JP2021105520A - Biochemical/coagulation combined analyzer - Google Patents

Abstract

To solve problems in a biochemical/coagulation analyzer used for biochemistry or blood coagulation analysis, that an automatic analyzer does not automatically update the number of reaction vessels, an analysis cannot be performed as reaction vessels run out during the analysis, or the use is started from a reaction vessel at a position different from the intention of a user, if a sensor that automatically recognizes an erected reaction vessel is not installed, and if the user newly installs the reaction vessel on the reaction vessel erection rack.SOLUTION: The present invention provides a biochemical/coagulation analyzer with improved convenience of device operation, such as confirming the presence or absence of a reaction vessel by confirming whether or not a mechanism for transporting the reaction vessel can grip the reaction vessel, warning a user that resetting is forgotten when the user forgets to reset, or resetting automatically depending on the conditions.SELECTED DRAWING: Figure 2

Description

The present invention relates to a biochemical and blood coagulation analyzer that measures proteins and enzymes, tumor markers, blood coagulation test items, etc. contained in a sample by colorimetric analysis or light scattering analysis.

As a sample test in the field of clinical testing, the amount of transmitted light or the amount of scattered light of a single or multiple wavelengths obtained by irradiating a reaction solution in which a sample and a reagent are mixed with light from a light source is measured to determine the amount of light and concentration. An automatic analyzer that calculates the amount of components from the relationship is known.

There are also automatic analyzers that measure the coagulation ability of blood. Blood flows while maintaining fluidity inside blood vessels, but once bleeding, coagulation factors present in plasma and platelets are activated in a chain reaction, and fibrinogen in plasma is converted to fibrin and precipitated. It leads to hemostasis. Such blood coagulation ability includes an exogenous one in which blood leaked to the outside of a blood vessel coagulates and an endogenous one in which blood coagulates in a blood vessel. Measurement items related to blood coagulation ability (blood coagulation time) include prothrombin time (PT) for extrinsic blood coagulation test, activated partial thromboplastin time (APTT) for intrinsic blood coagulation test, and fibrinogen amount (Fbg). Exists.

Patent Document 1 is a technology equipped with a sensor that can be driven in the front-back and left-right directions (X-axis and Y-axis directions) and detects the presence or absence of the sample rack as a mechanism for transporting the sample rack containing the sample to the sample suction unit. Is disclosed.

Patent Document 2 discloses a technique for giving a warning to the user when the number of consumable parts actually supplied to the analyzer increases with respect to the number of consumable parts (consumable parts management value). There is.

Japanese Unexamined Patent Publication No. 2010-139501 Japanese Unexamined Patent Publication No. 2008-241670

The biochemical / coagulation combined automatic analyzer has a reaction vessel erection rack in which a plurality of empty solidification reaction vessels can be erected. The user fully erections the reaction vessel on the reaction vessel erection rack and starts the analysis. Then, when the user installs a new empty reaction vessel in an empty place of the reaction vessel erection rack with all or half of the reaction vessels in the reaction vessel erection rack used, the reaction vessel is automatically erected. In the absence of a sensor to detect, the device is unaware that the reaction vessel erection rack is full of reaction vessel. In this case, it is necessary to reset the location (number) of the reaction vessels stored in the control unit. If you forget to reset, the number of reaction vessels in the reaction vessel erection rack and the number of reaction vessels managed by the control unit will not match. If it is memorized that there is no reaction vessel or the number of reaction vessels is small, the reaction vessel cannot be analyzed, or the reaction vessel is used from the middle of the reaction vessel erection rack, unlike the intention of the user. Then, even though the reaction vessel is replenished, a state such as stopping occurs when all the remaining number of the recorded reaction vessels is used. Further, when a sensor that automatically detects the installation of the reaction vessel is installed, there is a problem that the equipment cost becomes high.

