CN111065929B

CN111065929B - Biochemical-solidification composite analyzer

Info

Publication number: CN111065929B
Application number: CN201980004385.XA
Authority: CN
Inventors: 泽田孝宪; 佐佐木信彦
Original assignee: Hitachi High Technologies Corp
Current assignee: Hitachi High Tech Corp
Priority date: 2018-03-15
Filing date: 2019-01-23
Publication date: 2023-09-19
Anticipated expiration: 2039-01-23
Also published as: WO2019176297A1; DE112019000197T5; CN111065929A; JP2021105520A

Abstract

In a biochemical-coagulation analyzer used for biochemical or blood coagulation analysis, even if a user newly mounts a reaction container on a reaction container mounting frame, the automatic analyzer has the following problems in the case where a sensor for automatically recognizing the mounted reaction container is not provided: the number of reaction containers is not automatically updated, and the reaction containers disappear during the analysis, so that the analysis is not performed, or the reaction containers are used from a position different from the user's intention. The present application provides a biochemical-coagulation analyzer which can confirm whether the reaction vessel is held by a mechanism for conveying the reaction vessel, and can warn the user to forget to reset or automatically reset according to the condition even if the user forgets to reset.

Description

Biochemical-solidification composite analyzer

Technical Field

The present application relates to a biochemical and blood coagulation analyzer for measuring proteins, enzymes, tumor markers, blood coagulation test items, and the like contained in a sample by colorimetric analysis or light scattering analysis.

Background

As a sample test in the field of clinical tests, an automatic analyzer is known which measures the amount of transmitted light or scattered light of a single or a plurality of wavelengths obtained by irradiating a reaction solution, which is a mixture of a sample and a reagent, with light from a light source, and calculates the component amount from the relationship between the amount of light and the concentration.

There are also automatic analyzers for measuring the clotting ability of blood. Blood remains flowable and flows in the blood vessel, but once bleeding occurs, blood coagulation factors present in plasma and platelets are activated in linkage, and fibrinogen in plasma is converted into fibrin and separated out, thereby achieving hemostasis. Such blood coagulation ability includes an exogenous blood coagulation ability of blood coagulation leaking out of the blood vessel and an endogenous blood coagulation ability of blood coagulation in the blood vessel. As measurement items related to blood coagulation ability (blood coagulation time), there are Prothrombin Time (PT) of an exogenous blood coagulation reaction test, activated Partial Thromboplastin Time (APTT) of an endogenous blood coagulation reaction test, fibrinogen amount (Fbg), and the like.

Patent document 1 discloses the following technique: as a mechanism for transporting the sample holder containing the sample to the sample suction unit, a sensor for detecting the presence or absence of the sample holder can be mounted by being driven in the front-rear-left-right direction (X-axis direction and Y-axis direction).

Patent document 2 discloses the following technique: when the number of consumable parts (consumable part management value) is actually increased, the user is alerted that the number of consumable parts to be supplied to the analysis device is increased.

Prior art literature

Patent literature

Patent document 1: japanese patent application laid-open No. 2010-139501

Patent document 2: japanese patent laid-open No. 2008-241670

Disclosure of Invention

Problems to be solved by the application

The biochemical-solidification complex type automatic analyzer has a reaction vessel rack capable of rack a plurality of empty solidification reaction vessels. The user fills the reaction vessel with the reaction vessel rack and starts the analysis. Then, when a user sets a new empty reaction vessel in the empty space of the reaction vessel setting frame in a state where all or some of the reaction vessels of the reaction vessel setting frame are used, the apparatus does not recognize that the reaction vessel is filled in the reaction vessel setting frame without a sensor for automatically sensing the setting of the reaction vessel. In this case, it is necessary to reset the positions (number) of the reaction vessels stored as the residues in the control unit. If the replacement is forgotten, the number of reaction containers in the reaction container rack does not match the number of reaction containers managed by the control unit. If there are no reaction vessels and few reaction vessels, analysis is not performed, or the reaction vessels are used from the middle of the reaction vessel rack unlike the intention of the user. Further, a state may occur in which the reaction vessel is replenished, but the stored reaction vessel is stopped if the remaining amount is used in its entirety. Further, in the case of providing a sensor for automatically detecting the erection of the reaction vessel, there is a problem in that the cost of the apparatus increases.

