JP2021109006A - Injection device - Google Patents

Abstract

To provide an injection device which can smoothly inject a first fluid and a second fluid into a prescribed part to be injected.SOLUTION: An injection device includes: a first container part 2 for housing a first fluid; a second container part 3 for housing a second fluid which makes the first fluid into a gel; a first lead-out pipe part 4 for leading out the first fluid from the first container part 2; a second lead-out pipe part 5 for leading out the second fluid from the second container part 3; a first extruding member 6 for extruding the first fluid in the first container part 2 toward the first lead-out pipe part 4; a second extruding member 7 for extruding the second fluid in the second container part 3 toward the second lead-out pipe part 5; a first operation part 6a for operating the first extruding member 6 to press; and a second operation part 7a for operating the second extruding member 7 to press independently of the first operation part 6a. The first lead-out pipe part 4 and the second lead-out pipe part 5 are adjacent to each other.SELECTED DRAWING: Figure 1

Description

The present invention relates to an injection device capable of sequentially injecting a first fluid and a second fluid into a predetermined injection position.

When a defect occurs in cartilage of animals including humans, for example, articular cartilage such as knee, a method of repairing the defect is known. One of the methods is to fill the cartilage defect with a biocompatible material and use the biocompatible material as a scaffold to regenerate the chondrocytes in the defect. Examples of the material to be filled in the cartilage defect include collagen, hyaluronic acid, alginate and the like.

In particular, when filling the alginate defect with alginate, the alginate sol is injected with an injection device, and then a gelling agent (for example, calcium chloride) is added to the alginate sol of the defect to form alginate. The salt sol is gelled (see Patent Document 1 below).

As the above-mentioned injection device, a general injection tool in which an injection needle is attached to a syringe can be used. In this case, two injection tools are required, one for injecting the alginate sol and the other for adding the gelling agent.

Further, in order to inject two kinds of fluids into a predetermined injection portion, two chemical solutions are taken out from two syringes each containing the two chemical solutions to one outlet tube, and the two chemical solutions are injected prior to injection into the injection portion. Injecting devices that allow mixing are known (see, for example, Patent Documents 2, 3 and 4 below).

The injection device described in Patent Document 1 is for simultaneously deriving a fibrinogen solution and a collagen solution, mixing them, and injecting them into a cartilage defect. The injection device described in Patent Document 2 is for mixing hyaluronic acid and taurolidine and injecting them into a joint. The injection device described in Patent Document 3 is for mixing a liquid containing gelatin and a liquid for solidifying gelatin (such as a liquid containing glutaraldehyde) and applying it to a living tissue.

Japanese Patent No. 4740369 Special Table 2016-502448 Special Table 2018-526445 Japanese Unexamined Patent Publication No. 2012-161473

However, when injecting the alginate sol and adding the gelling agent in sequence using the two injection tools, the injection tools must be inserted and removed. Therefore, not only a lot of man-hours and time are required, but also alginate sol may leak from the cartilage defect due to vibration at the time of inserting and removing the injection tool.

In particular, when injecting alginate sol into a defect in articular cartilage such as the knee by arthroscopic surgery, the operator checks the image taken by the camera and checks the image of the joint, which is a narrow space called the joint cavity. The injection tool must be placed in the proper position in the space. Therefore, it may be difficult to properly place the injection tool in the joint cavity.

On the other hand, although the injection device in Patent Documents 2 to 4 does not require the work of inserting and removing the two injection tools, each of them is one before the fluid derived from the two syringes reaches the injection portion. It is mixed in the lead-out tube. At this time, if the fluids drawn out from the two syringes are an alginate sol and a gelling agent, the fluids are mixed in one lead-out tube and rapidly gelled in the lead-out tube, so that the defect can be smoothly reached. There is a problem that injection cannot be performed.

The injection device of Patent Document 3 heats the lead-out tube by a heating means when the liquid containing gelatin solidifies in the lead-out tube, changes the state to a liquid having a low viscosity, and clears the clogging of the lead-out tube. There is. However, for example, gelled alginate does not easily decrease in viscosity due to heat, so that the clogging of the lead-out tube cannot be cleared even if the lead-out tube is heated, and it becomes difficult to inject it into the defective portion.

