JP2021520942A - 閾値下強度における電気パルスによる神経ブロック - Google Patents

閾値下強度における電気パルスによる神経ブロック Download PDF

Info

Publication number
JP2021520942A
JP2021520942A JP2020556963A JP2020556963A JP2021520942A JP 2021520942 A JP2021520942 A JP 2021520942A JP 2020556963 A JP2020556963 A JP 2020556963A JP 2020556963 A JP2020556963 A JP 2020556963A JP 2021520942 A JP2021520942 A JP 2021520942A
Authority
JP
Japan
Prior art keywords
nerve
intensity
neuron
excitement
increased
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020556963A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021520942A5 (cg-RX-API-DMAC7.html
Inventor
チャンフェン、タイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of JP2021520942A publication Critical patent/JP2021520942A/ja
Publication of JP2021520942A5 publication Critical patent/JP2021520942A5/ja
Priority to JP2024187316A priority Critical patent/JP2025013960A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36164—Sub-threshold or non-excitatory signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
JP2020556963A 2018-04-16 2019-04-15 閾値下強度における電気パルスによる神経ブロック Pending JP2021520942A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024187316A JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862658147P 2018-04-16 2018-04-16
US62/658,147 2018-04-16
PCT/US2019/027471 WO2019204198A1 (en) 2018-04-16 2019-04-15 Nerve block by electrical pulses at sub-threshold intensity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024187316A Division JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

Publications (2)

Publication Number Publication Date
JP2021520942A true JP2021520942A (ja) 2021-08-26
JP2021520942A5 JP2021520942A5 (cg-RX-API-DMAC7.html) 2022-04-15

Family

ID=68239950

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020556963A Pending JP2021520942A (ja) 2018-04-16 2019-04-15 閾値下強度における電気パルスによる神経ブロック
JP2024187316A Pending JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024187316A Pending JP2025013960A (ja) 2018-04-16 2024-10-24 閾値下強度における電気パルスによる神経ブロック

Country Status (8)