In order to solve the above problems, the present application provides a biochemical-coagulation analyzer which is applied to a biochemical-coagulation analyzer for analyzing biochemical or blood coagulation and which can confirm whether or not a reaction container is held by a reaction container conveying mechanism for conveying the reaction container, thereby confirming whether or not the reaction container is present, and which can alert a user to forget to reset or automatically reset according to conditions even if the user forgets to reset.

Means for solving the problems

In order to solve the above-described problems, an exemplary configuration of the application disclosed in the present application provides an automatic analyzer, comprising: a reaction vessel for dispensing a sample and a reagent; a dispensing mechanism for sucking and discharging the reagent into the reaction vessel; a sample suction/discharge mechanism for sucking and discharging the sample into and from the reaction vessel; a detection unit for measuring a mixture of the sample and the reagent; a reaction vessel rack for accommodating a plurality of reaction vessels; a reaction vessel conveying mechanism for conveying the reaction vessel to the detection unit; a control unit for controlling operations of the dispensing mechanism, the sample suction/discharge mechanism, and the reaction container transport mechanism; and a display unit, wherein the control unit confirms whether or not the reaction container is present, based on whether or not the reaction container is gripped by the reaction container conveying mechanism.

Effects of the application

According to the present application, when a user mounts a new reaction vessel on the reaction vessel mounting frame, it is possible to confirm whether or not the remaining number of reaction vessels stored in the apparatus before the start of analysis matches the actual number of reaction vessels, and it is possible to prevent the reaction vessels from being insufficient for the analysis and the requested measurement from being impossible. The present application can avoid the problem that a new reaction vessel is installed, but the analysis cannot be performed without the reaction vessel, or the reaction vessel is used from the middle of the reaction vessel installation frame against the intention of the user, and can improve the convenience of the user in the device operation. The problems, configurations, and effects other than those described above will be further apparent from the following description of the embodiments.

Drawings

FIG. 1 is a diagram showing a configuration example of a biochemical-solidification complex type automatic analyzer.

FIG. 2 is an analysis flow chart of the biochemical-solidification complex type automatic analysis apparatus.

FIG. 3 is a view showing an example of the reaction vessel mounting frame when the reaction vessel is filled.

FIG. 4 is a view showing an example of the reaction vessel mounting rack in use.

FIG. 5 is an analysis flow chart of the biochemical-solidification complex type automatic analysis apparatus.

FIG. 6 is a GUI requiring a reaction vessel reset.

Fig. 7 is an analysis flow chart including automatic reset of a biochemical-coagulation complex automatic analysis device.

FIG. 8 is a GUI designating the start of a reaction vessel.

FIG. 9 is an analytical flow chart of reaction vessel assignment including a biochemical-solidification complex type automatic analysis apparatus.

Detailed Description

Hereinafter, embodiments of the present application will be described with reference to the drawings. The embodiments of the present application are not limited to the examples of the embodiments described above, and various modifications are possible within the scope of the technical idea.

Example 1

Fig. 1 shows a schematic configuration of a biochemical-solidification complex type automatic analyzer 100. The sample container 102 on the sample tray 101 accommodates a sample such as serum or plasma. A plurality of reaction containers 104 for measuring blood coagulation test items are accommodated in the reaction container rack frames 103a, 103b. The reagent trays 105a and 105b store reagents to be added to the sample. The reagent disks 105a and 105b house a plurality of reagent bottles 106a and 106b. The reaction vessel 104 is used for mixing the sample with the reagents. The sample sucked from the sample container 102 is discharged to the reaction vessel 104 placed at the sample discharge position 107 or the reaction cell 109 on the reaction disk 108. The reagent sucked from the reagent bottles 106a and 106b is discharged to the reaction cell 109 from which the sample is discharged or to which the sample is empty.