As described above, the injection device in Patent Documents 2 to 4 is not suitable when the fluid derived from the syringe is an alginate sol and a gelling agent.

In view of such inconvenience, the present invention can smoothly inject the first fluid and the second fluid into a predetermined injection portion by omitting the work of inserting and removing the injection tool in the arthroscopic surgery. It is an object of the present invention to provide an injection device capable of significantly reducing the burden on the operator.

In order to achieve such an object, the present invention is an injection device capable of sequentially injecting a first fluid and a second fluid into a predetermined injection portion, and a cylinder containing the first fluid inside. A first container portion having a shape, a second tubular portion accommodating a second fluid for gelling the first fluid, and a first fluid being drawn out from the inside of the first container portion. The first outlet pipe portion to be injected into the injected portion, the second outlet pipe portion to draw a second fluid from the inside of the second container portion and inject it into the injected portion, and the inside of the first container portion thereof. The first extruding member that moves along the longitudinal direction and pushes the first fluid toward the first outlet pipe portion, and the second fluid that moves along the longitudinal direction in the second container portion and pushes the second fluid. 2 A second extruding member that pushes out toward the lead-out pipe portion, a first operating portion that presses the first extruding member, and a second operating portion that presses the second extruding member independently of the first operating portion. It is characterized in that it includes an operation unit, and the first lead-out pipe portion and the second lead-out pipe portion are adjacent to each other.

The injection device of the present invention includes a first container portion and a second container portion, and further includes a first outlet pipe portion and a second outlet pipe portion. Further, the downstream ends of the first lead-out pipe portion and the second lead-out pipe portion are adjacent to each other.

As a result, after injecting the first fluid into the injected portion by operating the first operating portion, only the second operating portion is subsequently operated without inserting or removing the lead-out pipe portion. A second fluid can be injected into the part to be injected.

Moreover, since the first lead-out pipe portion and the second lead-out pipe portion lead out the first fluid and the second fluid in a non-contact (non-mixed) state, the first lead-out pipe portion is used until it reaches the injected portion. Gelation does not occur due to mixing of the fluid and the second fluid.

As described above, according to the present invention, the first fluid and the second fluid can be smoothly injected into a predetermined injection portion.

Further, in the present invention, the first lead-out pipe portion is provided in a state of being inserted into the inside of the second lead-out pipe portion, and the first lead-out pipe portion is provided between the first lead-out pipe portion and the second lead-out pipe portion. It is characterized in that 2 fluids are derived.

The first lead-out pipe portion and the second lead-out pipe portion are adjacent to each other because the first lead-out pipe portion is inserted inside the second lead-out pipe portion. Since the first lead-out pipe portion is inserted into the inside of the second lead-out pipe portion, it can be handled in the same manner as a single lead-out pipe portion, and the operability is improved.

Further, in the present invention, the first container portion and the second container portion are provided adjacent to each other.

According to this, it is not necessary to switch between the first container portion and the second container portion.

At this time, the second container portion includes a tubular outer wall and a tubular inner side wall facing the inner surface of the outer wall at a predetermined distance, and the outer wall and the inner side wall are provided with each other. The second fluid is accommodated between them, and the first container portion is provided by being inserted into the inner wall surface of the second container portion.

The first container portion and the second container portion are adjacent to each other because the first container portion is inserted and provided inside the second container portion. Since the first container portion is inserted and provided inside the second container portion, not only can the injection device be compactly formed, but also the injection device can be gripped in the same manner as a single container portion. Operability is improved.

In addition, the first container portion and the second container portion are connected to each other with a first holding portion for holding the first container portion and a second holding portion for holding the second container portion. It may be freely connected by a member.

Further, a frame portion that rotatably supports the connecting member and a frame portion provided on the frame portion, when the first container portion is rotated to a predetermined position by the connecting member, abuts on the first operating portion. The first extruded member can be pressed through the first operating portion, and when the second container portion is rotated to a predetermined position by the connecting member, the second operating portion comes into contact with the second operating portion. A pressing rod that enables the second extrusion member to be pressed and operated may be provided.

