JP2021505611A5 - - Google Patents

Download PDF

Info

Publication number
JP2021505611A5
JP2021505611A5 JP2020531104A JP2020531104A JP2021505611A5 JP 2021505611 A5 JP2021505611 A5 JP 2021505611A5 JP 2020531104 A JP2020531104 A JP 2020531104A JP 2020531104 A JP2020531104 A JP 2020531104A JP 2021505611 A5 JP2021505611 A5 JP 2021505611A5
Authority
JP
Japan
Prior art keywords
inhibitor
ikk
pharmaceutical
treatment
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020531104A
Other languages
English (en)
Japanese (ja)
Other versions
JP7527639B2 (ja
JP2021505611A (ja
Filing date
Publication date
Priority claimed from EP17205864.6A external-priority patent/EP3494994A1/en
Application filed filed Critical
Publication of JP2021505611A publication Critical patent/JP2021505611A/ja
Publication of JP2021505611A5 publication Critical patent/JP2021505611A5/ja
Application granted granted Critical
Publication of JP7527639B2 publication Critical patent/JP7527639B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020531104A 2017-12-07 2018-12-07 免疫疾患の予防または治療のためのripk1阻害剤とikk阻害剤の組み合わせ Active JP7527639B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17205864.6A EP3494994A1 (en) 2017-12-07 2017-12-07 Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases
EP17205864.6 2017-12-07
PCT/EP2018/084055 WO2019110832A1 (en) 2017-12-07 2018-12-07 Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases

Publications (3)

Publication Number Publication Date
JP2021505611A JP2021505611A (ja) 2021-02-18
JP2021505611A5 true JP2021505611A5 (https=) 2022-01-11
JP7527639B2 JP7527639B2 (ja) 2024-08-05

Family

ID=60629504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020531104A Active JP7527639B2 (ja) 2017-12-07 2018-12-07 免疫疾患の予防または治療のためのripk1阻害剤とikk阻害剤の組み合わせ

Country Status (7)

Country Link
US (1) US20200383995A1 (https=)
EP (2) EP3494994A1 (https=)
JP (1) JP7527639B2 (https=)
CN (1) CN111670049A (https=)
CA (1) CA3103847A1 (https=)
MX (1) MX2020007036A (https=)
WO (1) WO2019110832A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021046515A1 (en) * 2019-09-06 2021-03-11 Board Of Regents, The University Of Texas System Inhibitors of receptor interacting protein kinase i for the treatment of disease
IL291665B2 (en) 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
JP2023502514A (ja) 2019-11-26 2023-01-24 ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム 疾患の処置のための受容体相互作用プロテインキナーゼiの阻害剤
EP4209213A1 (en) * 2022-01-05 2023-07-12 Universität zu Köln Signalling-pathway inhibitor combinations for use in the treatment of cancer diseases
WO2024170776A1 (en) 2023-02-17 2024-08-22 Universität Zu Köln Triple kinase inhibition for the treatment of type i interferon response associated disorders
CN119064582B (zh) * 2024-09-02 2025-05-27 南方医科大学南方医院 RIPK1 O-GlcNAc糖基化抑制剂在制备增强肾细胞癌舒尼替尼敏感性药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03006817A (es) * 2001-02-01 2003-11-13 Bristol Myers Squibb Co Metodo de tratamiento de enfermedades inflamatorias e inmunes usando inhibidores de la ikb cinasa (ikk).
JP2009539865A (ja) * 2006-06-06 2009-11-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換3−アミノ−チエノ[2,3−b]ピリジン2−カルボン酸アミド化合物及び製造方法及びそれらの使用
ES2555160B1 (es) * 2014-06-24 2016-10-25 Aptus Biotech, S.L. Aptámeros específicos de TLR-4 y usos de los mismos
EP3017825A1 (en) * 2014-11-06 2016-05-11 Ludwig-Maximilians-Universität München An inhibitor of the RIPK1-dependent necrosis pathway and a pharmaceutical composition comprising the same

Similar Documents

Publication Publication Date Title
JP2021505611A5 (https=)
Li et al. Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals
Robert et al. Characterization of the MMP/TIMP imbalance and collagen production induced by IL-1β or TNF-α release from human hepatic stellate cells
Ma et al. Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
Egners et al. The response of macrophages and neutrophils to hypoxia in the context of cancer and other inflammatory diseases
McGeer et al. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
Zhu et al. Gene silencing of NALP3 protects against liver ischemia–reperfusion injury in mice
KR102760315B1 (ko) C/EBP 알파 saRNA 조성물 및 사용 방법
Culig Cytokine disbalance in common human cancers
Pensa et al. Stat3 and the inflammation/acute phase response in involution and breast cancer
US8007790B2 (en) Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
Grande Mechanisms of progression of renal damage in lupus nephritis: pathogenesis of renal scarring
Dong et al. Inhalable siRNA targeting IL-11 nanoparticles significantly inhibit bleomycin-induced pulmonary fibrosis
CN111741763B (zh) 包含apl型肽的药用组合物
US9750718B2 (en) Methods of treating hepatic fibrosis and associated diseases by regulating Rev-ERB activity
Araújo et al. Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model
JP2013504603A5 (https=)
Zheng et al. Pivotal role of cerebral interleukin-23 during immunologic injury in delayed cerebral ischemia in mice
CN113750089B (zh) 2-芳基-1,3二氢苯并咪唑衍生物在制备治疗慢性肝病的药物中的用途
CN115590880A (zh) 工程化的巨噬细胞联用在治疗纤维化疾病中的应用
Huang et al. IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
Feng et al. Senescence-and immunity-related changes in the central nervous system: A comprehensive review
Haghikia et al. Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells
US20180002698A1 (en) C-rel-specific sirna and its use for preventing and treating autoimmune psoriasis
US11628163B2 (en) 1-piperidinepropionic acid for treating a fibrosing disease