Therefore, in order to solve these problems, the present invention is a biochemical / coagulation analyzer used for biochemistry or blood coagulation analysis, and whether or not the reaction vessel transport mechanism for transporting the reaction vessel can grip the reaction vessel. By confirming the presence of the reaction vessel, even if the user forgets to reset, the user is warned of forgetting to reset, or the device is automatically reset depending on the conditions, improving the convenience of device operation. Provides a chemical / solidification analyzer.

In order to solve the above problems, among the inventions disclosed in the present application, typical configurations are a reaction vessel into which a sample and a reagent are dispensed, and a reaction vessel.
A dispensing mechanism for sucking and discharging the reagent into the reaction vessel,
A sample suction / discharge mechanism for sucking / discharging the sample into the reaction vessel,
A detection unit that measures from a mixture of the sample and the reagent, and
A reaction vessel erection rack for accommodating a plurality of the reaction vessels and
A reaction vessel transport mechanism that transfers the reaction vessel to the detection unit,
In an automatic analyzer provided with a control unit and a display unit that control the operation of the dispensing mechanism, the sample suction / discharge mechanism, and the reaction vessel transport mechanism.
The control unit provides an automatic analyzer characterized in that the presence or absence of the reaction vessel is confirmed by the reaction vessel transport mechanism depending on whether or not the reaction vessel can be gripped.

According to the present invention, when a new reaction vessel is erected on the reaction vessel erection rack, it is confirmed before the start of analysis whether the remaining number of the reaction vessel stored by the apparatus matches the actual remaining number of the reaction vessel. This makes it possible to prevent the reaction vessel from becoming insufficient during analysis and making the requested measurement impossible. Despite the installation of a new reaction vessel, it is possible to avoid analysis because there is no reaction vessel, or the reaction vessel is not used in the middle of the reaction vessel erection rack against the intention of the user, and the user's equipment operation It is possible to improve the convenience of. Issues, configurations and effects other than those described above will be clarified by the following description of the embodiments.

The figure which shows the structural example of the biochemical / coagulation type automatic analyzer. Analysis flowchart of biochemical / coagulation combined automatic analyzer. Display example when the reaction vessel of the reaction vessel erection rack is full. Display example when using the reaction vessel of the reaction vessel erection rack. Analysis flowchart of biochemical / coagulation combined automatic analyzer. GUI for reaction vessel reset request. An analysis flowchart including an automatic reset of a biochemical / coagulation combined automatic analyzer. GUI with start reaction vessel designation. An analysis flowchart including the designation of the reaction vessel of the biochemical / coagulation combined automatic analyzer.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. It should be noted that the embodiments of the present invention are not limited to the examples of the described contents, and various modifications can be made within the scope of the technical idea.

FIG. 1 shows a schematic configuration of the biochemical / coagulation combined automatic analyzer 100. Samples such as serum and plasma are stored in the sample container 102 on the sample disk 101. The reaction vessel erection racks 103a and 103b accommodate a plurality of reaction vessels 104 for measuring blood coagulation test items. Reagent disks 105a and 105b contain reagents to be added to the sample. The reagent discs 105a and 105b contain a plurality of reagent bottles 106a and 106b. The reaction vessel 104 is used for mixing the sample and the reagent. The sample sucked from the sample container 102 is discharged to the reaction container 104 placed at the sample discharge position 107 or the reaction cell 109 on the reaction disk 108. The reagents sucked from the reagent bottles 106a and 106b are discharged into the reaction cell 109 where the sample is discharged or empty.