According to this, first, the pressing rod is brought into contact with the first operating portion to perform the pressing operation, and when the injection of the first fluid into the injected portion is completed, then the connecting member is rotated to perform the pressing operation. Is in contact with the second operation unit. Then, the pressing operation of the second operating portion is performed by the pressing rod, and the second fluid is injected into the injected portion.

In this way, since the connecting member can be rotated and the pressing operation of the two operating portions can be selectively performed by the pressing rod, it is possible to prevent simultaneous pressing of the two operating portions. Moreover, since it is only necessary to operate one pressing rod when injecting the fluid, high operability can be obtained.

Further, in the present invention, when the first outlet pipe portion is provided in a state of being inserted into the inside of the second outlet pipe portion, the second outlet pipe portion is connected to the first container portion. An insertion port into which the first outlet pipe portion is inserted and a connection portion provided at a position different from the insertion port and connecting the second container portion may be provided.

Further, in the present invention, it is preferable that the first fluid is a sol, for example, sodium alginate sol, and the second fluid is a gelling agent for the sol, for example, a calcium chloride solution.

The sodium alginate sol rapidly gels when it comes into contact with the calcium chloride solution, but the first outlet tube portion and the second outlet tube portion lead out the sodium alginate sol and the calcium chloride solution in a non-contact state. Therefore, it is possible to prevent gelation before reaching the injection portion, and smooth injection into the injection portion becomes possible.

Further, according to the present invention, when performing an operation for repairing a defect formed in articular cartilage such as a knee, the injection device of the present invention is used to inject sodium alginate together with a calcium chloride solution as a gelling agent into the defect. Regarding sol.

The side view which shows the injection apparatus of 1st Embodiment of this invention. Explanatory sectional view of the injection apparatus of 1st Embodiment. Exploded view of the injection device of the first embodiment. The operation explanatory drawing of the injection device of 1st Embodiment. The side view which shows the injection apparatus of 2nd Embodiment of this invention. Explanatory plan view of the connecting member in the injection device of 2nd Embodiment. Explanatory sectional view which shows the modification of the injection apparatus of 2nd Embodiment. FIG. 5 is a side view of the connecting member adopted in the injection device of FIG. 7. The plan view of the connecting member of FIG. Top view of other connecting members. Explanatory sectional view which shows the injection apparatus of 3rd Embodiment of this invention. Explanatory sectional view schematically showing the injection apparatus of 4th Embodiment of this invention. Explanatory cross-sectional view of the second outlet pipe part in the injection apparatus of 4th Embodiment.

The first embodiment of the present invention will be described with reference to FIGS. 1 to 4. The injection device 1 in the first embodiment includes a first container portion 2 and a second container portion 3 as shown in FIGS. 1, 2 and 3. The first outlet pipe portion 4 is connected to the first container portion 2. A second outlet pipe portion 5 is connected to the second container portion 3.

The first container portion 2 and the first outlet pipe portion 4 are detachably inserted into the inside of the second container portion 3 and the second outlet pipe portion 5. As a result, the first container portion 2 and the second container portion 3 are equivalent to being adjacent to each other, and the first outlet pipe portion 4 and the second outlet pipe portion 5 are equivalent to being adjacent to each other. It has become. Therefore, the injection device 1 in the first embodiment is relatively compact.

The tip of the first lead-out pipe 4 extends a predetermined length from the opening of the tip of the second lead-out pipe 5. The length of the tip of the first outlet pipe portion 4 extending from the tip of the second outlet pipe portion 5 is preferably 2 mm to 13 mm.

The material of the first outlet tube portion 4 can be stainless steel as in the case of a normal injection needle, but may be polyurethane, fluororesin, or the like.

The length of the first lead-out pipe portion 4 is appropriately set according to the application of the injection device of the present invention. For example, when the injection device of the present invention fills the defect portion of the articular cartilage of the knee with fluid, the length of the first lead-out tube portion 4 is preferably 50 mm to 120 mm.

As shown in FIG. 2, the first container portion 2 is formed in a cylindrical shape, and a fluid accommodating space is formed therein. In the present embodiment, the sodium alginate sol (first fluid) is accommodated in the accommodating space inside the first container portion 2.