The biochemical-solidification complex type automatic analyzer 100 has a reaction container transporting mechanism 110, and the reaction container transporting mechanism 110 moves in the X-axis direction and the Y-axis direction of the biochemical-solidification complex type automatic analyzer 100. The reaction vessel transporting mechanism 110 holds the reaction vessel 104 on the reaction vessel mounting frames 103a and 103b and transports the reaction vessel to the sample discharge position 107. The sample suction/discharge mechanism 111 disposed in the biochemical-solidification complex-type automatic analyzer 100 sucks the sample stored in the sample container 102, and discharges the sample to the reaction container 104 or the empty reaction cell 109 at the sample discharge position 107. Thereafter, the reaction vessel transporting mechanism 110 grips the reaction vessel 104 in which the sample is stored or the sample is discharged from the position 107 to transport the sample to the solidification detecting portion 112 a.

The reagent sucking and discharging mechanisms 113a and 113b disposed in the biochemical-solidification complex-type automatic analyzer 100 suck the reagent from the reagent bottles 106a and 106b placed on the reagent trays 105a and 105b, and discharge the reagent into the sample-discharged or empty reaction cell 109. The biochemical-solidification complex type automatic analyzer 100 further includes a solidification reagent dispensing mechanism 114, and the solidification reagent dispensing mechanism 114 moves in the X-axis direction of the biochemical-solidification complex type automatic analyzer 100. The coagulated reagent dispensing mechanism 114 sucks the reagent or the mixed solution of the sample and the reagent from the reaction cell 109 in which the reagent is discharged or in which the mixed solution of the sample and the reagent is stored, and discharges the reagent or the mixed solution of the sample and the reagent to the sample or the empty reaction container 104 mounted on the coagulation detection portion 112 a.

The coagulation detection portion 112b is configured to detect the intensity of scattered light in the coagulation process. The input unit 115 is a keyboard, a mouse, a touch panel, or the like. The display unit 116 is a liquid crystal monitor or the like. In the case of a touch panel or the like, the input unit and the display unit may be the same. The control unit 117 is a computer that controls the operation of the entire apparatus and records data.

Next, an outline of the device operation procedure when the user performs the coagulation measurement is shown. The user fills the reaction container 104 with the reaction container rack frames 103a and 103b (step 201), and presses the "reaction container reset" button on the input unit 115 (step 202). By pressing "reaction vessel reset", the control unit 117 records and recognizes that the reaction vessel 104 is filled in the reaction vessel mounting frames 103a and 103b.

The order of use of the reaction vessels 104 mounted on the reaction vessel mounting frames 103a and 103b will be described. Fig. 3 shows reaction vessel mounting frames 103a and 103b provided in the biochemical-solidification complex type automatic analyzer 100. In fig. 3, there are 2 reaction vessel mounting frames 103a and 103b, but the number of reaction vessel mounting frames may vary depending on the size of the biochemical-solidification complex type automatic analysis apparatus 100. The maximum number of reaction containers 104 mounted on the reaction container mounting frames 103a and 103b is 88, but the number of reaction containers may vary depending on the sizes of the reaction container mounting frames 103a and 103b. When the user performs steps 201 and 202, the control unit 117 recognizes that the number of the reaction containers 104 mounted on the reaction container mounting frames 103a and 103b is 88, and displays the number, positions, and the like of the reaction containers 104 present in the reaction containers 103a and 103b on the display unit 116. For example, the display unit may be as shown in fig. 3. First, the reaction vessel 104 located at the position A1 of the reaction vessel rack 103a is used, and then, the reaction vessels are used in the order of b1→c1→d1→e1→f1→g1→h1→i1→j1→k1 of the reaction vessel rack 103 a. After the position K1, the reaction vessel 104 is used in the order of A2 to K2, A3 to K3, A4 to K4, a51 to K5, A6 to K6, A7 to K7, A8 to K8 from 103 a. In synchronization with this control, the number of reaction vessels 104 remaining in 103a is 88→87→86→slightly smaller→0 on the display unit 116. For example, as shown in fig. 4, a state in the middle of use may be displayed on the display unit.