Country Link
US (3) US11865346B2 (cg-RX-API-DMAC7.html)
EP (1) EP3781252B1 (cg-RX-API-DMAC7.html)
JP (2) JP2021520942A (cg-RX-API-DMAC7.html)
KR (1) KR102873485B1 (cg-RX-API-DMAC7.html)
CN (1) CN112368047A (cg-RX-API-DMAC7.html)
AU (1) AU2019255603B2 (cg-RX-API-DMAC7.html)
CA (1) CA3097142A1 (cg-RX-API-DMAC7.html)
WO (1) WO2019204198A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
BR112020011807A2 (pt) 2017-12-13 2020-11-17 Neuros Medical, Inc. dispositivos de implantação de bainha do nervo
KR102505594B1 (ko) 2018-04-09 2023-03-06 뉴로스 메디컬 인코포레이티드 전기 용량 설정을 위한 장치 및 방법
WO2019204198A1 (en) * 2018-04-16 2019-10-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nerve block by electrical pulses at sub-threshold intensity
US12370079B2 (en) 2018-06-19 2025-07-29 Thermaquil, Inc. Apparatus and method for thermal blockade of nerves
AU2021219722A1 (en) 2020-02-11 2022-09-08 Neuros Medical, Inc. System and method for quantifying qualitative patient-reported data sets
CN115040230B (zh) * 2022-07-12 2024-04-23 上海宏桐实业有限公司 一种脉冲电场消融系统及电子设备
KR102682382B1 (ko) * 2023-11-28 2024-07-08 (주)리솔 통증 완화 장치 및 그 제어방법
CN118105624B (zh) * 2024-01-30 2024-09-13 上海诺诚电气股份有限公司 神经电刺激监测方法和系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
JP2011502586A (ja) * 2007-11-05 2011-01-27 ネヴロ コーポレイション マルチ周波数神経治療、および関連するシステムおよび方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6421566B1 (en) * 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US8626302B2 (en) * 1998-06-03 2014-01-07 Spr Therapeutics, Llc Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US20070025608A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Enhancing intrinsic neural activity using a medical device to treat a patient
US20070173908A1 (en) * 2006-01-20 2007-07-26 Cyberonics, Inc. Transcutaneous trigeminal nerve stimulation to treat motion sickness
US9020597B2 (en) * 2008-11-12 2015-04-28 Endostim, Inc. Device and implantation system for electrical stimulation of biological systems
WO2009018518A1 (en) 2007-08-02 2009-02-05 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and systems for achieving a physiological response by pudendal nerve stimulation and bockade
US20090105786A1 (en) * 2007-10-22 2009-04-23 University Of Washington Method and device for strengthening synaptic connections
US8918178B2 (en) 2009-03-20 2014-12-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
WO2011041526A2 (en) 2009-10-01 2011-04-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Non-invasive method to treat urological and gastrointestinal disorders
US10279163B2 (en) 2011-03-10 2019-05-07 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
AU2012340365B2 (en) 2011-11-15 2017-08-31 GSK Consumer Healthcare S.A. Apparatus and method for relieving pain using transcutaneous electrical nerve stimulation
US20140243943A1 (en) * 2013-02-25 2014-08-28 Boston Scientific Neuromodulation Corporation System and method for stimulating intraosseous nerve fibers
US20150032181A1 (en) 2013-07-26 2015-01-29 Boston Scientific Neuromodulation Corporation Systems and methods of providing modulation therapy without patient-perception of stimulation
US10335596B2 (en) * 2014-03-14 2019-07-02 Nalu Medical, Inc. Method and apparatus for neuromodulation treatments of pain and other conditions
US20160158551A1 (en) * 2014-12-05 2016-06-09 Pacesstter, Inc. System and method for dorsal root block during spinal cord stimulation
US20170361091A1 (en) 2014-12-23 2017-12-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Devices, Systems and Methods for Treating Urological and Gastrointestinal Disorders by Electrical Stimulation of the Foot
US9962547B2 (en) * 2015-02-05 2018-05-08 Stimgenics, Llc Method and apparatus for multimodal electrical modulation of pain
US10765863B2 (en) * 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
WO2016141184A1 (en) * 2015-03-03 2016-09-09 Georgia Tech Research Corporation Glucose regulation via electrical stimulation of nerves innervating the liver
WO2017142948A1 (en) * 2016-02-19 2017-08-24 Nalu Medical, Inc. Apparatus with enhanced stimulation waveforms
EP3463557A1 (en) * 2016-06-02 2019-04-10 Boston Scientific Neuromodulation Corporation Priming-assisted neuromodulation therapy
US11285318B2 (en) 2017-05-04 2022-03-29 University of Pittsburgh—of the Commonwealth System of Higher Education Peripheral neuromodulation to treat bladder and bowel dysfunction
WO2019204198A1 (en) * 2018-04-16 2019-10-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Nerve block by electrical pulses at sub-threshold intensity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127953A1 (en) * 2001-02-20 2004-07-01 Kilgore Kevin L. Systems and methods for reversibly blocking nerve activity
JP2011502586A (ja) * 2007-11-05 2011-01-27 ネヴロ コーポレイション マルチ周波数神経治療、および関連するシステムおよび方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUANGNING YANG, CHANGFENG TAI ET AL.: "Post-stimulation block of frog sciatic nerve by high-frequency(kHz) biphasic stimulation", MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, vol. Vol.55, pp.585-593, JPN6023051952, 2017, ISSN: 0005354500 *

Also Published As

Publication number Publication date
KR102873485B1 (ko) 2025-10-20
AU2019255603B2 (en) 2024-09-05
AU2019255603A1 (en) 2020-11-12
US11826572B2 (en) 2023-11-28
US20210283401A1 (en) 2021-09-16
WO2019204198A1 (en) 2019-10-24
CN112368047A (zh) 2021-02-12
US20210106831A1 (en) 2021-04-15
US20240042211A1 (en) 2024-02-08
EP3781252A1 (en) 2021-02-24
US11865346B2 (en) 2024-01-09
KR20210002535A (ko) 2021-01-08
CA3097142A1 (en) 2019-10-24
JP2025013960A (ja) 2025-01-28
EP3781252B1 (en) 2024-11-20
EP3781252A4 (en) 2021-12-15

Similar Documents

Publication Publication Date Title
US11826572B2 (en) Nerve block by electrical pulses at sub-threshold intensity
JP7176949B2 (ja) 経皮直流電流ブロックによる神経伝導変更システム及び方法
US7203548B2 (en) Cavernous nerve stimulation via unidirectional propagation of action potentials
US7860570B2 (en) Implantable microstimulators and methods for unidirectional propagation of action potentials
US7292890B2 (en) Vagus nerve stimulation via unidirectional propagation of action potentials
US6937904B2 (en) System and method for providing recovery from muscle denervation
US20100016929A1 (en) Method and system for controlled nerve ablation
WO2001010375A2 (en) Inhibition of action potentials
AU2020300506B2 (en) Neural block by super-threshold low frequency electrical stimulation
Tyler Peripheral nerve stimulation
WO2004000416A1 (en) Implantable microstimulators for unidirectional propagation of action potentials
WO2025090654A1 (en) Closed loop nerve conditioning for selective fiber stimulation
Tai An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220407

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220407

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230515

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230711

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231006

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231219

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240319

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240625