A first plunger 6 (first extrusion member) is provided inside the first container portion 2. The first plunger 6 is provided so as to be movable in the first container portion 2 along the longitudinal direction thereof. The exposed one end surface of the first plunger 6 is the first operation unit 6a. By pressing the first operation unit 6a, the first plunger 6 is pushed in and the sodium alginate sol in the first container unit 2 is led out from the first outlet pipe unit 4.

As shown in FIG. 2, the second container portion 3 includes a cylindrical outer wall surface 3a and a cylindrical inner wall surface 3b facing the inner surface of the outer wall surface 3a at a predetermined distance. A fluid accommodating space is formed between the outer side wall 3a and the inner side wall 3b, and an insertion space for the first container portion 2 is formed inside the inner side wall 3b. In the present embodiment, the calcium chloride solution (second fluid) is stored in the storage space inside the second container portion 3.

A second plunger 7 (second extruded member) is provided in the space between the outer wall 3a and the inner side wall 3b of the second container portion 3. The second plunger 7 is provided so as to be movable along the longitudinal direction of the second container portion 3. A second operating portion 7a is formed on the outer periphery of the exposed end of the second plunger 7 so as to project in a brim shape. By pressing the second operation unit 7a, the second plunger 7 is pushed in and the calcium chloride solution in the second container unit 3 is led out from the second outlet pipe unit 5.

The volumes of the first container portion 2 and the second container portion 3 may be set according to the required amounts of sodium alginate sol and calcium chloride solution, respectively. The required amount of sodium alginate sol to be filled in the cartilage defect portion of the knee joint is, for example, 0.1 mL to 5.0 mL, and the required amount of the calcium chloride solution in that case is, for example, 5 mL to 20 mL.

The sodium alginate sol filled in the cartilage defect is not particularly limited, but can be a material having a relatively high viscosity (for example, 320 mPa · s to 6000 mPa · s), and thus serves as a route for deriving the sodium alginate sol. 1 It may be preferable that the inner diameter of the lead-out pipe portion 4 is a certain value or more.

On the other hand, if the inner diameter of the first lead-out tube portion 4 is too large, it may be difficult to fill the desired position (cartilage defect portion) with sodium alginate sol. Therefore, the inner diameter of the first lead-out pipe portion 4 is preferably 0.2 mm to 0.9 mm, and for example, the needle can be in the range of 18 G to 27 G according to the gauge standard.

The work of injecting the cartilage of the knee joint into the defective portion (injected portion) using the injection device 1 having the above configuration will be described. First, as shown in FIG. 3, the first container portion 2 and the second container portion 3 are separated from each other, the first container portion 2 is filled with sodium alginate sol, and the second container portion 3 is filled with a calcium chloride solution. Fill. The sodium alginate sol may be provided as a so-called pre-filled syringe preparation in a state of being pre-filled in the first container portion 2.

Then, the first container portion 2 filled with the sodium alginate sol is inserted along the axis of the second container portion 3 filled with the calcium chloride solution, and integrated as shown in FIG. Next, when performing injection work by endoscopic (arthroscopic) endoscopic surgery, although not shown, the first lead-out tube is placed in a cannula in which the tip is placed in advance near the cartilage defect of the knee joint. The part 4 and the second lead-out pipe part 5 are inserted. At this time, the first lead-out pipe portion 4 and the second lead-out pipe portion 5 are integrated and are in the same state as a single lead-out pipe, so that the desired position (in the present embodiment, the knee joint) is reached via the cannula. ) Can be inserted extremely smoothly.

Subsequently, the tip opening of the first lead-out tube portion 4 is opposed to the cartilage defect portion of the knee joint, and as shown in FIG. 4A, the first operation portion 6a is pressed to inject sodium alginate sol. As a result, the cartilage defect of the knee joint is filled with sodium alginate sol. At this time, the sodium alginate sol led out by the first lead-out pipe portion 4 does not come into contact with the calcium chloride solution contained in the second container portion 3, so that it does not inadvertently gel.

Moreover, since the tip of the first lead-out pipe portion 4 extends from the tip of the second lead-out pipe portion 5 and maintains an outer diameter smaller than that of the second lead-out pipe portion 5, the first lead-out pipe portion is maintained. The tip opening of 4 can be accurately opposed to the defective portion.