The biochemical / solidification composite automatic analyzer 100 has a reaction vessel transport mechanism 110, and the reaction vessel transport mechanism 110 moves in the X-axis direction and the Y-axis direction of the biochemical / solidification composite automatic analyzer 100. The reaction vessel transport mechanism 110 grabs the reaction vessel 104 on the reaction vessel erection racks 103a and 103b and conveys the reaction vessel 104 to the sample discharge position 107. The sample suction / discharge mechanism 111 arranged in the biochemical / coagulation combined automatic analyzer 100 sucks the sample stored in the sample container 102 and discharges the sample into the reaction container 104 at the sample discharge position 107 or the empty reaction cell 109. .. After that, the reaction vessel transport mechanism 110 grabs the reaction vessel 104 at the sample discharge position 107 in which the sample is stored or is empty, and conveys the sample to the solidification detection unit 112a.

The reagent suction / discharge mechanisms 113a and 113b arranged in the biochemical / coagulation combined automatic analyzer 100 sucked the reagent from the reagent bottles 106a and 106b placed on the reagent disks 105a and 105b, and the sample was discharged. Alternatively, the reagent is discharged into the empty reaction cell 109. Further, the biochemical / coagulation combined automatic analyzer 100 has a coagulation reagent dispensing mechanism 114, and the coagulation reagent dispensing mechanism 114 moves in the X-axis direction of the biochemical / coagulation combined automatic analysis 100. The coagulation reagent dispensing mechanism 114 sucks the reagent or the sample and the reagent mixture from the reaction cell 109 in which the reagent is discharged or contains the sample and the reagent mixture, and is installed in the coagulation detection unit 112a. Discharge to the sample or empty reaction vessel 104.

The solidification detection unit 112b is used to detect the scattered light intensity in the solidification process. The input unit 115 is a keyboard, a mouse, a touch panel, or the like. The display unit 116 is a liquid crystal monitor or the like. In the case of a touch panel or the like, the input unit and the display unit may be the same. The control unit 117 is a computer that controls the operation of the entire device and records data.

Next, the outline of the device operation procedure when the user performs solidification measurement is shown. The user fully erections the reaction vessel 104 on the reaction vessel erection racks 103a and 103b (step 201), and presses the "reaction vessel reset" button at the input unit 115 (step 202). By pressing the "reaction vessel reset", the control unit 117 records and recognizes that the reaction vessel 104 is full in the reaction vessel erection racks 103a and 103b.

Here, the order of use of the reaction vessels 104 erected on the reaction vessel erection racks 103a and 103b will be described. FIG. 3 shows the reaction vessel erection racks 103a and 103b installed in the biochemical / solidification composite automatic analyzer 100. In FIG. 3, there are two reaction vessel erection racks 103a and 103b, but the number of reaction vessel erection racks may vary depending on the size of the biochemical / solidification composite automatic analyzer 100. The maximum number of reaction vessels 104 mounted on the reaction vessel erection racks 103a and 103b is 88, but the number of reaction vessels may change depending on the size of the reaction vessel erection racks 103a and 103b. When the user executes steps 201 and 202, the control unit 117 recognizes that the number of reaction vessels 104 erected on the reaction vessel erection racks 103a and 103b is 88, respectively, and displays 103a and 103b on the display unit 116. The number, position, etc. of the existing reaction vessels 104 are displayed. For example, it may be displayed on the display unit as shown in FIG. First, the reaction vessel 104 in the position A1 of the reaction vessel erection rack 103a is used, and then the reaction vessel 104 in the order of B1 → C1 → D1 → E1 → F1 → G1 → H1 → I1 → J1 → K1 of 103a is used. After position K1, reaction vessels 104 are used in the order of A2 to K2, A3 to K3, A4 to K4, A51 to K5, A6 to K6, A7 to K7, and A8 to K8 of 103a. In synchronization with this control, the number of reaction vessels 104 remaining in 103a is displayed on the display unit 116 as 88 → 87 → 86 → halfway omitted → 0. Further, for example, as shown in FIG. 4, a state in use may be displayed on the display unit.

After the reaction vessel 104 at position K8 of the reaction vessel erection rack 103a is used, the reaction vessel 104 erected at position 103b position A1 is used. After that, the reaction vessel 104 is used in the same order as 103a. Further, similarly to the display of the remaining number of reaction vessels in 103a, the remaining number of reaction vessels is displayed on the display unit 116 for 103b. The above contents may also be displayed in a diagram.

