JP2021505525A5 - - Google Patents

Info

Publication number

JP2021505525A5

JP2021505525A5 JP2020511429A JP2020511429A JP2021505525A5 JP 2021505525 A5 JP2021505525 A5 JP 2021505525A5 JP 2020511429 A JP2020511429 A JP 2020511429A JP 2020511429 A JP2020511429 A JP 2020511429A JP 2021505525 A5 JP2021505525 A5 JP 2021505525A5

Authority

JP

Japan

Prior art keywords

variant

amino acid

fragment

seq

peptide

Prior art date

2018-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000012634 fragment Substances 0.000 claims 21
• 230000002163 immunogen Effects 0.000 claims 19
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 235000018102 proteins Nutrition 0.000 claims 12
• 108090000623 proteins and genes Proteins 0.000 claims 12
• 102000004169 proteins and genes Human genes 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 101001066720 Rattus norvegicus Nuclear envelope pore membrane protein POM 121 Proteins 0.000 claims 9
• 235000001014 amino acid Nutrition 0.000 claims 6
• 241000124008 Mammalia Species 0.000 claims 5
• 108010078791 Carrier Proteins Proteins 0.000 claims 4
• 102000014914 Carrier Proteins Human genes 0.000 claims 4
• 229940024606 amino acid Drugs 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 230000036039 immunity Effects 0.000 claims 4
• 230000016379 mucosal immune response Effects 0.000 claims 4
• 238000006467 substitution reaction Methods 0.000 claims 4
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 2
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
• 241000894006 Bacteria Species 0.000 claims 2
• 102000016607 Diphtheria Toxin Human genes 0.000 claims 2
• 108010053187 Diphtheria Toxin Proteins 0.000 claims 2
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
• 206010061372 Streptococcal infection Diseases 0.000 claims 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
• 229960001230 asparagine Drugs 0.000 claims 2
• 235000009582 asparagine Nutrition 0.000 claims 2
• 238000007918 intramuscular administration Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 230000005847 immunogenicity Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 210000003928 nasal cavity Anatomy 0.000 claims 1