When the filling of the sodium alginate sol into the defective portion is completed, as shown in FIG. 4B, the second operating portion 7a is pressed to inject the calcium chloride solution into the defective portion. At this time, since it is not necessary to insert and remove the outlet pipe portions 4 and 5, leakage of the sodium alginate sol from the defective portion is prevented. Then, the calcium chloride solution is added to the sodium alginate sol filled in the defect portion, so that gelation proceeds rapidly. The calcium chloride solution contained in the second container portion 3 is led out from the second outlet pipe portion 5, which is shorter than the first outlet pipe portion 4, but is led out from the second outlet pipe portion 5. Injection into the defect is smoothly performed along the outer surface of the tip of the tube.

As described above, the injection device 1 having the above configuration not only has a compact outer shape, but also sequentially transfers the sodium alginate sol and the calcium chloride solution to the cartilage defect portion of the knee joint without moving its holding state. Since it can be injected into, etc., its operability is extremely high. Moreover, since gelation during the injection of the sodium alginate sol can be prevented, the injection work can be smoothly performed.

Next, the second embodiment of the present invention will be described with reference to FIGS. 5 to 10. As shown in FIG. 5, the injection device 10 in the second embodiment includes a first container portion 11 and a second container portion 12. The first outlet pipe portion 13 is connected to the first container portion 11. A second outlet pipe portion 14 is connected to the second container portion 12.

The first container portion 11 and the second container portion 12 are connected to each other by a connecting member 15. The first lead-out pipe portion 13 and the second lead-out pipe portion 14 are adjacent to each other in parallel over substantially the entire length except for the base end portions 13a and 14a.

In the second embodiment, the first lead-out pipe portion 13 and the second lead-out pipe portion 14 are provided in parallel with each other so that they are adjacent to each other. Similar to the first embodiment, the one in which the first lead-out pipe portion 13 is inserted inside the second lead-out pipe portion 14 to form a double structure may be adopted.

As shown in FIG. 6, the connecting member 15 has a first holding portion 15a that detachably fits and holds the first container portion 11 and a second container portion 12 that detachably fits and holds the second container portion 12. 2 The holding portion 15b is integrally provided. Since the injection device 10 is configured by connecting the two container portions 11 and 12 using the connecting member 15, for example, two existing syringes can be used to configure the injection device 10 at a relatively low cost.

The work of injecting the cartilage of the knee joint into the defective portion (injected portion) using the injection device 10 having the above configuration will be described. First, as shown in FIG. 5, the first container portion 11 filled with sodium alginate sol and the second container portion 3 filled with a calcium chloride solution are connected by a connecting member 15.

Next, the first outlet pipe portion 13 and the second outlet pipe portion 14 are connected to the first container portion 11 and the second container portion 12, respectively.

Subsequently, when the injection work is performed by endoscopic (arthroscopic) endoscopic surgery, although not shown, the first derivation is performed on a cannula in which the tip is placed in advance near the cartilage defect of the knee joint. The pipe portion 13 and the second outlet pipe portion 14 are inserted through the pipe portion 13. At this time, since the first lead-out pipe portion 13 and the second lead-out pipe portion 14 are adjacent to each other, the insertion work to the desired position (knee joint in the present embodiment) is extremely smoothly performed via the cannula. be able to.

Subsequently, the tip openings of the first lead-out tube portion 13 and the second lead-out tube portion 14 are made to face the cartilage defect portion of the knee joint, and the first operation portion 16a of the first plunger 16 (first extruded member) is pressed. Manipulate to inject sodium alginate sol and fill the defect with sodium alginate sol. At this time, the sodium alginate sol led out by the first lead-out tube portion 13 does not come into contact with the calcium chloride solution contained in the second container portion 12, so that it does not inadvertently gel.

Subsequently, the calcium chloride solution is injected into the defective portion by pressing the second operating portion 17a of the second plunger 17 (second extrusion member) with almost no change in the holding state of the injection device. At this time, since it is not necessary to insert and remove the outlet pipe portions 13 and 14, leakage of the sodium alginate sol from the defective portion is prevented. Then, the calcium chloride solution is added to the sodium alginate sol filled in the defect portion, so that gelation proceeds rapidly.