Next, an example of the analysis operation when the number of existing reaction vessels 104 is displayed on the display unit 116 as 88 will be described with reference to FIG. When the user executes step 203, the biochemical / coagulation combined automatic analyzer 100 performs an analysis preparation operation (step 204). An example of the analysis preparation operation will be described. The reaction vessel transport mechanism 110 confirms the presence or absence of the reaction vessel 104 at the reaction vessel erection racks 103a and 103b / position A1 (step 205), and if there is a reaction vessel 104 at the position A1 of 103a and 103b, the process proceeds to step 206 for analysis. To start. If there is no reaction vessel 104 in either position A1 of 103a or 103b, an alarm is displayed on the display 116 (step 207), and the analysis ends (step 208).
Thus, when the reaction vessel erected in the reaction vessel erection rack is full before the start of analysis, the reaction in the reaction vessel position that should normally be used first in each reaction vessel erection rack, for example, the reaction at position A1 in the case of this embodiment. It is possible to confirm the presence or absence of a container, warn the user with an alarm if there is no reaction container, and avoid stopping the analysis requested at an unintended place by the inventor.
The biochemical / solidification composite type automatic analyzer 100 confirms the presence / absence of the reaction vessel 104 depending on whether or not the reaction vessel transport mechanism 110 can grip the reaction vessel 104. The reaction vessel is confirmed by the reaction vessel transport mechanism 110 as to whether or not it can be gripped, but confirmation by detection by an optical sensor, for example, confirmation of a detection plate by an optical sensor, confirmation by a contact sensor, etc. is possible. be.

Next, as an example, the number of reaction vessels 104 existing in 103a is 11 and the number of reaction vessels 104 existing in 103b is 88 on the display unit 116 as if the reaction vessel of the reaction vessel erection rack is used (FIG. The analysis operation of the biochemical / coagulation composite type automatic analyzer 100 when displayed as 4) will be described with reference to FIG. When the user executes step 501, the biochemical / coagulation combined automatic analyzer 100 performs an analysis preparation operation (step 502). An example of the analysis preparation operation will be described. The reaction vessel transport mechanism 110 confirms the presence or absence of the reaction vessel 104 on the reaction vessel erection rack 103a (step 503). If there is no reaction vessel 104 at position A1 of 103a, the presence or absence of reaction vessel 104 is confirmed at position A1 of 103b (step 504). If the reaction vessel 104 is present at the position A1 of 103b, the presence or absence of the reaction vessel 104 is confirmed at the position A8 of 103a (step 505). If there is a reaction vessel 104 in position A8 of 103a, the process proceeds to step 506 and analysis is started. This is the case where the number of remaining reaction vessels recorded in the control unit and the number of reaction vessels erected in the reaction vessel erection rack at the time of analysis match.

If the reaction vessel 104 is present in step 503, an alarm is displayed on the display unit 116 (step 507, FIG. 6), and the analysis is completed (step 509). This is because the user erected a new empty reaction vessel in an empty space on the reaction vessel erection rack, and the number of remaining reaction vessels recorded in the control unit and the reaction erected on the reaction vessel erection rack at the time of analysis. This is the case when the number of containers does not match. Therefore, the GUI of the reaction vessel reset request of FIG. 6 is displayed so as to reset the number of reaction vessels of the control unit by the user, and it is possible to avoid forgetting to reset the user.

If there is no reaction vessel 104 in position A1 of 103b in step 504 and there is no reaction vessel 104 in position A8 of 103a in step 505, an alarm is displayed on the display unit 116 (step 508), and the analysis is completed (step 508). 509). When these alarms are displayed and the analysis is terminated, the number of remaining reaction vessels recorded in the control unit does not match the number of reaction vessels installed in the reaction vessel erection rack at the time of analysis. be. Therefore, it is possible to avoid a state such as a stop during the analysis contrary to the intention of the user before the start of the analysis by displaying an alarm for confirming the number of reaction vessels.

