulation of nerves innervating the liver
AU2017221321B2 (en) * 2016-02-19 2021-04-15 Nalu Medical, Inc. Apparatus with enhanced stimulation waveforms
WO2017210433A1 (en) * 2016-06-02 2017-12-07 Boston Scientific Neuromodulation Corporation Priming-assisted neuromodulation therapy
WO2018204492A1 (en) 2017-05-04 2018-11-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Peripheral neuromodulation to treat bladder and bowel dysfunction
CA3097142A1 (en) * 2018-04-16 2019-10-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nerve block by electrical pulses at sub-threshold intensity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
JP2011502586A (ja) * 2007-11-05 2011-01-27 ネヴロ コーポレイション マルチ周波数神経治療、および関連するシステムおよび方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUANGNING YANG, CHANGFENG TAI ET AL.: "Post-stimulation block of frog sciatic nerve by high-frequency(kHz) biphasic stimulation", MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, vol. Vol.55, pp.585-593, JPN6023051952, 2017, ISSN: 0005354500 *

Also Published As

Publication number Publication date
EP3781252B1 (en) 2024-11-20
CA3097142A1 (en) 2019-10-24
WO2019204198A1 (en) 2019-10-24
AU2019255603A1 (en) 2020-11-12
JP2025013960A (ja) 2025-01-28
EP3781252A4 (en) 2021-12-15
US20240042211A1 (en) 2024-02-08
US11826572B2 (en) 2023-11-28
KR20210002535A (ko) 2021-01-08
CN112368047A (zh) 2021-02-12
EP3781252A1 (en) 2021-02-24
AU2019255603B2 (en) 2024-09-05
US20210283401A1 (en) 2021-09-16
KR102873485B1 (ko) 2025-10-20
US20210106831A1 (en) 2021-04-15
US11865346B2 (en) 2024-01-09

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