As described above, the injection device 10 having the above configuration includes the first container portion 11 and the second container portion 12 integrated by the connecting member 15, and the first outlet pipe portion 13 and the second outlet pipe portion 14 are connected to each other. Operability is good because they are adjacent to each other. Moreover, since the flow paths of the sodium alginate sol and the calcium chloride solution are different for each of the first outlet pipe portion 13 and the second outlet pipe portion 14, gelation during the injection operation can be prevented.

As a modification in which the same action and effect as the connecting member 15 can be obtained, as shown in FIG. 7, a connecting member 22 that accommodates and integrates the first container portion 20 and the second container portion 21 can be mentioned. can. As shown in FIGS. 8 and 9, the connecting member 22 includes two holding holes 22b and 22c penetrating the block-shaped body 22a. The shape of the body 22a can be reduced in weight by forming the shape along the holding holes 22b and 22c as shown in FIG.

Next, the third embodiment of the present invention will be described with reference to FIG. As shown in FIG. 11A, the injection device 30 in the third embodiment includes a first container portion 31 and a second container portion 32. The first outlet pipe portion 33 is connected to the first container portion 31. A second outlet pipe portion 34 is connected to the second container portion 32. The first lead-out pipe portion 33 and the second lead-out pipe portion 34 are adjacent to each other over substantially the entire length except for the base end portions 33a and 34a. The first container portion 31 and the second container portion 32 are integrally connected by a connecting member 35. The connecting member 35 is rotatably supported by the frame portion 36.

A first plunger 37 (first extrusion member) is provided inside the first container portion 31. The first plunger 37 is provided so as to be movable in the first container portion 31 along the longitudinal direction thereof. One end surface of the first plunger 37 is a first operation unit 37a.

A second plunger 38 (second extrusion member) is provided inside the second container portion 32. The second plunger 38 is provided so as to be movable in the second container portion 32 along the longitudinal direction thereof. One end surface of the second plunger 38 is the second operation unit 38a.

The frame portion 36 includes a pressing rod 39. The pressing rod 39 is provided so as to be able to advance and retreat along the same direction as the first plunger 37 and the second plunger 38. The pressing rod 39 is the second of the first operating portion 37a of the first plunger 37 and the second plunger 38 depending on the positions of the first container portion 31 and the second container portion 32 as the connecting member 35 rotates with respect to the frame portion 36. It selectively faces any one of the operation unit 38a.

The work of injecting the cartilage of the knee joint into the defective portion (injected portion) using the injection device 30 having the above configuration will be described. First, when performing injection work by endoscopic (arthroscopic) endoscopic surgery, the first lead-out tube portion 33 and the first lead-out tube portion 33 and the first lead-out tube portion 33 are placed in a cannula in which the tip is arranged in advance near the cartilage defect of the knee joint. 2 The lead-out tube portion 34 is inserted so that the tip openings of the first lead-out tube portion 33 and the second lead-out tube portion 34 face the cartilage defect portion of the knee joint. At this time, since the first lead-out pipe portion 33 and the second lead-out pipe portion 34 are adjacent to each other, the operability is equivalent to that in the case of a single lead-out pipe, and the desired position (in the present embodiment) via the cannula. Can be inserted into the knee joint) extremely smoothly.

Then, as shown in FIG. 11A, the pressing rod 39 is brought into contact with the first operating portion 37a of the first plunger 37 of the first container portion 31 filled with the sodium alginate sol, and as shown in FIG. 11B, the pressing rod is brought into contact with the first operating portion 37a. Press 39. As a result, sodium alginate sol is injected and filled in the cartilage defect of the knee joint.

Next, as shown in FIG. 11C, the pressing rod 39 is separated from the first operating portion 37a of the first plunger 37 of the first container portion 31, and the connecting member 35 is rotated with respect to the frame portion 36. Subsequently, the pressing rod 39 is brought into contact with the second operating portion 38a of the second plunger 38 of the second container portion 32 filled with the calcium chloride solution.

Then, as shown in FIG. 11D, the pressing rod 39 is pressed to inject the calcium chloride solution into the defective portion. As a result, the calcium chloride solution is added to the sodium alginate sol filled in the defect portion, and gelation proceeds rapidly.