Next, as an example, the analysis operation of the biochemical / coagulation composite type automatic analyzer 100 including the operation of automatic reset will be described with reference to FIG. 7.

For example, as in Example 2, the number of reaction vessels 104 existing in 103a is 11 and the number of reaction vessels 104 existing in 103b is 88 on the display unit 116 as if the reaction vessel of the reaction vessel erection rack is used. When the number (FIG. 4) is displayed, when the user executes step 701, the biochemical / coagulation combined automatic analyzer 100 performs an analysis preparation operation (step 702). An example of the analysis preparation operation will be described. The reaction vessel transport mechanism 110 confirms the presence or absence of the reaction vessel 104 at positions A1 of the reaction vessel erection racks 103a and 103b (steps 703 and 704). If there is no reaction vessel 104 at position A1 of 103a and there is a reaction vessel 104 at position A1 of 103b, the presence or absence of reaction vessel 104 is confirmed at position A8 of 103a (step 705). If there is a reaction vessel 104 in position A8 of 103a, the process proceeds to step 709 and analysis is started. This is the case where the number of remaining reaction vessels recorded in the control unit and the number of reaction vessels erected in the reaction vessel erection rack at the time of analysis match.
Further, if there is a reaction vessel 104 at position A1 at 103a in step 703, the presence or absence of the reaction vessel 104 at position A1 at 103b is confirmed (step 706), and if there is a reaction vessel 104, the number of reaction vessels at 103a and 103b Is automatically reset (step 707) and analysis is started (step 709). In this case, the user installs a new empty reaction vessel in an empty part of the reaction vessel erection rack, and the number of remaining reaction vessels recorded in the control unit and the reaction erected in the reaction vessel erection rack at the time of analysis. It is assumed that the number of containers does not match, but it is suggested that the number of reaction vessels in the reaction vessel erection rack is full, and by automatically resetting the number of reaction vessels, analysis can be performed without the user's work. By doing so, the time is shortened and the convenience of device operation is improved.

In these cases, such as when there is no reaction vessel 104 in position A1 of 103b in step 704, there is no reaction vessel 104 in position A8 of 103a in step 705, or there is no reaction vessel 104 in position A1 of 103b in step 706. Displays an alarm on the display unit 116 (step 708), and the analysis ends (step 710). These are the same as in the second embodiment, but it is possible to avoid a state such as a stop during the analysis contrary to the intention of the user before the start of the analysis by displaying an alarm for confirming the number of reaction vessels. ..

An example in which the position of the reaction vessel 104 to be used first by the user can be specified will be described with reference to FIGS. 8 and 9. FIG. 8 shows an example of a display screen for designating the use start position of the reaction vessel 104. On the screen, there is a column for inputting the use start position in the reaction vessel erection racks 103a and 103b. As an example, check the check box of 103b and enter the start position of use as A1. When the user executes step 901, the biochemical / coagulation combined automatic analyzer 100 performs an analysis preparation operation (step 902). An example of the analysis preparation operation will be described. The reaction vessel transport mechanism 110 confirms the presence or absence of the reaction vessel 104 at the reaction vessel erection rack 103b / position A1 (step 903), and if the reaction vessel 104 is present at the position A1 of 103b, the process proceeds to step 904 and analysis is started. If there is no reaction vessel 104 in position A1 of 103b in step 903, an alarm is displayed on the display unit 116 (step 905), and the analysis ends (step 906). The order of use of the reaction vessel 104 erected on the reaction vessel erection rack is as described in Example 1. When an alarm is displayed and the analysis is completed, it is possible to avoid a state such as a stop during the analysis contrary to the intention of the user before the start of the analysis by displaying an alarm for confirming the number of reaction vessels.