After using the reaction vessel 104 positioned at the position K8 of the reaction vessel mounting frame 103a, the reaction vessel 104 mounted at the position A1 of 103b is used. Then, the reaction vessel 104 was used in the same order as 103 a. In addition, as with the remaining number of reaction vessels shown in 103a, the remaining number of reaction vessels is also shown in display 116 for 103b. The above may also be shown graphically.

Next, an example of the analysis operation when 88 reaction vessels 104 are present is displayed on the display unit 116 will be described with reference to fig. 2. When the user performs step 203, the biochemical-solidification complex type automatic analyzer 100 performs an analysis preparation operation (step 204). An example of the analysis preparation operation will be described. The reaction vessel transfer mechanism 110 confirms the presence or absence of the reaction vessel 104 at the position A1 of the reaction vessel mounting frames 103a and 103b (step 205), and if the reaction vessel 104 is present at the positions A1 of the reaction vessel mounting frames 103a and 103b, the routine proceeds to step 206 to start the analysis. If either one of the positions A1 of the positions 103a and 103b does not have the reaction vessel 104, an alarm is displayed on the display unit 116 (step 207), and the analysis is ended (step 208).

In this way, when the reaction vessel mounted on the reaction vessel mounting frame before the start of the analysis is full, it is confirmed whether or not the reaction vessel is present at the reaction vessel position where the reaction vessel mounting frame should be used normally first, for example, in the case of the present embodiment, it is confirmed whether or not the reaction vessel is present at the position A1, and if the reaction vessel is not present, it is possible to avoid stopping the requested analysis at a place where the inventors did not want by giving an alarm to the user. The biochemical-solidification complex type automatic analyzer 100 confirms whether or not the reaction vessel 104 is present, based on whether or not the reaction vessel conveying mechanism 110 can hold the reaction vessel 104. The confirmation of whether or not the reaction container can be held is performed by the reaction container transporting mechanism 110, but can be confirmed by detection using an optical sensor, for example, a detection plate using an optical sensor, or by confirmation using a contact sensor.

Example 2

Next, the analysis operation of the biochemical-solidification complex-type automatic analyzer 100 will be described with reference to fig. 5, as an example, when the number of reaction vessels 104 present in 103a is 11 and the number of reaction vessels 104 present in 103b is 88 (fig. 4) on the display unit 116, as in the case of the reaction vessels using the reaction vessel rack. When the user performs step 501, the biochemical-solidification complex type automatic analyzer 100 performs an analysis preparation operation (step 502). An example of the analysis preparation operation will be described. The reaction vessel transfer mechanism 110 confirms the presence or absence of the reaction vessel 104 by the reaction vessel mounting frame 103a (step 503). If there is no reaction vessel 104 at position A1 of 103a, the presence or absence of reaction vessel 104 is checked at position A1 of 103b (step 504). If the reaction vessel 104 is present at the position A1 of 103b, the presence or absence of the reaction vessel 104 is checked at the position A8 of 103a (step 505). If there is a reaction vessel 104 at position A8 of 103a, then the flow proceeds to step 506 where analysis begins. This is the case where the number of remaining reaction containers recorded in the control unit matches the number of reaction containers mounted on the reaction container mounting frame at the time of analysis.

If the reaction vessel 104 is present in step 503, an alarm is displayed on the display unit 116 (step 507, fig. 6), and the analysis is completed (step 509). In this case, the user sets a new empty reaction vessel at a position where the reaction vessel is set, and the number of remaining reaction vessels recorded in the control unit does not match the number of reaction vessels set at the reaction vessel set at the time of analysis. Therefore, the GUI shown in FIG. 6 requiring the reaction vessel reset for the user to reset the number of reaction vessels of the control part can prevent the user from forgetting to reset.