As described above, the injection device 30 having the above configuration presses the single pressing rod 39 by rotating the connecting member 35, and sequentially delivers the sodium alginate sol and the calcium chloride solution to the cartilage defect of the knee joint. Since it can be injected into a part or the like, high operability can be obtained without having to change the holding of the container part. Moreover, since gelation during the injection of the sodium alginate sol can be prevented, the injection work can be smoothly performed.

Next, a fourth embodiment of the present invention will be described with reference to FIGS. 12 and 13. As shown in FIG. 12, the injection device 40 in the fourth embodiment includes a second outlet pipe portion 44 that can be used as a cannula. That is, the injection device 40 includes a first container portion 41 and a second container portion 42. The first outlet pipe portion 43 is connected to the first container portion 41, and the second outlet pipe portion 44 is connected to the second container portion 42 via a flexible extension pipe 45.

The injection device 40 uses a general syringe as the first container portion 41 and the second container portion 42, and uses a general needle as the first outlet pipe portion 43.

As shown in FIG. 13, the second lead-out pipe portion 44 includes a cylindrical cannula-shaped main body portion 44a and a connecting portion 44b protruding from the peripheral wall of the cannula-shaped main body portion 44a. One end of the cannula-shaped main body portion 44a is an insertion port 44c that opens to insert the first lead-out pipe portion 43.

As shown in FIG. 13, the connecting portion 44b communicates with the inside of the cannula-shaped main body portion 44a and opens at a position different from the insertion port 44c. The axis S2 of the connecting portion 44b intersects the axis S1 of the cannula-shaped main body portion 44a at an angle θ. At this time, the angle θ at which the axis S2 of the connecting portion 44b intersects the axis S1 of the cannula-shaped main body 44a is preferably 60 ° (error range ± 5 °). An extension pipe 45 is connected to the connection portion 44b, and a second container portion 42 is connected to the extension pipe 45.

In the injection device 40 of the fourth embodiment, as shown in FIG. 12, the first outlet pipe portion 43 is inserted into the cannula-shaped main body portion 44a to form the first outlet pipe portion 43 and the second outlet pipe portion 44. Are adjacent to each other.

The work of injecting the cartilage of the knee joint into the defective portion W (injected portion) using the injection device 40 having the above configuration will be described. First, the first container portion 41 is filled with sodium alginate sol, and the second container portion 42 is filled with a calcium chloride solution.

Then, the cannula-shaped main body portion 44a of the second lead-out tube portion 44 is placed with the tip arranged in the vicinity of the cartilage defect portion of the knee joint. As a result, the second lead-out pipe portion 44 can function as a cannula.

Next, the first lead-out pipe portion 43 is inserted into the cannula-shaped main body portion 44a of the second lead-out pipe portion 44, and the tip of the first lead-out pipe portion 43 is made to face the defective portion W. Then, by pressing the first operating portion 46a of the first plunger 46 of the first container portion 41, the sodium alginate sol is injected and filled into the defective portion W.

Subsequently, the second operation portion 47a of the second plunger 47 of the second container portion 42 is pressed. As a result, the calcium chloride solution is derived from the second container portion 42. The second container portion 42 is connected to the connecting portion 44b of the second outlet pipe portion 44 via a flexible extension pipe 45. Therefore, even if vibration or the like occurs in the second container portion 42 when the second operation portion 47a of the second container portion 42 is pressed, it is hardly transmitted to the second outlet pipe portion 44.

Further, since the angle θ of the axis S2 of the connecting portion 44b with respect to the axis S1 of the cannula-shaped main body 44a intersects at 60 ° (error range ± 5 °), it was introduced from the connecting portion 44b to the cannula-shaped main body 44a. The calcium chloride solution is inclined and abuts on the inner surface of the cannula-shaped main body 44a to prevent inadvertent scattering and the like.

Further, since the calcium chloride solution introduced into the cannula-shaped main body 44a abuts on the inner surface of the cannula-shaped main body 44a and then heads toward the defective portion W, the flow velocity is appropriately suppressed and the defective portion W is filled. The surface of the sodium alginate sol can be smoothly gelled.

