JP2021519622A - エラストグラフィ撮像およびビスコエラストグラフィ撮像のためのシステムおよび方法 - Google Patents
エラストグラフィ撮像およびビスコエラストグラフィ撮像のためのシステムおよび方法 Download PDFInfo
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Abstract
Description
本出願は、譲受人に譲渡され、2018年3月24日に「エラストグラフィ撮像およびビスコエラストグラフィ撮像のためのシステムおよび方法」の名称で出願された米国仮特許出願第62/647,672号および2018年8月8日に「エラストグラフィ撮像およびビスコエラストグラフィ撮像のためのシステムおよび方法」の名称で出願された米国仮特許出願第62/716,303号に基づく米国特許法第119条の規定による優先権を主張し、その内容を参照により本明細書に援用される。
(i)非アルコール性脂肪性肝炎(NASH)のすべての段階を識別することができる深部肝臓ビスコエラストグラフィ、
(ii)超音波ビスコエラストグラフィを、X線のイオン化や不快感がない胸部マンモグラフィに対する潜在的な代替物、潜在的にバイオプシに対するニーズに取って代わることが可能な1〜3mmという解像度、
(iii)残響せん断波ビスコエラストグラフィと共に利用された場合、腎臓の微小細胞粘性の変化が、特定の腎臓癌の重要な指標である、腎臓のようなエコー組織を撮像することができること、
(iv)超音波ビスコエラストグラフィは、前立腺癌の検出、甲状腺、脾臓、角膜、睾丸、筋肉、靭帯、腱、ガイド付きバイオプシ、治療モニタリングなど多くの他のアプリケーションでの一般的化された放射線医学ツールであること、
(v)特殊なバージョンは、(a)損傷した心臓組織をマッピングするための心臓壁剛性撮像および(b)血管壁剛性の撮像などのアプリケーションに使用できること、および
(vi)橋梁および建物ベアリングの非破壊テストならびに地下撮像などの非医療アプリケーション。
Claims (20)
- ターゲットの物体内の関心のあるエリアを撮像するための高解像度ビスコエラストグラフィ(HDVE)慣性ドライバ装置であって、
2つ以上のHDVE慣性ドライバデバイスと、各々のHDVE慣性ドライバデバイスは、
ドライバ信号をコントローラから受信することを可能とするドライバインタフェースと、
共鳴表面と、
前記ドライバインタフェースに通信可能に結合され、前記共鳴表面に機械的に結合されて、前記共鳴表面の共鳴変位を独立に生成する慣性ドライバとを含み、
前記2つ以上のHDVE慣性ドライバデバイスをターゲットの物体と音響的接触するように位置決めして、前記ターゲットの物体内の前記関心のあるエリアの容積を通じてせん断波場を生成する支持部材とを備える、前記HDVE慣性ドライバ装置。 - 前記2つ以上のドライバインタフェースの各々に対する独立したシーケンス化されたドライバ信号を生成して、(i)クローリング波、(ii)残響波および(iii)一方向波のうちの選択された一つを含む前記せん断波場を誘導する前記コントローラをさらに備える、請求項1に記載のHDVE慣性ドライバ装置。
- 前記コントロールは、0.1〜50マイクロメータ(μm)の範囲内の変位を生成するに充分な出力を持つ10Hz〜80kHzの音響周波数範囲内の前記独立したシーケンス化されたドライバ信号を生成する、請求項2に記載のHDVE慣性ドライバ装置。
- 音響センサと、
前記音響センサに通信可能に結合された音響周波数分析器と、
(i)複数の周波数波形信号を生成し、(ii)前記複数の周波数波形信号を増幅して、前記音響周波数分析器により弾性および粘性を測定するための前記せん断波場を生成するドライバ信号を生成する前記コントローラとをさらに備える、請求項2に記載のHDVE慣性ドライバ装置。 - 前記2つ以上のHDVE慣性ドライバデバイスのうちの一つに結合された温度センサをさらに備え、前記コントローラは、前記温度センサに通信可能に結合されて、前記温度センサによる温度測定値に対して、選択された独立したドライバ信号の出力の量を減少させて、前記対応する共鳴表面の制御温度を緩和することにより応答する、請求項2に記載のHDVE慣性ドライバ装置。
- 前記共鳴表面は、前記慣性ドライバにより生成された熱を前記ターゲットの物体から奪う熱ヒートシンクを含む、請求項1に記載のHDVE慣性ドライバ装置。
- 少なくとも1つの共鳴表面がラウドスピーカであり、
前記ターゲットの物体に接触し、前記共鳴表面を前記ターゲットの物体の表面から分離させる空気カラムを密閉する接触表面を有する筐体を含み、
前記共鳴表面を前記ターゲットの物体の表面から分離させる距離が、1cm未満、好ましくは0.5cm未満、最も好ましくは0.25cm未満である、請求項1に記載のHDVE慣性ドライバ装置。 - 少なくとも1つの共鳴表面が、前記ターゲットの物体に適合し、音響的に透過性である弾力的表面を含む、請求項1に記載のHDVE慣性ドライバ装置。
- 関心のあるエリア内に形成された前記せん断波場を検出するために、前記ターゲットの物体に対して位置決め可能な音響センサをさらに備える、請求項1に記載のHDVE慣性ドライバ装置。
- 前記支持部材は、前記2つ以上のHDVE慣性ドライバデバイスの対を、前記音響センサの両側に間隔を置いた線形のアラインメントで取り付ける、請求項9に記載のHDVE慣性ドライバ装置。
- 前記支持部材は、前記ターゲットの物体を取り囲む調整可能ハーネスを含む、請求項1に記載のHDVE慣性ドライバ装置。