In addition, in step 504, when the reaction vessel 104 is not present at the position A1 of 103b, and in step 505, when the reaction vessel 104 is not present at the position A8 of 103a, an alarm is displayed on the display unit 116 (step 508), and the analysis is completed (step 509). The case where the analysis is ended by displaying an alarm is a case where the number of remaining reaction containers recorded in the control unit does not match the number of reaction containers mounted on the reaction container mounting frame during the analysis. Therefore, by confirming the alarm display such as the number of reaction vessels, it is possible to avoid a state such as stopping in the middle of analysis, which violates the intention of the user, before the analysis starts.

Example 3

Next, an analysis operation of the biochemical-solidification complex type automatic analysis device 100 including an automatic reset operation will be described with reference to fig. 7 as an example.

For example, in the same manner as in example 2, when the display unit 116 shows that the number of reaction vessels 104 present in 103a is 11 and the number of reaction vessels 104 present in 103b is 88 (fig. 4) as in the case of using the reaction vessels of the reaction vessel rack, the biochemical-solidification complex automatic analyzer 100 performs an analysis preparation operation (step 702) when the user executes step 701. An example of the analysis preparation operation will be described. The reaction vessel transfer mechanism 110 confirms the presence or absence of the reaction vessel 104 at the position A1 of the reaction vessel mounting frames 103a and 103b (steps 703 and 704). If there is no reaction vessel 104 at position A1 of 103a and there is a reaction vessel 104 at position A1 of 103b, the presence or absence of a reaction vessel 104 is confirmed at position A8 of 103a (step 705). If there is a reaction vessel 104 at position A8 of 103a, the process proceeds to step 709, where analysis is started. This is the case where the number of remaining reaction containers recorded in the control unit matches the number of reaction containers mounted on the reaction container mounting frame at the time of analysis.

If the reaction vessel 104 at the position A1 of 103a is present in step 703, the presence or absence of the reaction vessel 104 at the position A1 of 103b is confirmed (step 706), and if the reaction vessel 104 is present, the numbers of the reaction vessels 103a and 103b are automatically reset (step 707), and the analysis is started (step 709). This can be assumed to be a case where a user sets a new empty reaction vessel at an empty position of the reaction vessel setting frame, and the remaining number of reaction vessels recorded in the control unit does not match the number of reaction vessels set in the reaction vessel setting frame at the time of analysis, and the number of reaction vessels is automatically reset by obtaining an indication that the number of reaction vessels set in the reaction vessel setting frame is full, so that the user does not need to operate the reaction vessel setting frame to perform analysis, and the time is shortened and the convenience of the device operation is improved.

In step 704, when the reaction vessel 104 is not present at the position A1 of 103b, in step 705, when the reaction vessel 104 is not present at the position A8 of 103a, in step 706, when the reaction vessel 104 is not present at the position A1 of 103b, or the like, an alarm is displayed on the display unit 116 in these cases (step 708), and the analysis is completed (step 710). In the same manner as in example 2, by confirming the alarm display such as the number of reaction vessels, it is possible to avoid a state of stopping in the middle of the analysis, which violates the user's intention, before the analysis starts.