As described above, in the injection device 40 having the above configuration, the installation of the second outlet tube portion 44 is completed by the work of inserting the cannula into the defective portion W of the cartilage of the knee joint, and the second outlet tube portion 44 functions as a cannula. Since the first lead-out pipe portion 43 can be inserted up to the defective portion W, the man-hours can be reduced and the work can be performed efficiently.

Then, when the sodium alginate sol and the calcium chloride solution are sequentially injected into the defect portion W, the first outlet pipe portion 43 and the second outlet pipe portion 44 are in an adjacent state, so that the outlet pipe portion can be inserted and removed. Since it becomes unnecessary and vibration or the like does not occur at that time, leakage of sodium alginate sol from the defective portion is prevented. Moreover, since gelation during the injection of the sodium alginate sol can be prevented, the injection work can be smoothly performed.

W ... Defect part (injected part), 1,10,30,40 ... Injection device, 2,11,20,31,41 ... First container part, 3,12,21,32,42 ... Second container part 3, 3a ... outer wall, 3b ... inner side wall, 4,13,33,43 ... first lead-out pipe portion, 5,14,34,44 ... second lead-out pipe portion, 6,16,37,46 ... first plunger (1st extrusion member), 6a, 16a, 37a, 46a ... 1st operation unit, 7, 17, 38, 47 ... 2nd plunger (2nd extrusion member), 7a, 17a, 38a, 47a ... 2nd operation unit , 15, 22, 35 ... Connecting member, 36 ... Frame part, 39 ... Pressing rod, 44b ... Connecting part, 44c ... Insertion port.

Claims (8)

An injection device capable of sequentially injecting a first fluid and a second fluid into a predetermined injection portion.
A tubular first container that houses the first fluid inside,
A tubular second container portion for accommodating a second fluid for gelling the first fluid, and a tubular second container portion.
A first outlet pipe portion that draws out a first fluid from the inside of the first container portion and injects it into the injected portion, and a first outlet pipe portion.
A second outlet pipe portion that draws out a second fluid from the inside of the second container portion and injects it into the injected portion, and a second outlet pipe portion.
A first extrusion member that moves in the first container portion along its longitudinal direction and pushes a first fluid toward the first outlet pipe portion.
A second extrusion member that moves along the longitudinal direction of the second container portion and pushes the second fluid toward the second outlet pipe portion.
A first operation unit that presses the first extrusion member and
It is provided with a second operation unit that presses and operates the second extrusion member independently of the first operation unit.
An injection device characterized in that the first lead-out pipe portion and the second lead-out pipe portion are adjacent to each other. The first lead-out pipe portion is provided in a state of being inserted into the inside of the second lead-out pipe portion.
The injection device according to claim 1, wherein the second fluid is led out from between the first lead-out pipe portion and the second lead-out pipe portion. The injection device according to claim 1 or 2, wherein the first container portion and the second container portion are provided adjacent to each other. The second container portion includes a tubular outer wall and a tubular inner side wall facing the inner surface of the outer wall at a predetermined distance, and is said to be between the outer wall and the inner side wall. The second fluid is contained and
The injection device according to claim 3, wherein the first container portion is inserted and provided inside the inner side wall of the second container portion. The first container portion and the second container portion are detachably connected by a connecting member including a first holding portion that holds the first container portion and a second holding portion that holds the second container portion. The injection device according to claim 3, wherein the injection device is provided. A frame portion that rotatably supports the connecting member and
When the first container portion is rotated to a predetermined position by the connecting member provided on the frame portion, the first container portion is brought into contact with the first operation portion and the first extrusion member is pressed via the first operation portion. When the second container portion is rotated to a predetermined position by the connecting member, the second container portion abuts on the second operating portion and the second extruded member is pressed through the second operating portion so that the second extruded member can be pressed. The injection device according to claim 5, further comprising a rod. The second outlet pipe portion is an insertion port for inserting the first outlet pipe portion connected to the first container portion, and a connection portion provided at a position different from the insertion port and connecting the second container portion. The injection device according to claim 2, further comprising: The injection device according to any one of claims 1 to 7, wherein the first fluid is a sodium alginate sol, and the second fluid is a calcium chloride solution.

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