The present invention is not limited to the above examples, and includes various modifications. For example, the use example of the reaction vessel in FIG. 3 shows the order of use from A1 to K1, but the order of use may be from A1 to A8. Even if it is used, it can be handled by replacing the position etc. It is also possible to add the configuration of another embodiment to the configuration of one embodiment. Further, it is possible to add / delete / replace a part of the configuration of each embodiment with another configuration.

100 ... Biochemical / coagulation combined automatic analyzer 101 ... Sample disk 102 ... Sample container 103a, b ... Reaction container erection rack 104 ... Reaction container 105a, b ... Reagent disk 106a, b ... Reagent bottle 107 ... Sample discharge position 108 ... Reaction disk 109 ... Reaction cell 110 ... Reaction vessel transport mechanism 111 ... Specimen suction / discharge mechanism 112a, b ... Coagulation detection unit 113a, b ... Reagent suction / discharge mechanism 114 ... Coagulation reagent dispensing mechanism 115 ... Input unit 116 ... Display unit 117 ... Control unit

Claims (8)

The reaction vessel from which the sample and reagent are dispensed,
A dispensing mechanism for sucking and discharging the reagent into the reaction vessel,
A sample suction / discharge mechanism for sucking / discharging the sample into the reaction vessel,
A detection unit that measures from a mixture of the sample and the reagent, and
A reaction vessel erection rack for accommodating a plurality of the reaction vessels and
A reaction vessel transport mechanism that transfers the reaction vessel to the detection unit,
In an automatic analyzer provided with a control unit and a display unit that control the operation of the dispensing mechanism, the sample suction / discharge mechanism, and the reaction vessel transport mechanism.
The control unit is an automatic analyzer characterized in that the presence or absence of a reaction vessel is confirmed by the reaction vessel transport mechanism depending on whether or not the reaction vessel can be gripped. The automatic analyzer according to claim 1, wherein the presence or absence of a reaction vessel to be used first in the reaction vessel erection rack is confirmed. In the automatic analyzer according to claim 1,
The control unit records the number of reaction vessels remaining in the reaction vessel erection rack and the presence or absence of a reaction vessel at the reaction vessel position of the reaction vessel erection rack, displays it on the display unit, and reacts by the reaction vessel transport mechanism. An automatic analyzer characterized in determining whether to continue or end an analysis by comparing it with the result of checking the presence or absence of a container. In the automatic analyzer according to claim 3,
Furthermore, in an automatic analyzer equipped with multiple reaction vessel erection racks,
The control unit is at least the first and second reaction vessel erection racks, and is an automatic analyzer characterized in that the presence or absence of the reaction vessel in the first position to be used is confirmed by the reaction vessel transport mechanism. In the automatic analyzer according to claim 4,
The control unit is at least a first or second reaction vessel erection rack, and when there is no reaction vessel in the first position to be used and the control unit determines that the analysis is completed, an alarm is displayed on the display unit. An automatic analyzer characterized by this. In the automatic analyzer according to claim 3,
The control unit has a reaction vessel in the first position to be used in the reaction vessel erection rack, and records the number of reaction vessels remaining in the reaction vessel erection rack, or the presence or absence of the reaction vessel position. When compared to, when different
An automatic analyzer characterized in that an alarm is displayed on the display unit and the analysis is completed. In the automatic analyzer according to claim 3,
Furthermore, in an automatic analyzer equipped with multiple reaction vessel erection racks,
The control unit resets the recorded number of reaction vessels when it is confirmed that there is a reaction vessel in the first position to be used in all the reaction vessel erection racks. .. In the automatic analyzer according to claim 2,
The control unit is characterized in that the reaction vessel erection rack to be started to be used and the screen for designating the position of the reaction vessel are displayed on the display unit, and the reaction vessel is controlled to start to be used from the designated reaction vessel position. Automatic analyzer.

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