Example 4

An example in which a user can specify the position of the reaction vessel 104 to be used first will be described with reference to fig. 8 and 9. Fig. 8 shows an example of a display screen for specifying the start position of use of the reaction vessel 104. In this screen, a column is input as a use start position in the reaction vessel mounting frames 103a and 103b. As an example, the use start position is input as A1 by the tick of the tick field 103b. When the user performs step 901, the biochemical-solidification complex type automatic analyzer 100 performs an analysis preparation operation (step 902). An example of the analysis preparation operation will be described. The reaction vessel transfer mechanism 110 confirms the presence or absence of the reaction vessel 104 at the position A1 of the reaction vessel mounting frame 103b (step 903), and if the reaction vessel 104 is present at the position A1 of 103b, the routine proceeds to step 904 to start the analysis. In step 903, when the reaction vessel 104 is not present at the position A1 of 103b, an alarm is displayed on the display unit 116 (step 905), and the analysis is completed (step 906). The order of use of the reaction vessels 104 mounted on the reaction vessel mounting frame is as described in example 1. When the alarm is displayed and the analysis is completed, by confirming the alarm display such as the number of reaction vessels, it is possible to avoid a state such as stopping in the middle of the analysis, which violates the intention of the user, before the analysis starts.

The present application is not limited to the above-described embodiments, and includes various modifications. For example, the use sequence from A1 to K1 is shown for the use example of the reaction vessel described above in FIG. 3, but the use sequence from A1 to A8 may be used. The position can be replaced and the like can be dealt with when in use. In addition, the configuration of the other embodiment may be added to the configuration of the certain embodiment. In addition, some of the components of the embodiments may be added, deleted, or replaced with other components.

Symbol description

100 … biochemical-solidification composite automatic analysis device

101 … sample tray

102 … sample container

103a, b … reaction vessel erection frame

104 … reaction vessel

105a, b … reagent disk

106a, b … reagent bottle

107 … sample discharge position

108 … reaction disk

109 … reaction tank

110 … reaction vessel conveying mechanism

111 … sample suction-discharge mechanism

112a, b … solidification detection portion

113a, b … reagent suction-discharge mechanism

114 … coagulating agent divides annotates mechanism

115 … input

116 … display part

117 … control section.

Claims

1. An automatic analyzer, comprising:

a reaction vessel for dispensing a sample and a reagent;

a dispensing mechanism for sucking and discharging the reagent into the reaction vessel;

a sample suction/discharge mechanism for sucking and discharging the sample into and from the reaction vessel;

a detection unit for measuring a mixture of the sample and the reagent;

at least first and second reaction vessel mounting frames for receiving a plurality of said reaction vessels;

a reaction vessel conveying mechanism for conveying the reaction vessel to the detection unit; and

and a control unit configured to control operations of the dispensing mechanism, the sample suction/discharge mechanism, and the reaction container transport mechanism, wherein the reaction container transport mechanism is configured to: the presence or absence of the reaction vessel stored in the reaction vessel rack can be checked according to whether or not the reaction vessel can be held,

the control unit confirms, by the reaction vessel conveying mechanism, the presence or absence of a reaction vessel at a first initial position in the first reaction vessel mounting frame, and confirms, when there is no reaction vessel at the first initial position and confirms the presence or absence of a reaction vessel at a second initial position in the second reaction vessel mounting frame, the presence or absence of a reaction vessel at the second initial position,

confirming the presence or absence of the reaction vessel in a predetermined position other than the first starting position in the first reaction vessel mounting frame, and as a result of the confirmation, when the reaction vessel is present in the predetermined position, analyzing from the predetermined position,

the predetermined position is a first-use position of the remaining reaction vessel determined based on the number of remaining reaction vessels recorded in the control unit.

2. The automatic analyzer according to claim 1, further comprising a display unit configured to: the predetermined position in the first reaction vessel mounting frame can be displayed.

3. The automatic analyzer according to claim 1, wherein the control unit includes a storage unit that stores the number of reaction containers stored in the first and second reaction container mounting frames and the presence or absence of the reaction containers in each position of the first and second reaction container mounting frames,

when the information stored in the storage unit matches the result of confirmation of the presence or absence of the reaction vessel in the first and second starting positions and the predetermined position, analysis is started from the predetermined position.

4. The automatic analyzer according to claim 1, wherein,

and a step of confirming whether or not a reaction vessel is present in a predetermined position other than the first starting position in the first reaction vessel mounting frame, and generating an alarm when the reaction vessel is not present in the predetermined position as a result of the confirmation.