- 前記支持部材は、前記ターゲットの物体が設置される可撓性基板を含む、請求項1に記載のHDVE慣性ドライバ装置。
- 前記支持部材は、前記ターゲットの物体を支持する台に調整可能に係合された対向するクランプデバイスの対を含む、請求項1に記載のHDVE慣性ドライバ装置。
- 前記対向するクランプデバイスの対のうちの少なくとも一方が、前記台の細長いチャネル内にスライド的に受容される係合部材を含む、請求項13に記載のHDVE慣性ドライバ装置。
- 前記2つ以上のHDVE慣性ドライバデバイスのうちの各々の一つが、
台構造により支持可能であるベースと、
前記ベースと、前記共鳴表面との間にそれぞれ取り付けられた複数のスプリング部材とを含む、請求項1に記載のHDVE慣性ドライバ装置。 - 前記2つ以上のHDVE慣性ドライバデバイスは独立して駆動され、前記2つ以上のHDVE慣性ドライバデバイスの各々の一つの前記それぞれのベースは、ユニタリベースの隣接する部分を含み、前記装置は、前記ユニタリベース内に音響的分離材料をさらに含む、請求項1に記載のHDVE慣性ドライバ装置。
- 高解像度ビスコエラストグラフィ(HDVE)慣性ドライバ装置であって、
2つ以上のHDVE慣性ドライバデバイスと、各々のHDVE慣性ドライバデバイスは、
ドライバ信号をコントローラから受信することを可能とするドライバインタフェースと、
共鳴表面と、
前記ドライバインタフェースに通信可能に結合され、前記共鳴表面に機械的に結合されて、前記共鳴表面の共鳴変位を独立に生成する慣性ドライバとを含み、
前記2つ以上のHDVE慣性ドライバデバイスをターゲットの物体と音響的接触するように位置決めして、前記ターゲットの物体内の材料の容積を通じてせん断波場を生成する支持部材とを含む、前記HDVE慣性ドライバ装置と、
前記2つ以上のドライバインタフェースの各々に対する独立したシーケンス化されたドライバ信号を生成して、前記せん断波場を誘導する前記2つ以上のHDVE慣性ドライバデバイスの前記それぞれのドライバインタフェースに通信可能に結合されたコントローラと、
前記ターゲットの物体上に位置決めされた音響センサと、
前記音響センサに通信可能に結合された音響周波数分析器と、
(i)複数の周波数波形信号を生成し、(ii)前記複数の周波数波形信号を増幅して、前記音響周波数分析器により弾性および粘性を測定するための前記せん断波場を生成するドライバ信号を生成するコントローラと、
前記弾性および粘性の測定値を処理して、粘性画像を含み得るエラストグラフィ画像を形成するプロセッサと、
前記粘性画像を含み得る前記エラストグラフィ画像を表示するためのディスプレイモニタとを備える、撮像システム。 - 前記せん断波場は、0.1〜50μmの範囲内の変位を生成するに充分な出力を持つ20Hz〜80kHzの音響周波数範囲内にある(i)クローリング波、(ii)残響波および(iii)一方向波のうちの選択された一つを含む、請求項17に記載の撮像システム。
- 複数の周波数波形信号を生成して、それらをドライバ信号になるように増幅することと、
ターゲットの物体に対して保持された共鳴表面の共鳴変位を生成する2つ以上の高解像度ビスコエラストグラフィ(HDVE)慣性ドライバデバイスのうちのそれぞれの慣性ドライバを駆動することと、
各々のHDVE慣性ドライバデバイス装置に結合されたドライバ信号を生成して、前記ターゲットの物体内の材料の容積を通じてせん断波場を生成することと、
前記ターゲットの物体に対して保持された音響センサにより音響波を受信することと、
ドライバ信号を生成することと、
前記ターゲットの物体の材料を通じて通過した前記複数の周波数波形信号の周波数に対する周波数応答を分析して、組織の弾性または粘弾性を測定することと、
各々のHDVE慣性ドライバデバイス装置に結合されたドライバ信号を修正して、前記ターゲットの物体内の材料の前記容積を通じて通過するせん断波場を改善することと、
前記ターゲットの物体内の材料の前記容積を通じて通過する前記せん断波場が満足できるようになるまで、前記分析および修正を繰り返すことと、
前記せん断波場に基づいて弾性および粘性を測定することとを含む、方法。 - 前記ターゲットの物体内の組織の前記容積を通じる前記せん断波場は、0.1〜50μmの範囲内の変位を生成するに充分な出力を持つ20Hz〜80kHzの音響周波数範囲内にある(i)クローリング波、(ii)残響波および(iii)一方向波のうちの選択された一つを含む、請求項19に記載の方法。
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- 2019-03-25 JP JP2020549594A patent/JP7228214B2/ja active Active
- 2019-03-25 US US17/040,824 patent/US20210018606A1/en active Pending
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EP3773233A1 (en) | 2021-02-17 |
US20210018606A1 (en) | 2021-01-21 |
JP7228214B2 (ja) | 2023-02-24 |
CN112367918A (zh) | 2021-02-12 |
EP3773233A4 (en) | 2022-01-12 |
KR20210003756A (ko) | 2021-01-12 |
WO2019191009A1 (en) | 2019-10-03 |
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